Hegel's Philosophical Discourse of Political Ethics and Spirit of Enchantment

Philosophy of Right as the text of Hegel's thought of practical philosophy has been the most important academic dominance on Hegel.The differences of ethical spirit between Phenomenology of Spirit and Philosophy of Right were lack of attention.The former focuses on historical consciousness in formation of modern spirit.The latter which is construction practice is based on the former.This concern will enable us to maintain a clear understanding of the particularity behind universal ethical values in globalization era and multi-cultural dialogue.

A preliminary report on adjuvant analgesic efficacy of HANS in opioid tolerant patients with cancer pain

Objective： To observe the adjuvant analgesic efficacy of Han＇s Acupoint Nerve Stimulator （HANS） in opioid tolerant patients with cancer pain. Methods： A prospective non-controlled study was conducted. Opioid tolerant patients with cancer pain were enrolled and treated with both routinely analgesics and adjuvant HANS （2/100 Hz for 30 min/d, 5 d on and 2 d off for two weeks）. Cancer pain, quality of life （QOL）, anxiety and depression were assessed before enrollment and on d 8 and d 15 with the BPI-C, EORTC QLQ-C30, and self-rating anxiety scale （SAS）/ self-rating depression scale （SDS）, respectively; the therapeutic frequency of breakthrough pain （BP） and daily opioid dose were also recorded. Results： Totally 47 patients meeting the inclusion criteria participated in this study; 43 patients completed the two-week treatment and assessment. The mean scores of patient＇s ＂worst＂ and ＂least＂ pain intensity assessed with BPI-C decreased significantly on d 8 and d 15; the therapeutic frequency of BP also significantly decreased; but the average daily dose of opioids did not change significantly. For the nine symptoms in EORTC QLQ-C30 assessment, the mean scores of pain, fatigue, constipation and insomnia were significantly lower on d 8 and d 15 compared with baseline; the mean scores of the overall health status, nausea/vomiting and the incidence rates of both anxiety and depression also decreased significantly on d 15. Conclusions： To opioid tolerant patients with cancer pain, adjuvant treatment with HANS could improve pain release and patients＇ QOL by decreasing the severity of pain, fatigue, constipation, insomnia and other concomitant symptoms; it could also decrease the incidence rates of anxiety and depression.

A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet's disease in a Chinese Han population

AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han population.METHODS:A total of eight SNPs in the candidate gene region(rs11792633,rs7025417,rs10975519 and rs1048274 in IL33;rs2310220,rs12712142,rs13424006 and rs3821204 in IL1RL1)were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array i PLEX platform.RESULTS:A statistically significant association was observed between IL1RL1 rs12712142 and BD patients.The frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls(OR=0.8,95%CI:0.69-0.94,Pc=0.039);the genotype distribution(Pc=0.043)and additive and dominant genetic model analyses(OR=0.8,95%CI:0.69-0.94,Pc=0.040 and OR=0.72,95%CI:0.58-0.88,Pc=0.011)also indicated a strong association between rs12712142 and BD patients.CONCLUSION:This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population,indicating a protective role of IL1RL1 in the pathogenesis of BD.

SLC26A4 gene polymorphism and late-onset Alzheimer’s disease in a Han Chinese population from Qingdao,China

In a recent genome-wide association study, the SLC26A4 gene rs2072064 polymorphism was found to be associated with late-onset Alzheimer＇s disease in Caucasians. Here, we investigated this association in a large Northern Han Chinese cohort consisting of 599 sporadic late-onset Alzheimer＇s disease patients and 598 healthy controls matched for sex and age in a Northern Han Chinese population from Qingdao, China. Genotyping by the polymerase chain reaction-ligase detection reaction revealed that there were significant differences in the genotype （P = 0.017） and allele （P = 0.007） frequencies of the rs2072064 polymorphism between late-onset Alzheimer＇s disease patients and controls. The A allele of this polymorphism was significantly associated with a reduced risk of late-onset Alzheimer＇s disease （odds ratio （OR） = 0.792, 95% confidence interval （CI） = 0.670-0.937, P = 0.007）. When the data were stratified by the apolipoprotein E E4 status, there was a significant difference only among apolipoprotein E E4 non-carriers （genotypic P = 0.001, allelic P = 0.001）. Furthermore, the association between rs2072064 and late-onset Alzheimer＇s disease remained significant by logistic regression analysis after adjustment for age, gender, and the apolipoprotein E E4 carrier status （dominant model： OR = 0.787, 95% CI = 0.619-1.000, P = 0.050; recessive model： OR = 0.655, 95% CI = 0.448-0.959, P= 0.030; additive model： OR = 0.792, 95% CI = 0.661-0.950, P = 0.012）. These findings suggest that SLC26A4 is a susceptibility gene for late-onset Alzheimer＇s disease in a Northern Han Chinese population from the Qingdao area.

