Effects of prostaglandin E combined with continuous renal replacement therapy on septic acute kidney injury

BACKGROUND The effects of prostaglandin E(PGE)combined with continuous renal replacement therapy(CRRT)on renal function and inflammatory responses in patients with septic acute kidney injury(SAKI)remain unclear.AIM To investigate the effects of PGE combined with CRRT on urinary augmenter of liver regeneration(ALR),urinary Na+/H+exchanger 3(NHE3),and serum inflammatory cytokines in patients with SAKI.METHODS The clinical data of 114 patients with SAKI admitted to Yichang Second People's Hospital from May 2017 to January 2019 were collected.Fifty-three cases treated by CRRT alone were included in a control group,while the other 61 cases treated with PGE combined with CRRT were included in an experimental group.Their urinary ALR,urinary NHE3,serum inflammatory cytokines,renal function indices,and immune function indices were detected.Changes in disease recovery and the incidence of adverse reactions were observed.The 28-d survival curve was plotted.RESULTS Before treatment,urinary ALR,urinary NHE3,blood urea nitrogen(BUN),serum creatinine(SCr),CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio in the control and experimental groups were approximately the same.After treatment,urinary ALR and NHE3 decreased,while BUN,SCr,CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio increased in all subjects.Urinary ALR,urinary NHE3,BUN,and SCr in the experimental group were significantly lower than those in the control group,while CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio were significantly higher than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α,interleukin-18,and high sensitivity C-reactive protein in the experimental group were significantly lower than those in the control group(P<0.05).The time for urine volume recovery and intensive care unit treatment in the experimental group was significantly shorter than that in the control group(P<0.05),although there was no statistically significant difference in hospital stays between the two groups.The total incidence of adverse reactions did not differ statistically between the two groups.The 28-d survival rate in the experimental group(80.33%)was significantly higher than that in the control group(66.04%).CONCLUSION PGE combined with CRRT is clinically effective for treating SAKI,and the combination therapy can significantly improve renal function and reduce inflammatory responses.

Premature ovarian insufficiency identified as a kidney deficiency and liver constraint pattern treated by Professor Zhiqiang Guo:A retrospective analysis

Objective:To study the efficacy of Professor Zhiqiang Guo's unique sequential herbal therapy in the treatment of premature ovarian insufficiency(POI)of the kidney deficiency and liver constraint pattern.Methods:Ninety patients with POI who consulted with Professor Guo at Dongzimen Hospital,Beijing University of Chinese Medicine from January 2012 to December 2015 were enrolled.Treatment consisted of sequential therapy using traditional Chinese medicine formulae with the actions of nourishing the liver and kidney.Course of treatment was 3 consecutive menstrual cycles for each participant except for those who became pregnant during treatment.Baseline data including age,course of disease,past medical history,lifestyle,pregnancy outcome,menstrual status(cycle length,menstrual flow duration and volume),as well as gonadal hormone levels before and after treatment were recorded and analyzed.Results:During treatment,18(20.0%)participants became pregnant.Symptoms including scanty menstrual flow,irritability,low libido,insomnia and excessive dreaming at night,nightsweats,hot flashes,and depression were markedly alleviated.Changes in follicle-stimulating hormone(FSH)and luteinizing hormone(LH)levels at early follicular stage were observed(P=.009 and P=.002,respectively),and FSH/LH differed significantly pre-and posttreatment(P=.0.44).Conclusion:Professor Guo's sequential Chinese herbal therapy with the actions of nourishing the liver and kidney to treat POI can enhance ovarian function,promote pregnancy,and improve quality of life.

