Impact of Water-Sediment Regulation on Variations of Amino Acids in the Middle-Lower Yellow River, China

In order to examine the impacts of water-sediment regulation on regional carbon cycling,we collected water,particulate and sediment samples from the middle-lower Yellow River in late June and early July,2015 and analyzed their specific amino acids(AA),DOC,POC,and bacteria abundance.Summarized by 14 specific AA,the total hydrolysable AA(THAA),particulate AA(PAA),and sediment AA(SAA)varied in ranges of 2.29-9.05μmol L^-1,5.22-22.96μmol L^-1,and 81.7-137.19μg g^-1 dry weight.After the regulation,dissolved free AA(DFAA)decreased by 29%while DCAA increased by 72%.These variations suggested that DFAA were further degraded,while DCAA molecules were further activated.Meanwhile,PAA increased almost 4 times as many as those before regulation,and SAA increased as well.After regulation,the amounts of bioactive amino acids(Asp,Glu and Gly)increased in THAA but decreased in PAA,with little changes in SAA.The ratios of Asp/Gly in different phases increased after regulation,indicating the AA contributions were promoted by calcareous organisms rather than by siliceous organisms.Multiple correlation analysis showed that PAA was primary representatives of AA and organic carbon,followed by DCAA and POC.Moreover,bacterial reproduction played a key role in shaping the AA compositions and properties,followed by the redox condition and acid-base balance.The results of this study provided a clear evidence for the effects of water-sediment regulation on regional biogeochemistry of organic carbon in the middle-lower Yellow River.

AN ANALYSIS OF THE POLICY－MAKING IN REGULATING THE INDUSTRIAL STRUCTURE AND DISTRIBUTION IN TRADITIONAL INDUSTRIAL BASE IN MIDDLE LIAONING PROVINCE

Vigorous development of old industrial bases is one of the decisive strategies accomplishing the industrial modemizatinn in China. From a new viewpoint, thetraditional economic-geographical factors such as structure of mine resources, economic and technical base, and natural environment, and new factors such as evolution of industrial structure,the change of macro-regional and-industrial policies, reform of economic system and management and transform of industrial organization arecomprehensively studied and analyzed. The conditions to regulate industrial structureand distribution in old industrial bases are evaluated. The Program for regulating industrial structure and distribution of old heaVy industrial base in middle Liaoning Provinceincluding five cities of Shenyang, Anshan, Fushun, Benxi and Liaoyang is Put forward,which is accepted by the Territorial Planning of Liaoning Province worked out from1988 to 1990. With the aid of the analySis of hierarchical process (AHP), the Program isexamined and evidenced.

Psychosocial Factors Affecting the Use of Mammography Testing for Breast Cancer Susceptibility: An Eight-Month Follow-Up Study in a Middle-Aged Japanese Woman Sample

We examined the psychosocial factors affecting middle-aged Japanese women’s intentions to undergo mammography, as well as their actual usage of mammography by applying the Parallel Processing Model (PPM) of self regulation longitudinally. A total of 1030 middle-aged women living in all parts of Japan participated in this study through internet research from September 2010 to May 2011. The participants were evaluated on the basis of a battery of questionnaires mainly including demographics, perceived breast cancer risk, worry about breast cancer, mammography testing beliefs, intentions to use mammography, seeking information about mammography, and actual usage of mammography thrice over an eight-month period. The main results were as follows: 1) Perceived risk and cancer worry affected the intention of undergoing mammography, and this effect was mediated by beliefs about mammography testing. 2) Intention to use mammography and past mammography usage predicted future usage of mammography, with past mammography usage being the strongest predictor. 3) Information seeking about mammography was the strongest predictor of using mammography during the eight-month follow-up period of middle-aged women who had not undergone any mammography testing. PPM was a useful model to explain the mechanism behind middle-aged Japanese women’s intentions to use mammography, as well as their actual usage of mammography. In addition, past mammography experience was the strongest predictor of regular mammography usage and information seeking was a critical factor for the first-usage of mammography.

