OVER the past 2,500years, the principles setout by Sun Zi in The Artof War have been appliedin innumerable wars, and hisstrategies have also been utilizedwithin a broad scope of competi-tion. The book is consequentlyi...OVER the past 2,500years, the principles setout by Sun Zi in The Artof War have been appliedin innumerable wars, and hisstrategies have also been utilizedwithin a broad scope of competi-tion. The book is consequentlyindispensable to military strate-展开更多
Single-photon entanglement(SPE) is an important source in quantum communication. In this paper, we put forward a single-photon-assisted noiseless linear amplification protocol to protect the SPE of an arbitrary polari...Single-photon entanglement(SPE) is an important source in quantum communication. In this paper, we put forward a single-photon-assisted noiseless linear amplification protocol to protect the SPE of an arbitrary polarization–time-bin qudit from the photon transmission loss caused by the practical channel noise. After the amplification, the fidelity of the SPE can be effectively increased. Meanwhile, the encoded polarization–time-bin features of the qudit can be well preserved. The protocol can be realized under the current experimental conditions. Moreover, the amplification protocol can be extended to resist complete photon loss and partial photon loss during the photon transmission. After the amplification, we can not only increase the fidelity of the target state, but also solve the decoherence problem simultaneously. Based on the above features, our amplification protocol may be useful in future quantum communication.展开更多
Supported by a new generation of mobile devices, e-commerce is now in the process of being converted into m-commerce. While the traditional fixed PC access to the Internet continues to be important, the mobile access ...Supported by a new generation of mobile devices, e-commerce is now in the process of being converted into m-commerce. While the traditional fixed PC access to the Internet continues to be important, the mobile access appears to attract more people because of its flexibility. The purpose of this paper is to develop and analyze a mathematical model for capturing how e-commerce performance would be affected by the mobile access to the Internet, where the original paper by Sumita and Yoshii (2010) is extended for better reality. The traditional e-commerce via the fixed PC access is compared with m-commerce which accommodates both the fixed PC access and the mobile access. The distribution of the number of products purchased by time t and the distribution of the time required for selling K products are derived explicitly. Numerical examples are given for illustrating behavioral differences between m-commerce consumers and traditional e-commerce consumers.展开更多
In this paper,a review was finished according to a novel-"The Time Traveler's Wife".It use time travel to explore miscommunication and distance in relationships.A lot of knowledge could be obtained from ...In this paper,a review was finished according to a novel-"The Time Traveler's Wife".It use time travel to explore miscommunication and distance in relationships.A lot of knowledge could be obtained from the passage.展开更多
In modern datacenters, the most common method to solve the network latency problem is to minimize flow completion time during the transmission process. Following the soft real-time nature, the optimization of transpor...In modern datacenters, the most common method to solve the network latency problem is to minimize flow completion time during the transmission process. Following the soft real-time nature, the optimization of transport latency is relaxed to meet a flow's deadline in deadline-sensitive services. However, none of existing deadline-sensitive protocols consider deadline as a constraint condition of transmission.They can only simplify the objective of meeting a flow's deadline as a deadline-aware mechanism by assigning a higher priority for tight-deadline constrained flows to finish the transmission as soon as possible, which results in an unsatisfactory effect in the condition of high fan-in degree. It drives us to take a step back and rethink whether minimizing flow completion time is the optimal way in meeting flow's deadline. In this paper, we focus on the design of a soft real-time transport protocol with deadline constraint in datacenters and present a flow-based deadline scheduling scheme for datacenter networks(FBDS).FBDS makes the unilateral deadline-aware flow transmission with priority transform into a compound centralized single-machine deadlinebased flow scheduling decision. In addition, FBDS blocks the flow sets and postpones some flows with extra time until their deadlines to make room for the new arriving flows in order to improve the deadline meeting rate. Our simulation resultson flow completion time and deadline meeting rate reveal the potential of FBDS in terms of a considerable deadline-sensitive transport protocol for deadline-sensitive interactive services.展开更多
In order to meet the needs of work in numerical weather forecast and in numerical simulations for climate change and ocean current, a kind of difference scheme in high precision in the time direction developed from th...In order to meet the needs of work in numerical weather forecast and in numerical simulations for climate change and ocean current, a kind of difference scheme in high precision in the time direction developed from the completely square-conservative difference scheme in explicit way is built by means of the Taylor expansion. A numerical test with 4-wave Rossby-Haurwitz waves on them and an application of them on the monthly mean current the of South China Sea are carried out, from which, it is found that not only do the new schemes have high harmony and approximate precision but also can the time step of the schemes be lengthened and can much computational time be saved. Therefore, they are worth generalizing and applying.展开更多
