Crime cases from snatch thefts to murders, are becoming increasingly common in Malaysia according to the database of the Royal Malaysian Police (RMP), the current overall Crime Index in Malaysia was 147,062 for 2013...Crime cases from snatch thefts to murders, are becoming increasingly common in Malaysia according to the database of the Royal Malaysian Police (RMP), the current overall Crime Index in Malaysia was 147,062 for 2013 compared with 65,237 in 1977. The database also revealed that the number of property crimes reported in this country has always exceeded the number of violent crimes. Although in 2013, crimes related to property are higher (117,687) than violent crime (29,375), the gradual increase in the latter does worry Malaysians. Likewise, Malaysian Government had implemented a "safe community" concept, inspired by the Malaysian Crime Prevention Foundation (MCPF), a non-government organization, as they were concerned that the threat of violent crime and non-violent crime would eventually reduce the quality of life for many individuals. The concept is very important to the public as it is perceived as improved safety for the public with less crime. This study analyzes the public safety through their perceptions on the effectiveness of the policeman and suggesting few prevention actions against crime. The data were collected using a self-administered survey questionnaire. Specifically, this study focuses on the more developed states in this country. From the cross tabulation analysis, the majority of respondents agreed that the police are effective in controlling crime. Approximately, 72.1% of respondents felt that the police are efficient in controlling crime.展开更多
This paper contrasts Military Power of the People's Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People's Republic of China from the year 2010 to 2013 with corpus ...This paper contrasts Military Power of the People's Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People's Republic of China from the year 2010 to 2013 with corpus analysis. It distinguishes the new reports' differences from the old ones and tries to explore American's discourse colonization and discourse hegemony through corpus software WordSmith 5.0-Keywords and Concordance analysis of high frequency words. The significance of the study is that it enlightens military texts which will influence audiences' viewpoints and provides a new perspective for strategies replying American media war.展开更多
Objective This study aimed to explore the roles of three common single nucleotide polymorphisms in the X-ray repair cross-complementing group-1 gene (XRCC1) and of life style factors and their possible interactions ...Objective This study aimed to explore the roles of three common single nucleotide polymorphisms in the X-ray repair cross-complementing group-1 gene (XRCC1) and of life style factors and their possible interactions in the risk of esophageal squamous cell carcinoma (ESCC) in China. Methods A population-based case-control study of 432 cases and 915 controls was conducted in Yangzhong County, Jiangsu Province, China. Subjects were interviewed by trained interviewers using a structured questionnaire that included questions on demographics and life style. XRCC1 genotypes were analyzed using a polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP) assay. Unconditional logistic regression analysis was used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for associations of ESCC with XRCCI polymorphisms and lifestyle-related factors. Results Both the drinking of river water and alcohol intake history were significantly associated with an increased risk of ESCC among men with aORs of 4.20 (95% Ch 2.90-6.07) and 2.03 (95% Ch 1.43-2.89), respectively. For women, the corresponding odds ratios were 8.37 (95% CI: 5.09-13.75) for river water drinking and 12.78 (95% CI: 2.69-60.69) for long-term stored rice intake. After the XRCC1 G28152A polymorphism was adjusted for potential confounders, subjects with GA and AA genotypes had an increased risk for ESCC (aOR: 1.21, 95% CI: 0.93-1.56), compared with subjects with a GG genotype, and a positive multiplicative interaction between intake of long-term stored rice and the XRCC1 G28152A polymorphism was observed (P=O.009).Conclusions Our findings suggest that both lifestyle-related factors, including drinking river water, long-term stored rice and alcohol intake, and the XRCC1 G28152A polymorphism were possible risk factors for ESCC, and that the XRCC1 G28152A polymorphism modified the effect of long-term stored rice intake on the risk of ESCC among Chinese people.展开更多
This article explains reasons from the consular perspective why people to people exchange between China and India is not so active. Review of evolution of bilateral consular relations reveals that the basis of cross...This article explains reasons from the consular perspective why people to people exchange between China and India is not so active. Review of evolution of bilateral consular relations reveals that the basis of cross border personnel exchanges is weak with the closing of consulates of both countries in each other’s territory for nearly three decades. Relatively, small number of Chinese and Indian consular posts in each other’s territory means inconvenience for citizens to apply for visa for visiting the other and seeking consular assistance and protection. Inflexible visa policy of both countries toward citizens of the other party also accounts for the none-activeness. Considering the important role played by civilian exchange in advancing bilateral relations, China and India should establish more consular posts in each other’s territory and further relax visa requirements.展开更多