Expression of vascular endothelial growth factor and its role in oncogenesis of human gastric carcinoma

AIM: To establish the role of vascular endothelial growth factor (VEGF) in the oncogenesis of human gastric carcinoma more directly. METHODS: The expression of VEGF and its receptor kinase-domain insert containing receptor (KDR) in human gastric cancer tissue were observed by immunohistochemical staining. VEGF levels were manipulated in human gastric cancer cell using eukaryotic expression constructs designed to express the complete VEGF(165) complimentary DNA in either the sense or antisense orientation. The biological changes of the cells were observed in which VEGF was up-regulated or down-regulated. RESULTS: VEGF-positive rate was 50%, and VEGF was mainly localized in the cytoplasm and membrane of the tumor cells, while KDR was mainly located in the membrane of vascular endothelial cells in gastric cancer tissues and peri-cancerous tissue. In 2 cases of 50 specimens, the gastric cancer cells expressed KDR, localized in both the cytoplasm and membrane. Introduction of VEGF(165) antisense into human gastric cancer cells (SGC-7901, immunofluorescence intensity, 31.6%)) resulted in a significant reduction in VEGF-specific messenger RNA and total and cell surface VEGF protein (immunofluorescence intensity, 8.9%) (P【0.05). Conversely, stable integration of VEGF(165) in the sense orientation resulted in an increase in cellular and cell surface VEGF (immunofluorescence intensity, 75.4%) (P【0.05). Lowered VEGF levels were associated with a marked decrease in the growth of nude mouse xenografted tumor (at 33 days postimplantation, tumor volume: 345.40 +/- 136.31 mm3)(P【0.05 vs control SGC-7901 group: 1534.40 +/- 362.88 mm3), whereas up-regulation of VEGF resulted in increased xenografted tumor size (at 33 days postimplantation, tumor volume: 2350.50 +/- 637.70 mm3) (P【0.05 vs control SGC-7901 group). CONCLUSION: This study provides direct evidence that VEGF plays an important role in the oncogenesis of human gastric cancer.

Flood risk control of dams and dykes in middle reach of Huaihe River

Three stochastic mathematical models for calculation of the reservoir flood regulation process, river course flood release, and flood risk rate under flood control were established based on the theory of stochastic differential equations and features of flood control systems in the middle reach of the Huaihe River from Xixian to the Bengbu floodgate, comprehensively considering uncertain factors of hydrology, hydraulics, and engineering control. They were used to calculate the flood risk rate with flood regulation of five key reservoirs, including the Meishan, Xianghongdian, Nianyushan, Mozitan, and Foziling reservoirs in the middle reach of the Huaihe River under different flood frequencies, the flood risk rate with river course flood release under design and check floods for the trunk of the Huaihe River in conjunction with relevant flood storage areas, and the flood risk rate with operation of the Linhuaigang Project under design and check floods. The calculated results show that （l） the five reservoirs can withstand design floods, but the Xianghongdian and Foziling reservoirs will suffer overtopping accidents under check floods; （2） considering the service of flood storage areas under the design flood conditions of the Huaihe River, the mean flood risk rate with flood regulation of dykes and dams from Xixian to the Bengbu floodgate is about 0.2, and the trunk of the Huaihe River can generally withstand design floods; and （3） under a check flood with the flood return period of 1 000 years, the risk rate of overtopping accidents of the Linhuaigang Project is not larger than 0.15, indicating that it has a high flood regulation capacity. Through regulation and application of the flood control system of the Linhuigang Project, the Huaihe River Basin can withstand large floods, and the safety of the protected area can be ensured.

Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology

INTRODUCTIONThe mechanism that DNA hypomethylation leads toactivation of oncogene and occurrence of malignantneoplasm is being increasingly recognized byresearchers. Normal DNA methylation playsimportant role in stabilizing the phenotype of cell.DNA methylation status reduction and/or patternalteration are related to activation and abnormallyhigh expression of some oncogenes and cellularmalignancy[1-6]. c-fms oncogene encodes for colonystimulating factor 1 receptor (CSF-1R)[7], c-fms/CSF-1R was highly expressed in hepatocellularcarcinoma (HCC) tissue, but the mechanismremained obscure[8,9].

