Correlation between the neuroendocrine axis,microbial species,inflammatory response,and gastrointestinal symptoms in irritable bowel syndrome

BACKGROUND This study examines the complex relationships among the neuroendocrine axis,gut microbiome,inflammatory responses,and gastrointestinal symptoms in patients with irritable bowel syndrome(IBS).The findings provide new insights into the pathophysiology of IBS and suggest potential therapeutic targets for improving patient outcomes.AIM To investigate the interactions between the neuroendocrine axis,gut microbiome,inflammation,and gastrointestinal symptoms in patients with IBS.METHODS Patients diagnosed with IBS between January 2022 and January 2023 were selected for the study.Healthy individuals undergoing routine check-ups during the same period served as the control group.Data were collected on neuroendocrine hormone levels,gut microbiome profiles,inflammatory biomarkers,and gastrointestinal symptomatology to analyze their interrelations and their potential roles in IBS pathogenesis.RESULTS IBS patients exhibited significant dysregulation of the neuroendocrine axis,with altered levels of cortisol,serotonin,and neuropeptides compared to healthy controls.The gut microbiome of IBS patients showed reduced diversity and specific alterations in bacterial genera,including Bifidobacterium,Lactobacillus,and Faecalibacterium,which were associated with neuroendocrine disturbances.Additionally,elevated levels of inflammatory markers,such as C-reactive protein,interleukin-6,and tumor necrosis factor-α,were observed and correlated with the severity of gastrointestinal symptoms like abdominal pain,bloating,and altered bowel habits.CONCLUSION The findings suggest that targeting the neuroendocrine axis,gut microbiome,and inflammatory pathways may offer novel therapeutic strategies to alleviate symptoms and improve the quality of life in IBS patients.

On the Relationship Between Human Rights and Sovereignty

The relationship between human lights and sovereignty is a key theoretical and practical issue that has aroused heated debate in the international human lights field. What are the viewpoints and positions of Western countries and developing countries on this issue？ What is the deeply rooted reason for this debate？ How can the relationship between the two be properly handled？ This article will analyze these questions.

On the Relationship between Human Rights Protection and Economic Development

British Economist Angus Maddison said that eco nomic development is a recent phenomenon inhuman history. Although human species have lived on the planet at least 2.5 million years, economic development only appeared around the 1850s. In pursuit of economic development, not all nationalities have been equally lucky. Among more than 200 countries in the world, only dozens of countries are devel oped. Onethird of the world＇s total population of 6.5 billion are living in poverty. In both developing and developed countries, the wealth gap is often obvious. Therefore, eco nomic development is the goal of each country, the aim of each politi cal party, and the wish of all people. However, economic development usually baffles people. As a result, understanding the relationship be tween economic development and human rights protection is a matter of urgency.

Practice and Outlook of China's Regulation on the Extraterritorial Human Rights Responsibilities of Transnational Corporations

As China’s overseas investment and business operations continue to expand,the issue of human rights risks faced by Chinese transnational corporations abroad has attracted sustained attention from society.In recent years,China has enacted a series of laws,regulations,and policies to better regulate the overseas business conduct of transnational corporations,urging them to respect the human rights of the people in host countries and fulfill their social responsibilities to achieve sustainable development.Meanwhile,China has actively participated in the formulation of the Legally Binding Instrument on Activities of Transnational Corporations and Other Business Enterprises in International Human Rights Law,providing a Chinese solution to promote global governance of transnational corporations.However,in practice,the lack of institutional mechanisms,systems,and industry rules to supervise and guide transnational enterprises in fulfilling their human rights responsibilities,as well as the limited awareness of human rights risks among these enterprises,have resulted in ongoing human rights risks in their overseas business operations,particularly regarding labor rights and environmental rights.In response,China should take its national conditions into consideration and focus on the development trends of human rights issues in the business sector at the international level.Drawing on the experiences of other countries,China should explore and establish institutional and practical measures to regulate the human rights responsibilities of transnational enterprises through legislation,administration,and judiciary actions,in order to address the risks and challenges faced by Chinese enterprises in foreign investments and contribute to the sustainable development of the world and global human rights governance.

