Research on the Digital Economy,Technological Innovation,and Transformation and Upgrading of the Manufacturing Industry in Shandong Province

Based on panel data from 16 cities in Shandong Province from 2013 to 2022,and grounded in theoretical analysis,this paper constructs a benchmark regression model,a mediating effect model,and a heterogeneity test for empirical analysis.The results show that:(1)the digital economy has a significant positive effect on promoting the transformation and upgrading of the manufacturing industry in Shandong Province;(2)the digital economy can drive the transformation and upgrading of the manufacturing industry through technological innovation;and(3)the impact of the digital economy on the transformation and upgrading of the manufacturing industry in Shandong Province is evidently heterogeneous.

Pathway and Countermeasure of Farmers' Livelihood Transformation in the Ecological Development Area of Northern Guangdong Province from the Perspective of Ecological Protection

[Objectives]To explore pathways and countermeasures for transforming farmers livelihoods in the way of reducing their dependence on land while promoting sustainable development and alleviating ecological degradation.[Methods]A combination of field research,literature review,and policy analysis was employed to identify key factors affecting farmers livelihoods and potential strategies for transformation.[Results]The study found that developing ecological agriculture and modern agriculture,promoting agricultural transformation and upgrading,cultivating alternative industries,strengthening ecological engineering construction,and establishing diversified ecological compensation methods and supporting policies are effective strategies for transforming farmers livelihoods.[Conclusions]Implementing these strategies can help alleviate the contradiction between ecological protection and farmers livelihood development,promoting coordinated development of both.This approach not only benefits farmers but also contributes to sustainable environmental management and biodiversity conservation.

Landscape Upgrading and Transformation of Old Urban Parks from the Perspective of Place Attachment:A Case Study of Nanchang Bayi Park

On the basis of combing the relevant theories of place attachment, the planning framework of upgrading and reconstruction of old parks based on place attachment was put forward. Taking Nanchang Bayi Park as an example, the methods and key points of landscape improvement and transformation of old urban parks based on place attachment were explained to provide new ways and references for the renewal of old urban parks.

Megacity pathways in China under the dual carbon goal:The case of Shanghai

The pathways to achieving carbon neutrality at the city level are diverse due to varying energy supply and demand conditions.Shanghai faces obstacles such as limited land resources,high costs of renewable energy technologies,and instability of renewable energy.These challenges hinder the city’s efforts to achieve carbon peak and carbon neutrality(dual carbon).Therefore,Shanghai must identify and optimize its development path for renewable energy under the dual carbon goal.We employed the Low Emissions Analysis Platform Shanghai(LEAP-SH)model to simulate the impact of policies,such as industrial upgrading,energy efficiency improvement,energy structure optimization,increased technical innovation on energy,and ecological restoration,on the carbon emission pathways from 2022 to 2060 using five different scenarios.Our results indicate that Shanghai has the potential to achieve carbon neutrality in 2059 by promoting carbon reduction,pollution control,and green expansion.Moreover,we determined that the manufacturing industry;power generation industry;and transportation,storage,and mail services are the three major sectors for emission reduction under the dual carbon goal.Furthermore,the capacity and output of coal-fired power plants will be gradually replaced by offshore wind power in the dual carbon pathway.Finally,this study proposes countermeasures and suggestions for Shanghai to attain the dual carbon goal and high-quality development.

Cultivating New Agricultural Operators to Promote the Transformation and Upgrading of Traditional Agriculture——A Case Study of Nanchong City

In order to provide reference for cultivating new agricultural operators to promote the transformation and upgrading of traditional agriculture,the main practices,achievements and problems of cultivating new agricultural operators to promote the transformation and upgrading of traditional agriculture in Nanchong City,Sichuan Province were analyzed firstly,and then some measures were proposed.

Research on the transformation and upgrading of manufacturing industry based on the Intemet Plus

Along with the development oflntemet plus and information technology, the future industrial pattern will appear new change. The Internet represents a new economic model, and it uses the results of the development of the developed communication technology and the Internet platform with the existing various areas of known and unknown fields of social and economic to integration depth, giving full play to the advantages of integration, enhancing the innovation ability of the economic and the production adaptability, to create more new opportunities, thus forming a sustainable excellent ecosystem.