Blood purification for treatment of non-liquefied multiple liver abscesses and improvement of T-cell function:A case report

BACKGROUND Non-liquefied multiple liver abscesses(NMLA)can induce sepsis,septic shock,sepsis-associated kidney injury(SA-AKI),and multiple organ failure.The inability to perform ultrasound-guided puncture and drainage to eradicate the primary disease may allow for the persistence of bacterial endotoxins and endogenous cytokines,exacerbating organ damage,and potentially causing immunosuppression and T-cell exhaustion.Therefore,the search for additional effective treatments that complement antibiotic therapy is of great importance.CASE SUMMARY A 45-year-old critically ill female patient presented to our hospital’s intensive care unit with intermittent vomiting,diarrhea,and decreased urine output.The patient exhibited a temperature of 37.8℃.Based on the results of liver ultrasonography,laboratory tests,fever,and oliguria,the patient was diagnosed with NMLA,sepsis,SA-AKI,and immunosuppression.We administered antibiotic therapy,entire care,continuous renal replacement therapy(CRRT)with an M100 hemofilter,and hemoperfusion(HP)with an HA380 hemofilter.The aforementioned treatment resulted in a substantial reduction in disease severity scores and a decrease in the extent of infection and inflammatory factors.In addition,the treatment stimulated the expansion of the cluster of differentiation 8^(+)(CD8^(+))Tcells and led to the complete recovery of renal function.The patient was discharged from the hospital.During the follow-up period of 28 d,she recovered successfully.CONCLUSION Based on the entire therapeutic regimen,the early combination of CRRT and HP therapy may control sepsis caused by NMLA and help control infections,reduce inflammatory responses,and improve CD8^(+)T-cell immune function.

Strategies for Activating Blood Circulation-Regulating Gan(Liver)-Tonifying Shen(Kidney) Sequential Therapy of Endometriosis-Associated Infertility

Endometriosis(EM) is a major cause of infertility and has a complex pathogenesis,which brings severe challenges in both clinical treatment and scientific research.Current clinical research focuses on the difficult problem of improving the pregnancy rate of EM patients.Our studies found that Chinese medicine has significant advantages in terms of improving the pregnancy rate of EM patients.

Therapeutic observation of 'warming-unblocking needling technique'for knee osteoarthritis due to deficiency of liver and kidney

Objective:To compare the clinical efficacy between'warming-unblocking needling technique7 and reinforcing method by twirling in treating knee osteoarthritis(KOA)due to deficiency of liver and kidney.Methods:A total of 72 patients with KOA were divided into a warming-unblocking group and a reinforcing group by complete randomized method,with 36 cases in each group.Xuehai(SP 10),Heding(EX-LE 2),Liangqiu(ST 34);Neixiyan(EX-LE 4),Xizhong(Extra),Dubi(ST 35),Yinlingquan(SP 9),Zusanli(ST 36)and Yanglingquan(GB 34)were the main points in both groups.Taichong(LR 3),Taixi(Kl 3)and Sanyinjiao(SP 6)were the combined points.'Warming-unblocking needling technique'was applied in the warming-unblocking group,and reinforcing method by twirling was applied in the reinforcing group.The treatments were performed once a day,10 times as a treatment course,at a 2-day interval between two courses,for 3 courses in total.The scores of Western Ontario and McMaster Universities osteoarthritis index(WOMAC)in the two groups were observed before and after the treatment,and the clinical efficacy was compared.Results:After treatment,the total effective rate was 94.3%in the warming-unblocking group and 87.9%in the reinforcing group,and the difference between the two groups was statistically significant(P<0.05).The component scores of pain,stiffness and daily activities in WOMAC and total WOMAC scores in both groups decreased after treatment(all P<0.01).The component and total WOMAC scores in the warming-unblocking group were lower than those in the reinforcing group(P<0.05 or P<0.01).Conclusion:'Warming-unblocking needling technique' has significant efficacy than reinforcing method by twirling in treating KOA due to deficiency of liver and kidney.It can significantly improve pain,stiffness and daily functional activities of patients.

