Euler’s First-Order Explicit Method–Peridynamic Differential Operator for Solving Population Balance Equations of the Crystallization Process

Using Euler’s first-order explicit(EE)method and the peridynamic differential operator(PDDO)to discretize the time and internal crystal-size derivatives,respectively,the Euler’s first-order explicit method–peridynamic differential operator(EE–PDDO)was obtained for solving the one-dimensional population balance equation in crystallization.Four different conditions during crystallization were studied:size-independent growth,sizedependent growth in a batch process,nucleation and size-independent growth,and nucleation and size-dependent growth in a continuous process.The high accuracy of the EE–PDDO method was confirmed by comparing it with the numerical results obtained using the second-order upwind and HR-van methods.The method is characterized by non-oscillation and high accuracy,especially in the discontinuous and sharp crystal size distribution.The stability of the EE–PDDO method,choice of weight function in the PDDO method,and optimal time step are also discussed.

Distribution Pattern Scale of Natural Toona ciliata Population

In order to research the population distribution pattern of endangered species Toona ciliata Roem., the sampling quadrats of 5 mx5 m and 3 m×3 m in size, accurate to 1 mxl m, were established in 2 newly-found only existing T. cili- ata Roem. communities （T1 and T2） with contiguous grid quadrate method, in the Nanhe River valley, Gucheng County. By X2 test, t-test of distribution coefficient Cx method, and F test of Morisita pattern index Iδ whether the distribution patterns of the T. ciliata Roem. populations conformed to Poisson distribution were checked. The results indicated that, population T1 was in Poisson distribution under 5 m×5 m and 3 m×3 m in size by Cx and 16 methods, but in clumped distribution pattern un- der 5 m×5 m in size by the Chi-square test; however, the population was in Pois- son distribution under the dimension of 3 m×3 m. Population T2 under human dis- turbance had higher population density, indicating clumped distribution under 3 above-mentioned tests. If Chi-square test is satisfied, a distribution pattern is in Poisson distribution, and size and quantity of sampling quadrats should be given pri- ority to; and if df is greater, both theoretical values and observed values tend to- wards normal distribution more probably, and the test of distribution pattern, there- fore will be more dependable.

Review of chip-scale atomic clocks based on coherent population trapping

Research on chip-scale atomic clocks （CSACs） based on coherent population trapping （CPT） is reviewed. The back- ground and the inspiration for the research are described, including the important schemes proposed to improve the CPT signal quality, the selection of atoms and buffer gases, and the development of micro-cell fabrication. With regard to the re- liability, stability, and service life of the CSACs, the research regarding the sensitivity of the CPT resonance to temperature and laser power changes is also reviewed, as well as the CPT resonance＇s collision and light of frequency shifts. The first generation CSACs have already been developed but its characters are still far from our expectations. Our conclusion is that miniaturization and power reduction are the most important aspects calling for further research.

Role of Accessibility and Socio-Economic Variables in Modelling Population Change at Varying Scale

During past decades, effects of accessibility to growth have been considered extensively. In previous studies, however, matter of scale has been largely ignored. In this study, relevance of travel accessibility and essential socio-economic variables for explaining population change analysed with a multi-scalar study setting by the case of Finland. The analytical framework of the study relies on applied geographical information systems (GIS). Relationships between population change and explanatory variables were established with non-linear multiple regression, generalised additive models (GAMs). The data consist of population and socio-economic grid cell databases based on authentic records, transport network models, including complete digital road network database. Models were established at six resolutions between 2 km × 2 km and 24 km × 24 km. The main result is that the performance of the models, explaining and predicting population change, strongly relies on potential accessibility particularly at accurate resolutions. An important finding is also that it is possible to establish explain and predict population change tolerably at accurate resolutions and well at coarse resolutions, as the performance of models increases with scale.