Studies of biodiversity dynamics have been cast on either long(systematics)or short(ecology)time scales,leaving a gap in coverage for moderate time scales of decades to centuries.Large-scale biodiversity information r...Studies of biodiversity dynamics have been cast on either long(systematics)or short(ecology)time scales,leaving a gap in coverage for moderate time scales of decades to centuries.Large-scale biodiversity information resources now available offer opportunities to fill this gap for many parts of the world via detailed,quantitative comparisons of assemblage composition,particularly for regions without rich time series datasets.We explore the possibility that such changes in avifaunas across the United States and Canada before and after the first three decades of marked global change(i.e.,prior to 1980 versus after 2010)can be reconstructed and characterized from existing primary biodiversity data.As an illustration of the potential of this methodology for sites even in regions not as well sampled as the United States and Canada,we also explored changes at a single site in Mexico(Chichén-Itzá).We analyzed two large-scale datasets:one summarizing bird records in the United States and Canada before 1980,and one for the same region after 2010.We used probabilistic inventory completeness analyses to identify sites that have avifaunas that have likely been inventoried more or less completely.We prepared detailed comparisons between the two time periods to analyze species showing distributional changes over the time period analyzed.We identified 139 sites on a 0.05°grid that were demonstrably well-inventoried before 1980 in the United States and Canada,of which 108 were also well-inventoried after 2010.Comparing presence/absence patterns between the two time periods for 601 bird species,we found significant spatial autocorrelation in overall avifaunal turnover(species gained and lost),but not in numbers of species lost.We noted potential northward retractions of ranges of several species with high-latitude(boreal)distributions,while other species showed dominant patterns of population loss,either rangewide(e.g.,Tympanuchus cupido)or regionally(e.g.,Thryomanes bewickii).We developed linear models to explore a suite of potential drivers of species loss at relatively fine-grained resolutions(<6km),finding significant effects of precipitation increase,particularly on the eastern border of the United States and Canada.Our exploration of biotic change in Chichén-Itzáincluded 265 species and showed intriguing losses from the local avifauna(e.g.,Patagioenas speciosa),as well as vagrant and recent invasive species in the Yucatán Peninsula.The present work documents both the potential for and the problems involved in an approach integrating primary biodiversity data across time periods.This method potentially allows researchers to assess intermediate-time-scale biodiversity dynamics that can reveal patterns of change in biodiversity-rich regions that lack extensive time-series information.展开更多
The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its pilots.The difference in times is then attributable to the skills of the drivers,but considering the data ...The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its pilots.The difference in times is then attributable to the skills of the drivers,but considering the data from the races could test this assumption.The objective of this work was to establish a trajectory model to predict race times.A cross-sectional,correlational,and explanatory work was carried out with a sample of 18,474 records in the period from 2020 to 2023 of the IndyCar series.The results show that the time span predicts the time differences.In relation to the studies of acceptance of the technology,the adjustment of this to human capacities to explain the time differences in the series of racing cars is discussed.展开更多
BACKGROUND Epidemiologically,in China,locally advanced rectal cancer is a more common form of rectal cancer.Preoperative neoadjuvant concurrent chemoradiotherapy can effectively reduce the size of locally invasive tum...BACKGROUND Epidemiologically,in China,locally advanced rectal cancer is a more common form of rectal cancer.Preoperative neoadjuvant concurrent chemoradiotherapy can effectively reduce the size of locally invasive tumors and improve disease-free survival(DFS)and pathologic response after surgery.At present,this modality has become the standard protocol for the treatment of locally advanced rectal cancer in many centers,but the optimal time for surgery after neoadjuvant therapy is still controversial.AIM To investigate the impact of time interval between neoadjuvant therapy and surgery on DFS and pathologic response in patients with locally advanced rectal cancer.METHODS A total of 231 patients who were classified as having clinical stage II or III advanced rectal cancer and underwent neoadjuvant chemoradiation followed by surgery at the National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College from November 2014 to August 2017 were involved in this retrospective cohort study.The patients were divided into two groups based on the different time intervals between neoadjuvant therapy and surgery:139(60.2%)patients were in group A(≤9 wk),and 92(39.2%)patients were in group B(>9 wk).DFS and pathologic response were analyzed as the primary endpoints.The secondary endpoints were postoperative complications and sphincter preservation.RESULTS For the 231 patients included,surgery was performed at≤9 wk in 139(60.2%)patients and at>9 wk in 92(39.8%).The patients’clinical characteristics,surgical results,and tumor outcomes were analyzed through univariate analysis combined with multivariate regression analysis.The overall pathologic complete response(pCR)rate was 27.2%(n=25)in the longer time interval group(>9 wk)and 10.8%(n=15)in the shorter time interval group(≤9 wk,P=0.001).The postoperative complications did not differ between the groups(group A,5%vs group B,5.4%;P=0.894).Surgical procedures for sphincter preservation were performed in 113(48.9%)patients,which were not significantly different between the groups(group A,52.5%vs group B,43.5%;P=0.179).The pCR rate was an independent factor affected by time interval(P=0.009;odds ratio[OR]=2.668;95%CI:1.276-5.578).Kaplan-Meier analysis and Cox regression analysis showed that the longer time interval(>9 wk)was a significant independent prognostic factor for DFS(P=0.032;OR=2.295;95%CI:1.074-4.905),but the time interval was not an independent prognostic factor for overall survival(P>0.05).CONCLUSION A longer time interval to surgery after neoadjuvant therapy may improve the pCR rate and DFS but has little impact on postoperative complications and sphincter preservation.展开更多