A Study on Foreign Trade Strategies from the Perspective of China’s Economic Transformation and Upgrading

Under the perspective of China’s economic transformation and upgrading,foreign trade is facing pressure from the transformation of internal economic capacity and external trade environment.It is urgent to explore new paths and directions,in order to realize the common evolution of the society,economy,system,and environment in China.From the rapid expansion of foreign trade in China towards high quality development,it is necessary to emphasize on the system,motivation,ability,and pattern;explore new development modes,change the development philosophy,delve into the connotation and characteristics of development,system supply,and organizational and technological innovation;as well as focus on cultivating a constant innovation drive,while capturing value and optimizing the foreign trade environment.

Economic feasibility and efficiency enhancement approaches for in situ upgrading of low-maturity organic-rich shale from an energy consumption ratio perspective

The technical feasibility of in situ upgrading technology to develop the enormous oil and gas resource potential in low-maturity shale is widely acknowledged.However,because of the large quantities of energy required to heat shale,its economic feasibility is still a matter of debate and has yet to be convincingly demonstrated quantitatively.Based on the energy conservation law,the energy acquisition of oil and gas generation and the energy consumption of organic matter cracking,shale heat-absorption,and surrounding rock heat dissipation during in situ heating were evaluated in this study.The energy consumption ratios for different conditions were determined,and the factors that influence them were analyzed.The results show that the energy consumption ratio increases rapidly with increasing total organic carbon(TOC)content.For oil-prone shales,the TOC content corresponding to an energy consumption ratio of 3 is approximately 4.2%.This indicates that shale with a high TOC content can be expected to reduce the project cost through large-scale operation,making the energy consumption ratio after consideration of the project cost greater than 1.In situ heating and upgrading technology can achieve economic benefits.The main methods for improving the economic feasibility by analyzing factors that influence the energy consumption ratio include the following:(1)exploring technologies that efficiently heat shale but reduce the heat dissipation of surrounding rocks,(2)exploring technologies for efficient transformation of organic matter into oil and gas,i.e.,exploring technologies with catalytic effects,or the capability to reduce in situ heating time,and(3)establishing a horizontal well deployment technology that comprehensively considers the energy consumption ratio,time cost,and engineering cost.

Opportunities and Challenges of Digital Development in Circulation under the Background of Rural Revitalization

The rural revitalization strategy aims to prioritize the development of agriculture and rural areas and promote the modernization of agriculture and rural areas.With the continuous advancement of the Fourth Industrial Revolution and breakthroughs in technologies such as artificial intelligence,big data,and blockchain,the traditional circulation industry is undergoing intelligent and digital transformation and upgrade.The digital development of agricultural product circulation will be a significant boost for the implementation of the rural revitalization strategy in the future.However,taking full advantage of the productive capacity of digitalized agricultural product circulation is currently accompanied by both opportunities and challenges.This article first analyzes the current status of digital development in circulation in China,provides a detailed analysis of the advantages and opportunities of digital circulation in the context of rural revitalization,and examines the shortcomings and challenges that may be faced behind these opportunities.Finally,the article proposes relevant policy recommendations to address the existing issues and promote the development of digitalized rural circulation.

Intelligent Transformation and Upgrading of Oil Refining & Petrochemical Industries in China:Investigation & Application

The oil refining and petrochemical industry in China has made great achievements after decades of development, and its capacity has already ranked second in the world. However, the refining industry is suffering some challenges, such as severe overcapacity at present, and has entered a new economic normal, in which the technological progress develops rapidly, the demand for green and low-carbon development is stricter, the market competition is increasingly fiercer and the profit margins are gradually narrowing. In such a situation, informatization and its new technologies are driving the significant reforming of manufacturing patterns, marketing patterns, management and decision-making patterns. Intelligent development is the inevitable choice for the transformation and upgrading of oil refining and petrochemical industry. It is suggested that the intelligent evaluating model and method should be adopted to enterprise’s intelligentializing transformation and upgrading by laying a solid foundation of digital refinery and implemenation of digital upgrading.