A small molecule fibrokinase inhibitor in a model of fibropolycystic hepatorenal disease

AIM To evaluate the novel platelet-derived growth factor receptor and vascular endothelial growth factor receptor dual kinase inhibitor ANG3070 in a polycystic kidney disease-congenital hepatic fibrosis model.METHODS At 6 wk of age, PCK rats were randomized to vehicle or ANG3070 for 4 wk. At 10 wk, 24 h urine and left kidneys were collected and rats were continued on treatment for 4 wk. At 14 wk, 24 h urine was collected, rats were sacrificed, and liver and right kidneys were collected for histological evaluation. For Western blot studies, PCK rats were treated with vehicle or ANG3070 for 7 d and sacrificed approximately 30 min after the last treatments.RESULTS Compared to the wild-type cohort, the PCK kidney(Vehicle cohort) exhibited a marked increase in kidney and liver mass, hepato-renal cystic volume, hepato-renal fibrosis and hepato-renal injury biomarkers. Intervention with ANG3070 in PCK rats decreased kidney weight, reduced renal cystic volume and reduced total kidney hydroxyproline, indicating significantly reduced rental interstitial fibrosis compared to the PCK-Vehicle cohort. ANG3070 treatment also mitigated several markers of kidney injury, including urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, cystatin C and interleukin-18 levels. In addition, this treatment attenuated key indices of renal dysfunction, including proteinuria, albuminuria and serum blood urea nitrogen and creatinine, and significantly improved renal function compared to the PCK-Vehicle cohort. ANG3070 treatment also significantly decreased liver enlargement, hepatic lesions, and liver fibrosis, and mitigated liver dysfunction compared to the PCK-Vehicle cohort.CONCLUSION These results suggest that ANG3070 has the potential to slow disease, and may serve as a bridge toward hepato-renal transplantation in patients with fibropolycystic disease.

Chief Physician Defen Wang’s Clinical Experience in Dialectical Treatment with Mediation Method of Perimenopausal Sweating

The objective of this paper is to outline Chief Physician Defen Wang’s clinical experience in perimenopausal sweating syndrome differentiation and treatment,to inherit Mr.Gao’s academic concept of mediation technique,and to integrate multiple prescriptions under Mr.Gao’s thinking.The deficiency is based on the deficiency of liver and kidney Yin,the weakness of spleen and stomach,and the standard is the imbalance of Ying and Wei,the imbalance of Qi,blood and body fluid,and the main method of treatment is nourishing liver and kidney,soothing liver and invigorating spleen,regulating Ying and Wei,as well as tonifying Qi and absorbing fluid.

滋肾疏肝化痰法和知柏地黄丸轮替疗法用于女童性早熟临床研究

目的评估滋肾疏肝化痰法和知柏地黄丸轮替疗法用于性早熟的临床效果,探索中医药治疗方法。方法采用回顾性研究,观察56例性早熟女童采用滋肾疏肝化痰法和知柏地黄丸轮替疗法的临床效果,收集临床数据并分析。结果经6个月干预,患儿雌二醇、促性腺激素水平,子宫、卵巢容积及骨龄指数较干预前均下降,预测成年终身高较干预前增加,且中医证候积分较治疗前均下降,差异有统计学意义(P<0.05)。治疗总有效率为85.71%(48/56),其中显效26例(46.43%)、好转22例(39.29%)、无效8例(14.29%)。结论将滋肾疏肝化痰法和知柏地黄丸轮替疗法用于性早熟患儿,能够控制患儿第二性征发育、降低骨龄指数、改善临床症状、延缓骨龄快速进展,改善性早熟儿童预测成年终身高。