The ideological and political education for students in institutions of higher learning is a complicated, systematic project. To unequivocally cultivate the socialist core values of these students and deeply influence...The ideological and political education for students in institutions of higher learning is a complicated, systematic project. To unequivocally cultivate the socialist core values of these students and deeply influence their ideological understanding and behaviors, the concept of "education involved by all related people" is necessarily implemented in all aspects, and the joint force of "imparting knowledge and educating people" , "educating people by management" , and "educating people by service" is formed. As a result, the actual effectiveness of the ideological and political education is improved in institutions of higher learning.展开更多
Background:The paper reviews alcohol consumption patterns and alcohol-related social and health issues among 15-29-year old young people in Asian countries,and discusses strategies for preventing and controlling alcoh...Background:The paper reviews alcohol consumption patterns and alcohol-related social and health issues among 15-29-year old young people in Asian countries,and discusses strategies for preventing and controlling alcohol use and related harms.Methods:We searched Google Scholar,PubMed,and Web of Science for reports,reviews and journal articles published in English between 1st Jan 1990 and 31st August 2016.Results:Forty-one reports,reviews and journal papers were identified and included in the final review.The current drinking levels and prevalence among young people are markedly different between eight included Asian countries,ranging from 4.2%in Malaysia to 49.3%in China.In a majority of the selected Asian countries,over 15%of total deaths among young men and 6%among young women aged 15-29 years are attributable to alcohol use.Alcohol use among young people is associated with a number of harms,including stress,family violence,injuries,suicide,and sexual and other risky behaviours.Alcohol policies,such as controlling sales,social supply and marketing,setting up/raising a legal drinking age,adding health warning labels on alcohol containers,and developing a surveillance system to monitor drinking pattern and risky drinking behaviour,could be potential means to reduce harmful use of alcohol and related harm among young people in Asia.Conclusions:The review reveals that drinking patterns and behaviours vary across eight selected Asian countries due to culture,policies and regional variations.The research evidence holds substantial policy implications for harm reduction on alcohol drinking among young people in Asian countries-especially for China,which has almost no alcohol control policies at present.展开更多
Introduction: Malaria is an important disease, causing high morbidity and mortality, especially in Sub-Saharan Africa. Measuring malaria prevalence using malaria rapid diagnostic tests (mRDTs), particularly among a vu...Introduction: Malaria is an important disease, causing high morbidity and mortality, especially in Sub-Saharan Africa. Measuring malaria prevalence using malaria rapid diagnostic tests (mRDTs), particularly among a vulnerable population sub-group, is a vital public health step in discovering effective methods of prevention and control. This study set out to examine the association between “place” and other risk factors with malaria prevalence among Batwa Indigenous People (IP). Methods: An analytical cross-sectional study design was implemented. Two surveys January 2014 (n = 572) and April 2014 (n = 541) involving interviews and testing for malaria using mRDTs were conducted in 10 Batwa settlements where a total of 1113 Batwa of all ages were surveyed and tested. The data were first compiled in MS Excel and then imported and analyzed using STATA ver.14. Descriptive statistics, were generated, followed by bivariable and multivariable regression model analysis to establish associations between the predictor and outcome variables with p ≤ 0.05 considered statistically significant. Results: Overall prevalence was 13.94% (n = 146). There is a significant relationship between settlement (place) and malaria prevalence AOR 11.7, 95% CI (1.38 - 98.93), p-value = 0.02. More males 16.97% (n = 84) tested positive compared to females 11.23% (n = 62) but there was no statistically significant association between gender and mRDT (p-value > 0.005). Children less than 5 years registered high prevalence and there was a significant relationship between age and mRDT (p-value ≤ 0.005). Wealth proxy indicators showed no association with prevalence p-value = 0.390. Season had no association with prevalence (p-value = 0.80). However, the proportion of the day spent in the forest/woodlands was significantly associated with malaria prevalence COR 12.83, 95% CI (1.14 - 143.73) p-value = 0.04. Low elevation was significantly associated with malaria prevalence COR 2.42, 95% CI (1.32 - 4.41), p = 0.004 but sleeping under a net and level of education did not show any association with malaria prevalence. Conclusion: This study highlights the importance of place in predicting malaria prevalence among Batwa Indigenous People a marginalized and remortely located sub-population. This study has shown that place matters in determining malaria prevalence. However, other factors like age, elevation and gender also contribute to malaria prevalence. Batwa have higher prevalence than the national and even non-indigenous populations in the same district. We recommend targeting hotspots intervention approach since it has proven reasonable impact on reducing malaria prevalence.展开更多