Impact of endoscopically minimal involvement on IL-8 mRNA expression in esophageal mucosa of patients with non-erosive reflux disease

AIM:Little has been known about the pathogenesis of non- erosive reflux disease(NERD).Recent studies have implicated interleukin 8(IL-8)in the development and progression of gastroesophgeal reflux disease(GERD).The purpose of this study was to determine IL-8 RNA expression levels in NERD patients with or without subtle mucosal changes. METHODS:We studied 26 patients with NERD and 13 asymptomatic controls.Biopsy sample was taken from the esophagus 3 cm above the gastroesophageal junction and snap frozen for measurement of IL-8 mRNA levels by real-time quantitative polymerase chain reaction(PCR).We also examined mRNA expression of IL-8 receptors,CXCR-1 and -2 by reverse transcriptase PCR.The patients were endoscopically classified into grade M(mucosal color changes without visible mucosal break)and N(neither minimal involvement nor mucosal break)of the modified Los Angeles classification. RESULTS:The relative IL-8 mRNA expression levels were significantly higher in esophageal mucosa of NERD patients than those in esophageal mucosa of the controls.There was a significant difference in IL-8 mRNA levels between grades M and N.The CXCR-1 and -2 mRNAs were constitutively expressed in esophageal mucosa.CONCLUSION: Our results suggest that high IL-8 levels in esophageal mucosa may be involved in the pathogenesis of NERD through interaction with its receptors. NERD seems to be composed of a heterogeneous population in terms of not only endoscopically minimal involvement but also immune and inflammatory processes.

Influence of Ren and Du meridian electro-acupuncture on neural stem cell proliferation and extracellular signal-regulated kinase pathway in a rat model of focal cerebral ischemia injury

BACKGROUND： Studies have shown that electro-acupuncture at the Ren meridian could improve proliferation of subventricular zone neural stem cells in cerebral-ischemic rats. However, there are few reports on the influence of electro-acupuncture at the Du meridian on neural stem cell proliferation. OBJECTIVE： To observe the influence of electro-acupuncture at Ren and Du meridians on neural stem cell proliferation in the subventricular zone and altered signal transduction in cerebral ischemia rats. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Laboratory of Human Anatomy, Medical College of Sun Yat-sen University from May 2006 to February 2008. MATERIALS： Mouse anti-rat bromodeoxyuridine （BrdU） monoclonal antibody was provided by Sigma, USA; mouse anti-rat nestin monoclonal antibody and extracellular signal-regulated protein kinase （ERK） specific inhibitor PD98059 were provided by Calbiochem, Germany; acupuncture needle was provided by Suzhou Acupuncture Supplies, China. METHODS： A total of 126 rats were randomly assigned to four groups： model （n = 36）, Du meridian （n = 36）, Ren/Du meridian （n = 36）, and Ren/Du meridian ＋ PD98059 （n = 18）. Rats in the Ren/Du meridian ＋ PD98059 group were observed on days 7 （n = 6） and 14 （n = 12） after cerebral ischemia injury. Rats in the model, Du meridian, and Ren/Du meridian groups were observed on days 7, 14, and 28 after cerebral ischemia injury, with 12 rats per group at each time point. Thread occlusion was used to establish middle cerebral artery occlusion models. Electro-acupuncture was performed at Renzhong （DU 26） and Baihui （DU 20） acupoints in the Du meridian group, as well as Chengjiang （RN 24）, Guanyuan （RN 4）, Renzhong, and Baihuiacupoints in the Ren/Du meridian and Ren/Du meridian ＋ PD98059 groups 2 days after model establishment. In addition, electro-acupuncture stimulation with disperse-dense waves was performed, with 30 Hz disperse wave, 100 Hz dense wave, and 5 V intensity for 20 minutes. Rats in the Ren/Du meridian ＋ PD98059 group were treated with 0.2 pg PD98059 injection into the subventricular zone, 2 pL per rat. Rats in the model group were not treated with electro-acupuncture. MAIN OUTCOME MEASURES： BrdU/nestin immunofluorescent staining was used to detect proliferating neural stem cells in the subventricular zone of cerebral ischemia rats; Western blot was used to determine phosphorylated ERK1 and 2 （pERK1/2） expression in the subventricular zone. RESULTS： On days 14 and 28 after cerebral ischemia, there were significantly more BrdU-positive and BrdU/nestin-positive cells in the Ren/Du meridian group compared with the Du meridian group （P 〈 0.05）. PD98059 decreased the number of BrdU-positive and BrdU/nestin-positive cells induced by electro-acupuncture at the/：ten and Du meridians （P 〈 0.05）. On days 7, 14, and 28 after treatment, pERK1/2 expression was significantly greater in the Du meridian and Ren/Du meridian groups compared with the model group （P 〈 0.05）. The promoting effect of electro-acupuncture at Ren and Du meridians on ERK1/2 phosphorylation was superior to electro-acupuncture at the Du meridian alone on day 14 after model induction （P 〈 0.05）. However, PD98059 completely abolished the promoting effect of electro-acupuncture at Ren/Du meridians on pERK1/2 expression （P 〈 0.05）. CONCLUSION： Electro-acupuncture at Ren and Du meridians increased proliferation of subventricular zone neural stem cells, which was related to activation of the ERK pathway in a rat model of cerebral ischemia injury.

