The relationship between human beings and nature influences the expressions and manifestations of literature. Literature can spy on the nature exploration of human society and ideological values in the thinking and be...The relationship between human beings and nature influences the expressions and manifestations of literature. Literature can spy on the nature exploration of human society and ideological values in the thinking and behavior patterns,expressing the relationship between human beings and nature. Through expressions of literature in China and the West,we draw lessons from W estern literary expressions in the developing relationship between man and nature,and get inspiration for the development of Chinese literature.展开更多
It is well established that environmental pollutions are most popular topics recendy and the factor of that is a dominant element that is worth to investigate to large extent.According to lots of human performance so ...It is well established that environmental pollutions are most popular topics recendy and the factor of that is a dominant element that is worth to investigate to large extent.According to lots of human performance so far,negative human activities are like to be a vital driving force of pollutions in some cases.Therefore,the relationship between environment and negative human performance should be researched,which can give better methods to protect natural environment.展开更多
The relationship between human lights and sovereignty is a key theoretical and practical issue that has aroused heated debate in the international human lights field. What are the viewpoints and positions of Western c...The relationship between human lights and sovereignty is a key theoretical and practical issue that has aroused heated debate in the international human lights field. What are the viewpoints and positions of Western countries and developing countries on this issue? What is the deeply rooted reason for this debate? How can the relationship between the two be properly handled? This article will analyze these questions.展开更多
British Economist Angus Maddison said that eco nomic development is a recent phenomenon inhuman history. Although human species have lived on the planet at least 2.5 million years, economic development only appeared a...British Economist Angus Maddison said that eco nomic development is a recent phenomenon inhuman history. Although human species have lived on the planet at least 2.5 million years, economic development only appeared around the 1850s. In pursuit of economic development, not all nationalities have been equally lucky. Among more than 200 countries in the world, only dozens of countries are devel oped. Onethird of the world's total population of 6.5 billion are living in poverty. In both developing and developed countries, the wealth gap is often obvious. Therefore, eco nomic development is the goal of each country, the aim of each politi cal party, and the wish of all people. However, economic development usually baffles people. As a result, understanding the relationship be tween economic development and human rights protection is a matter of urgency.展开更多
Lawrence is regarded as one of most accomplished short story writers in twentieth century,with "Odour of Chrysanthemums" one of his early works.Through the death of a miner,the text shows how humanity was ru...Lawrence is regarded as one of most accomplished short story writers in twentieth century,with "Odour of Chrysanthemums" one of his early works.Through the death of a miner,the text shows how humanity was ruined by industrial civilization.This essay is intended to unveil the destructive force by analyzing the relationship between the husband and wife.展开更多
Fetal eutaneous wounds that oeeur in earlygestation heal without sear formation.Althoughmueh work has been done to eharaeterize the roleof transforming growth
The relationship between the Heaven and human beings is a central issue in the transformation of Confucianism in the Mid-Tang Dynasty.The discourses on the Heaven by Han Yu,Liu Zongyuan,and Liu Yuxi helped to promote ...The relationship between the Heaven and human beings is a central issue in the transformation of Confucianism in the Mid-Tang Dynasty.The discourses on the Heaven by Han Yu,Liu Zongyuan,and Liu Yuxi helped to promote the transformation and greatly influenced the transformation in literature.The differences in the poetry among the three authors may also be interpreted from the perspective of their perceptions of the Heaven—Han Yu’s discourse on the Heaven focused on the enemy-relationship between the Heaven and human beings,so his poems always showed tension and loss.Liu Zongyuan was interested in the alienation between the heaven and human beings,so his poems were more rational and placid than Han Yu’s.However,Liu Yuxi’s discourse on the Heaven paid attention to the positive influence of the Heaven on human beings,and most of his poems were filled with reason.The changes in the relationship between the Heaven and human beings lead to the broadened themes,innovated vocabulary,diversified styles,and varied fresh imageries.Likewise,the relationship between the Heaven and human beings established in the Song Dynasty led accordingly to a new type of literature different from the Tang literature.展开更多
