BACKGROUND The incidence rate of cerebral infarction in young people is increasing day by day,the age of onset tends to be younger,and its internal pathogenesis and mechanism are very complicated,which leads to greate...BACKGROUND The incidence rate of cerebral infarction in young people is increasing day by day,the age of onset tends to be younger,and its internal pathogenesis and mechanism are very complicated,which leads to greater difficulties in treatment.Therefore,it is essential to analyze the key pathway that affects the onset of cerebral infarction in young people from the perspective of genetics.AIM To compare the differentially expressed genes in the brain tissue of young and aged rats with middle cerebral artery occlusion and to analyse their effect on the key signalling pathway involved in the development of cerebral ischaemia in young rats.METHODS The Gene Expression Omnibus 2R online analysis tool was used to analyse the differentially expressed genes in the GSE166162 dataset regarding the development of cerebral ischaemia in young and aged groups of rats.DAVID 6.8 software was further used to filter the differentially expressed genes.These genes were subjected to Gene Ontology(GO)function analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis to determine the key gene pathway that affects the occurrence of cerebral ischaemia in young rats.RESULTS Thirty-five differentially expressed genes(such as Igf2,Col1a2,and Sfrp1)were obtained;73 GO enrichment analysis pathways are mainly involved in biological processes such as drug response,amino acid stimulation response,blood vessel development,various signalling pathways,and enzyme regulation.They are involved in molecular functions such as drug binding,protein binding,dopamine binding,metal ion binding,and dopamine neurotransmitter receptor activity.KEGG pathway enrichment analysis showed a significantly enriched pathway:The cyclic adenosine monophosphate(c-AMP)signalling pathway.CONCLUSION The c-AMP signalling pathway might be the key pathway in the intervention of cerebral infarction in young people.展开更多
The Belt and Road Initiative is a new concept of opening-up put forward by Chinese leader Xi Jinping after he took office.It is the most influential international initiative since China’s reform and opening up.Its im...The Belt and Road Initiative is a new concept of opening-up put forward by Chinese leader Xi Jinping after he took office.It is the most influential international initiative since China’s reform and opening up.Its implementation has achieved remarkable results in the past few years,with more than expected results.More and more countries in the world have supported and responded to the Belt and Road Initiative.China and the UK are countries with important influence in the world.The Belt and Road Initiative has great potential and far-reaching impact between two countries.This paper analyzes the theory of influence of the Belt and Road and discusses the practical problems existing in the China-UK Belt and Road Cooperation.By applying the research method of matching theory with reality,the author puts forward some measures to enhance the influence of the Belt and Road Cooperation between the two countries.It is of great academic and practical significance to study the Belt and Road Theory and the international relations between China and Britain.展开更多
An important part of the "Belt and Road " Initiative is to achieve people-to-people bonds. People-to-people bonds are certainly based on cultural self-confidence and cultural self-awareness. Cultural self-co...An important part of the "Belt and Road " Initiative is to achieve people-to-people bonds. People-to-people bonds are certainly based on cultural self-confidence and cultural self-awareness. Cultural self-confidence is an important cultural strategy put forward by the party and the country in the vision of contemporary society,and an important deployment to realize the great rejuvenation of the Chinese nation. This paper first gives a brief overview of the advantages of cultural self-confidence in external communication,and then analyzes the opportunities and challenges that cultural self-confidence faces in external communication in the newera. Finally,it focuses on exploration on the external communication ways of cultural self-confidence in the "Belt and Road"Initiative. O nly based on the deep understanding of local culture can we can shape the soul of culture in the process of further opening-up and external communication to the outside world,and enhance the cultural self-aw areness of the people; build a solid foundation of culture and promote cultural exchanges with other countries.展开更多
文摘BACKGROUND The incidence rate of cerebral infarction in young people is increasing day by day,the age of onset tends to be younger,and its internal pathogenesis and mechanism are very complicated,which leads to greater difficulties in treatment.Therefore,it is essential to analyze the key pathway that affects the onset of cerebral infarction in young people from the perspective of genetics.AIM To compare the differentially expressed genes in the brain tissue of young and aged rats with middle cerebral artery occlusion and to analyse their effect on the key signalling pathway involved in the development of cerebral ischaemia in young rats.METHODS The Gene Expression Omnibus 2R online analysis tool was used to analyse the differentially expressed genes in the GSE166162 dataset regarding the development of cerebral ischaemia in young and aged groups of rats.DAVID 6.8 software was further used to filter the differentially expressed genes.These genes were subjected to Gene Ontology(GO)function analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis to determine the key gene pathway that affects the occurrence of cerebral ischaemia in young rats.RESULTS Thirty-five differentially expressed genes(such as Igf2,Col1a2,and Sfrp1)were obtained;73 GO enrichment analysis pathways are mainly involved in biological processes such as drug response,amino acid stimulation response,blood vessel development,various signalling pathways,and enzyme regulation.They are involved in molecular functions such as drug binding,protein binding,dopamine binding,metal ion binding,and dopamine neurotransmitter receptor activity.KEGG pathway enrichment analysis showed a significantly enriched pathway:The cyclic adenosine monophosphate(c-AMP)signalling pathway.CONCLUSION The c-AMP signalling pathway might be the key pathway in the intervention of cerebral infarction in young people.
文摘The Belt and Road Initiative is a new concept of opening-up put forward by Chinese leader Xi Jinping after he took office.It is the most influential international initiative since China’s reform and opening up.Its implementation has achieved remarkable results in the past few years,with more than expected results.More and more countries in the world have supported and responded to the Belt and Road Initiative.China and the UK are countries with important influence in the world.The Belt and Road Initiative has great potential and far-reaching impact between two countries.This paper analyzes the theory of influence of the Belt and Road and discusses the practical problems existing in the China-UK Belt and Road Cooperation.By applying the research method of matching theory with reality,the author puts forward some measures to enhance the influence of the Belt and Road Cooperation between the two countries.It is of great academic and practical significance to study the Belt and Road Theory and the international relations between China and Britain.
基金one of the research findings of Open Fund of“Research Center for Sustainable Development of Three Gorges Reservoir Area”in2016(No:16sxxyjd04).
文摘An important part of the "Belt and Road " Initiative is to achieve people-to-people bonds. People-to-people bonds are certainly based on cultural self-confidence and cultural self-awareness. Cultural self-confidence is an important cultural strategy put forward by the party and the country in the vision of contemporary society,and an important deployment to realize the great rejuvenation of the Chinese nation. This paper first gives a brief overview of the advantages of cultural self-confidence in external communication,and then analyzes the opportunities and challenges that cultural self-confidence faces in external communication in the newera. Finally,it focuses on exploration on the external communication ways of cultural self-confidence in the "Belt and Road"Initiative. O nly based on the deep understanding of local culture can we can shape the soul of culture in the process of further opening-up and external communication to the outside world,and enhance the cultural self-aw areness of the people; build a solid foundation of culture and promote cultural exchanges with other countries.