Down-regulation of PTH/PTHrP receptor in the kidney of patients with renal impairment

OBJECTIVE: To investigate whether the down-regulation of renal parathyroid hormone/parathyroid hormone related protein (PTH/PTHrP) receptor messenger ribonucleic acid (mRNA) expression is a general phenomenon in patients with different stages of renal disease, besides chronic renal failure. METHODS: Twenty-five patients were divided into the following groups: (1) chronic glomerulonephritis with normal renal function (GNN) (2) chronic glomerulonephritis with moderate renal insufficiency (GNI) (3) severe chronic renal failure undergoing maintenance dialysis (CRF) (4) acute renal failure during oliguric phase (ARF) (5) normal control without renal suffering (NC). Using relatively quantitative reverse transcription/polymerase chain reaction (RT/PCR) method, we investigated PTH/PTHrP receptor mRNA expression in renal specimens obtained through biopsy or operation. The levels of plasma C-terminal PTH, serum phosphorus and calcium were also observed at the same time. RESULTS: Plasma C-terminal PTH levels in GNI, CRF and ARF patients were 1.90, 9.73 and 8.63 times higher than those in NC. However, the difference between GNN and NC was insignificant. CRF and ARF patients also presented obviously elevated serum phosphorus (1.61, 1.86 vs 1.14 mmol/L) and reduced serum calcium (1.82, 1.71 vs 2.26 mmol/L) compared with that in the control. These two parameters for GNN and GNI patients were normal. The levels of PTH/PTHrP receptor mRNA (corrected by beta-actin mRNA) in the kidney of GNN, GNI, CRF and ARF patients was markedly decreased by up to 35.7%, 68.5%, 77.9% and 92.2%, respectively. CONCLUSIONS: The down-regulation of renal PTH/PTHrP receptor mRNA occurs much earlier than the changes of renal function, plasma PTH, serum phosphorus and calcium in the course of human renal disease.

A clinical trial of active immunotherapy with anti-idiotypic vaccine in nasopharyngeal carcinoma patients

OBJECTIVE: To investigate the effect of active immunotherapy with anti-idiotypic vaccine in patients with nasopharyngeal carcinoma (NPC). METHODS: Anti-idiotypic antibodies (2H4/5D3) bearing the internal image of the NPC antigen were used in active immunotherapy in NPC patients receiving radiotherapy. Antibodies and cytokine levels in patient sera were determined using ELISA before and after active immunotherapy. IL-2 mRNA expression in the peripheral blood mononuclear cells (PBMC) was measured by in situ hybridization. RESULTS: Nineteen patients with NPC at stage IV were treated with alum-precipitated 2H4 or 5D3. Neither hypersensitivity nor adverse side effects were observed. The levels of anti-anti-idiotypic antibodies (Ab3) and anti-NPC antibodies (Ab1') were increased. Human anti-mouse antibodies (HAMA) were seen in 19 patients of the experimental group; the levels of Ab1' did not increase in the control group. Serum IL-2, IFN-gamma and TNF-alpha levels were increased in most patients in the experimental group, while no differences were observed in Ab1' and cytokine levels between pre- and post-therapy in the control group. In addition, IL-2 mRNA expression in PBMCs from NPC patients was closely related to serum IL-2 (r = + 0.8829) levels by in situ hybridization. CONCLUSIONS: Anti-idiotype vaccine is safe for clinical active immunotherapy. Anti-idiotypic vaccine might be able to enhance humoral and/or cellular immunity in NPC patients receiving radiotherapy.