A class of nonidentical parallel machine scheduling problems are considered in which the goal is to minimize the total weighted completion time. Models and relaxations are collected. Most of these problems are NP-hard...A class of nonidentical parallel machine scheduling problems are considered in which the goal is to minimize the total weighted completion time. Models and relaxations are collected. Most of these problems are NP-hard, in the strong sense, or open problems, therefore approximation algorithms are studied. The review reveals that there exist some potential areas worthy of further research.展开更多
Decreasing the flow completion time(FCT) and increasing the throughput are two fundamental targets in datacenter networks(DCNs), but current mechanisms mostly focus on one of the problems. In this paper, we propose OF...Decreasing the flow completion time(FCT) and increasing the throughput are two fundamental targets in datacenter networks(DCNs), but current mechanisms mostly focus on one of the problems. In this paper, we propose OFMPC, an Open Flow based Multi Path Cooperation framework, to decrease FCT and increase the network throughput. OFMPC partitions the end-to-end transmission paths into two classes, which are low delay paths(LDPs) and high throughput paths(HTPs), respectively. Short flows are assigned to LDPs to avoid long queueing delay, while long flows are assigned to HTPs to guarantee their throughput. Meanwhile, a dynamic scheduling mechanism is presented to improve network efficiency. We evaluate OFMPC in Mininet emulator and a testbed, and the experimental results show that OFMPC can effectively decrease FCT. Besides, OFMPC also increases the throughput up to more than 84% of bisection bandwidth.展开更多
AIM To analyse clinical and long-term oncologic results after laparoscopic complete mesocolic excision(CME) for colonic cancer over a 10-year period.METHODS Consecutive patients who received laparoscopic CME at our ho...AIM To analyse clinical and long-term oncologic results after laparoscopic complete mesocolic excision(CME) for colonic cancer over a 10-year period.METHODS Consecutive patients who received laparoscopic CME at our hospital from 2007 to 2017 were prospectively registered and retrospectively analysed. In total, 341 patients were included with tumour-nodal-metastasis(TNM) stages 0-Ⅲ.RESULTS The mean age of the patients was 71.9 years. The median length of stay was 5 d. The mean lymph node harvest was 17.8. The mortality rate was 1.2%. Fifteen patients were reoperated on for anastomotic leaks. The local recurrence rate was 2.3%. Five-year TTR and cancer-specific survival CSS were 83.1% and 90.3%. The location of the tumour was not a significant variable for survival in unadjusted and adjusted survival analysis. TNM stage and anastomotic leaks were significant variables with respect to survival.CONCLUSION Laparoscopic CME results in acceptable complication rates and long-term oncologic results. It is important to avoid anastomotic leaks because of their negative effect on survival.展开更多
According to the high operating costs and a large number of energy waste in the current data center network architectures, we propose a kind of trusted flow preemption scheduling combining the energy-saving routing me...According to the high operating costs and a large number of energy waste in the current data center network architectures, we propose a kind of trusted flow preemption scheduling combining the energy-saving routing mechanism based on typical data center network architecture. The mechanism can make the network flow in its exclusive network link bandwidth and transmission path, which can improve the link utilization and the use of the network energy efficiency. Meanwhile, we apply trusted computing to guarantee the high security, high performance and high fault-tolerant routing forwarding service, which helps improving the average completion time of network flow.展开更多
An analytical algorithm was presented for the exact computation of the probability distribution of the project completion time in stochastic networks,where the activity durations are mutually independent and continuou...An analytical algorithm was presented for the exact computation of the probability distribution of the project completion time in stochastic networks,where the activity durations are mutually independent and continuously distributed random variables. Firstly,stochastic activity networks were modeled as continuous-time Markov process with a single absorbing state by the well-know method of supplementary variables and the time changed from the initial state to absorbing state is equal to the project completion time.Then,the Markov process was regarded as a special case of Markov skeleton process.By taking advantage of the backward equations of Markov skeleton processes,a backward algorithm was proposed to compute the probability distribution of the project completion time.Finally,a numerical example was solved to demonstrate the performance of the proposed methodology.The results show that the proposed algorithm is capable of computing the exact distribution function of the project completion time,and the expectation and variance are obtained.展开更多
As an classical book which disputes endlessly on the completed time but systematic and detailed record on official function, rituals and sacrificial vessels, Zhouli (Rites of Zhou) has become a paradoxical existence: ...As an classical book which disputes endlessly on the completed time but systematic and detailed record on official function, rituals and sacrificial vessels, Zhouli (Rites of Zhou) has become a paradoxical existence: on the one hand, it’s a crucial reference document frequently quoted for reconstructing the propriety in the past dynasties and explaining the ritual remains in modern archeology;on the other hand, its authenticity and edition age are always questioned. So the completed time of Zhouli is still a bottleneck problem and cannot be ignored. This article focuses on the tradition of sacrificial jade Bi and Gui based on the written documents and archeological findings, demonstrate once again that Zhouli was completed in early Han dynasty.展开更多