An Analysis of Specific Categories of Birth Defects and Developmental Disabilities for Children of Participants of the Air Force Health Study

Background: The Air Force Health Study collected reproductive outcomes for live-born children of male Air Force veterans of the Vietnam War. Methods: Dioxin values for participants were obtained from blood samples. Analyses were conducted of occurrence of 16 specific categories of birth defects and developmental disabilities. Children were categorized as conceived before and after the start of participants’ Vietnam War service. Children conceived before the start of Vietnam War service were treated as being conceived when their fathers had unquantifiable dioxin values. Children conceived after the start of Vietnam War service for participants with missing dioxin values were excluded from primary analyses, but were used to assess the impact of their exclusion on conclusions. Correlation between values for specific categories for multiple children fathered by the same participant was accounted for. The dose-response relationship was treated as a step function increasing for dioxin values larger than adaptively identified individual thresholds changing with the specific category. Results: For 15 of 16 specific categories, the probability of occurrence increased substantially for a sufficiently high dioxin level above identified thresholds. Exclusion of children due to missing dioxin likely did not affect these results. Conclusions: Results supported the conclusion of substantial adverse effects on a wide variety of specific categories of birth defects and developmental disabilities due to sufficiently high exposures to dioxin, a toxic contaminant of Agent Orange used for herbicide spraying in the Vietnam War. Results may hold more generally, but might also have been affected by a variety of limitations.

Enterprise innovation, corporate social responsibility and their interactive relationship: A review

Under the new normal economic growth, lack of motivation, structural imbalances in the economy, the shortage of resources, resource utilization inefficiency, environmental damage and other issues have become increasingly prominent, enterprises as the carrier of economy is one of the root of the problem. Research on enterprise innovation and corporate social responsibility issues, it is conducive to the development of enterprise itself and the transformation of Chinese economy. This paper reviewed the research status of relationships between innovation and corporate social responsibility, through comb the aspects of the definitions and evolution of enterprise innovation and social responsibility, also include both the relationship and the new way(responsible innovation) of combination of them, we found the presence of index system is not perfect, and lack of in-depth comprehensive study and opportunities for future research is prospected.

Interaction Relationship Between Corporate Social Responsibility and Corporate Performance:Evidence from 201 Chinese Listed Companies and Preliminary Study of Its Underlying Mechanism

Corporations actively fulfilling corporate social responsibility(CSR)is of more significance to society's sustainable development nowadays.This research discusses the interaction between CSR and corporate performance and then adopts other mediation variables to explain the underlying mechanism.The empirical analyses are performed on a sample of 201 listed Chinese firms.The result shows that CSR has a weak negative impact on corporate perfbnnance while being positively influenced by corporate performance significantly.Further study finds the reason may be CSR requires financial support,but has little to do with increasing shareholder wealth.

RELATIONSHIP BETWEEN MAN AND NATURE IN TRADITIONAL HUMAN RIGHTS CONCEPTS OF CHINA AND WEST

As the process of economic globalization gathers momentum, dialogue between different cultures has become extremely important. There should be dialogue between the Chinese and Western cultures under the principle of equality and mutual respect and understanding to increase consensus for mutual development.

A review of the health effects and exposure-responsible relationship of diesel particulate matter for underground mines

The increasing use of diesel-powered equipment in confined spaces(underground mines) has the potential to over expose underground miners under the threat of diesel particulate matter(DPM). Miners in underground mines can be exposed to DPM concentrations far more than works in other industries. A great number of animal and epidemiological studies have shown that both short-term and long-term DPM exposure have adverse health effect. Based on reviews of related studies, especially some recent evidence, this paper investigated the long and short-term health effects based on animal studies and epidemiological studies. The exposure-response relationship studies were also explored and compared to the current DPM regulation or standards in some countries. This paper found that the DPM health effect studies specifically for miners are not sufficient to draw solid conclusions, and a recommendation limit of DPM concentration can be put in place for better protection of miners from DPM health risk. Current animal studies lack the use of species that have similar lung functions as human for understanding the cancer mode of action in human. And finally, the DPM health hazard will continue to be a challenging topic before the mode of action and reliable exposure-response relationship are established.

Network Biological Modeling:A Novel Approach to Interpret the Traditional Chinese Medicine Theory of Exterior-Interior Correlation Between the Lung and Large Intestine

Objective To study the common pathogenesis of pneumonia and colitis using modern biological network analysis tools,and to explore the theory that the lung and large intestine are exteriorly and interiorly related.Methods The relevant target genes(hereinafter,“targets”)of pneumonia and colitis were separately queried on the GeneCards database.The main targets of the two diseases were then screened out according to their correlation scores and intersected to obtain those common to the two diseases.Metascape was used to analyze the main and common targets identified,and the Database for Annotation,Visualization and Integrated Discovery(DAVID)was used to enrich and analyze the common targets.Cytoscape 3.7.2 software was used to build the network diagram.Results In total,54 targets,such as TNF,IL-10,IL-6,IL-2,IL-4,TLR4,TLR2,CXCL8,IL-17A and IFNG,etc.,are common to pneumonia and colitis,which are mainly enriched in these processes such as cytokine–cytokine receptor interaction,the Tcell receptor signaling pathway,the Toll-like receptor signaling pathway and the Jak-STAT signaling pathway.The Metascape modular analysis identified 11 modules for pneumonia,six modules for colitis,and two modules for the common targets.Conclusions Pneumonia and colitis have the same pathogenic targets and mechanisms of action and finally interact with each other through inflammatory reactions and immune responses.This provides a probable molecular mechanism that explains the theory that the lung and large intestine are exteriorly and interiorly related.

