Research Progress on the Role of miRNA-448 in Tumor

MicroRNA (miRNA) is a class of endogenous non-coding and regulatory single stranded small RNA molecules, about 18 - 24 nucleotides in length. More than 800 miRNA coding genes have been identified in the human genome, and about 113 target genes are predicted to be regulated, which distinguishes it from most oligonucleotides and functional RNA degraded fragments. It is involved in the regulation of cell proliferation, differentiation, apoptosis and other cell activities. At the same time, it is abnormal in liver cancer, breast cancer, glioma and other tumors, becoming a new biomarker, and participating in cancer differentiation, invasion and metastasis through the interaction with multiple target genes, such as SATB1, NF-KB and 5-HT2B. Mir-448 is abnormally expressed in a variety of tumor cells, such as liver cancer and non-small cell lung cancer. mirNA-448 may play a very important role in tumors. In order to deepen the understanding of the role of mirNA-448 in tumors, this paper reviews the research progress of the role of mirNA-448 in tumors.

COMPREHENSIVE INTERNATIONAL COOPERATION PROGRESS IN THE RESEARCH ON CAPILLARY ELECTROPHORESIS

With the help and support of the CAS and the National Foundation for Natural Sciences(NFNS) of China,the research team headed by research fellow Lin Bingcheng at our Institute succeeded recently in unfolding a series of research activities yielding notable results,such as participation in international projects,attendance of overseas symposia,and invitation of Chinese scholars residing abroad to return home and give lectures.The move not only promoted the completion of related research assign-

Researchers in Xi'an Jiaotong University have made important progress in the research of flexible epitaxial magnetic nanowire arrays

In recent years,flexible materials are widely concerned by scientists because of their unique bendingproperties and potential applications in flexible wearable electronic devices.Magnetic material,especially one dimensional nano structure with high orientation,are also research focus for researchers due to their important applications in the fields of high density magnetic storage and sensors.Compared

Progress on the Study of the Anti-Tumor Effect of Emodin

Cancer is a disease caused by the loss of normal cell regulation and excessive proliferation. At present, there are a lot of anticancer drugs, but most of them are not ideal, with sereve side effects. Besides, during the treatment, the patients feel very bad, and they are always in great pain. Emodin is a natural anthraquinone derivative found in a variety of herbal preparations. Many studies have shown that emodin has a significant therapeutic effect on lung cancer, liver cancer, breast cancer, and so on. After reviewing a large amount of literatures, this paper summarizes the research progresses of emodin anticancer in the past five years, in order to provide theoretical basis for further development and utilization of emodin and its metabolites.

Advances in the mechanism of liver injury caused by COVID-19

In addition to the performance of the respiratory system,COVID-19 can also have different degrees of abnormal liver function,and even liver injury and liver failure may occur in serious cases.In addition,infection with novel coronavirus will aggravate the liver damage of patients with chronic liver disease,resulting in a significant increase in severe morbidity and mortality.Based on this,this paper briefly reviews the mechanism of liver injury caused by COVID-19 and its impact on patients with chronic liver disease,in order to provide a theoretical basis for the prevention and treatment of COVID-19.

Review of Risk Factors and Intervention of Myopia in Children and Adolescents

When the adjustment function of the eye is still,the external parallel light can not form a clear image on the retina after passing through the refractive effect of the eye,and the phenomenon of imaging in front or behind the retina is called ametropia.Common refractive errors include:Myopia,hyperopia,astigmatism,presbyopia,and myopia is the most common ametropia in children and adolescents.Myopia refers to the refractive state in which the external parallel light(distance greater than 5 meters)enters the eye and focuses on the retina after passing through the ocular refractive system when the eye is in the state of adjustment and rest.In general,myopia can be diagnosed when se is less than-0.5d,and it can be divided into light,medium and high myopia according to the degree of myopia.Among them,mild myopia is 0d≤diopter<-3D,moderate myopia is-3D≤diopter<-6D,high myopia is diopter≥-6D.Nowadays,the myopia rate of children and adolescents is high in many countries,and it has become a global public health problem.Myopia not only affects the study and life of children and adolescents,but also causes a variety of serious ophthalmic complications(such as cataract,glaucoma,myopic macular degeneration and retinal detachment)with the growth of age.Studies have shown that as early as 2015,the global economic loss caused by uncorrected myopia was about 240 billion US dollars,of which the potential loss in East Asia,mainly China,was the largest.It is important to understand the prevalence,causes and intervention measures of myopia.Therefore,this paper summarizes the current situation of the research on the prevalence trend,influencing factors and intervention measures of myopia in children and adolescents.