Analysis and Study on Spatial Gravity Center of PM_(2.5) and Population Scale

With the rapid development of urbanization construction in China,population and industries are rapidly gathering in cities,bringing about economic development and also causing a large number of environmental problems,among which PM_(2.5) is the most concerned.In this paper,a spatial gravity center model was used to systematically analyze the spatiotemporal distribution characteristics of PM_(2.5) and population scale in China from 1999 to 2016.Conclusions were as below:(1)there were significant regional differences in PM_(2.5) pollution from 1999 to 2016,characterized by a spatial distribution of"high in the north and low in the south,and high in the inland and low in the coastal areas".(2)Nationwide,there was a significant spatial mismatch between the gravity center of PM_(2.5) pollution and the gravity center of population scale,with the two centers showing a trend of reverse dislocation development.

POPULATION EXPANSION IN CHINA'S METROPOLISES AND ITS SCALE-CONTROL

Metropolises are centers of politics, economy, culture and information, and also economic growth poles in comparatively large areas. After 1949, China’s urban structure have changed greatly, from original 'pyramid' shape into 'upside -down pyramid' shape, that is, more megalopolises and metropolises, fewer medium-sized and small cities. The most distinguishing feature of urban population growth was the remarkable increase of population in megalopolises and metropolises. The key reason for urban population expansion is to want to obtain the benefits of scale -agglomeration economy of metropolises. The number of urban functions directly determines the quality and quantity of urban population. Metropolises appeal not only agricultural population but also the population of medium-sized and small cities, which put much more population pressure on metropolises. The ideal goals of scale-control of metropolitan population are discussed in terms of economy, society and ecollogy. In order to control the

Population Pharmacokinetic Pharmacodynamic Modeling of Caffeine Using Visual Analogue Scales

Caffeine is a commonly ingested psychoactive substance which affects alertness and cognition. A clinical study was conducted to determine the effect of orally ingested caffeine on visual analogue scale (VAS) responses in healthy, moderate caffeine-consuming volunteers through the use of population pharmacokinetic-pharmacodynamic (PK-PD) modeling. Twelve subjects were recruited for a three-period cross-over study which utilized caffeine containing beverages. Each visit included 8-hour blood plasma and VAS response collection for PK and PD assessment respectively. The VAS used in the study, also called the caffeine analog scale, has been previously validated for caffeine. Population PK-PD modeling was conducted with NONMEM 7.2. Simultaneous and sequential modeling of PK-PD was attempted. Final model selection was based on parameter estimate precision, diagnostic plots, and visual predictive check (VPC) plots. Results showed that a one-compartment open model with first-order absorption and elimination best described the pharmacokinetics of caffeine. Sequential PK-PD modeling was successful and an effect compartment model with linear slope and baseline parameter best described caffeine pharmacodynamics. Diagnostic plots showed no major bias and VPC plots showed agreement between observations and predictions. The model was able to link VAS responses to caffeine concentration in healthy volunteers and may be useful in clinical trial simulations and design.

Allozyme Diversity and Population Genetic Structure of Three Medicinal Epimedium Species from Hubei

Three Epimedium species, E. pubescens Maxim., E. sagittatum （Sieb. ＆ Zucc.） Maxim., and E. wushanense T. S. Ying, which are sympatrically distributed in the western Hubei Province, have been used in traditional Chinese medicine （TCM） for about 2,000 years. Genetic variability and population genetic structure of 11 natural populations of these Epimedium species were investigated using isoelectric focusing in thin-layer polyacrylamide slab gels. Of the 22 enzyme systems prescreened, six coding for 13 loci and 45 alleles were resolved, which were used for analyzing genetic diversity and population structure at both intraspecific and interspecific levels. The results showed that： l） high levels of genetic diversity were observed in all three species （A = 2.6-3.2, P = 69.2%-84.6%, Ho= 0.274-0.377, HE= 0.282-0.369）, which were higher than that of other herbaceous and aulmal-pollinated species with similar life-history characteristics; 2） there was significant deviation from Hardy-Weinberg Equilibrium, with one half of the loci showing heterozygote excess and the other homozygote excess, in all populations, suggesting the complicated breeding system of Epimedium species; 3） the low level of intraspecific and interspecific genetic differentiation （GST= 0.0246-0.0409 and 0.0495-0.1213, respectively） indicated a high level of gene flow among populations and close genetic relationship among the three species; and 4） UPGMA cluster analysis further showed that E. pubescens was more closely related to E. sagittatum than to E. wushanense, which was in good agreement with the morphological characters and the recent phylogenetic analysis of these species. On the basis of these results, it was concluded that the mixed breeding system, long-lived perennial life form, ancient evolutionary history, and seed dispersal by ants in Epimedium are responsible for the genetic variation and population structure of these species.

