High rate of clinically relevant improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis

BACKGROUND The minimal clinically important difference(MCID)is defined as the smallest meaningful change in a health domain that a patient would identify as important.Thus,an improvement that exceeds the MCID can be used to define a successful treatment for the individual patient.AIM To quantify the rate of clinical improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis.METHODS Patients were treated with the Global Unite total shoulder platform arthroplasty between March 2017 and February 2019 at Herlev and Gentofte Hospital,Denmark.The patients were evaluated preoperatively and 3 months,6 months,12 months,and 24 months postoperatively using the Western Ontario Osteoarthritis of the Shoulder index(WOOS),Oxford Shoulder Score(OSS)and Constant-Murley Score(CMS).The rate of clinically relevant improvement was defined as the proportion of patients who had an improvement 24 months postoperatively that exceeded the MCID.Based on previous literature,MCID for WOOS,OSS,and CMS were defined as 12.3,4.3,and 12.8 respectively.RESULTS Forty-nine patients with a Global Unite total shoulder platform arthroplasty were included for the final analysis.Mean age at the time of surgery was 66 years(range 49.0-79.0,SD:8.3)and 65%were women.One patient was revised within the two years follow-up.The mean improvement from the preoperative assessment to the two-year follow-up was 46.1 points[95%confidence interval(95%CI):39.7-53.3,P<0.005]for WOOS,18.2 points(95%CI:15.5-21.0,P<0.005)for OSS and 37.8 points(95%CI:31.5-44.0,P<0.005)for CMS.Two years postoperatively,41 patients(87%)had an improvement in WOOS that exceeded the MCID,45 patients(94%)had an improvement in OSS that exceeded the MCID,and 42 patients(88%)had an improvement in CMS that exceeded the MCID.CONCLUSION Based on three shoulder-specific outcome measures we find that approximately 90%of patients has a clinically relevant improvement.This is a clear message when informing patients about their prognosis.

Role of immune relevant factors in regenerative processes of bone tissue: a bibliometric and visualized analysis

Background:There is a deficiency of bibliometric and visually represented analysis in research on the immunological related variables involved in bone tissue regeneration.Using bibliometric and visual analysis,this study sought to thoroughly examine the hotspots and future directions in the investigation of immunological important variables in bone tissue regeneration.Methods:The Web of Science Core Collection(WoSCC)database was searched and a collection of published works on the subject of immunological related factors in bone tissue regeneration between 2000 and 2021 was generated.The data chosen from the WoSCC were then subjected to a systematic bibliometric and visualized analysis using the online bibliometric analytics system,Apache ECharts,VOSviewer,Bibliographic Items Co-occurrence Matrix Builder 2.0,and Gcluto 1.0.Results:For this investigation,1,088 publications on the involvement of immune related components in bone tissue regeneration were chosen.Between 2000 and 2021,China maintained its supremacy in global research on the function of immune related components in bone tissue regeneration.Shanghai Jiao Tong University is the most productive institution.Biomaterials has published the most publications on the involvement of immune-related components in bone tissue regeneration.Xiao Y,Schmidt-Bleek K,and Ignatius A all played important roles in the study of immune-related variables in bone tissue regeneration.Research on the role of immune relevant factors in bone tissue regeneration has identified five hotspots:(1)macrophage-based immunomodulation on osteogenesis of mesenchymal stem cells(MSCs);(2)biomaterials for bone repair in bone tissue engineering;(3)osteoimmunomodulation mediated by inflammation and macrophages during bone healing;(4)osteoimmunomodulation in angiogenesis during bone regeneration;and(5)the effect of macrophage polarization regulated by bone tissue engineering on osteogenic differentiation of MSCs as bone tissue.Conclusion:This study represents the first-ever bibliometric and visualized examination of how immune factors contribute to bone tissue regeneration.The focus and forthcoming direction in bone regeneration research will be on macrophage-driven immunomodulation in the process of bone regeneration.