Cobetia marina is a model proteobacteria in researches on marine biofouling. Its taxonomic nomenclature has been revised many times over the past few decades. To better understand the role of the surface-associated li...Cobetia marina is a model proteobacteria in researches on marine biofouling. Its taxonomic nomenclature has been revised many times over the past few decades. To better understand the role of the surface-associated lifestyle of C. marina and the phylogeny of the family Halomonadaceae, we sequenced the entire genome of C. marina JCM 21022T using single molecule real-time sequencing technology (SMRT) and performed comparative genomics and phylogenomics analyses. The circular chromosome was 4 176 300 bp with an average GC content of 62.44% and contained 3 611 predicted coding sequences, 72 tRNA genes, and 21 rRNA genes. The C. marina JCM 2102U genome contained a set of crucial genes involved in surface colonization processes. The comparative genome analysis indicated the significant differences between C. marina JCM 21022T and Cobetia amphilecti KMM 296 (formerly named C. marina KMM 296) resulted from sequence insertions or deletions and chromosomal recombination. Despite these differences, pan and core genome analysis showed similar gene functions between the two strains. The phylogenomic study of the family Halomonadaceae is relationships were well resolved among every genera Cobetia, Kushneria, Zymobacter, and Halotalea. reported here for the first time. We found that the tested, including Chromohalobacter, Halomonas,展开更多
This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinati...This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinations.Initially,liver cancer treatment formulas were extracted from the aforementioned book,and Excel 2017 was employed for calculating the frequency,properties,and meridians associated with the TCMs.IBM SPSS Modeler 18.0 was utilized for the analysis of TCM association rules,and Cytoscape 3.7.2 was employed for the visualization of these rules.Subsequently,network pharmacology was utilized to analyze the action mechanisms of core TCM combinations,leveraging TCMSP,TCMID,Genecards,DAVID,and other databases.The results revealed the inclusion of 131 prescriptions encompassing 303 TCMs.The core TCMs predominantly comprised those invigorating blood circulation and removing blood stasis,clearing heat,and tonifying deficiencies.The flavor of the TCMs was chiefly bitter or pungent,with a prevailing cold property entering the liver and spleen meridians.Association analysis indicated that the support of Angelicae sinensis radix-Trionycis carapax was the highest.Network pharmacology predictions indicated that Angelicae sinensis radix-Trionycis carapax possessed 20 target genes associated with anti-liver cancer properties,including IL-6,MAPK3,and SRC.Gene survival analysis demonstrated high expression of MAPK3 and SRC in liver cancer patients,correlating with a poor prognosis.KEGG analysis identified major anti-liver cancer pathways for Angelicae sinensis radix-Trionycis carapax,encompassing the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.In summary,this study elucidated that TCMs for liver cancer treatment primarily consisted of invigorating blood circulation and removing blood stasis,antipyretic,and tonifying medicines.The core TCM pair,Angelicae sinensis radix-Trionycis carapax,appeared pivotal in this context.The underlying mechanism might involve the modulation of key genes,such as MAPK3 and SRC,and the regulation of pathways,including the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.展开更多
The paper presents a technique for solving the binary linear programming model in polynomial time. The general binary linear programming problem is transformed into a convex quadratic programming problem. The convex q...The paper presents a technique for solving the binary linear programming model in polynomial time. The general binary linear programming problem is transformed into a convex quadratic programming problem. The convex quadratic programming problem is then solved by interior point algorithms. This settles one of the open problems of whether P = NP or not. The worst case complexity of interior point algorithms for the convex quadratic problem is polynomial. It can also be shown that every liner integer problem can be converted into binary linear problem.展开更多
Background: Despite improved preoperative diagnostics, incidental postoperative detection of differentiated thyroid cancer in the final histology is still common. In most of these cases, completion thyroidectomy is re...Background: Despite improved preoperative diagnostics, incidental postoperative detection of differentiated thyroid cancer in the final histology is still common. In most of these cases, completion thyroidectomy is recommended by national and international guidelines, although secondary surgery is associated with an increased operative risk. The optimal timing of completion thyroidectomy is still controversial. Patients and Methods: The patients admitted to surgical oncology department, SECI, with diagnosis of differentiated thyroid cancer;during the period from January 2008 to December 2015;were rewired for age, sex, type of 1st operation, histopathological result, type of 2nd operation and time interval between the 2 operation, complication of 2nd operation and morbidity. 118 patients underwent completion thyroidectomy;those patients were divided according to timing of completion operation into 3 groups: Group A is from one week to 3 months and include 64 patients;Group B is from 3 - 6 months and include 30 patients;Group C is more than 6 months and include 24 patients. Clinical complications and oncologic outcomes were analyzed. The mean follow-up was 80 ± 10 months. Result: we record 118 patients under completion thyroidectomy. Ages range from 79 to 13 years. Papillary thyroid cancer were 96 and follicular thyroid cancer were 22. The overall rates of transient and persistent postoperative hypocalcemia were 19.5% and 4.2%, respectively. The rates of persistent hypocalcemia were found in group A and B but not in group C. Transient or persistent vocal cord paresis was observed in 9 (7.6%) and 3 patients (2.5%). The incidence of persistent vocal cord paresis (VCP) was significantly higher in groups A and B than in group C. There was no significant difference regarding survival among the 3 groups;however recurrence is higher in group A. Conclusion: Considering perioperative morbidity and oncologic outcomes, completion thyroidectomy should be performed at least 3 to 6 months after primary surgery.展开更多