Open Park Transformation and Upgrading Means of Comprehensive Park: A Case Study of Xuzhou Quanshan Forest Park

The transformation and upgrading of comprehensive park can not be only limited to the adjustment for structure, function and landscape facility of comprehensive park itself, which shall be carried out as a whole. Viewing from the macroscopic perspective of city, comprehensive park is an important constituent part of urban green space system, and its transformation is an integral part of overall perfection and development of urban green space system. Park is an organic integrity comprising many elements. The transformation of comprehensive park shall be carried out as a whole and handled by using the methods of "from top to bottom" and "from bottom to top", thus adjusting the relationship between park and city and within park on the whole. This research takes the open park transformation and upgrading of Xuzhou Quanshan Forest Park as an example to introduce the key points of open park transformation from such aspects as of entrance space, overall space structure, service function expansion and spatial form optimization in expectation of having a certain reference value.

Labor Market Changes during Transformation and Upgrading of China's Three Major Special Economic Zones

Regional economic integration can enhance the overall strength and competitiveness of the zone. The Yangtze River Delta,the Pearl River Delta and the Beijing-Tianjin-Hebei economic circles are the top three zones with economic viability in China. With the development of the economy,these three zones all follow the modern " tertiary,secondary,primary" industrial structure,while the corresponding employment population structure lags behind to a certain extent. Besides,the three major special economic zones are the regions receiving most of the migrant population in China. The inflow of labor has played a double-edged role in local economic and social development. Through systematically comparing the labor market changes in transformation and upgrading of the three major special economic zones,the reform experience could be obtained: urbanization can promote urban employment,industrial agglomeration can attract different employment types,and labor market system reform can enhance labor coordination in the zone.

Luteolin affects the EMT transformation and cell biological behavior of osteosarcoma U2OS cells via the PI3K/AKT/NF-κB signaling pathway

Objective:To investigate the effect of luteolin on the Epithelial-mesenchymal transition(EMT)of osteosarcoma cell line U2OS and its molecular mechanism by regulating phosphoinositide 3-kinase/protein kinase B/nuclear factor-kappa B(PI3K/AKT/NF-κB)signaling pathway.Methods:U2OS cells were treated in different concentrations(10,20 and 40μmol/L)of luteolin.MTT was used to detect the effect of luteolin on the proliferation of osteosarcoma U2OS cells.Transwell chamber assay was used to detect the influence of luteolin on migration of U2OS cells.qPCR was used to detect the influence of luteolin on the mRNA expression of Bax,Bcl-2 and Caspase-2 in U2OS cells.Western blot was used to observe the change of p-PI3K,p-AKT,p-IKK and NF-κB proteins.Immunofluorescence was used to detect the influence of luteolin on the protein expression of E-cadherin and vimentim.Results:Luteolin inhibited significantly the proliferation of U2OS cells(P<0.05)in a time-concentration-dependent manner.Luteolin inhibited significantly the migration of U2OS cells(P<0.05).After treatment with luteolin,the mRNA expression of Bax and Caspase-2 was increased significantly(P<0.05),but Bcl-2 was reduced significantly(P<0.05)in U2OS cells.The protein expression of p-PI3K,p-AKT,p-IKK,NF-κB,E-cadherin and vimentin was decreased significantly(P<0.05).Conclusions:Luteolin inhibits the proliferation,migration and EMT transformation of osteosarcoma U2OS cells,which may be related to the inhibition of PI3K/AKT/NF-κB signaling pathway.

FORUM MECHANISM FACILITATING TRANSFORMATION AND UPGRADING OF CHINA-AFRICA COOPERATION

2018 is the ＂forum year＂ for China-Arica cooperation. The Forum on China-Africa Cooperation （hereinafter referred to as the forum） is a plat-form for collective dialogue and mechanism of practical cooperation jointly created by China and African countries at the turn of the century, with the aim of establishing a new type of China-Africa strategic partnership for long-term stability and mutual benefits in the 21st century The Chinese government＇s promotion of the strategic importance of relations with Africa is due to a variety of factors, the most important of which is the change in demand for Africa triggered by the sustained and rapid growth of China＇s economy against the backdrop of globalization. Thanks to the effective operation of the forum mechanism, China-Africa relations have shown a good trend of comprehensive and rapid development.