益气养阴疏肝法对糖尿病合并郁证患者脑神经递质的影响

目的探讨益气养阴疏肝法治疗糖尿病郁证患者的临床效果。方法选取2021年5月至2023年4月广州医科大学附属中医医院内分泌科收治的60例糖尿病合并郁证患者作为研究对象,按照随机数字表法分为对照组(30例)和试验组(30例)。对照组采用常规药物治疗,试验组在对照组的基础上给予益气养阴疏肝法治疗,比较两组患者治疗前后的理化指标、中医症候评分,抑郁量表评分及脑神经递质的变化情况。结果两组糖化血红蛋白比较,差异无统计学意义(P>0.05)。试验组中医症状评分的总有效率高于对照组,治疗后试验组的脑神经递质水平低于对照组,差异有统计学意义(P<0.05)。结论运用益气养阴疏肝法可以改善糖尿病合并郁证患者的临床症状,其作用机制可能与调节神经递质水平相关。

基于“补肾生髓成肝”综合疗法治疗慢性乙型肝炎肝硬化腹水患者的临床观察

目的:探讨基于“补肾生髓成肝”综合疗法对慢性乙型肝炎肝硬化患者的中医症状积分、肝功能、肝硬度指标等的影响。方法:选取2021年1月至2023年12月在绍兴文理学院附属医院收治的慢性乙型肝炎肝硬化腹水患者60例,随机分为对照组和观察组,每组30例。对照组患者给予西医综合治疗,观察组患者在对照组治疗基础上采用基于“补肾生髓成肝”综合疗法(“补肾生髓成肝”辨证加减,配合西医综合治疗),治疗3个月后,观察两组患者治疗前后中医症状积分、肝功能(白蛋白、胆碱酯酶)、肝硬度、24 h尿量、体重等指标变化情况。结果:观察组患者临床症状积分均较对照组明显降低,差异有统计学意义(P<0.05);治疗后两组患者白蛋白、胆碱酯酶均较治疗前升高,差异有统计学意义(P<0.05);且观察组白蛋白、胆碱酯酶较对照组明显升高,差异有统计学意义(P<0.05)。治疗后两组患者肝硬度值均较治疗前降低,差异有统计学意义(P<0.05);观察组肝硬度值均较对照组明显降低,差异有统计学意义(P<0.05)。结论:基于“补肾生髓成肝”综合疗法治疗慢性乙型肝炎肝硬化腹水患者后可缓解临床症状,改善白蛋白、胆碱酯酶、肝硬度及腹水观察指标,优于单纯西医综合治疗。

中药益气血补肝肾法对辅助生育胚胎种植率的影响

【目的】探讨辅助生育技术结合中药益气血补肝肾法对体外受精胚胎种植率的影响。【方法】将130例不孕症患者随机分为对照组(70例)和试验组(60例)。对照组采用单纯辅助生育技术,试验组在单纯辅助生育技术基础上加用中药治疗[月经第4天开始服用经后增殖冲剂(由黄芪、党参、茯苓、熟地、肉桂、当归等中药组成),胚胎移植后服用促黄体方(由菟丝子、龟胶、鹿角胶、白术、枸杞、山茱萸等中药组成)]。比较两组获取卵子数、Ⅰ级胚胎数、Ⅱ级胚胎数、胚胎种植率和妊娠率。【结果】两组获取卵子数、Ⅰ级胚胎数和Ⅱ级胚胎数均无显著性差异(P>0.05);但试验组的胚胎种植率显著性高于对照组,两组比较,差异有显著性意义(P<0.05);试验组的妊娠率也有高于对照组的趋势,但差异无显著性意义(P>0.05)。【结论】在采取辅助生育技术的同时,运用中药益气血补肝肾法能提高子宫内膜容受性,从而提高胚胎种植率。