Pain management using Han’s acupoint nerve stimulator combined with patient-controlled analgesia following neurosurgery A randomized case control study

BACKGROUND： Han＇s acupoint nerve stimulator （HANS） has been frequently used to relieve pain by promoting the central nerve system＇s release of endogenous opioid peptides through electric stimulation to the body surface. OBJECTIVE： To investigate the pain-relieving effects of HANS, combined with patient-controlled analgesia, following neurosurgery, and to observe adverse reactions and effects. DESIGN, TIME AND SETTING： A randomized control observation was performed at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College （Ganzhou, Jiangxi Province, China） from January 2005 to February 2006. PARTICIPANTS： Forty patients, who were selected for craniotomy and required pain relief following surgery at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College （China）, were included in this study. METHODS： Forty patients underwent neurosurgery and were randomly divided into two groups： patient-controlled analgesia plus HANS （＋HANS, n = 20） and patient-controlled analgesia （-HANS, n = 20）. Both groups were well matched in baseline data. Automatic syringe infusion pump ZZB-150 was the product of Nantong Aipeng Medical Instruments Co., Ltd. （China）. Patient-controlled analgesia consisted of 100 mL 0.02% lappaconitine/0.02% metoclopramide. LH-402 HANS instrument was produced in Beijing （China）, with a serial number of 402183. The HANS instrumentation was used to stimulate the Hegu-Laogong acupoint on one side and Jiaogan, Shenmen penetrating Shen, Waifei, Naogan penetrating Pizhixia ear acupoints on the affected side for one hour, with 2-hour intervals. The disperse-dense wave was alternating, with a 2/100 Hz frequency of electrical stimulation. MAIN OUTCOME MEASURE： The scores of visual analogue scale and incidence of adverse reaction were observed in two groups following surgery. RESULTS： Compared with the HANS group, the visual analogue scale scores were remarkably lower in the ＋HANS group six hours after surgery （P 〈 0.01）, and the incidence rate of adverse reactions, such as nausea and vomiting, was also decreased （P 〈 0.05）.CONCLUSION： The application of HANS to induce body surface stimulation can enhance the effect of pain relief and reduce adverse reactions when used in combination with patient-controlled analgesia following neurosurgery. The effect of combined therapy is superior to patient-controlled analgesia alone.

Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population

A missense C/T polymorphism in exon 6 （the NCBI rslD is rs2227564） of the urokinase-type plasminogen activator gene has been identified as a possible hot spot for Alzheimer＇s disease risk. The present study analyzed urokinase-type plasminogen gene polymorphisms of rs2227564 with sporadic Alzheimer＇s disease by PCR-restriction fragment length polymorphism. Results showed that CC, CT and TT genotype distribution frequencies had significant differences between sporadic Aizheimer＇s disease patients and healthy controls, in-depth analysis of the association between urokinase-type plasminogen gene rs2227564 polymorphisms and sporadic Alzheimer＇s disease indicated that people with the C-positive genotype CC ＋ CT were at a higher risk for developing sporadic Alzheimer＇s disease. These results support the contribution of the polymorphisms of rs2227564 in the urokinase-type plasminogen gene to the pathogenesis of sporadicAIzheimer＇s disease in the Han Chinese population.

Rebellious Spirit in Shelley’s Poetry

雪莱的诗歌反映了他争取平等和自由的反叛思想。诗歌中揭示了他对上层阶级的诅咒 。

Series of Interpretation on Yellow Emperor’s Internal Classic (Ⅲ):Unity of Spirit and Body:Views from Huang Di Nei Jing (《黄帝内经》Yellow Emperor’s Internal Classic)

Human life activities are inevitably affected by the surrounding environment,such as natural and social environment.It is the basic principle of TCM to set a series of medical practice activities.TCM believes that the social environment has an inestimable influence on the mind and body of human beings.This study introduces the unity of spirit and body in traditional Chinese medicine.