As the process of economic globalization gathers momentum, dialogue between different cultures has become extremely important. There should be dialogue between the Chinese and Western cultures under the principle of e...As the process of economic globalization gathers momentum, dialogue between different cultures has become extremely important. There should be dialogue between the Chinese and Western cultures under the principle of equality and mutual respect and understanding to increase consensus for mutual development.展开更多
From the view of the ecological theory, this paper tries to analyze that Thoreau uses Chinese traditional philosophical thought--- the oneness of man and nature to deal with the relationship of human beings and the na...From the view of the ecological theory, this paper tries to analyze that Thoreau uses Chinese traditional philosophical thought--- the oneness of man and nature to deal with the relationship of human beings and the nature in Walden.展开更多
China is one of the countries with the most serious flooding disasters.In China,above 70% of big cities,50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas wi...China is one of the countries with the most serious flooding disasters.In China,above 70% of big cities,50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas with serious flooding.Therefore,enhancement of theoretical study and experience summarization of urban flood control is of great theoretical and practical significance.As economy is developing rapidly,urban scale is expanding fast,and urban flood control stand is promoted.Urban flood control calls for new concept and methods.This paper makes a systematic summarization of concept evolution and advanced methods concerning urban flood control at home and abroad.The concept of urban flood control has transformed from simple flood control and drainage to coexistence with and use of flood.Flood control measures have transferred form emphasis upon engineering ones to priority to both engineering and non-engineering ones,with special attention to ecological flood control,such as making full use of ecological revetment,ecological realignment of a river,multi-objective management of urban flood detention region,turning flood into resources and utilization of wetlands.展开更多
Fourty-three cases of globoid dysplasia and signet ring cell carcinoma were stained by mucin and CEA (ABC method). It was found that there were three kinds of mucins (neutral, sialo and sulphomucin in both globoid dys...Fourty-three cases of globoid dysplasia and signet ring cell carcinoma were stained by mucin and CEA (ABC method). It was found that there were three kinds of mucins (neutral, sialo and sulphomucin in both globoid dysplastic cells and signet ring cells. The percentages of the three kinds of mucins seen in the two kinds of cells were not much different. It was indicated that the altered mucins in the gastric epithelial cells must be a sign of dedifferentiation of the cells and the results of malfunction. The globoid dysplasia type I mainly contained neutral mucin, whereas type II, the acid mucin was predominant, especially the sulphomucin. The CEA positive reaction became stronger as the atypia being remarkable, and the characteristics of distribution of CEA positive particles were similar in the two kinds of cells namely, randomly or disorderly in the cells. Based on the analysis of the results, a conclusion can be made that the variety of mucins in globoid dysplastic cells can be used as a reference point in classification and is not much significant in grading, but the amount of CEA positive matter can be a reference point in grading. The globoid dysplasia is such a lesion with special features in morphology and function manifested in the process of de-differentiation towards signet ring cell carcinoma following the successive action of carcinogens upon the cells of gastric epithelium.展开更多
Elizabeth Bishop is a well-known American poet and short story writer, whose literary works have been appreciated by readers and received many awards. This paper intends to have an analysis of one of Elizabeth Bishop...Elizabeth Bishop is a well-known American poet and short story writer, whose literary works have been appreciated by readers and received many awards. This paper intends to have an analysis of one of Elizabeth Bishop’s poem, The Moose, from the perspective of human-nature relationship showed in it and finds out that a harmonious relationship between mankind and nature can be interpreted from the poem. This paper is divided into three parts, including a brief introduction of the poet and the poem, the analysis of the poem, and the conclusion reached after the analysis.展开更多