针刺保肝护脑对脑缺血再灌注肝损伤大鼠γ-谷氨酰半胱氨酸合成酶表达的影响

【目的】探讨针刺保肝护脑对脑缺血再灌注大鼠γ-谷氨酰半胱氨酸合成酶(γ-GCS)表达的影响。【方法】将40只SD雄性大鼠随机分为假手术组、模型组、针刺对照组、针刺保肝护脑组。采用线栓法复制缺血再灌注大鼠模型,测试各组大鼠行为学,血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-GCS,肝组织γ-GCS水平。【结果】模型组、针刺对照组和针刺保肝护脑组缺血2 h(电针治疗前)时神经功能缺损评分无显著差异;经10次电针治疗后,与模型组比较,针刺对照组和针刺保肝护脑组神经功能缺损评分显著降低(P<0.01);与针刺对照组比较,针刺保肝护脑组神经功能缺损评分降低更为显著(P<0.05)。电针治疗前,与假手术组比较,模型组血清ALT、AST水平显著增高(P<0.01),而血清、肝组织γ-GCS水平显著降低(P<0.01);与模型组比较,针刺对照组和针刺保肝护脑组血清ALT、AST水平显著降低(P<0.01),同时血清、肝组织γ-GCS水平显著升高(P<0.01);与针刺对照组比较,针刺保肝护脑组血清ALT、AST、γ-GCS和肝组织γ-GCS水平改善更为显著(P<0.05)。【结论】针刺保肝护脑对脑缺血再灌注大鼠的治疗效果较单纯针刺更为显著,其治疗机理可能与促进肝组织γ-GCS的表达相关。

杨宇飞教授运用“三交疏肝补肾方”中西医结合论治乳腺癌经验探析

杨宇飞教授是中国中医科学院西苑医院肿瘤科主任与创始人。她在中西医论治乳腺癌方面注重"以和立法"、"寓补于通",认为乳腺癌的根本病机除了传统认为的肝肾阴虚、肝郁脾虚,还有肝肾不通、心肾不交、少阳不和三大枢机,故临床中在疏肝健脾、补肾活血的基础上采取交通阴阳、心肾、半表半里之"三交"之法,在实践中逐渐形成了攻补兼施的"三交疏肝补肾方"。并且非常注重中医与西医结合治疗,尤其是与内分泌治疗相配合,在此方基础上进行多种加减取得了较好疗效。此外,还在治疗中注意患者免疫功能,重视健康宣教。

柔肝和化痰中药复方对膝骨关节炎患者关节功能及关节液软骨寡聚基质蛋白浓度的影响

目的:比较柔肝和化痰中药复方对膝骨关节炎患者膝关节功能及关节液软骨寡聚基质蛋白浓度的影响及其安全性。方法:将61例符合要求的膝骨关节炎患者随机分为2组,Ⅰ组32例,Ⅱ组29例。Ⅰ组患者口服柔肝中药复方治疗,Ⅱ组口服化痰中药复方治疗。分别于治疗前和治疗4周后采用酶联免疫吸附法测定患者膝关节液中软骨寡聚基质蛋白的浓度,并采用自拟的膝关节功能评分量表评定患者的膝关节功能,同时观察记录2组患者治疗期间的不良反应发生情况。结果:①关节液COMP浓度测定结果。治疗前2组患者膝关节液中软骨寡聚基质蛋白浓度比较,差异无统计学意义[(4.35±1.42)ng·mL-1,(4.77±1.74)ng·mL-1,t=1.437,P=0.601];治疗后2组患者膝关节滑液中软骨寡聚基质蛋白浓度均降低[(4.21±1.66)ng·mL-1,(3.51±1.25)ng·mL-1],Ⅱ组降低程度更明显[(0.35±0.12)ng·mL-1,(1.05±0.09)ng·mL-1,t=4.024,P=0.038]。②膝关节功能评定结果。治疗前2组患者膝关节功能评分比较,差异无统计学意义[(20.63±4.89)分,(19.94±4.92)分,t=1.458,P=0.546];治疗后2组患者膝关节功能评分均降低[(9.25±3.01)分,(9.13±2.83)分],2组治疗前后降低程度比较,差异无统计学意义[(10.54±4.15)分,(9.97±4.07)分,t=1.913,P=0.205]。③不良反应评定结果。2组患者治疗期间均未发生与药物相关的不良反应。结论:与柔肝中药复方相比,化痰中药复方能更好地抑制膝骨关节炎患者软骨寡聚基质蛋白分泌,但二者改善膝关节功能的作用及其安全性相当。

