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Forty-seven Cases of Gonitis Treated by A Combined Therapy of Chinese Drugs and Acupuncture
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作者 杨文鹤 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2001年第2期127-129,共3页
Osteoarthritis, a nonspecific inflammatory lesion, is a commonly seen joint disease. Clinically, it is mainly characterized by arthralgia, swelling, and motor impairment. Since the knee joint is the load-bearing joint... Osteoarthritis, a nonspecific inflammatory lesion, is a commonly seen joint disease. Clinically, it is mainly characterized by arthralgia, swelling, and motor impairment. Since the knee joint is the load-bearing joint of the human body, and is susceptible to trauma, gonitis tends to have the highest morbidity in the four limbs, which manifests itself arthritis of patella and femur at the early stage; narrowness or disappearance of the medial joint space at the mid stage; and damage of the cartilage accompanied with flexion deformity at the late stage. In recent years, based on the experience of Prof. Cao Yiming, the author has treated 47 cases of gonitis by combined use of Chinese drugs and acupuncture, and obtained satisfactory therapeutic results as reported in the following. 展开更多
关键词 acupuncture therapy ADULT Aged Aged 80 and over combined Modality therapy drugs chinese Herbal Female Humans Male Middle Aged Osteoarthritis Knee
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Treatment of Prolapse of Rectum with Acupuncture Combined with TCM Drugs in 38 Cases
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作者 高景芳 李铁成 +1 位作者 黄彦彬 陈正秋 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2003年第2期122-122,共1页
Prolapse of rectum usually occurs in the children with insufficient qi and blood, in the elders with declined qi and blood or deficiency of qi in the middle jiao (burner), in the women who made qi exhausted during lab... Prolapse of rectum usually occurs in the children with insufficient qi and blood, in the elders with declined qi and blood or deficiency of qi in the middle jiao (burner), in the women who made qi exhausted during labor resulting in deficiency of qi and blood, and in those with chronic diarrhea, habitual constipation and long-standing cough. All these may cause sinking of qi in middle jiao and induce the disorder. Therefore in treating the disorder, the primary causes should also be treated simultaneously. 展开更多
关键词 acupuncture therapy ADOLESCENT Adult Aged Child combined Modality therapy drugs chinese Herbal Female Humans Male Middle Aged PHYTOtheRAPY Rectal Prolapse
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Chinese Herbal Medicine and Acupuncture Used for Rehabilitation of the Impaired Urinary System in Patients with Paraplegia—A Report of 52 Cases
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作者 邹颖 周文艳 王新中 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2005年第1期18-20, ,共3页
Infection of the urinary system is frequently seen in the paraplegic patients with urinary complications,which is one of the main reasons for the late death in such cases. The effects of the therapeutic method adopted... Infection of the urinary system is frequently seen in the paraplegic patients with urinary complications,which is one of the main reasons for the late death in such cases. The effects of the therapeutic method adopted for the urinary rehabilitation are directly related to the life quality and survival time of the paraplegic patients. Since 1999-2002, the authors had applied Chinese herbal medicine combined with acupuncture for the urinary rehabilitation in 52 paraplegic patients, with quite good therapeuticresults as reported in the following. 展开更多
关键词 acupuncture therapy PHYTOtheRAPY ADULT combined Modality therapy drugs chinese Herbal Female Humans Male Middle Aged PARAPLEGIA Urinary Tract Infections
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CLINICAL OBSERVATION ON 40 CASES OF ANKYLOSING SPONDYLITIS TREATED WITH ACUPUNCTURE AND CHINESE DRUGS
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作者 贾红玲 张永臣 《World Journal of Acupuncture-Moxibustion》 2005年第3期18-22,共5页
Objective: To observe the clinical therapeutic effect of acupuncture plus Chinese herbal medicines for ankylceing Methods: A total of 80 cases of AS patients were evenly and randomly divided into treatment group and... Objective: To observe the clinical therapeutic effect of acupuncture plus Chinese herbal medicines for ankylceing Methods: A total of 80 cases of AS patients were evenly and randomly divided into treatment group and control group. In treatment group, patients were treated with acupuncture of Jiaji (夹脊 EX-B 2) and oral administration of Yishen Tongdu Won (益肾通督丸,Bolus for Reinforcing the Kidney and Dredging Governor Vessesl) and those of control group treated with oral administration of Sulfasalazin (0.5 g, twice daily). Before and after treatment, the thoracic-dilaion scale, Schober test, Bath ankylceing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), erythrocyte sedimentation rate (ESR) and C-reaction protein (CRP) were detected separately. Results: After 6 months of treatment, of the both 40cases in treatment and control groups, 27 (67.5%) and 13 (32.5%) were improved remarkably, 11 (27.5%) and 16 (40.0%) effective, and 2 (5.0%) and 11 (27.5%) failed, with the effective rates being 95.0% and 72.5% separately. The therapeutic effect of treatment group was significantly superior to that of control group (P〈 0.05). After treatment, the thoracicdilaion scale and Schober test values increased significantly ( P〈 0.05), while BASDAI, BASFI, ESR and CRP lowered considerably (P〈0.01, P〈0.05). Comparison between two groups indicated that after treatment, the decreased values of BASDAI, BASFI, ESR and CRP of treatment group were significantly lower than those of control group ( P〈 0.01 ), while those of the thoracio-dilaion scale and Schober test of treatment group were significantly higher than those of control group ( P 〈 0.05, P 〈 0.01 ). Results displayed that both acupuncture combined with Chinese drugs and Sulfasalazin could lower BASDAI, BASFI, ESR and CRP, raise the thoracic-dilaion scale and Schober test values considerably in AS patients, and the therapeutic effect of combined acupunclure and Chinese drugs was apparently superior to that of Westem medicine. Conclusion: Joint application of acupuncture and Chinese drugs is superior to Western medicine in the therapeutic effect for AS and has fewer side effects. 展开更多