To investigate the relationship between tendinopathy and higher production of prostaglandins E2 (PGE2) and leukotriene B4(LTB4) induced by cyclic stretching of human patellar tendon fibroblasts.Methods We used a novel...To investigate the relationship between tendinopathy and higher production of prostaglandins E2 (PGE2) and leukotriene B4(LTB4) induced by cyclic stretching of human patellar tendon fibroblasts.Methods We used a novel in vitro model system to mimic in vivo conditions,where human patellar tendon fibroblasts (HPTFs) were uniaxially stretched with different magnitudes of stretching (4%,8% and 12%).Non-stretched fibroblasts were used as control.The productions of PGE2 and LTB4 as well as the expression of cycloxygenase (COX) and 5-lipoxygenase (5-LO) were then measured every four hours of cyclic stretching.In addition,we treated the cells with inhibitors of COX or 5-LO.Results It was found that cyclic stretching of fibroblasts at 8% and 12% of stretching increased PGE2 and LTB4 levels.Blocking the COX enzyme with indomethacin (25 mol/L) decreased PGE2 levels but increased LTB4 production and vice versa.Whereas decreasing LTB4 production with MK-886 (10 μmol/L) could increase PGE2 levels compared to cells tretched without inhibitors.Conclusion Cyclic stretching of HPTFs produces high levels of PGE2 and LTB4,where a balance exists:blocking PGE2 production increases the production of LTB4,and vice versa.Therefore,this study raises the possibility that the routine use of COX inhibitors in clinical treatment of tendinopathy may exacerbate the condition by causing neutrophil-mediated inflammatory and degenerative changes in the tendon due to increased levels of LTB4,which is a potent chemoattractant for neutrophils.17 refs,3 figs.展开更多
Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal cancer.Herein,two series of chalcone derivatives were designed and synthesized aiming to find selective ...Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal cancer.Herein,two series of chalcone derivatives were designed and synthesized aiming to find selective and potent hNotum inhibitors.Structure–activity relationship(SAR)studies showed that 2-methoxyl and 5-bromine substitutions on A-ring significantly enhanced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum inhibition.Among all tested chalcones,B11 displayed the most potent anti-Notum effect(IC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic stability.Further investigations showed that B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer cells.Collectively,this study deciphers the SARs of chalcones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.展开更多
Flavonoids are structurally diverse and the most ubiquitous groups of polyphenols distributed in the various plants,which possess intensive biological activities.In this study,the interaction mechanisms between four f...Flavonoids are structurally diverse and the most ubiquitous groups of polyphenols distributed in the various plants,which possess intensive biological activities.In this study,the interaction mechanisms between four flavonoids containing one glucose unit with similar molecular weight isolated from the Tibetan medicinal herb Pyrethrum tatsienense,namely.apigenin-7-O-β-D-glucoside(1),luteolin-7-O-β-D-glucoside(2).quercetin-7-O-β-D-glucoside(3).quercetin-3-O-β-D-glycoside(4).and human serum albumin(HSA),were investigated by fluorescence.UV-vis absorbance,circular dichroism,and molecular modeling.The effects of biological metal ions Mg2+,Zn2+,and Cu2+ on the binding affinity between flavonoids and HSA were further examined.Structure-activity relationships of four flavonoids binding to HSA were discussed in depth and some meaningful conclusions have been drawn by the experiment data and theoretical simulation.In addition,an interesting phenomenon was observed that the microenvironment of the binding site I in HSA has hardly changed in the presence of 4 differentiating from the other three flavonoids on the basis of conformation investigations.展开更多
Robert Frost is one of the famous poets of the 20th century American literature who won the Pulitzer Prize for four times. The reason for his popularity is partially because he employs traditional verse form and iambi...Robert Frost is one of the famous poets of the 20th century American literature who won the Pulitzer Prize for four times. The reason for his popularity is partially because he employs traditional verse form and iambic pentameter pattern in poem writing, but the most important reason for the reputation of his poems lies in the thematic concern of something universal, such as death and life, love and hate, war and peace, the good and the evil, the wisdom of human life and etc. . A brief analysis will be given in the following text about the wisdoms of human life embodied in Robert Frost's poems from three aspects: 1. Relaxation and responsibility of man. 2. The decisions in life.展开更多