补肾调肝 健脾宁心针法治疗围绝经期抑郁症的临床观察

目的:观察补肾调肝、健脾宁心针法治疗围绝经期抑郁症的疗效。方法:将78例围绝经期抑郁症患者随机分为针刺组和对照组各39例。对照组予百优解20mg/日口服,针刺组予针刺治疗,取肾俞、肝俞、脾俞、心俞、百会、神门、三阴交、太冲等穴,治疗4周后观察治疗前后HAMD及KMI评分。结果:两组治疗后对HAMD及KMI评分均有改善,针刺组对绝经期症状的改善效果尤佳。结论:补肾调肝、健脾宁心针法治疗围绝经期抑郁症的疗效较好。

针刺保肝护脑对脑缺血再灌注肝损伤大鼠血红素氧合酶-1表达的影响

目的:探讨针刺保肝护脑对脑缺血再灌注肝损伤大鼠血红素氧合酶-1(HO-1)表达的影响。方法:将40只SD雄性大鼠随机分为4组,制作缺血再灌注模型,测试行为学、血清ALT、AST、HO-1含量、肝组织HO-1含量。结果:电针治疗后与模型组相比,针刺对照组和针刺保肝护脑组神经功能缺损评分显著减少(P<0.01),尤以针刺保肝护脑组效果更为明显(P<0.05)。模型组血清ALT、AST水平显著增高(P<0.01),而血清HO-1和肝组织HO-1含量明显降低(P<0.01);电针治疗后针刺对照组和保肝护脑针法组血清ALT、AST水平明显降低(P<0.01),血清HO-1和肝组织HO-1显著升高(P<0.01),尤以针刺保肝护脑组各项变化更为显著(P<0.05)。结论:针刺保肝护脑对脑缺血再灌注大鼠的治疗效果较单纯头穴针刺更为显著,其治疗机理与调节HO-1表达密切相关。

补肝肾通络针刺法联合鲑鱼降钙素治疗急性期女性膝关节骨性关节炎的临床研究

目的观察补肝肾通络针刺法联合鲑鱼降钙素治疗急性期女性膝关节骨性关节炎的有效性及安全性。方法将女性急性期膝骨性关节炎(肝肾亏虚证)患者99例按照随机数字表法分为联合组、针刺组、药物组各33例。针刺组给予补肝肾通络针刺法针刺,药物组给予鲑鱼降钙素治疗,联合组给予补肝肾通络针法联合鲑鱼降钙素治疗,连续观察2周。主要观察指标为视觉模拟量表(VAS)评分、Lysholm评分、西安大略和麦克马斯特大学骨关节炎指数膝关节评分量表(Womac)评分,次要观察指标为关节液中白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α),并进行临床疗效分析。结果治疗后各组膝关节Lysholm评分均升高(P<0.05),且联合组高于针刺组和药物组(P<0.05);各组患者VAS评分、Womac评分均下降(P<0.05),联合组明显低针刺组和药物组(P<0.05);各组关节腔内IL-6、IL-1β和TNF-α水平均下降(P<0.05),联合组较针刺组、药物组下降明显(P<0.05)。联合组总有效率明显高于针刺组、药物组(P<0.05)。结论补肝肾通络针刺法联合鲑鱼降钙素治疗女性急性期膝关节骨性关节炎能有效减轻患者疼痛,增强膝关节活动功能,提高其生活质量,并显著降低关节液中IL-6、IL-1β和TNF-α水平,且安全性较高。