Relevant Visual Semantic Context-Aware Attention-Based Dialog

The existing dataset for visual dialog comprises multiple rounds of questions and a diverse range of image contents.However,it faces challenges in overcoming visual semantic limitations,particularly in obtaining sufficient context from visual and textual aspects of images.This paper proposes a new visual dialog dataset called Diverse History-Dialog(DS-Dialog)to address the visual semantic limitations faced by the existing dataset.DS-Dialog groups relevant histories based on their respective Microsoft Common Objects in Context(MSCOCO)image categories and consolidates them for each image.Specifically,each MSCOCO image category consists of top relevant histories extracted based on their semantic relationships between the original image caption and historical context.These relevant histories are consolidated for each image,and DS-Dialog enhances the current dataset by adding new context-aware relevant history to provide more visual semantic context for each image.The new dataset is generated through several stages,including image semantic feature extraction,keyphrase extraction,relevant question extraction,and relevant history dialog generation.The DS-Dialog dataset contains about 2.6 million question-answer pairs,where 1.3 million pairs correspond to existing VisDial’s question-answer pairs,and the remaining 1.3 million pairs include a maximum of 5 image features for each VisDial image,with each image comprising 10-round relevant question-answer pairs.Moreover,a novel adaptive relevant history selection is proposed to resolve missing visual semantic information for each image.DS-Dialog is used to benchmark the performance of previous visual dialog models and achieves better performance than previous models.Specifically,the proposed DSDialog model achieves an 8% higher mean reciprocal rank(MRR),11% higher R@1%,6% higher R@5%,5% higher R@10%,and 8% higher normalized discounted cumulative gain(NDCG)compared to LF.DS-Dialog also achieves approximately 1 point improvement on R@k,mean,MRR,and NDCG compared to the original RVA,and 2 points improvement compared to LF andDualVD.These results demonstrates the importance of the relevant semantic historical context in enhancing the visual semantic relationship between textual and visual representations of the images and questions.

Contribution and Relevance of Transfontanellar Ultrasound in Newborns in Ouagadougou: Multicentre Study on 1000 Cases

Objectives: To demonstrate the contribution and relevance of ETFs through the study of 1000 examination reports carried out in the medical imaging departments of the OUAGADOUGOU CHU. Material and method: Analytical descriptive study with retrospective collection, extended from 1st January 2020 to 1st January 2022. Results: Of the 1000 transfontanellar ultrasound reports, the mean age of patients was 7.61 +/ 7.5 days, with extremes of zero and 28 days. Sex was specified in 989 cases. Males accounted for 54.49% and females for 45.51%. 555 transfontanellar ultrasound were performed in 2020. 441 in 2021 and 4 in 2022. 61.9% of transfontanellar ultrasound were performed at the Bogodogo University Hospital, 205 at Charles de Gaulle and 176 at Tengandogo. Indications for transfontanellar ultrasound were dominated by neonatal distress (65.8%), followed by convulsions (10.2%) and prematurity (9.1%). Transfontanellar ultrasound was normal in 570 cases (57%) and abnormal in 430 cases (43%). Abnormalities were dominated by haemorrhage and ischaemic lesions in 66.28% (285) and 21.63% (93) of cases respectively. In the group of normal transfontanellar ultrasound, neonatal distress represented 59.65% of indications and prematurity 10.7% of indications. As for abnormal transfontanellar ultrasound, neonatal suffering accounted for 73.95% of indications and convulsions for 12.56%. The average age ofpatients with an abnormal transfontanellar ultrasound was 8.74 days +/ 7.89 days. The indication for investigations was relevant in 42.2% of cases and irrelevant in 57.8%;of the transfontanellar ultrasound with relevant indications, 0.71 were normal and 99.29 abnormal;of the transfontanellar ultrasound with irrelevant indications, the transfontanellar ultrasound was normal in 98.1% and abnormal in 1.9%. Conclusion: Transfontanellar ultrasound is an important part of ultrasound in current practice. Haemorrhage, anoxic-ischaemic lesions and hydrocephalus are the most frequent pathologies found by this technique in newborns. Whether or not the examinations were normal depended on the appropriateness of the prescription.

Application Analysis of Nursing Students'Grades in Course Relevance Based on Association Rule Mining Algorithm Apriori

By analyzing the correlation between courses in students’grades,we can provide a decision-making basis for the revision of courses and syllabi,rationally optimize courses,and further improve teaching effects.With the help of IBM SPSS Modeler data mining software,this paper uses Apriori algorithm for association rule mining to conduct an in-depth analysis of the grades of nursing students in Shandong College of Traditional Chinese Medicine,and to explore the correlation between professional basic courses and professional core courses.Lastly,according to the detailed analysis of the mining results,valuable curriculum information will be found from the actual teaching data.

Relevant theoretic account of humor in sketches

Based on the relevant theory, this paper makes an analysis of humor in Chinese popular art form --sketch. It is believed that the maximal relevance and the optimal relevance of utterances, explicature and implicature of utterances, and the efforts made by hearers in dealing with utterances are three important aspects in showing humorous effects in sketches, among which sketch actors＇ violating the mutual cognitive environment so as to create an unexpected effect on hearers is the core in creating humor in sketches. Through analyzing some excerpts from the sketch Yesterday.Today.Tomorrow, the author tries to explore the relevance nature of language in sketch and creation of humor in it.