Objective: Accumulating evidence indicates that the gut microbiome has an increasingly important role in human disease and health. Fusobacterium nucleatum has been identified in several studies as the leading gut bact...Objective: Accumulating evidence indicates that the gut microbiome has an increasingly important role in human disease and health. Fusobacterium nucleatum has been identified in several studies as the leading gut bacterium which is present in colorectal cancer (CRC). Still it is not clear if Fusobacterium plays a causal role. Methods: To explore the cause-effect relationship between Fusobacterium nucleatum and colorectal cancer, a systematic review and re-analysis of studies published were performed. The method of the conditio sine qua non relationship was used to proof the hypothesis without Fusobacterium nucleatum infection, no colorectal cancer. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause-effect relationship between Fusobacterium nucleatum and colorectal cancer. Significance was indicated by a p-value of less than 0.05. Result: The data analyzed support the Null-hypothesis that without Fusobacterium nucleatum infection, no colorectal cancer. In the same respect, the studies analyzed provide highly significant cause-effect relationship between Fusobacterium nucleatum and colorectal cancer. Conclusion: The findings of this study suggest that Fusobacterium (nucleatum) is the cause of colorectal cancer.展开更多
文摘The relationship between human beings and nature influences the expressions and manifestations of literature. Literature can spy on the nature exploration of human society and ideological values in the thinking and behavior patterns,expressing the relationship between human beings and nature. Through expressions of literature in China and the West,we draw lessons from W estern literary expressions in the developing relationship between man and nature,and get inspiration for the development of Chinese literature.
文摘It is well established that environmental pollutions are most popular topics recendy and the factor of that is a dominant element that is worth to investigate to large extent.According to lots of human performance so far,negative human activities are like to be a vital driving force of pollutions in some cases.Therefore,the relationship between environment and negative human performance should be researched,which can give better methods to protect natural environment.
文摘The relationship between human lights and sovereignty is a key theoretical and practical issue that has aroused heated debate in the international human lights field. What are the viewpoints and positions of Western countries and developing countries on this issue? What is the deeply rooted reason for this debate? How can the relationship between the two be properly handled? This article will analyze these questions.
文摘British Economist Angus Maddison said that eco nomic development is a recent phenomenon inhuman history. Although human species have lived on the planet at least 2.5 million years, economic development only appeared around the 1850s. In pursuit of economic development, not all nationalities have been equally lucky. Among more than 200 countries in the world, only dozens of countries are devel oped. Onethird of the world's total population of 6.5 billion are living in poverty. In both developing and developed countries, the wealth gap is often obvious. Therefore, eco nomic development is the goal of each country, the aim of each politi cal party, and the wish of all people. However, economic development usually baffles people. As a result, understanding the relationship be tween economic development and human rights protection is a matter of urgency.
文摘Lawrence is regarded as one of most accomplished short story writers in twentieth century,with "Odour of Chrysanthemums" one of his early works.Through the death of a miner,the text shows how humanity was ruined by industrial civilization.This essay is intended to unveil the destructive force by analyzing the relationship between the husband and wife.
文摘Fetal eutaneous wounds that oeeur in earlygestation heal without sear formation.Althoughmueh work has been done to eharaeterize the roleof transforming growth
文摘The relationship between the Heaven and human beings is a central issue in the transformation of Confucianism in the Mid-Tang Dynasty.The discourses on the Heaven by Han Yu,Liu Zongyuan,and Liu Yuxi helped to promote the transformation and greatly influenced the transformation in literature.The differences in the poetry among the three authors may also be interpreted from the perspective of their perceptions of the Heaven—Han Yu’s discourse on the Heaven focused on the enemy-relationship between the Heaven and human beings,so his poems always showed tension and loss.Liu Zongyuan was interested in the alienation between the heaven and human beings,so his poems were more rational and placid than Han Yu’s.However,Liu Yuxi’s discourse on the Heaven paid attention to the positive influence of the Heaven on human beings,and most of his poems were filled with reason.The changes in the relationship between the Heaven and human beings lead to the broadened themes,innovated vocabulary,diversified styles,and varied fresh imageries.Likewise,the relationship between the Heaven and human beings established in the Song Dynasty led accordingly to a new type of literature different from the Tang literature.