The Qur'an embraces cultural pluralism, emphasising that “People, We created you all from a single man and a single woman, and made you into races and tribes so that you should recognize one another. ”(Q. 49: 13...The Qur'an embraces cultural pluralism, emphasising that “People, We created you all from a single man and a single woman, and made you into races and tribes so that you should recognize one another. ”(Q. 49: 13). Moreover, peace is the most fundamental value in the Qur'an and Islam. The majority of the classical Muslim jurists, especially Hanafi school, emphasised that the reason for Muslims' fight against non-Muslims is Muslims' defense themselves against attacks, not non-Muslims' faith. Bediuzzaman Said Nursi (d. 1960) states that the only kind of jihad that is appropriate for the present age is spiritual or moraljihad. Furthermore, regarding Qur'anic approach to relations between Muslims and the People of the Book, Muslim scholars, in general, advocate sincere relations and trust between Muslims and the People of the Book. In addition, Said Nursi is one of the great Muslim scholars in interfaith dialogue in the 20th century. Finally, there is the need for establishing culture of coexistence, which practised before within a religious tradition such as Islamic tradition for many centuries in the history. Through achieving a culture of coexistence and peace, most conflicts can be resolved.展开更多
Objective The paper aims to evaluate the risk factors for age‐related macular degeneration (AMD) in elderly Chinese population in Shenyang,a northeast city of China.Methods A case‐control study was conducted to in...Objective The paper aims to evaluate the risk factors for age‐related macular degeneration (AMD) in elderly Chinese population in Shenyang,a northeast city of China.Methods A case‐control study was conducted to investigate the risk factors for the prevalence of AMD.Ninety three AMD patients diagnosed by a complete ophthalmic examination were recruited as cases from the outpatient departments of two eye hospitals in Shenyang,while 108 normal subjects of similar age and sex were recruited as controls.A questionnaire was administered among both cases and controls.Results AMD patients aged 60 years and older accounted for 75.3%.There were significantly higher educational levels,shorter smoking history,less sunlight exposure and cataract,and higher proportion of antioxidants intake in controls than in AMD patients.The frequency of intake of fruits,legumes,fish and shrimps was significantly higher in controls than in AMD patients.In a binary logistic regression analysis,smoking and cataract were the risk factors for AMD (OR:4.44,95% CI:2.27‐8.69;OR:4.47,95% CI:2.26‐8.85 respectively).The high educational background was a protective factor for AMD (OR:0.761,95% CI:0.51‐0.98).Conclusion A low educational background,smoking and cataract are associated with a higher prevalence of AMD.展开更多
While criminal investigations are usually conducted after the crime has been committed, these investigations can benefit from community crime prevention initiatives. The use of citizen volunteers, citizen awareness ca...While criminal investigations are usually conducted after the crime has been committed, these investigations can benefit from community crime prevention initiatives. The use of citizen volunteers, citizen awareness campaigns, community-driven research, and programs that facilitate effective police-community relations can aid the investigator in collecting testimony that might otherwise go unreported. Specific examples of how cases have been cleared due to the beneficial inclusion of citizen satisfaction research, crime prevention resources, and volunteer personnel demonstrate how community, crime prevention, and investigation of criminal behavior can be interlinked. The theme of this paper rests on the notion that the community's sense of collective efficacy, crime prevention efforts, and criminal investigation processes are not mutually exclusive, but instead should be considered as related aspects of the crime-fighting spectrum.展开更多