Comparative Analysis of Improving Effects of 12 Maize Populations with Improved S_1 Selection Method

ln this study, 12 maize populations were improved with the improved S1 selection method, aiming to increase the improvement efficiency of maize popula-tions. The results showed that number of rows per spike, number of grains per row and 100-grain weight were the three important component traits of maize yield. The highest genetic increment was found in Mengqun 2, fol owed by Mengqun 4, Mengqun 1 and other 7 maize populations. Negative genetic increment was shown in Mengqun 3 and 3 introduced foreign maize populations. Some changes were shown in spikes, plant traits and genetic diversity of maize populations. Based on our results, we concluded that Mengqun 2, Mengqun 4, Zhongzong 7, Mengqun C and Mengqun A could be directly used for the line breeding by selfing for their higher genetic increment of yield and better improvement effects of other agricultural traits. Compared with these 5 populations, the improvement potential of other maize populations was limited for their lower genetic increment.

Character and Causes of Population Distribution in Shenyang City,China

Character of population distribution is one of the focuses studied by urban geography. Using the fifth national census data as basic data and using areal interpolation method, this paper analyzes character of urban population dis- tribution of Shenyang City, Northeast China, in terms of three aspects of statistical character, spatial auto-correlation and spatial structure. Furthermore, this research analyzes the factors affecting the population distribution of the city. The main conclusions include: 1) There is an obvious structure character of population distribution in the grid with a grain of 300m, which is appropriate scale when researching population distribution in Shenyang City. 2) Urban population dis- tribution has the character of assembling while population density distribution takes on variability in Shenyang City. 3) Population density distribution shows spatial auto-correlation within 7.36km. Spatial heterogeneity of population density is low. 4) Urban center, population distribution barycenter and population density maximum points separate each other. Population density distribution has multi-cores character. 5) Layout of governments, primary schools, middle schools, colleges, hospitals and marketplaces affects population distribution directly. With the increase of distance to these factors, population density decreases as logarithm.

Spatial Distribution Pattern of Populations of Isoetes sinensis Palmer, an Endangered Quillwort in China

The distribution pattern of Isoetes sinensis populations was investigated in relation to its biological characteristics such as age structure and regeneration mode, and the microenvironment. Contagious distribution pattern was found in populations of all sizes. Under the same climatic and site conditions, the heterogeneity of mieroenvironment resulting from the different depths of water and soil erosion significantly affecred the type and scale of distribution patterns of Isoetes sinensis populations. Even at the same site, the center and the edges of the water body had different effects on the distribution pattern of the plants. As one of the co-dominants, the distribution of Isoetes sinensis in communities was affected by other dominant species, especially by the evergreen grass species. Water is the major factor determining the distribution pattern of lsoetes sinensis in various communities. The pattern of contagious distribution was observed in different size of populations of I.sinensis, however the Lloyd indices obtained for the populations of various sizes differed significantly.

Comparisons of Three Recurrent Selection Methods in the Improvement of Maize Populations