基金国家自然科学基金面上项目“基于高压人群身心健康的工作环境绿色空间体系研究”(编号51978364)国家自然科学基金青年科学基金项目“北京地区城市森林疗养空间特征识别及健康效益定量评价”(编号51908310)Tsinghua-Toyota Joint Research Institute Cross discipline Program共同资助。
文摘As the process of economic globalization gathers momentum, dialogue between different cultures has become extremely important. There should be dialogue between the Chinese and Western cultures under the principle of equality and mutual respect and understanding to increase consensus for mutual development.
文摘From the view of the ecological theory, this paper tries to analyze that Thoreau uses Chinese traditional philosophical thought--- the oneness of man and nature to deal with the relationship of human beings and the nature in Walden.
基金supported by the Ministry of Construction Project,the research of the Code for urban planning on flood control(GB50XXX-20XX)
文摘China is one of the countries with the most serious flooding disasters.In China,above 70% of big cities,50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas with serious flooding.Therefore,enhancement of theoretical study and experience summarization of urban flood control is of great theoretical and practical significance.As economy is developing rapidly,urban scale is expanding fast,and urban flood control stand is promoted.Urban flood control calls for new concept and methods.This paper makes a systematic summarization of concept evolution and advanced methods concerning urban flood control at home and abroad.The concept of urban flood control has transformed from simple flood control and drainage to coexistence with and use of flood.Flood control measures have transferred form emphasis upon engineering ones to priority to both engineering and non-engineering ones,with special attention to ecological flood control,such as making full use of ecological revetment,ecological realignment of a river,multi-objective management of urban flood detention region,turning flood into resources and utilization of wetlands.
文摘Fourty-three cases of globoid dysplasia and signet ring cell carcinoma were stained by mucin and CEA (ABC method). It was found that there were three kinds of mucins (neutral, sialo and sulphomucin in both globoid dysplastic cells and signet ring cells. The percentages of the three kinds of mucins seen in the two kinds of cells were not much different. It was indicated that the altered mucins in the gastric epithelial cells must be a sign of dedifferentiation of the cells and the results of malfunction. The globoid dysplasia type I mainly contained neutral mucin, whereas type II, the acid mucin was predominant, especially the sulphomucin. The CEA positive reaction became stronger as the atypia being remarkable, and the characteristics of distribution of CEA positive particles were similar in the two kinds of cells namely, randomly or disorderly in the cells. Based on the analysis of the results, a conclusion can be made that the variety of mucins in globoid dysplastic cells can be used as a reference point in classification and is not much significant in grading, but the amount of CEA positive matter can be a reference point in grading. The globoid dysplasia is such a lesion with special features in morphology and function manifested in the process of de-differentiation towards signet ring cell carcinoma following the successive action of carcinogens upon the cells of gastric epithelium.
文摘Elizabeth Bishop is a well-known American poet and short story writer, whose literary works have been appreciated by readers and received many awards. This paper intends to have an analysis of one of Elizabeth Bishop’s poem, The Moose, from the perspective of human-nature relationship showed in it and finds out that a harmonious relationship between mankind and nature can be interpreted from the poem. This paper is divided into three parts, including a brief introduction of the poet and the poem, the analysis of the poem, and the conclusion reached after the analysis.
文摘To investigate the relationship between tendinopathy and higher production of prostaglandins E2 (PGE2) and leukotriene B4(LTB4) induced by cyclic stretching of human patellar tendon fibroblasts.Methods We used a novel in vitro model system to mimic in vivo conditions,where human patellar tendon fibroblasts (HPTFs) were uniaxially stretched with different magnitudes of stretching (4%,8% and 12%).Non-stretched fibroblasts were used as control.The productions of PGE2 and LTB4 as well as the expression of cycloxygenase (COX) and 5-lipoxygenase (5-LO) were then measured every four hours of cyclic stretching.In addition,we treated the cells with inhibitors of COX or 5-LO.Results It was found that cyclic stretching of fibroblasts at 8% and 12% of stretching increased PGE2 and LTB4 levels.Blocking the COX enzyme with indomethacin (25 mol/L) decreased PGE2 levels but increased LTB4 production and vice versa.Whereas decreasing LTB4 production with MK-886 (10 μmol/L) could increase PGE2 levels compared to cells tretched without inhibitors.Conclusion Cyclic stretching of HPTFs produces high levels of PGE2 and LTB4,where a balance exists:blocking PGE2 production increases the production of LTB4,and vice versa.Therefore,this study raises the possibility that the routine use of COX inhibitors in clinical treatment of tendinopathy may exacerbate the condition by causing neutrophil-mediated inflammatory and degenerative changes in the tendon due to increased levels of LTB4,which is a potent chemoattractant for neutrophils.17 refs,3 figs.