Culturally Relevant Pedagogy in Teaching Proficiency through Reading and Storytelling

When the demographics in American public schools became more diverse,educators have faced the challenge of working with diverse student learners.In the education field,culturally relevant pedagogy has been widely recognized as an effective practice for teaching about diversity and is used across different school subject areas.This article discusses the four aspects in which teachers can implement culturally relevant pedagogy in TPRS language classrooms:a caring learning community,establishing meaning,story asking,and story reading.Teachers can include and empower students by validating them as learning subjects and engaging them in knowledge creation and representation in curriculum and instruction.The goal is to develop academic success,culture and identity,equity,and excellence for all student learners in a multicultural and global society.

Relevant Analysis of Grassland Temperature and Ground Net Radiation in Guilin

[Objective] The aim was to study the relevance of grassland temperature and ground net radiation in Guilin.[Method] By dint of ground observation data and net radiation of national benchmark climate station in Guilin from 2007 to 2009,the changes of grassland temperature and ground net radiation were expounded and their relations were pointed out.[Result] The annual changes trends of grassland temperature and ground net radiation in Guilin were basically the same.Monthly average maximum value all appeared in summer(July to August).Monthly average lowest value appeared in winter(December to next January);monthly average grassland temperature and monthly average ground net radiation had positive relation.Grassland temperature and ground net radiation had basically same distribution in four seasons.The average largest value of ground net radiation in summer was the largest and average smallest value was the smallest;the average largest value of ground net radiation in cloudy days was the smallest and average minimum value was the largest;the daily difference was the largest in sunny day and daily difference was the smallest in cloudy day.The daily changes trend of grassland temperature and ground net radiation in different weather state were basically the same;when it was sunny or cloudy,the daily largest value of grassland temperature and ground net radiation occurred between 15:00 and 19:00;when it was overcast,there was no distinct peak and daily changes.The largest value of the daily extreme value of grassland temperature and ground net radiation took place from 12:00 to 15:00.The daily lowest value took place from 20:00 to 07:00 on the next day.[Conclusion] The study provided reference for the analysis of temperature changes in Guilin.

Latent Supportive Utility of Irrelevant Attributes in Feature Selection

This paper proposed a novel feature selection method LUIFS （ latent utility of irrelevant feature selection） that not only selects the relevant features, but also targets at discovering the latent useful irrelevant attributes by measuring their supportive importance to other attributes. The method minimizes the information lost and simultaneously maximizes the final classification accuracy. The classification error rates of the LUIFS method on 16 real-life datasets from UCI machine learning repository were evaluated using the ID3, Na^ve-Bayes, and IB （instance-based classifier） learning algorithms, respectively; and compared with those of the same algorithms with no feature selection （NoFS）, feature subset selection （FSS）, and correlation-based feature selection （CFS）. The empirical results demonstrate that the LUIFS can improve the performance of learning algorithms by taking the latent relevance for irrelevant attributes into consideration, and hence including those potentially important attributes into the optimal feature subset for classification.

Relevant Enzymes, Genes and Regulation Mechanisms in Biosynthesis Pathway of Stilbenes

Stilbenes are natural phenolic compounds which function as antimicrobial phytoalexins in plants and affect human health as cardioprotective, antibaceteria, antioxidative and antineoplastic agents. In this review, the progresses of study on relevant enzymes, genes, and regulation mechanism in biosynthesis pathway of stilbenes are described. Here we introduce a holistic and systematic method of researching relevant enzymes, genes and other regulatory factors in biosynthesis pathway of stilbenes—Systems biology. The application of knowledge of relative enzymes, genes and regulation mechanisms in stilbenes biosynthesis in metabolic engineering which is used as a tool of improving the disease resistance of plants and health caring quality of crops is also discussed.