文摘OVER the past 2,500years, the principles setout by Sun Zi in The Artof War have been appliedin innumerable wars, and hisstrategies have also been utilizedwithin a broad scope of competi-tion. The book is consequentlyindispensable to military strate-
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11474168 and 11747161)the Priority Academic Program Development of Jiangsu Higher Education Institutions,Chinathe China Postdoctoral Science Foundation(Grant No.2018M642293)
文摘Single-photon entanglement(SPE) is an important source in quantum communication. In this paper, we put forward a single-photon-assisted noiseless linear amplification protocol to protect the SPE of an arbitrary polarization–time-bin qudit from the photon transmission loss caused by the practical channel noise. After the amplification, the fidelity of the SPE can be effectively increased. Meanwhile, the encoded polarization–time-bin features of the qudit can be well preserved. The protocol can be realized under the current experimental conditions. Moreover, the amplification protocol can be extended to resist complete photon loss and partial photon loss during the photon transmission. After the amplification, we can not only increase the fidelity of the target state, but also solve the decoherence problem simultaneously. Based on the above features, our amplification protocol may be useful in future quantum communication.
文摘Supported by a new generation of mobile devices, e-commerce is now in the process of being converted into m-commerce. While the traditional fixed PC access to the Internet continues to be important, the mobile access appears to attract more people because of its flexibility. The purpose of this paper is to develop and analyze a mathematical model for capturing how e-commerce performance would be affected by the mobile access to the Internet, where the original paper by Sumita and Yoshii (2010) is extended for better reality. The traditional e-commerce via the fixed PC access is compared with m-commerce which accommodates both the fixed PC access and the mobile access. The distribution of the number of products purchased by time t and the distribution of the time required for selling K products are derived explicitly. Numerical examples are given for illustrating behavioral differences between m-commerce consumers and traditional e-commerce consumers.
基金Acknowledgements: The authors are grateful for professors LIN Yi-xun and YUAN Jin-jiang for the helpful suggestions. The research in part was supported by NSFC (10671183), NSFHN(082300410190), The Nature Science Foundation of the Education Department of Henan (2008AI10004), Science Foundation (07XJCO02) and Doctor Science Foundation of Henan University of Technology.
文摘In this paper,a review was finished according to a novel-"The Time Traveler's Wife".It use time travel to explore miscommunication and distance in relationships.A lot of knowledge could be obtained from the passage.
基金supported in part by the Fundamental Research Funds for the Central Universities under Grant No.2014JBM011 and No.2014YJS021in part by NSFC under Grant No.62171200,61422101,and 62132017+2 种基金in part by the Ph.D.Programs Foundation of MOE of China under Grant No.20130009110014in part by "NCET" under Grant No.NCET-12-0767in part by China Postdoctoral Science Foundation under Grant No.2015M570028,2015M580970
文摘In modern datacenters, the most common method to solve the network latency problem is to minimize flow completion time during the transmission process. Following the soft real-time nature, the optimization of transport latency is relaxed to meet a flow's deadline in deadline-sensitive services. However, none of existing deadline-sensitive protocols consider deadline as a constraint condition of transmission.They can only simplify the objective of meeting a flow's deadline as a deadline-aware mechanism by assigning a higher priority for tight-deadline constrained flows to finish the transmission as soon as possible, which results in an unsatisfactory effect in the condition of high fan-in degree. It drives us to take a step back and rethink whether minimizing flow completion time is the optimal way in meeting flow's deadline. In this paper, we focus on the design of a soft real-time transport protocol with deadline constraint in datacenters and present a flow-based deadline scheduling scheme for datacenter networks(FBDS).FBDS makes the unilateral deadline-aware flow transmission with priority transform into a compound centralized single-machine deadlinebased flow scheduling decision. In addition, FBDS blocks the flow sets and postpones some flows with extra time until their deadlines to make room for the new arriving flows in order to improve the deadline meeting rate. Our simulation resultson flow completion time and deadline meeting rate reveal the potential of FBDS in terms of a considerable deadline-sensitive transport protocol for deadline-sensitive interactive services.
文摘In order to meet the needs of work in numerical weather forecast and in numerical simulations for climate change and ocean current, a kind of difference scheme in high precision in the time direction developed from the completely square-conservative difference scheme in explicit way is built by means of the Taylor expansion. A numerical test with 4-wave Rossby-Haurwitz waves on them and an application of them on the monthly mean current the of South China Sea are carried out, from which, it is found that not only do the new schemes have high harmony and approximate precision but also can the time step of the schemes be lengthened and can much computational time be saved. Therefore, they are worth generalizing and applying.