基金financially supported by the National Natural Science Foundation of China(Nos.82104281,81922070,81973286,81801818 and 82273897)Shanghai Municipal Health Commission’s TCM research project(No.2022CX005)+1 种基金Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004)Three-year Action Plan for Shanghai TCM Development and Inheritance Program[No.ZY(2021–2023)-0401]。
文摘Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal cancer.Herein,two series of chalcone derivatives were designed and synthesized aiming to find selective and potent hNotum inhibitors.Structure–activity relationship(SAR)studies showed that 2-methoxyl and 5-bromine substitutions on A-ring significantly enhanced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum inhibition.Among all tested chalcones,B11 displayed the most potent anti-Notum effect(IC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic stability.Further investigations showed that B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer cells.Collectively,this study deciphers the SARs of chalcones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.
基金financially supported by the National Natural Science Foundation of China(30960530)
文摘Flavonoids are structurally diverse and the most ubiquitous groups of polyphenols distributed in the various plants,which possess intensive biological activities.In this study,the interaction mechanisms between four flavonoids containing one glucose unit with similar molecular weight isolated from the Tibetan medicinal herb Pyrethrum tatsienense,namely.apigenin-7-O-β-D-glucoside(1),luteolin-7-O-β-D-glucoside(2).quercetin-7-O-β-D-glucoside(3).quercetin-3-O-β-D-glycoside(4).and human serum albumin(HSA),were investigated by fluorescence.UV-vis absorbance,circular dichroism,and molecular modeling.The effects of biological metal ions Mg2+,Zn2+,and Cu2+ on the binding affinity between flavonoids and HSA were further examined.Structure-activity relationships of four flavonoids binding to HSA were discussed in depth and some meaningful conclusions have been drawn by the experiment data and theoretical simulation.In addition,an interesting phenomenon was observed that the microenvironment of the binding site I in HSA has hardly changed in the presence of 4 differentiating from the other three flavonoids on the basis of conformation investigations.
文摘Robert Frost is one of the famous poets of the 20th century American literature who won the Pulitzer Prize for four times. The reason for his popularity is partially because he employs traditional verse form and iambic pentameter pattern in poem writing, but the most important reason for the reputation of his poems lies in the thematic concern of something universal, such as death and life, love and hate, war and peace, the good and the evil, the wisdom of human life and etc. . A brief analysis will be given in the following text about the wisdoms of human life embodied in Robert Frost's poems from three aspects: 1. Relaxation and responsibility of man. 2. The decisions in life.
文摘Objective: Accumulating evidence indicates that the gut microbiome has an increasingly important role in human disease and health. Fusobacterium nucleatum has been identified in several studies as the leading gut bacterium which is present in colorectal cancer (CRC). Still it is not clear if Fusobacterium plays a causal role. Methods: To explore the cause-effect relationship between Fusobacterium nucleatum and colorectal cancer, a systematic review and re-analysis of studies published were performed. The method of the conditio sine qua non relationship was used to proof the hypothesis without Fusobacterium nucleatum infection, no colorectal cancer. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause-effect relationship between Fusobacterium nucleatum and colorectal cancer. Significance was indicated by a p-value of less than 0.05. Result: The data analyzed support the Null-hypothesis that without Fusobacterium nucleatum infection, no colorectal cancer. In the same respect, the studies analyzed provide highly significant cause-effect relationship between Fusobacterium nucleatum and colorectal cancer. Conclusion: The findings of this study suggest that Fusobacterium (nucleatum) is the cause of colorectal cancer.