The maize population Csyn 4 was improved for three cycles with three recurrent selection methods MS1, MS1-HS, and MHSRRS in northern China. A total of 40 NC Ⅱ testcrosses were made by four testers with Csyn 4 and 10 improved populations, which were evaluated in four environments in the cropping season of 2005. Analysis of variance indicated a significant progress （P〈 0.05） in yield and other chief agronomic traits in the improved populations and testcrosses, demonstrating that the three recurrent selection methods were effective for increasing grain yield of testcrosses and improvement of general combining ability in maize population. The average grain yield increase of population Csyn 4 in MS1, MS1-HS, and MHSRRS recurrent selections was 266.7 kg ha^-1 （5.3%）, 288.0 kg ha^-1 （5.7%）, and 231.3 kg ha^-1 （4.6%） per cycle, while the grain yield of S 1 progeny of population for Csyn 4 was increased by 420.0 kg ha^-1 （10.9%）, 376.0 kg ha^-1 （9.8%）, and 414.7 kg ha^-1 （10.8%） per cycle in MS1, MS1-HS, and MHSRRS recurrent selections, respectively. Linear responses （b） in the MS1, MS1-HS, and MHSRRS recurrent selections were the same as the realized responses of the selection （G） for grain yield increase of Csyn 4 and S1 progeny of the populations. The grain yield of testcrosses increased by 3.3-5.2% on average per cycle. The value of heterosis did not display any differences amongst the different cycles of selections. The GCA for yield component traits of population Csyn 4 was improved significantly by means of three selection methods, whereas the GCA for plant height, ear height, days to silking, and days to pollen did not show significant increase in the recurrent selections. GCA for the number of tassel branches were decreased in the selections, while GCA for the number of plant leaves were increased, but the difference was not significant.

Safety and Efficacy of a Proprietary Undenatured Beta-Glucan on Different Human Populations

After proving safety in animal and human models, a series of clinical trials were conducted to examine the administration of 1 mg/mL bid of an undenatured beta-glucan on the immune system;and on self-perceived effects on subjects’ quality of life (QoL) using a Visual Analogue Scale (VAS). In one study, a subject population that was self-perceived to be fatigued was administered an undetaured beta-glucan, to determine if this supplementation affected their quality-of-life as a result of an increased immune system response. 44 subjects were administered 1 mg/mL bid of the undenatured beta-glucan (Lentinex®) for four weeks. Prior to the beginning of the administration, and following the four-week administration period, the subjects were asked to fill out a quality-of-life VAS questionnaire. The changes in the two questionnaires revealed differences that occurred as a result of the beta-glucan administration. More than 75% of the subjects scored “better” (more than 1 cm on the VAS) with regard to feeling in a good mood, and feeling rested. More than 60% increased their energy and reduced their tiredness and exhaustion, and 70% felt less stressed. In a second study, subjects aged 40 years and older, believed to be in good general health, seeking therapy for tiredness/exhaustion/fatigue or similar conditions (neurasthenia) which were administered 1 mg/mL bid Lentinex®. The overall results indicated that the subjects felt significantly better (mean VAS = 5.91) after the last week of the study compared to how they felt initially (VAS = 4.73) (p < 0.0001). A statistically significant (p < 0.0001) change in distribution favoring a better situation after 4 weeks intake of supplement, with a remarkable fall in number of subjects scoring below normal (from 61.4% to 18.2%) accompanied by a significant shift in subjects feeling above normal, from 9.2% to 50.0%. These clinical studies, and others, showed that Lentinex® administration improved the perceived quality-of-life of subjects whose immune system was probably not functioning at optimal levels.

Hu Huanyong:Father of China's Population Geography

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A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet's disease in a Chinese Han population

AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han population.METHODS:A total of eight SNPs in the candidate gene region(rs11792633,rs7025417,rs10975519 and rs1048274 in IL33;rs2310220,rs12712142,rs13424006 and rs3821204 in IL1RL1)were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array i PLEX platform.RESULTS:A statistically significant association was observed between IL1RL1 rs12712142 and BD patients.The frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls(OR=0.8,95%CI:0.69-0.94,Pc=0.039);the genotype distribution(Pc=0.043)and additive and dominant genetic model analyses(OR=0.8,95%CI:0.69-0.94,Pc=0.040 and OR=0.72,95%CI:0.58-0.88,Pc=0.011)also indicated a strong association between rs12712142 and BD patients.CONCLUSION:This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population,indicating a protective role of IL1RL1 in the pathogenesis of BD.