Effects of Ultrasonication on Genetic Transformation via the Pollen-Tube Pathway in Chinese Cabbage

[Objective] This research aimed to explore the method to increase conversion rate of pollen-tub pathway in Chinese cabbage.[Method] Chinese cabbage varieties Yuqing and No.03 were used as materials for the selection of germination buffer and parameters for ultrasonication.[Result] The optimal buffer for pollen germination of Chinese cabbage was 200 g/L sucrose ＋ 100 mg/L boric acid ＋ 200 mg/L calcium nitrate,the preferred ultrasonic processing power was 150 W,processing time was 5 s,interval time was 5 s and processing frequency was 8.Three T1-generation plants were obtained through selection with 200 mg/L kanamycin.[Conclusion] This research laid foundation for the further genetic transformation of Chinese cabbage.

Upgrading Pathways of Intelligent Manufacturing in China:Transitioning across Technological Paradigms

Intelligent technologies are leading to the next wave of industrial revolution in manufacturing.In developed economies,firms are embracing these advanced technologies following a sequential upgrading strategy-from digital manufacturing to smart manufacturing(digital-networked),and then to newgeneration intelligent manufacturing paradigms.However,Chinese firms face a different scenario.On the one hand,they have diverse technological bases that vary from low-end electrified machinery to leading-edge digital-network technologies;thus,they may not follow an identical upgrading pathway.On the other hand,Chinese firms aim to rapidly catch up and transition from technology followers to probable frontrunners;thus,the turbulences in the transitioning phase may trigger a precious opportunity for leapfrogging,if Chinese manufacturers can swiftly acquire domain expertise through the adoption of intelligent manufacturing technologies.This study addresses the following question by conducting multiple case studies:Can Chinese firms upgrade intelligent manufacturing through different pathways than the sequential one followed in developed economies?The data sources include semistructured interviews and archival data.This study finds that Chinese manufacturing firms have a variety of pathways to transition across the three technological paradigms of intelligent manufacturing in nonconsecutive ways.This finding implies that Chinese firms may strategize their own upgrading pathways toward intelligent manufacturing according to their capabilities and industrial specifics;furthermore,this finding can be extended to other catching-up economies.This paper provides a strategic roadmap as an explanatory guide to manufacturing firms,policymakers,and investors.

The transition from traditional banking to mobile internet finance:an organizational innovation perspective-a comparative study of Citibank and ICBC

The development of Financial Technology(FinTech)in areas such as mobile Internet,cloud computing,big data,search engines,and blockchain technology have significantly changed the financial industry.FinTech is expected to overturn the traditional banking business model,forcing banks to upgrade and transform.This study adopts a comparative case study method to contrast and analyze the Industrial and Commercial Bank of China(ICBC)and Citibank.It analyzes the strategies,organizations,HR systems,and product innovations adopted by these two banks in response to the impact of FinTech.This paper proposes an“electric vehicle”mode for ICBC and an“airplane mode”for Citibank.Further,it describes the difficulties encountered by the Chinese banking industry and proposes some feasible ways to upgrade.“Technology power”will become the core competitive concept for the financial institutions of the future.

The role of mechanical stretch and TGF-β2 in epithelial-mesenchymal transition of retinal pigment epithelial cells