A Warrior’s Spirit

Striker Nyasha Mushekwi has earned his place in the hearts of Dalian Yifang Football Club supporters. Over the last three years,he has had a brilliant international career. Even Sun Xishuang, the team＇s owner, has praised the skills of the ＂Zimbabwean warrior,＂ who he described as a real fighter hungry for success.

The Birth of Modern Poetry:Tradition and Individual Talent——An Understanding of T. S. Eliot's Critical Essay‘Tradition and Individual Talent'in comparison with Nietzsche's Spirits of Tragedy

As one of the most significant critical essays of T.S.Eliot,Tradition and Individual Talent has defined writing as a process during which the primitive oneness has seized the individual writer of figurative descriptions to help represent itself.This theory has latter been practiced in Eliot’s Wasteland,and shows its similarity with The Birth of Tragedy,written by Friedrick Nietzsche,the German philosopher.Eliot’s‘tradition’has been concluded by Nietzsche as‘Dionysian Spirit’,which represents oneness transcending good and evil,past and present,while‘individual talent’has resembled‘Apollonian Spirit’in the urge for original figuration as an apparatus.The paper aims to explain and compare the definitions of‘tradition’and‘individual talent’of Eliot’s work with that of‘Dionysian spirit’and‘Apollonian Spirit’in Nietzsche’s illustrations,so as to provide a deeper understanding of these two works by unveiling the individual and social sameness and difference of Eliot and Nietzsche.

Cultivation of Craftsman’s Spiritin Solar Cell Fundamental and Applications Teaching

Higher education is one of the critical education stages,which has an important influence on the student’s future work and life.Science and engineering courses such as solar cells fundamental and applications should not only teach students professional knowledge but also run through ideological and political education elements to improve students’quality in an all-round way.Craftsman’s spiritis especially important for science and engineering students,and it is an important foundation to realizing the“Made in China 2025”strategy.Through typical cases,the craftsman’s spiritis organically integrated into the course design of“Solar Cell Fundamental and Applications”,which is of great significance to the development of our country and society.

浅谈西安的包容精神——以周秦汉唐为例

周、秦、汉、唐均建都古城长安(今西安)。周人以礼仪贤德包容四海,制礼作乐,统治天下。秦人以宽广的胸怀招贤纳士,秋风扫叶,创建基制,震慑四方。汉人以“大一统”的梦想构筑帝国,始开丝路,融合匈奴,汉匈和睦,天下归一。唐人以开放的心态、宏伟的气势以前朝为鉴,创大唐盛世,胡汉融合,万国来朝。故以周、秦、汉、唐为例,论述西安具有的包容精神,以斑窥豹,就教方家。

汉代“大一统”国家的文人精神与文学气象

汉代“大一统”国家体制以及思想建构离不开汉代儒生博士实现儒家政治理想的努力,这是一种依存度非常高的双向建构。儒家士人对于汉代政治的参与,以浸润的方式在西汉宣、元帝时期达到了高峰,在东汉明、章帝时期趋于鼎盛。为实现儒家政治理想以辞章自鸣依经取义而又斟酌其辞的儒家士人焕发出了极大的政治热情,形成了“大一统”国家的政治、文人乃至于文学的新气象。无论是从藩国文学到宫廷文学,还是从铺张扬厉的汉代大赋到发凡起例的史家著作,都精心营构着汉代文章学的范式,秉承着国家文学“美政”“讽谏”“须颂”的使命。东汉党锢之祸后,凝聚涵养了四百年的文人精神趋于涣散并不断改辙易途,士人的家国情怀以及“大一统”文学精神走向了末路并消解,魏晋时代迎来了哲学与文学的狂欢。

哲学视域下教师发展的德性存在、构成与实践

教师德性是教师发展内在、自主的驱动力量,是教师得以实现持续性发展的逻辑起点。这一德性存在根植于关系视域,以教师的社会性存在为基础,呈现为人与物的关系、人与人的关系。教师在发展过程中要具有时代性的德性知识、审辩性的德性能力、超越性的德性信仰。只有在人自觉、对象性的活动中,综合性的德性品格才会生成,因此还要关注教师发展的德性实践,了解教师生活活动样态中内在善的生成与外在善的实现。只有在哲学视域下建构起对教师德性的存在、构成和实践的整体逻辑认知,才能促进教师发展的自主和持续性发生。