文摘Studies of biodiversity dynamics have been cast on either long(systematics)or short(ecology)time scales,leaving a gap in coverage for moderate time scales of decades to centuries.Large-scale biodiversity information resources now available offer opportunities to fill this gap for many parts of the world via detailed,quantitative comparisons of assemblage composition,particularly for regions without rich time series datasets.We explore the possibility that such changes in avifaunas across the United States and Canada before and after the first three decades of marked global change(i.e.,prior to 1980 versus after 2010)can be reconstructed and characterized from existing primary biodiversity data.As an illustration of the potential of this methodology for sites even in regions not as well sampled as the United States and Canada,we also explored changes at a single site in Mexico(Chichén-Itzá).We analyzed two large-scale datasets:one summarizing bird records in the United States and Canada before 1980,and one for the same region after 2010.We used probabilistic inventory completeness analyses to identify sites that have avifaunas that have likely been inventoried more or less completely.We prepared detailed comparisons between the two time periods to analyze species showing distributional changes over the time period analyzed.We identified 139 sites on a 0.05°grid that were demonstrably well-inventoried before 1980 in the United States and Canada,of which 108 were also well-inventoried after 2010.Comparing presence/absence patterns between the two time periods for 601 bird species,we found significant spatial autocorrelation in overall avifaunal turnover(species gained and lost),but not in numbers of species lost.We noted potential northward retractions of ranges of several species with high-latitude(boreal)distributions,while other species showed dominant patterns of population loss,either rangewide(e.g.,Tympanuchus cupido)or regionally(e.g.,Thryomanes bewickii).We developed linear models to explore a suite of potential drivers of species loss at relatively fine-grained resolutions(<6km),finding significant effects of precipitation increase,particularly on the eastern border of the United States and Canada.Our exploration of biotic change in Chichén-Itzáincluded 265 species and showed intriguing losses from the local avifauna(e.g.,Patagioenas speciosa),as well as vagrant and recent invasive species in the Yucatán Peninsula.The present work documents both the potential for and the problems involved in an approach integrating primary biodiversity data across time periods.This method potentially allows researchers to assess intermediate-time-scale biodiversity dynamics that can reveal patterns of change in biodiversity-rich regions that lack extensive time-series information.
文摘The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its pilots.The difference in times is then attributable to the skills of the drivers,but considering the data from the races could test this assumption.The objective of this work was to establish a trajectory model to predict race times.A cross-sectional,correlational,and explanatory work was carried out with a sample of 18,474 records in the period from 2020 to 2023 of the IndyCar series.The results show that the time span predicts the time differences.In relation to the studies of acceptance of the technology,the adjustment of this to human capacities to explain the time differences in the series of racing cars is discussed.
基金Supported by the National Key Research and Development Plan"Research on Prevention and Control of Major Chronic Non-Communicable Diseases",No.2019YFC1315705the Medicine and Health Technology Innovation Project of Chinese Academy of Medical Sciences,No.2017-12M-1-006.
文摘BACKGROUND Epidemiologically,in China,locally advanced rectal cancer is a more common form of rectal cancer.Preoperative neoadjuvant concurrent chemoradiotherapy can effectively reduce the size of locally invasive tumors and improve disease-free survival(DFS)and pathologic response after surgery.At present,this modality has become the standard protocol for the treatment of locally advanced rectal cancer in many centers,but the optimal time for surgery after neoadjuvant therapy is still controversial.AIM To investigate the impact of time interval between neoadjuvant therapy and surgery on DFS and pathologic response in patients with locally advanced rectal cancer.METHODS A total of 231 patients who were classified as having clinical stage II or III advanced rectal cancer and underwent neoadjuvant chemoradiation followed by surgery at the National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College from November 2014 to August 2017 were involved in this retrospective cohort study.The patients were divided into two groups based on the different time intervals between neoadjuvant therapy and surgery:139(60.2%)patients were in group A(≤9 wk),and 92(39.2%)patients were in group B(>9 wk).DFS and pathologic response were analyzed as the primary endpoints.The secondary endpoints were postoperative complications and sphincter preservation.RESULTS For the 231 patients included,surgery was performed at≤9 wk in 139(60.2%)patients and at>9 wk in 92(39.8%).The patients’clinical characteristics,surgical results,and tumor outcomes were analyzed through univariate analysis combined with multivariate regression analysis.The overall pathologic complete response(pCR)rate was 27.2%(n=25)in the longer time interval group(>9 wk)and 10.8%(n=15)in the shorter time interval group(≤9 wk,P=0.001).The postoperative complications did not differ between the groups(group A,5%vs group B,5.4%;P=0.894).Surgical procedures for sphincter preservation were performed in 113(48.9%)patients,which were not significantly different between the groups(group A,52.5%vs group B,43.5%;P=0.179).The pCR rate was an independent factor affected by time interval(P=0.009;odds ratio[OR]=2.668;95%CI:1.276-5.578).Kaplan-Meier analysis and Cox regression analysis showed that the longer time interval(>9 wk)was a significant independent prognostic factor for DFS(P=0.032;OR=2.295;95%CI:1.074-4.905),but the time interval was not an independent prognostic factor for overall survival(P>0.05).CONCLUSION A longer time interval to surgery after neoadjuvant therapy may improve the pCR rate and DFS but has little impact on postoperative complications and sphincter preservation.