AIM: To explore the effects and mechanisms of mechanical stress and transforming growth factor-beta2(TGF-β2) on epithelial-mesenchymal transition(EMT) in cultured human retinal pigment epithelial(RPE) cells. METHODS: Human RPE cells were inoculated on BioF ex 6-well plates and RPE cells received 0, 1, 2, 3, or 4 mild stretch injuries delivered 3h apart after 24h of culture. The device of mechanical stress parameters were set to sine wave, frequency 1 Hz, stretch strength 20%. For treatment with TGF-β2, when the inoculated RPE cells in 6-well plates were around 60% confluent, serum was reduced to 0 for 12h and recombinant human TGF-β2(0, 1, 5, 10 ng/mL)was added for 48h. α-SMA, Vimentin and N-Cadherin, fibronectin proteins expressions were detected by Western blotting, confocal cell immunofluorescence and quantitative real-time polymerase chain reaction(q RT-PCR). Then we detected the change of mi RNA-29b and ascertained the changes of phosphatidylinositol 3-kinase-serine threonine protein kinase(PI3K/Akt) pathway after RPE cells were stretched by the device of mechanical stress and induced by TGF-β2 by Western blotting, confocal cell immunofluorescence and qR T-PCR. RESULTS: Mechanical stress induce EMT and activate the PI3K/Akt pathway in ways that lead to the EMT process. TGF-β2 induce RPE cells EMT and in a certain range and TGF-β2 decrease the miR NA-29b expression in RPE cells, and the inhibitory effect is more obvious with the increase of TGF-β2 concentration. CONCLUSION: Our findings are crucial steps in determining the critical roles of the PI3K/Akt signaling pathway and mi RNA-29b in pathogenesis of proliferative vitreoretinopathy(PVR) which may be a potential target for preventing or treating PVR.

Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish

Zebrafish and human genomes are highly homologous;however,despite this genomic similarity,adult zebrafish can achieve neuronal proliferation,regeneration and functional restoration within 6–8 weeks after spinal cord injury,whereas humans cannot.To analyze differentially expressed zebrafish genes between axon-regenerated neurons and axon-non-regenerated neurons after spinal cord injury,and to explore the key genes and pathways of axonal regeneration after spinal cord injury,microarray GSE56842 was analyzed using the online tool,GEO2R,in the Gene Expression Omnibus database.Gene ontology and protein-protein interaction networks were used to analyze the identified differentially expressed genes.Finally,we screened for genes and pathways that may play a role in spinal cord injury repair in zebrafish and mammals.A total of 636 differentially expressed genes were obtained,including 255 up-regulated and 381 down-regulated differentially expressed genes in axon-regenerated neurons.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were also obtained.A protein-protein interaction network contained 480 node genes and 1976 node connections.We also obtained the 10 hub genes with the highest correlation and the two modules with the highest score.The results showed that spectrin may promote axonal regeneration after spinal cord injury in zebrafish.Transforming growth factor beta signaling may inhibit repair after spinal cord injury in zebrafish.Focal adhesion or tight junctions may play an important role in the migration and proliferation of some cells,such as Schwann cells or neural progenitor cells,after spinal cord injury in zebrafish.Bioinformatic analysis identified key candidate genes and pathways in axonal regeneration after spinal cord injury in zebrafish,providing targets for treatment of spinal cord injury in mammals.

Facile synthesis of Bi_(12)O_(17)Br_2 and Bi_4O_5Br_2 nanosheets:In situ DRIFTS investigation of photocatalytic NO oxidation conversion pathway

Bi12O17Br2and Bi4O5Br2visible‐light driven photocatalysts,were respectively fabricated by hydrothermal and room‐temperature deposition methods with the use of BiBr3and NaOH as precursors.Both Bi12O17Br2and Bi4O5Br2were composed of irregular nanosheets.The Bi4O5Br2nanosheets exhibited high and stable visible‐light photocatalytic efficiency for ppb‐level NO removal.The performance of Bi4O5Br2was markedly higher than that of the Bi12O17Br2nanosheets.The hydroxyl radical(?OH)was determined to be the main reactive oxygen species for the photo‐degradation processes of both Bi12O17Br2and Bi4O5Br2.However,in situ diffuse reflectance infrared Fourier transform spectroscopy analysis revealed that Bi12O17Br2and Bi4O5Br2featured different conversion pathways for visible light driven photocatalytic NO oxidation.The excellent photocatalytic activity of Bi4O5Br2resulted from a high surface area and large pore volumes,which facilitated the transport of reactants and intermediate products,and provided more active sites for photochemical reaction.Furthermore,the Bi4O5Br2nanosheets produced more?OH and presented stronger valence band holeoxidation.In addition,the oxygen atoms of NO could insert into oxygen‐vacancies of Bi4O5Br2,whichprovided more active sites for the reaction.This work gives insight into the photocatalytic pollutant‐degradation mechanism of bismuth oxyhalide.