生态调度控制汉江中游入侵沉水植物过度生长效果研究

针对汉江中游江段入侵沉水植物伊乐藻(Elodea nuttallii)过度生长的问题,以2019年调查监测为基础,采用生物量、分布面积、流速、流量等指标,于2020-2021年在汉江丹江口水库联合王甫洲水利枢纽开展了控制伊乐藻过度生长的生态调度试验并评估其生态效果。结果表明:(1)丹江口−王甫洲区间适宜入侵沉水植物伊乐藻生长的水域面积达16.8 km^(2),主要分布在坝前两岸浅水区、泄水闸上游洲滩、水岸新城、中洲岛、木排港、羊皮滩等区域;(2)生态调度的控制效果显著,伊乐藻生物量和分布面积呈逐年减少趋势,其年度峰值生物量变化与春季萌发期1-3月流量极值比(r=-0.997)和生长旺盛期4−8月平均流量(r=-0.963)的相关系数均大于0.9,与全年平均流量(r=-0.748)和4−8月平均水温(r=0.732)的相关系数大于0.7,流量(流速)和水温是影响伊乐藻生物量的关键因子;(3)根据王甫洲坝前漂浮伊乐藻日打捞量与入库流量统计,可以对伊乐藻成熟团聚体产生明显冲刷影响的王甫洲入库流量(即丹江口水库下泄流量)条件为不小于1500m^(3)/s;丹江口水库峰值流量为3500m^(3)/s的单次汛期调度过程,可减少研究区间内约40%的伊乐藻生物量。

孔立从“三焦理论”论治脓毒症心肾综合征

孔立教授认为“三焦功能紊乱”是脓毒症心肾综合征的根本病机,上、中、下三焦部位相连,功能互用,脓毒症心肾综合征主要病位在上、下二焦,中焦既是因上下二焦而受累,又可致上下二焦功能失调。孔立教授提出从“三焦理论”论治脓毒症诱发的心肾综合征,认为在治疗脓毒症的基础上,应以通下焦利小便为先,调上焦复心肺之能为要,强调护中焦调胃气贯穿治疗始终。

附子理中汤联合骨髓间充质干细胞调控变应性鼻炎大鼠鼻黏膜T-bet和GATA3 mRNA表达的研究

目的研究附子理中汤联合骨髓间充质干细胞(MSCs)对变应性鼻炎大鼠鼻黏膜T盒转录因子(T-bet)、锌指蛋白3(GATA3)mRNA表达的影响。方法将40只雄性SD大鼠随机分为5组,每组8只。对照组大鼠不造模、不干预;模型组、MSCs组、附子理中汤组、附子理中汤+MSCs组大鼠均进行变应性鼻炎造模,其中模型组造模后不治疗,MSCs组造模后给予骨髓MSCs尾静脉注射1次,附子理中汤组造模后给予附子理中汤连续灌胃14 d,附子理中汤+MSCs组造模后给予骨髓MSCs尾静脉注射1次和附子理中汤连续灌胃14 d。比较各组大鼠干预前后的行为学积分;干预结束后ELISA法检测鼻腔灌洗液中白细胞介素-4(IL-4)、白细胞介素-13(IL-13)、干扰素-γ(IFN-γ)水平,qRT-PCR法检测鼻黏膜组织中T-bet和GATA3 mRNA表达情况。结果MSCs组、附子理中汤组和附子理中汤+MSCs组大鼠干预后行为学积分均明显低于干预前及模型组(P均<0.05),且附子理中汤+MSCs组大鼠干预后行为学积分均明显低于MSCs组和附子理中汤组(P均<0.05)。与对照组比较,模型组大鼠鼻腔灌洗液中IL-4、IL-13水平和鼻黏膜组织中GATA3 mRNA相对表达量均明显升高(P均<0.05),鼻腔灌洗液中IFN-γ水平和鼻黏膜组织中T-bet mRNA相对表达量均明显降低(P均<0.05)。与模型组比较,MSCs组、附子理中汤组和附子理中汤+MSCs组大鼠鼻腔灌洗液中IL-4、IL-13水平和鼻黏膜组织中GATA3 mRNA相对表达量均明显降低(P均<0.05),附子理中汤组和附子理中汤+MSCs组大鼠鼻腔灌洗液中IFN-γ水平和鼻黏膜组织中T-bet mRNA相对表达量均明显升高(P均<0.05),MSCs组大鼠鼻腔灌洗液中IFN-γ水平和鼻黏膜组织中T-bet mRNA相对表达量均无明显变化(P均>0.05);且附子理中汤+MSCs组大鼠鼻腔灌洗液中IL-4、IL-13水平和鼻黏膜组织中GATA3 mRNA相对表达量均明显低于MSCs组(P均<0.05),鼻腔灌洗液中IFN-γ水平和鼻黏膜组织中T-bet mRNA相对表达量均明显高于MSCs组(P均<0.05)。结论附子理中汤联合骨髓MSCs能上调T-bet mRNA和下调GATA3 mRNA表达,进而调节Th1/Th2细胞的平衡,抑制炎症反应,改善变应性鼻炎症状。