平肝补肾法联合肌肉起止点针刺对中晚期帕金森病患者运动、平衡功能及日常生活活动能力的影响

【目的】观察平肝补肾法联合肌肉起止点针刺治疗中晚期帕金森病的临床疗效。【方法】将60例中晚期帕金森病患者随机分为西药治疗组、普通针刺组和复合针刺组,每组各20例。西药治疗组给予美多芭片口服,普通针刺组在西药治疗组的基础上加用平肝补肾法针刺治疗,复合针刺组在普通针刺组的基础上加用肌肉起止点针刺治疗,14 d为1个疗程,共治疗2个疗程。治疗28 d后,观察3组患者治疗前后统一帕金森病评定量表(UPDRS)评分的变化情况,包括精神、行为和情绪评分(UPDRS-Ⅰ)、日常生活活动评分(UPDRS-Ⅱ)和运动检查评分(UPDRS-Ⅲ),并比较3组患者治疗前后Berg平衡量表评分的变化情况。【结果】(1)治疗后,3组患者的UPDRS-Ⅰ评分较治疗前均明显改善(P<0.05或P<0.01),但治疗后3组间差异无统计学意义(P>0.05)。(2)治疗后,3组患者的UPDRS-Ⅱ评分、UPDRS-Ⅲ评分较治疗前均明显改善(P<0.01),且复合针刺组在改善UPDRS-Ⅱ评分、UPDRS-Ⅲ评分方面明显优于西药治疗组和普通针刺组,差异均有统计学意义(P<0.05)。(3)治疗后,3组患者的Berg平衡量表评分较治疗前均明显改善(P<0.01),且复合针刺组在改善Berg平衡量表评分方面均明显优于西药治疗组和普通针刺组,差异有统计学意义(P<0.05)。【结论】平肝补肾法联合肌肉起止点针刺治疗中晚期帕金森病,能明显改善患者的运动、平衡功能和日常生活活动能力,进一步提高患者的生活质量,疗效显著。

新型养生枕与中药合用治疗原发性高血压临床研究

目的观察新型养生枕与以"滋补乙癸、育阴潜阳法"为治则的固定组方中药颗粒剂合用,对眩晕病(原发性高血压)病人睡眠质量、血压平均值及血压变异性的影响。方法眩晕病(原发性高血压1级、2级)、属肝肾阴虚、肝阳上亢证病人180例,随机分为3组。对照组(氨氯地平)60例,中药对照组(氨氯地平+固定组方中药颗粒剂)60例,治疗组(氨氯地平+固定组方中药颗粒剂+新型养生枕)60例,疗程为28 d。观察睡眠质量、血压平均值及血压变异性变化。结果中药对照组和治疗组可显著降低病人的阿森斯失眠量表总积分,治疗组较中药对照组,在降低病人的阿森斯失眠量表总积分方面更加有效;中药对照组和治疗组可以显著降低血压平均值及血压变异性,与对照组比较具有统计学意义。结论新型养生枕加用以"滋补乙癸、育阴潜阳法"为治则的固定组方中药颗粒剂,可以显著改善原发性高血压病人的睡眠质量,有效降低病人血压,避免血压较大波动。

林丽珠中医维持治疗鼻咽癌用药规律的数据挖掘分析

收集林丽珠教授中医维持治疗鼻咽癌门诊患者的处方,采用“中医传承辅助平台”分析林丽珠教授中医维持治疗鼻咽癌的用药规律。结果共筛选出林丽珠教授中医维持治疗鼻咽癌的处方360首,涉及中药168味;使用频次在52次以上的药物有39味,前3味分别是甘草、红豆杉、僵蚕;用药频次居前58位的中药主要可归为宣肺清热药、化痰散结药、养阴补肾药、祛瘀通络药和健脾益气药共5类药;聚类分析后演化得到11首新方组合。分析结果提示林丽珠教授中医维持治疗鼻咽癌用药以宣肺清热、疏肝理气、滋补肝肾为主,常辅以化痰祛瘀、利窍通络之品,体现其诊治鼻咽癌多从肺、肝、肾三脏入手,在整体观念指导下将辨病与辨证、扶正与祛邪相结合,着重提高患者的生活质量及延长生存期,倡导“带瘤生存”的理念。