Unit Environmental Property Rights: Efficiency, Responsibility and System

The inexplicit efficiency of environmental property rights lies in its fuzziness. Based on the character of environmental property rights discussed, unit environment shows intra relationship between efficiency and duty of environmental property rights, and constructs a symmetrical system arrangement. Through analyzing the possibility and feasibility of unit environmental property rights, the significance of symmetrical system arrangement to avoid the inexplicit efficiency of environmental property rights is discussed in this dissertation from the aspect of the validity of offering and implementing system.

Research on Current Situation and Legal Regulation of Cosmetics Live Streaming E-commerce in China

Analyze the compatibility between cosmetics and live streaming e-commerce from its own nature,marketing means and supply chain characteristics.According to the prominent problems,sort out the relationship between all parties in the cosmetics live e-commerce industry chain.Combined with the latest regulatory policies of live streaming e-commerce and cosmetics,the responsibilities of different subjects in cosmetics live streaming e-commerce are summarized,and relevant suggestions and countermeasures are put forward for the standardization and development of live streaming e-commerce.Cosmetics brand owners are the first responsible persons for product quality.Anchors,as a mixed identity between intermediary,advertising spokesperson and operator,should bear stricter joint and several liability when recommending products related to consumers’health.If anchors fail to clearly identify themselves in the recommendation process,thus causing consumers to mistake them for the operator of the cosmetics,they should assume the obligations of the operator.

On the Rule of Law Path for Inclusive Education to Empower Education Assistance for Persons with Disabilities

Inclusive education is the mainstream of developing education for persons with disabilities worldwide.It advocates the recognition and protection of the right of persons with disabilities to receive inclusive education in mainstream schools.From the perspective of inclusive education,the educational assistance system for persons with disabilities represents a theoretical innovation in traditional educational support methods,playing a crucial role in integrating persons with disabilities into society,reversing their disadvantaged status,and maintaining educational equity.At present,China's legal system for inclusive education assistance for persons with disabilities needs improvement,and faces several obstacles,including conceptual“limited capacity”,“monotonous”subjects,“crowding-out”obstacles and supervision“absence”obstacles.It is urgent to begin with the transformation of the rule of law concept,clarify the legal positioning of multiple responsibility subjects,achieve mutual reinforcement of education law and education aid legislation,establish a supervision system for inclusive education assistance,and improve the legal framework for educational assistance for persons with disabilities.This will ensure that persons with disabilities can successfully realize their right to education,share in the benefits of social development,and ultimately contribute to achieving common prosperity.

The Effects of Community Responsibility on the Long-Term Performance of Small Grocery Store Industry in Thailand

This research currently investigates the severe situation of fierce competition for traditional small grocery stores in grocery retailing industry and the studies of corporate social responsibility （CSR） of small grocery retailing shops in Thailand. There are gaps in literatures： （1） Most of the researches try to study CSR for small- and medium-size enterprises （SMEs） business related to general society. Thus, no paper has studied CSR for a specific community, where the small grocery stores are located; and （2） Papers studying the relationship of marketing as the successful strategy for small grocery stores in competing among grocery retailing industry are scarce. Therefore, the author proposes a new variable---community responsibility and the model of the effects of community responsibility on the long-term performance, in order to reduce the serious problem. By testing the model with the survey data, the author finds that the effects of community responsibility of grocery stores （product） on the long-term relationship are strongly and positively significant. While the effects of community responsibility of grocery stores （environment） on the long-term relationship are not significant.

Analysis on Epidemiology Causality Relationship Theory under Food and Drug Safety Context

Violation of food and drug safety and other hazard crimes have the features of long latency and multiple factors. Traditional criminal law causality theory is no controversy to determine causality of criminal responsibility, thus it is necessary to introduce the epidemiology causality theory-it is a kind of causality theory based on epidemic diseases, and it is the high degree of probability in the determination of causality in criminal laws so as to solve the traditional attribution problem, but the theory also exists applicable restriction conditions in judicial practice.