论传承周恩来崇高精神为推进中国式现代化建设提供强大力量

周恩来是社会主义现代化建设的开拓者、奠基者和推动者。坚守信仰、对党忠诚、热爱人民、自我革命、勇于担当、严于律己等六个方面是周恩来身上展现出来的崇高精神。周恩来的崇高精神,为中国式现代化筑牢了思想之基、政治之基、力量之基、创新之基、实干之基和廉政之基,成为我们推进中国式现代化建设的强大力量。

弘扬教育家精神,建构中国教育学自主知识体系——人民教育家于漪先生访谈

于漪先生深耕基础教育七十余载,是我国基础教育第一位被授予“人民教育家”称号的教师,同时她写就700余万字的教育论著,以深刻的教育理念和教学思想,成为“精心育人的一代师表,潜心教改的一面旗帜”。访谈中她强调教师在教书育人的具体工作中要融入胸怀天下的气概,理性思考、真情投入,才是对中国特有的教育家精神的真正领会和践行;在教师教育方面,她指出职前培养应着力实现高质量的学科专业与教育科学的深度融合,职后培训则应基于教师的实践需求,致力于提升其专业发展的软实力;最后,她鼓励学界要对中国教育充满自信,基于长时间、大规模、广范围的实践探索,努力建构中国教育学自主知识体系。

加快推进广东省灌区水效“领跑者”创建的思考

深入学习习近平总书记治水重要论述精神,在新阶段进一步推进节水工作,挖掘灌区节水潜力。跟进我国灌区水效领跑者引领行动的积极进展,总结各省的先进做法和经验,聚焦分析行动过程中的实施难点,立足广东省实际和农业用水管理发展需求、新阶段水利高质量发展要求,为广东省加快创建灌区水效“领跑者”提供基础支撑和有效思路。

GSTM1与GSTP1基因多态性对红细胞GST酶活性的影响

目的研究单独或结合GSTM1纯合缺失基因型时,不同GSTP1基因型对红细胞GST酶活性的影响。方法GST酶活性参照Habig等报道的方法用紫外分光光度法测定。用多重PCR分析GSTM1基因多态性,PCRRFLP检测GSTP15号外显子105位密码子基因多态性。结果汉族人的GSTM1纯合缺失频率为56.1%,GSTP1105I/I、I/V和V/V基因型频率分别为60.7%、35.2%和4.1%。杂合I/V基因型组的平均GST酶活性(3.53±0.63U·g-1Hb)比野生I/I基因型的GST酶活性低(4.25±1.07U·g-1Hb,P=0.000),比突变V/V基因型的GST酶活性高(2.44±0.67U·g-1Hb,P=0.004)。在GSTM1(-)基因组,GSTM1(-)/GSTP1I/I基因型携带者的GST酶活性比GSTM1(-)/GSTP1I/V或V/V携带者的高,而在GSTM1(+)组,两组间的酶活性无差异。不同年龄组平均GSTs活性无差异,而女性的平均GSTs活性比男性的平均值高,但差异无显著性。结论尽管其它GST酶可能会稀释GSTP1基因型对GST酶活性的效果,GST酶活性仍与GSTP1105Val基因型呈很强的相关性。

龙江韩氏妇科对“肝肾同源”理论的传承应用

“肝肾同源”最早见于《易经》,医学概念源自《黄帝内经》。五行中肝属木,肾属水,水生木,肾为肝之母,肝为肾之子,肝肾同源,乙癸同源,精血互生互化,二者在生理上互相联系,病理上互相影响。龙江韩氏妇科历代医家重视“肝肾同源”理论,发展并应用于指导临床。龙江韩式妇科奠基人韩百灵教授,最早提出“肝肾学说”,其子韩延华教授作为代表性传承人,在韩百灵教授的理论思想指导下,创新性提出“肝主冲任”理论,并创立百灵育阴汤、补肾活血调经汤和百灵调肝汤等代表性方剂,运用于临床不孕症、闭经和月经先后不定期的治疗中,取得良效。本文围绕“肝肾同源”理论,追溯其起源,阐述韩氏妇科对其传承及应用,体现中医理论的传承和创新,为妇科同行提供借鉴。