The proportion of elderly people rises in the developed countries. The increased susceptibility of the elderly to infectious diseases is caused by immune dysfunction, especially T cell functional decline. Age-related ...The proportion of elderly people rises in the developed countries. The increased susceptibility of the elderly to infectious diseases is caused by immune dysfunction, especially T cell functional decline. Age-related hematopoietic stem cells deviate from lymphoid lineage to myeloid lineage. Thymus shrinks early in life, which is followed by the decline of na?ve T cells. T-cell receptor repertoire diversity declines by aging, which is caused by cytomegalovirus-driven T cell clonal expansion. Functional decline of B cell induces antibody affinity declines by aging. Many effector functions including phagocytosis of myeloid cells are down regulated by aging. The studies of aging of myeloid cells have some controversial results. Although M1 macrophages have been shown to be replaced by antiinflammatory(M2) macrophages by advanced age, many human studies showed that pro-inflammatory cytokines are elevated in older human. To solve this discrepancy here we divide age-related pathological changes into two categories. One is an aging of immune cell itself. Second is involvement of immune cells to age-related pathological changes. Cellular senescence and damaged cells in aged tissue recruit pro-inflammatory M1 macrophages, which produce pro-inflammatory cytokines and proceed to agerelated diseases. Underlying biochemical and metabolic studies will open nutritional treatment.展开更多
文摘Crime cases from snatch thefts to murders, are becoming increasingly common in Malaysia according to the database of the Royal Malaysian Police (RMP), the current overall Crime Index in Malaysia was 147,062 for 2013 compared with 65,237 in 1977. The database also revealed that the number of property crimes reported in this country has always exceeded the number of violent crimes. Although in 2013, crimes related to property are higher (117,687) than violent crime (29,375), the gradual increase in the latter does worry Malaysians. Likewise, Malaysian Government had implemented a "safe community" concept, inspired by the Malaysian Crime Prevention Foundation (MCPF), a non-government organization, as they were concerned that the threat of violent crime and non-violent crime would eventually reduce the quality of life for many individuals. The concept is very important to the public as it is perceived as improved safety for the public with less crime. This study analyzes the public safety through their perceptions on the effectiveness of the policeman and suggesting few prevention actions against crime. The data were collected using a self-administered survey questionnaire. Specifically, this study focuses on the more developed states in this country. From the cross tabulation analysis, the majority of respondents agreed that the police are effective in controlling crime. Approximately, 72.1% of respondents felt that the police are efficient in controlling crime.
文摘This paper contrasts Military Power of the People's Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People's Republic of China from the year 2010 to 2013 with corpus analysis. It distinguishes the new reports' differences from the old ones and tries to explore American's discourse colonization and discourse hegemony through corpus software WordSmith 5.0-Keywords and Concordance analysis of high frequency words. The significance of the study is that it enlightens military texts which will influence audiences' viewpoints and provides a new perspective for strategies replying American media war.
基金supported by the National Natural Science Foundation of China (30600508)the Shanghai Leading Academic Discipline Project (B118)
文摘Objective This study aimed to explore the roles of three common single nucleotide polymorphisms in the X-ray repair cross-complementing group-1 gene (XRCC1) and of life style factors and their possible interactions in the risk of esophageal squamous cell carcinoma (ESCC) in China. Methods A population-based case-control study of 432 cases and 915 controls was conducted in Yangzhong County, Jiangsu Province, China. Subjects were interviewed by trained interviewers using a structured questionnaire that included questions on demographics and life style. XRCC1 genotypes were analyzed using a polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP) assay. Unconditional logistic regression analysis was used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for associations of ESCC with XRCCI polymorphisms and lifestyle-related factors. Results Both the drinking of river water and alcohol intake history were significantly associated with an increased risk of ESCC among men with aORs of 4.20 (95% Ch 2.90-6.07) and 2.03 (95% Ch 1.43-2.89), respectively. For women, the corresponding odds ratios were 8.37 (95% CI: 5.09-13.75) for river water drinking and 12.78 (95% CI: 2.69-60.69) for long-term stored rice intake. After the XRCC1 G28152A polymorphism was adjusted for potential confounders, subjects with GA and AA genotypes had an increased risk for ESCC (aOR: 1.21, 95% CI: 0.93-1.56), compared with subjects with a GG genotype, and a positive multiplicative interaction between intake of long-term stored rice and the XRCC1 G28152A polymorphism was observed (P=O.009).Conclusions Our findings suggest that both lifestyle-related factors, including drinking river water, long-term stored rice and alcohol intake, and the XRCC1 G28152A polymorphism were possible risk factors for ESCC, and that the XRCC1 G28152A polymorphism modified the effect of long-term stored rice intake on the risk of ESCC among Chinese people.
基金This article is part of a Research Project funded by China National Social Science Foundation entitled Improvement of China’s Consular Service under the Initiative of OBOR(16BGJ015).