The development of a culturally relevant preventive intervention

Researchers often publish the numerical findings of their intervention studies while overlooking the experiential findings that could help promote more appropriate and effective interventions in the future. The present paper describes the process by which we developed a culturally relevant preventive intervention for Korean American adolescents aged 11 to 14 years and their parents. We discuss the main findings of a series of pilot studies and demonstrated how lessons learned from each study guided the development process and informed the research that followed. Program development is an iterative process that incorporates feedback from study participants. Cultural relevance is ensured when participants’ voices are reflected in the program development, implementation, and evaluation process. The final outcome of the development process was the preventive intervention improving parent-child relationships, increasing parental knowledge, enhancing parental self-efficacy, and decreasing parental stress among Korean American parents, and ultimately promoting Korean American adolescents’ mental health. The specific aims of this two-group, repeated-measures, controlled randomized study were to test the feasibility of the PRIDE (Promoting Intergenerational Dialogue about Emotional Problems) intervention and to compare its efficacy with an attention control (AC) group regarding parental knowledge, parental and filial self-efficacy, parent-child (P-C) communication, P-C conflicts, and P-C satisfaction.

Correction to:The dissemination of relevant information on wildlife utilization and its connection with the illegal trade in wildlife

Correction to:J.For.Res.https://doi.org/10.1007/s11676-021-01306-y The article“The dissemination of relevant information on wildlife utilization and its connection with the illegal trade in wildlife”,written by Zhifan Song·Qiang Wang·Zhen Miao·Wei Zhang and Xuehong Zhou,was originally pub-lished electronically on the publisher’s internet portal on 11th March 2021 without open access.

Using density functional calculations to elucidate atomic ordering of Pd-Rh nanoparticles at sizes relevant for catalytic applications

Pd-Rh nanoparticles are known to easily undergo surface restructuring in reactive environment. This study quantifies, with the help of density functional(DFT) calculations and a novel topological approach, atomic ordering and surface segregation effects in Pd-Rh particles with compositions 1:3, 1:1 and 3:1 containing up to 201 atoms(ca. 1.7 nm). The obtained data are used to reliably optimise energetically preferred atomic orderings in inaccessible by DFT Pd-Rh particles containing thousands of atoms and exhibiting sizes exceeding 5 nm, which are typical for catalytic metal particles. It is outlined, how segregation effects on the surface arrangement of Pd-Rh nanoalloy catalysts induced by adsorbates can be evaluated in a simple way within the present modelling setup.

X-Ray Induced Mutation Frequency at the <i>Hypoxanthine Phosphoribosyltransferase</i>Locus in Clinically Relevant Radioresistant Cells

To elucidate the molecular mechanisms underlying cellular radioresistance, clinically relevant radioresistant cell lines were established via long-term exposure to X-rays with stepwise dose escalation. Established cells continue to proliferate despite exposure to 2 Gy X-rays/day for more than 30 days, a standard protocol in cancer radiotherapy. DNA repair fidelity in radioresistant and the parental cells by evaluating the mutation frequency at the hypoxanthine phosphoribosyltransferase (HPRT) locus after exposure to X-rays was determined. Mutation spectrum at the HPRT locus was examined by multiplex polymerase chain reaction. Rejoining kinetics of X-ray-induced DNA double strand breaks (dsbs) was evaluated by the detection of phosphorylated histone H2AX (γH2AX) after X-irradiation. The fold increase in the HPRT mutation frequency due to acute radiation was similar between radioresistant and the parental cell lines. However, fractionated radiation (FR) consisting of 2 Gy X-rays/day increased the mutation frequency at the HPRT locus in parental but not in radioresistant cells. Analysis of the FR-induced mutations at the HPRT locus revealed a high frequency of deletion mutations (>70%) in parental but not in radioresistant cells. As assessed by γH2AX immunostaining, DNA dsbs induced by acute exposure to 10 Gy of X-rays were repaired to the control level within 7 days in radioresistant but not in the parental cells. Moreover, 2 Gy × 5 FR increased the number of γH2AX-positive cells in parental cultures but not in radioresistant cultures. DNA dsbs induced by 2 Gy/day FR are repaired with fidelity in radioresistant but not in parental cells.

Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula:A narrative review

Clinically relevant postoperative pancreatic fistula(CR-POPF)has continued to compromise patient recovery post-pancreatectomy despite decades of research seeking to improve risk prediction and diagnosis.The current diagnostic criteria for CR-POPF requires elevated drain fluid amylase to present alongside POPFrelated complications including infection,haemorrhage and organ failure.These worrying sequelae necessitate earlier and easily obtainable biomarkers capable of reflecting evolving CR-POPF.Drain fluid has recently emerged as a promising source of biomarkers as it is derived from the pancreas and hence,capable of reflecting its postoperative condition.The present review aims to summarise the current knowledge of CR-POPF drain fluid biomarkers and identify gaps in the field to invigorate future research in this critical area of clinical need.These findings may provide robust diagnostic alternatives for CR-POPF and hence,to clarify their clinical utility require further reports detailing their diagnostic and/or predictive accuracy.