从三焦理论探讨恶性胸腹腔积液的治疗

恶性胸腹腔积液病机为三焦阻滞,水饮内停,元气运行受阻,血液凝滞,痰瘀内结,治疗应在行气利水、淡渗利湿或峻下逐水、逐瘀利水通利三焦的基础上,兼顾肺、脾,肾三脏的功能失调。通利三焦多为宣上通下的行气利水药物,如柴胡、枳实、桔梗等,同时配以淡渗利湿药物或者峻下逐水药物以通调水道,如茯苓、猪苓、泽泻等,尚需加用利水逐瘀药物,如水蛭、桃仁、泽兰等。兼顾肺、脾,肾三脏的功能失调,分别以开宣肺气、健脾益气、温补肾阳之法,开宣肺卫通利三焦用以麻黄为基础的方药如越婢汤、越婢加术汤、甘草麻黄汤及大小青龙汤;健脾渗湿疏利三焦用以黄芪为基础的方药如防己茯苓汤、桂枝加黄芪汤、桂枝苦酒汤;温补肾阳用附子,干姜。同时尚需要考虑恶性肿瘤癌毒这一主要病理因素,加用祛除癌毒之邪药物如山慈菇、蛇六谷、全蝎等。

枳壳中3,5,6,7,8,3′,4′-七甲氧基黄酮对湿阻中焦大鼠的改善作用研究

目的研究枳壳中3,5,6,7,8,3′,4′-七甲氧基黄酮(HMF)对湿阻中焦大鼠的改善作用。方法将大鼠随机分为正常组、模型组、阳性对照组(消旋山莨菪碱片,1 mg/kg)和HMF低、中、高剂量组(0.3、0.6、0.9 mg/kg),每组7只。除正常组外,其余各组大鼠均采用内因加外因复合因素法造模。造模成功后,各组大鼠灌胃相应药物或生理盐水,每日1次,连续14 d。观察各组大鼠饮食量、饮水量及精神状态等一般行为学状态,测定大鼠粪便含水率及唾液流率。采用苏木素-伊红染色法观察大鼠胃和小肠组织的病理形态学变化;检测大鼠血浆中醛固酮含量;检测大鼠胃组织中水通道蛋白3(AQP3)表达水平。结果与正常组比较,模型组大鼠饮食量、饮水量均显著减少(P<0.01),粪便含水率、唾液流率、血浆中醛固酮含量和胃组织中AQP3表达水平均显著增加/升高(P<0.01);大鼠胃组织损伤侵及黏膜肌层,黏膜肌层断裂;小肠出现少量肠绒毛糜烂,腺体结构破坏等病理形态学变化。与模型组比较,HMF各剂量组大鼠饮食量、饮水量均增加,粪便含水率、唾液流率、血浆中醛固酮含量和胃组织中AQP3表达水平均减少/降低,上述差异大部分有统计学意义(P<0.05或P<0.01);胃和小肠组织的病理形态学变化均有不同程度改善。结论枳壳燥性成分HMF对湿阻中焦大鼠症状有一定的改善作用,其机制可能与降低血浆醛固酮含量、下调胃组织中AQP3表达有关。

基于肠道菌群从“土郁夺之”论治慢性前列腺炎

慢性前列腺炎是男科常见疾病,具有病程迁延、症状复杂、易于复发等特点。本文从肠道菌群、“土郁”与慢性前列腺炎相关性,以及“夺之”在治疗慢性前列腺炎的具体运用方面阐释三者紧密关联,进而基于“土郁夺之”论述扶脾阳泄水湿以调节肠道菌群,治以“培助中土,以运为夺”“升木达郁,以疏为夺”“祛瘀通络,以消为夺”三法,从而达到治疗慢性前列腺炎目的,以期为临床提供参考。