SLC26A4 gene polymorphism and late-onset Alzheimer’s disease in a Han Chinese population from Qingdao,China

In a recent genome-wide association study, the SLC26A4 gene rs2072064 polymorphism was found to be associated with late-onset Alzheimer＇s disease in Caucasians. Here, we investigated this association in a large Northern Han Chinese cohort consisting of 599 sporadic late-onset Alzheimer＇s disease patients and 598 healthy controls matched for sex and age in a Northern Han Chinese population from Qingdao, China. Genotyping by the polymerase chain reaction-ligase detection reaction revealed that there were significant differences in the genotype （P = 0.017） and allele （P = 0.007） frequencies of the rs2072064 polymorphism between late-onset Alzheimer＇s disease patients and controls. The A allele of this polymorphism was significantly associated with a reduced risk of late-onset Alzheimer＇s disease （odds ratio （OR） = 0.792, 95% confidence interval （CI） = 0.670-0.937, P = 0.007）. When the data were stratified by the apolipoprotein E E4 status, there was a significant difference only among apolipoprotein E E4 non-carriers （genotypic P = 0.001, allelic P = 0.001）. Furthermore, the association between rs2072064 and late-onset Alzheimer＇s disease remained significant by logistic regression analysis after adjustment for age, gender, and the apolipoprotein E E4 carrier status （dominant model： OR = 0.787, 95% CI = 0.619-1.000, P = 0.050; recessive model： OR = 0.655, 95% CI = 0.448-0.959, P= 0.030; additive model： OR = 0.792, 95% CI = 0.661-0.950, P = 0.012）. These findings suggest that SLC26A4 is a susceptibility gene for late-onset Alzheimer＇s disease in a Northern Han Chinese population from the Qingdao area.

China’s Tibetan Population and Population in Tibet

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GROWTH, REPRODUCTION & POPULATION STRUCTURE OF THE FRESHWATER CRAB SINOPOTAMON YANG TSEKIENSE BOTT, 1967, FROM ZHEJIANG, CHINA

Monthly investigatiom were made on the population of Chinese freshwater crab, Sinopotamon yangteskiense Bott, 1967 from April, 1984 to Match, 1985. The data on 4413 specimens show that the growth was affected mainly by temperature. During the April to November growth period, the crabs’ major development occured from June through October. One year was required for a fine white oocyte to develop into a mature egg. The reproduction period was June-October. Females bearing eggs were taken from June-August, and crabs with young were found from July-October. The females reproduced once a year but could for more than one year. The number of eggs carried by a female varied greatly according to the size of the crab, ranging from 30 to 100 eggs. New-bom crabs become mature after 1-2 yeats. The sex ratio was approximately 1:1 in the overall population. However, the larger crabs are predominantly male. The age distribution of S. yangtsekinese was estimated from size frequency histograms. There were more adult

Fair Plan 8: Earth’s Climate Future—Pope Francis’ Population Mistake

Pope Francis wrote in his Encyclical Letter Laudato Si’: On Care for Our Common Home: “Instead of resolving the problems of the poor and thinking of how the world can be different, some can only propose a reduction in the birth rate.” … “To blame population growth instead of extreme and selective consumerism on the part of some is one way of refusing to face the issues.” Here, we test the hypothesis that population size does not matter. We do so in terms of the effect of the size of the human population on its emission of greenhouse gases. We find that the hypothesis is false = PO-PULATION MATTERS. Ceteris paribus, the larger the population of human beings on Planet Earth, the more difficult it will be to reduce, and finally eliminate, the emission of greenhouse gases by humanity and, thereby, constrain human-caused climate change = Anthropogenic Global Warming.

Sand-dust Storm, Population and Environment in Northwest China

Sand-dust storms are the result of the integrated influences of climate, geography, society and human factors. A theoretical framework is built to explain the coherence of population growth, agriculture change and environmental degradation. On the basis of the analysis of the causes of the sand-dust storm in terms of human factors, a discussion will be given to show that these factors are internally consistent with the theoretical framework. After that, it will look at China's Agenda 21 and try to find relevant measures to reduce such large sand-dust storms happening in Northwest China and eventually make this area develop sustainably.