文摘This article explains reasons from the consular perspective why people to people exchange between China and India is not so active. Review of evolution of bilateral consular relations reveals that the basis of cross border personnel exchanges is weak with the closing of consulates of both countries in each other’s territory for nearly three decades. Relatively, small number of Chinese and Indian consular posts in each other’s territory means inconvenience for citizens to apply for visa for visiting the other and seeking consular assistance and protection. Inflexible visa policy of both countries toward citizens of the other party also accounts for the none-activeness. Considering the important role played by civilian exchange in advancing bilateral relations, China and India should establish more consular posts in each other’s territory and further relax visa requirements.
文摘The ideological and political education for students in institutions of higher learning is a complicated, systematic project. To unequivocally cultivate the socialist core values of these students and deeply influence their ideological understanding and behaviors, the concept of "education involved by all related people" is necessarily implemented in all aspects, and the joint force of "imparting knowledge and educating people" , "educating people by management" , and "educating people by service" is formed. As a result, the actual effectiveness of the ideological and political education is improved in institutions of higher learning.
基金funded by the China Medical Board to Xiaojun Xiang(Global Health Project 13–132)by the National Nature Science Foundation of China to Xiaojun Xiang(81571306)H.J’s work was partially funded by the China Studies Research Centre and La Trobe Asia,La Trobe University。
文摘Background:The paper reviews alcohol consumption patterns and alcohol-related social and health issues among 15-29-year old young people in Asian countries,and discusses strategies for preventing and controlling alcohol use and related harms.Methods:We searched Google Scholar,PubMed,and Web of Science for reports,reviews and journal articles published in English between 1st Jan 1990 and 31st August 2016.Results:Forty-one reports,reviews and journal papers were identified and included in the final review.The current drinking levels and prevalence among young people are markedly different between eight included Asian countries,ranging from 4.2%in Malaysia to 49.3%in China.In a majority of the selected Asian countries,over 15%of total deaths among young men and 6%among young women aged 15-29 years are attributable to alcohol use.Alcohol use among young people is associated with a number of harms,including stress,family violence,injuries,suicide,and sexual and other risky behaviours.Alcohol policies,such as controlling sales,social supply and marketing,setting up/raising a legal drinking age,adding health warning labels on alcohol containers,and developing a surveillance system to monitor drinking pattern and risky drinking behaviour,could be potential means to reduce harmful use of alcohol and related harm among young people in Asia.Conclusions:The review reveals that drinking patterns and behaviours vary across eight selected Asian countries due to culture,policies and regional variations.The research evidence holds substantial policy implications for harm reduction on alcohol drinking among young people in Asian countries-especially for China,which has almost no alcohol control policies at present.
文摘Introduction: Malaria is an important disease, causing high morbidity and mortality, especially in Sub-Saharan Africa. Measuring malaria prevalence using malaria rapid diagnostic tests (mRDTs), particularly among a vulnerable population sub-group, is a vital public health step in discovering effective methods of prevention and control. This study set out to examine the association between “place” and other risk factors with malaria prevalence among Batwa Indigenous People (IP). Methods: An analytical cross-sectional study design was implemented. Two surveys January 2014 (n = 572) and April 2014 (n = 541) involving interviews and testing for malaria using mRDTs were conducted in 10 Batwa settlements where a total of 1113 Batwa of all ages were surveyed and tested. The data were first compiled in MS Excel and then imported and analyzed using STATA ver.14. Descriptive statistics, were generated, followed by bivariable and multivariable regression model analysis to establish associations between the predictor and outcome variables with p ≤ 0.05 considered statistically significant. Results: Overall prevalence was 13.94% (n = 146). There is a significant relationship between settlement (place) and malaria prevalence AOR 11.7, 95% CI (1.38 - 98.93), p-value = 0.02. More males 16.97% (n = 84) tested positive compared to females 11.23% (n = 62) but there was no statistically significant association between gender and mRDT (p-value > 0.005). Children less than 5 years registered high prevalence and there was a significant relationship between age and mRDT (p-value ≤ 0.005). Wealth proxy indicators showed no association with prevalence p-value = 0.390. Season had no association with prevalence (p-value = 0.80). However, the proportion of the day spent in the forest/woodlands was significantly associated with malaria prevalence COR 12.83, 95% CI (1.14 - 143.73) p-value = 0.04. Low elevation was significantly associated with malaria prevalence COR 2.42, 95% CI (1.32 - 4.41), p = 0.004 but sleeping under a net and level of education did not show any association with malaria prevalence. Conclusion: This study highlights the importance of place in predicting malaria prevalence among Batwa Indigenous People a marginalized and remortely located sub-population. This study has shown that place matters in determining malaria prevalence. However, other factors like age, elevation and gender also contribute to malaria prevalence. Batwa have higher prevalence than the national and even non-indigenous populations in the same district. We recommend targeting hotspots intervention approach since it has proven reasonable impact on reducing malaria prevalence.