南水北调中线工程水源区环境规制对经济高质量发展的影响

为研究南水北调中线工程水源区环境规制通过水资源利用对区域发展质效的影响,基于2005—2022年南水北调中线工程水源区12个城市的面板数据,构建基准回归模型、中介效应模型和门槛效应模型,实证分析了环境规制、水资源利用效率和经济高质量发展之间的关系。结果表明:环境规制对经济高质量发展具有正向促进效应,该促进效应在不同区域间存在异质性,环境规制的促进作用在用水量小的地区更加显著,而在用水量大的地区,丰富的水资源限制了环境规制对经济高质量发展的促进作用;在环境规制影响区域,水资源利用效率在经济高质量发展过程中发挥出显著的中介作用,水资源利用效率中介效应占环境规制总促进效应的比例为13.5%;水资源利用效率在环境规制对经济高质量发展影响中具有门槛效应,当水资源利用效率超过4.3后,环境规制对经济高质量发展的促进效应显著增强。

浅析前胡之推陈致新功用

前胡味苦、辛,性微寒,归肺经,《神农本草经》《本草经集注》等均记载其有推陈致新功效,可祛除在表之水饮,解在表之邪气,从而达到“推陈”之功,且其味甘可健中焦,补益胃气,故在祛除病理产物的同时还具有补益之功。柴胡、前胡均能疗伤寒寒热,发表散风,推陈致新,清里散结,而前胡更偏于除里之痰饮水气,散表之风邪,其与半夏相配能制痰饮痞结,降逆化浊;与黄芩相配可泻厥阴伏火;与桂枝相配能散表之风邪;与生姜相配意在温胃化饮。前胡之推陈致新功用既体现在气机层面,可理气、散气,对不同程度的气机瘀滞、气机凝结等均有效;又表现在活血通脉方面,在理气的基础上,通行血脉,活血化瘀。散气、活血均是“推陈”的体现,“陈”包括机体的病理产物如痰浊、水饮、瘀血、滞气、燥矢等,推出体内陈旧之代谢废物,促使新生之物产生,从而使机体达到气血通畅、五脏安和的状态。

基于“中焦斡旋”理论探析半夏泻心汤在慢性阻塞性肺疾病稳定期中的应用

中焦脾胃,居人之中州,是人体气机、气血精津液转运的枢纽,调和人体气机之升降、上下水火之交融、清浊阴阳之互通,是全身脏腑经络生理功能得以正常发挥的重要保障,此乃中焦斡旋之总章。中焦失于斡旋则气机升降乖戾,上下水火不济,清浊阴阳不辨,终致百病丛生。慢性阻塞性肺疾病稳定期的“咳痰喘”和半夏泻心汤主症之“呕痞泄”二者的病机即中焦斡旋失司。因此,本文应用半夏泻心汤治疗慢性阻塞性肺疾病稳定期患者有了理论依据,其临床疗效也令人满意,这为慢性阻塞性肺疾病稳定期的中医药防治工作提供了新思路和新方法。

安徽庐枞矿集区沙溪斑岩型铜金矿床中硒、碲的赋存状态及富集规律研究

硒和碲是重要的战略性关键金属,在现代工业和国防建设中有着广泛的应用。硒和碲通常很难形成独立矿床,目前全球大部分硒和碲来自斑岩型铜金矿床。长江中下游成矿带是我国东部重要的斑岩-矽卡岩型铜金矿床成矿带之一,前人虽然对成矿带内矽卡岩型矿床中伴生关键金属已开展了相关研究,但对成矿带内斑岩矿床中关键金属的赋存状态、分布和富集规律尚关注较少。本次工作以成矿带内沙溪斑岩型铜金矿床为研究对象,系统采集了矿床不同深度、不同类型的岩矿石样品,通过扫描电子显微镜、全岩化学分析、TIMA及矿物原位LA-ICP-MS微量成分测试等分析技术方法对矿床中硒和碲等关键金属开展了系统的研究。结果表明,沙溪矿床中硒和碲元素发生显著富集,与主成矿元素铜具有明显的正相关关系。估算矿床中伴生硒资源量约为1196t、碲资源量约为96.6t,其中硒达到大型规模,具有潜在利用价值。与成矿带内其他典型矽卡岩矿床(包括斑岩-矽卡岩矿床)相比,沙溪斑岩型矿床中硒和碲的含量明显偏低,这可能是深部成矿岩浆演化过程的差异导致的。矿床中有91.64%的硒、87.48%的碲是以独立矿物形式存在。沙溪矿床硒、碲与主成矿元素铜和金的富集规律一致,流体混合过程中氧逸度的变化可能是硒和碲的主要的沉淀机制。