基金the National Natural Science Foundation of China (70631003)the Hefei University of Technology Foundation (071102F).
文摘A class of nonidentical parallel machine scheduling problems are considered in which the goal is to minimize the total weighted completion time. Models and relaxations are collected. Most of these problems are NP-hard, in the strong sense, or open problems, therefore approximation algorithms are studied. The review reveals that there exist some potential areas worthy of further research.
基金supported by the State Key Development Program for Basic Research of China under Grant No.2012CB315806the National Natural Science Foundation of China under Grant Nos.61103225 and 61379149+1 种基金Jiangsu Province Natural Science Foundation of China under Grant No.BK20140070Jiangsu Future Networks Innovation Institute Prospective Research Project on Future Networks under Grant No.BY2013095-1-06
文摘Decreasing the flow completion time(FCT) and increasing the throughput are two fundamental targets in datacenter networks(DCNs), but current mechanisms mostly focus on one of the problems. In this paper, we propose OFMPC, an Open Flow based Multi Path Cooperation framework, to decrease FCT and increase the network throughput. OFMPC partitions the end-to-end transmission paths into two classes, which are low delay paths(LDPs) and high throughput paths(HTPs), respectively. Short flows are assigned to LDPs to avoid long queueing delay, while long flows are assigned to HTPs to guarantee their throughput. Meanwhile, a dynamic scheduling mechanism is presented to improve network efficiency. We evaluate OFMPC in Mininet emulator and a testbed, and the experimental results show that OFMPC can effectively decrease FCT. Besides, OFMPC also increases the throughput up to more than 84% of bisection bandwidth.
文摘AIM To analyse clinical and long-term oncologic results after laparoscopic complete mesocolic excision(CME) for colonic cancer over a 10-year period.METHODS Consecutive patients who received laparoscopic CME at our hospital from 2007 to 2017 were prospectively registered and retrospectively analysed. In total, 341 patients were included with tumour-nodal-metastasis(TNM) stages 0-Ⅲ.RESULTS The mean age of the patients was 71.9 years. The median length of stay was 5 d. The mean lymph node harvest was 17.8. The mortality rate was 1.2%. Fifteen patients were reoperated on for anastomotic leaks. The local recurrence rate was 2.3%. Five-year TTR and cancer-specific survival CSS were 83.1% and 90.3%. The location of the tumour was not a significant variable for survival in unadjusted and adjusted survival analysis. TNM stage and anastomotic leaks were significant variables with respect to survival.CONCLUSION Laparoscopic CME results in acceptable complication rates and long-term oncologic results. It is important to avoid anastomotic leaks because of their negative effect on survival.
基金supported by the National Natural Science Foundation of China(The key trusted running technologies for the sensing nodes in Internet of things: 61501007The outstanding personnel training program of Beijing municipal Party Committee Organization Department (The Research of Trusted Computing environment for Internet of things in Smart City: 2014000020124G041
文摘According to the high operating costs and a large number of energy waste in the current data center network architectures, we propose a kind of trusted flow preemption scheduling combining the energy-saving routing mechanism based on typical data center network architecture. The mechanism can make the network flow in its exclusive network link bandwidth and transmission path, which can improve the link utilization and the use of the network energy efficiency. Meanwhile, we apply trusted computing to guarantee the high security, high performance and high fault-tolerant routing forwarding service, which helps improving the average completion time of network flow.
基金Project(10671212) supported by the National Natural Science Foundation of ChinaProject(20050533036) supported by the Specialized Research Found for the Doctoral Program Foundation of Higher Education of China
文摘An analytical algorithm was presented for the exact computation of the probability distribution of the project completion time in stochastic networks,where the activity durations are mutually independent and continuously distributed random variables. Firstly,stochastic activity networks were modeled as continuous-time Markov process with a single absorbing state by the well-know method of supplementary variables and the time changed from the initial state to absorbing state is equal to the project completion time.Then,the Markov process was regarded as a special case of Markov skeleton process.By taking advantage of the backward equations of Markov skeleton processes,a backward algorithm was proposed to compute the probability distribution of the project completion time.Finally,a numerical example was solved to demonstrate the performance of the proposed methodology.The results show that the proposed algorithm is capable of computing the exact distribution function of the project completion time,and the expectation and variance are obtained.
文摘As an classical book which disputes endlessly on the completed time but systematic and detailed record on official function, rituals and sacrificial vessels, Zhouli (Rites of Zhou) has become a paradoxical existence: on the one hand, it’s a crucial reference document frequently quoted for reconstructing the propriety in the past dynasties and explaining the ritual remains in modern archeology;on the other hand, its authenticity and edition age are always questioned. So the completed time of Zhouli is still a bottleneck problem and cannot be ignored. This article focuses on the tradition of sacrificial jade Bi and Gui based on the written documents and archeological findings, demonstrate once again that Zhouli was completed in early Han dynasty.