文摘The Qur'an embraces cultural pluralism, emphasising that “People, We created you all from a single man and a single woman, and made you into races and tribes so that you should recognize one another. ”(Q. 49: 13). Moreover, peace is the most fundamental value in the Qur'an and Islam. The majority of the classical Muslim jurists, especially Hanafi school, emphasised that the reason for Muslims' fight against non-Muslims is Muslims' defense themselves against attacks, not non-Muslims' faith. Bediuzzaman Said Nursi (d. 1960) states that the only kind of jihad that is appropriate for the present age is spiritual or moraljihad. Furthermore, regarding Qur'anic approach to relations between Muslims and the People of the Book, Muslim scholars, in general, advocate sincere relations and trust between Muslims and the People of the Book. In addition, Said Nursi is one of the great Muslim scholars in interfaith dialogue in the 20th century. Finally, there is the need for establishing culture of coexistence, which practised before within a religious tradition such as Islamic tradition for many centuries in the history. Through achieving a culture of coexistence and peace, most conflicts can be resolved.
基金supported by a grant from the Nutritional Science Foundation of the Chinese Nutrition Society (No. 07016), China
文摘Objective The paper aims to evaluate the risk factors for age‐related macular degeneration (AMD) in elderly Chinese population in Shenyang,a northeast city of China.Methods A case‐control study was conducted to investigate the risk factors for the prevalence of AMD.Ninety three AMD patients diagnosed by a complete ophthalmic examination were recruited as cases from the outpatient departments of two eye hospitals in Shenyang,while 108 normal subjects of similar age and sex were recruited as controls.A questionnaire was administered among both cases and controls.Results AMD patients aged 60 years and older accounted for 75.3%.There were significantly higher educational levels,shorter smoking history,less sunlight exposure and cataract,and higher proportion of antioxidants intake in controls than in AMD patients.The frequency of intake of fruits,legumes,fish and shrimps was significantly higher in controls than in AMD patients.In a binary logistic regression analysis,smoking and cataract were the risk factors for AMD (OR:4.44,95% CI:2.27‐8.69;OR:4.47,95% CI:2.26‐8.85 respectively).The high educational background was a protective factor for AMD (OR:0.761,95% CI:0.51‐0.98).Conclusion A low educational background,smoking and cataract are associated with a higher prevalence of AMD.
文摘While criminal investigations are usually conducted after the crime has been committed, these investigations can benefit from community crime prevention initiatives. The use of citizen volunteers, citizen awareness campaigns, community-driven research, and programs that facilitate effective police-community relations can aid the investigator in collecting testimony that might otherwise go unreported. Specific examples of how cases have been cleared due to the beneficial inclusion of citizen satisfaction research, crime prevention resources, and volunteer personnel demonstrate how community, crime prevention, and investigation of criminal behavior can be interlinked. The theme of this paper rests on the notion that the community's sense of collective efficacy, crime prevention efforts, and criminal investigation processes are not mutually exclusive, but instead should be considered as related aspects of the crime-fighting spectrum.
文摘The proportion of elderly people rises in the developed countries. The increased susceptibility of the elderly to infectious diseases is caused by immune dysfunction, especially T cell functional decline. Age-related hematopoietic stem cells deviate from lymphoid lineage to myeloid lineage. Thymus shrinks early in life, which is followed by the decline of na?ve T cells. T-cell receptor repertoire diversity declines by aging, which is caused by cytomegalovirus-driven T cell clonal expansion. Functional decline of B cell induces antibody affinity declines by aging. Many effector functions including phagocytosis of myeloid cells are down regulated by aging. The studies of aging of myeloid cells have some controversial results. Although M1 macrophages have been shown to be replaced by antiinflammatory(M2) macrophages by advanced age, many human studies showed that pro-inflammatory cytokines are elevated in older human. To solve this discrepancy here we divide age-related pathological changes into two categories. One is an aging of immune cell itself. Second is involvement of immune cells to age-related pathological changes. Cellular senescence and damaged cells in aged tissue recruit pro-inflammatory M1 macrophages, which produce pro-inflammatory cytokines and proceed to agerelated diseases. Underlying biochemical and metabolic studies will open nutritional treatment.