New Developments and Challenges in the UN Norms on Human Rights Responsibilities of Transnational Corporations

With the adoption of the"Legally Binding Instrument to Regulate,in International Human Rights Law,the Activities of Transnational Corporations and other Business Enterprises"and its revised draft,the codification of the human rights responsibilities of transnational corporations has entered a new era The instrument aims to supplement the shortcomings of transnational corporations in fulfilling their human rights responsibilities by strengthening the obligations of states and to improve the host country’s inadequate remedies for human rights violations by establishing extraterritorial human rights jurisdiction of home countries But the instrument has encountered various challenges because the human rights obligations and legal responsibilities of states go beyond the current domestic human rights systems and impact the existing theories and practices of international human rights law In order to resolve the differences among countries,the future codification of the instrument should be based on existing domestic and international legal systems and practices striking a balance between the interests of developing and developed countries,taking into account the objectives of both the fair treatment of transnational corporations and human rights protection,to promote the regulatory effect of the human rights responsibilities of transnational corporations.

Human Rights Protection and Global Action under the Impact of the COVID-19 Pandemic——Overview of“2021·China-Europe Seminar on Human Rights”

The COVID-19 pandemic is the largest ever infectious disease facing mankind.It challenges national governance capabilities and international patterns.On June 8,2021,the“2021 China-Europe Seminar on Human Rights”was held in Chongqing,China.Its theme was“COVID-19 Pandemic and the Protection of the Right to Life and Health,”which focused on five topics:the impact of the COVID-19 pandemic on the protection of the rights to life and health,the response of countries against the pandemic,the protection of the right to life and health of specific groups during the pandemic response,the national responsibility for the protection of the right to life and health in the public health crisis,and global cooperation in the prevention and control of the COVID-19 pandemic.The conference reached two consensuses:First,in the face of the pandemic,countries must take responsibility for the people and protect the people’s right to life and health;second,an effective international mechanism for fighting the COVID-19 pandemic must be established as soon as possible.

Customer Concentration and Corporate Social Responsibility——An Empirical Study Based on Chinese Agricultural Listed Companies

Taking the agricultural companies listed in the A-share markets in Shanghai and Shenzhen as samples,the relationship between customer concentration and corporate social responsibility was studied. In addition,the regulatory role of property rights and regional factors was examined. The results showed that the degree of customer concentration is negatively related to the degree of fulfillment of corporate social responsibility; for companies with different property rights and regions,there are significant differences in the influence of customer concentration on corporate social responsibility. In non-state-owned enterprises and mid-western areas,customer concentration has a greater impact on corporate social responsibility.

Constitutive relationship of ionic polymer-metal composite and static response character of its cantilever setup to voltage

As a new ionic polymer-metal composite(IPMC) for artificial muscle,the mechanical performance parameters and the relationship between the deformation and the electrical parameters of the IPMC were studied. With the digital speckle correlation method,the constitutive relationship of the IPMC was confirmed. With non-contact photography measurement,a cantilever setup was designed to confirm the relationship between the deformation of the IPMC film and the applied voltage. The relationship curve of tip displacement of the IPMC cantilever setup vs the voltage was achieved. The results indicate that the IPMC is isotropic,its elastic modulus is 232 MPa and Poisson ratio is 0.163. The curve achieved from the test of the tip displacement of the IPMC cantilever setup shows that the tip displacement reaches the maximum when the stimulated voltage is 5 V. And the tip displacement descends largely when the frequency of the applied voltage is between 30 mHz and 100 mHz.

Mechanism of Photothermal Energy on the Growth and Yield of Rice under Water Level Regulation

The flooding caused by heavy rainfall in rice irrigation area and the drought caused by the drop of groundwater level are the research focus in the field of irrigation and drainage.Based on the comparative experiment and farmland water level control technology,this paper studied the average soil temperature under different soil layers(TM),the daily temperature change(TDC),the photosynthetic accumulation of single leaf and canopy in rice,and response of photothermal energy to rice root characteristics and growth factors in the paddy field under drought conditions.The results showed that the peak soil temperature under drought treatment was basically synchronous with the conventional irrigation,and the it was delayed by 2–6 h under flooding treatment compared to the drought treatment.Under different water gradients,the temperature decreased according to T_(L)>T_(CK)>T_(H)(L,H and CK represented water flooding,drought and control treatments),and the TDC was opposite.In addition to milky stage,the daily photosynthetic(Pn)accumulation of single leaf and canopy in the flooding and drought treated paddy fields were lower than conventional irrigation,and had a negative impact on leaf area index(LAI)and yield(YR),but did not form fatal damage.The root characteristic factors,RL(root length),RW(root weight),R-CR(root-canopy ratio)were promoted with drought,and YR under light drought was slightly higher than that under heavy drought.There was a strong positive correlation between TM and R-CR in all rice growth stages,while TDC-5 was negatively correlated with effective panicle number,TDC and R-CR in 20 cm soil layer were positively correlated.The correlation between daily Pn accumulation and YR was low,and the correlation between Pn and YR factors was negative or weak positive or negative.The total Pn was positively correlated with yield factors,and the correlation coefficient was higher than that of daily Pn.