基金Supported by the National Natural Science Foundation of China(Nos.41006082,31372517)
文摘Cobetia marina is a model proteobacteria in researches on marine biofouling. Its taxonomic nomenclature has been revised many times over the past few decades. To better understand the role of the surface-associated lifestyle of C. marina and the phylogeny of the family Halomonadaceae, we sequenced the entire genome of C. marina JCM 21022T using single molecule real-time sequencing technology (SMRT) and performed comparative genomics and phylogenomics analyses. The circular chromosome was 4 176 300 bp with an average GC content of 62.44% and contained 3 611 predicted coding sequences, 72 tRNA genes, and 21 rRNA genes. The C. marina JCM 2102U genome contained a set of crucial genes involved in surface colonization processes. The comparative genome analysis indicated the significant differences between C. marina JCM 21022T and Cobetia amphilecti KMM 296 (formerly named C. marina KMM 296) resulted from sequence insertions or deletions and chromosomal recombination. Despite these differences, pan and core genome analysis showed similar gene functions between the two strains. The phylogenomic study of the family Halomonadaceae is relationships were well resolved among every genera Cobetia, Kushneria, Zymobacter, and Halotalea. reported here for the first time. We found that the tested, including Chromohalobacter, Halomonas,
文摘This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinations.Initially,liver cancer treatment formulas were extracted from the aforementioned book,and Excel 2017 was employed for calculating the frequency,properties,and meridians associated with the TCMs.IBM SPSS Modeler 18.0 was utilized for the analysis of TCM association rules,and Cytoscape 3.7.2 was employed for the visualization of these rules.Subsequently,network pharmacology was utilized to analyze the action mechanisms of core TCM combinations,leveraging TCMSP,TCMID,Genecards,DAVID,and other databases.The results revealed the inclusion of 131 prescriptions encompassing 303 TCMs.The core TCMs predominantly comprised those invigorating blood circulation and removing blood stasis,clearing heat,and tonifying deficiencies.The flavor of the TCMs was chiefly bitter or pungent,with a prevailing cold property entering the liver and spleen meridians.Association analysis indicated that the support of Angelicae sinensis radix-Trionycis carapax was the highest.Network pharmacology predictions indicated that Angelicae sinensis radix-Trionycis carapax possessed 20 target genes associated with anti-liver cancer properties,including IL-6,MAPK3,and SRC.Gene survival analysis demonstrated high expression of MAPK3 and SRC in liver cancer patients,correlating with a poor prognosis.KEGG analysis identified major anti-liver cancer pathways for Angelicae sinensis radix-Trionycis carapax,encompassing the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.In summary,this study elucidated that TCMs for liver cancer treatment primarily consisted of invigorating blood circulation and removing blood stasis,antipyretic,and tonifying medicines.The core TCM pair,Angelicae sinensis radix-Trionycis carapax,appeared pivotal in this context.The underlying mechanism might involve the modulation of key genes,such as MAPK3 and SRC,and the regulation of pathways,including the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.
文摘The paper presents a technique for solving the binary linear programming model in polynomial time. The general binary linear programming problem is transformed into a convex quadratic programming problem. The convex quadratic programming problem is then solved by interior point algorithms. This settles one of the open problems of whether P = NP or not. The worst case complexity of interior point algorithms for the convex quadratic problem is polynomial. It can also be shown that every liner integer problem can be converted into binary linear problem.
文摘Background: Despite improved preoperative diagnostics, incidental postoperative detection of differentiated thyroid cancer in the final histology is still common. In most of these cases, completion thyroidectomy is recommended by national and international guidelines, although secondary surgery is associated with an increased operative risk. The optimal timing of completion thyroidectomy is still controversial. Patients and Methods: The patients admitted to surgical oncology department, SECI, with diagnosis of differentiated thyroid cancer;during the period from January 2008 to December 2015;were rewired for age, sex, type of 1st operation, histopathological result, type of 2nd operation and time interval between the 2 operation, complication of 2nd operation and morbidity. 118 patients underwent completion thyroidectomy;those patients were divided according to timing of completion operation into 3 groups: Group A is from one week to 3 months and include 64 patients;Group B is from 3 - 6 months and include 30 patients;Group C is more than 6 months and include 24 patients. Clinical complications and oncologic outcomes were analyzed. The mean follow-up was 80 ± 10 months. Result: we record 118 patients under completion thyroidectomy. Ages range from 79 to 13 years. Papillary thyroid cancer were 96 and follicular thyroid cancer were 22. The overall rates of transient and persistent postoperative hypocalcemia were 19.5% and 4.2%, respectively. The rates of persistent hypocalcemia were found in group A and B but not in group C. Transient or persistent vocal cord paresis was observed in 9 (7.6%) and 3 patients (2.5%). The incidence of persistent vocal cord paresis (VCP) was significantly higher in groups A and B than in group C. There was no significant difference regarding survival among the 3 groups;however recurrence is higher in group A. Conclusion: Considering perioperative morbidity and oncologic outcomes, completion thyroidectomy should be performed at least 3 to 6 months after primary surgery.