关键词 Ankylosing spondylitis acupuncture combined with chinese drugs Jiaji (EX-B 2) Western medicine
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TREATMENT OF 50 CASES OF SENILE DEMENTIA BY ACUPUNCTURE COMBINED WITH INHALATION OF HERBAL DRUGS AND OXYGEN
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作者 耿健 刘莉 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 1999年第4期287-289,共3页
Clinical DataCase selection: 100 cases who met thediagnostic criteria of senile dementiaformulated by American Association ofPsychiatry in Handbook of Diagnosis andStatistics (DSM-Ⅲ-R, 3rd revised edition)
关键词 acupuncture therapy Oxygen Inhalation therapy Administration Inhalation Aged Aged 80 and over Alzheimer Disease combined Modality therapy drugs chinese Herbal FEMALE Humans Male Middle Aged
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Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy 被引量:2
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作者 Weimin Wang Zhenyu Fan +6 位作者 Yongqin Zhang Yuxia Yang Yaqing Liu Xiaoli Dang Wenjun Song Yinping Wu Jiang Ye 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第3期208-217,共10页
One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a tradi... One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroencephalogram, and CT/MRI. Blood drug levels were monitored throughout the study. Before treatment with tall gastrodis tuber, 35 of the 100 cases had abnormal CT/MRI scans; 79 cases had abnormal single photon emission computed tomography images; 86 cases had abnormal electroencephalogram; and a total of 146 abnormal perfusion foci were observed across the 100 subjects. After treatment, the number of patients with normal single photon emission computed tomography images increased by 12; normal electroencephalogram was observed in an additional 27 cases and the number of patients with epileptiform discharge decreased by 29 (34% of 86); the total number of abnormal perfusion foci decreased by 52 (36%) and changes in abnormal loci were visible in 65 patients. These changes indicate that the administration of tall gastrodis tuber in combination with antiepileptic drugs repairs abnormal perfusion foci in patients with focal epilepsy Our results demonstrate that traditional Chinese drugs can repair abnormal perfusion foci and, as such, are a promising new pathway in the treatment of focal epilepsy. 展开更多
关键词 neural regeneration traditional chinese medicine neuroimaging brain injury tall gastrodis tuber antiepileptic drugs combination therapy focal epilepsy abnormal perfusion focus single photonemission computed tomography long-term vigilance-controlled electroencephalogram region ofinterest grant-supported paper photographs-containin^l paper: neuoreaeneration
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Thirty Cases of Acute Lumbar Sprain Treated by Acupuncture Combined with Point-Injection at Tianzhu 被引量:1
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作者 周珊玲 刘明元 陈正秋 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2003年第3期203-204,共2页
In recent years, the authors have treated 30 cases of acute lumbar sprain by acupuncture combined with point medicinal injection at Tianzhu (BL 10), and obtained quite good therapeutic results, as is reported in the f... In recent years, the authors have treated 30 cases of acute lumbar sprain by acupuncture combined with point medicinal injection at Tianzhu (BL 10), and obtained quite good therapeutic results, as is reported in the following. 展开更多
关键词 acupuncture therapy PHYTOtheRAPY acupuncture Points ADOLESCENT ADULT combined Modality therapy drugs chinese Herbal Female Humans INJECTIONS Low Back Pain MAGNOLIA Male Middle Aged Sprains and Strains
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An Approach to the Integration of Acupuncture and Drug
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作者 高希言 饶洪 +2 位作者 牛学恩 胡军 周永生 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2001年第1期45-49,共5页
Integration of acupuncture and drug is a therapeutic method in which acupuncture treatment and pharmacotherapy are synchronously performed in the same patient to prevent and treat the disease. Its importance can be tr... Integration of acupuncture and drug is a therapeutic method in which acupuncture treatment and pharmacotherapy are synchronously performed in the same patient to prevent and treat the disease. Its importance can be traced back to Sun Simiao (581-682 A.D.), a prominent physician of China's Tang Dynasty. He pointed out that: A physician who masters only acupuncture treatment in clinical practice but not moxibustion, or masters only moxibustion treatment but not acupuncture is not a skillful doctor; and a physician who is only aware of the application of acupuncture and moxibustion but ignorant of pharmacotherapy, or is only aware of pharmacotherapy but ignorant of the application of acupuncture and moxibustion also should not be a skillful one. Not only should a skillful doctor have the knack of applying acupuncture and moxibustion, but he should have the knack at pharmacotherapy in treating diseases. Each of acupuncture and moxibustion, and drug has its strong points. Therefore, both of them should be used simultaneously, thus bringing the strong points of both individuals into full play and offsetting their weaknesses so as to obtain a satisfactory therapeutic effect. With the development of modern medicine and introduction of advanced technology, there have been brilliant developments in the method and applied range of integration of acupuncture and drug, particularly in the studies on combined anesthesia induced by using acupuncture and drug, and administering drug by acupoint. All these have provided us a ground to further probe into the mechanism underlying the integration of acupuncture and drug. 展开更多
关键词 acupuncture Points acupuncture therapy combined Modality therapy drugs chinese Herbal Humans
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Effects of acupuncture combined with Kaijingtongmai Decoction on ATP sensitive potassium channel related proteins Kir6.1 and Kir6.2 in myocardial infarction rats
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作者 Kun Jian Lan-Shi Li Ying Wang 《Journal of Hainan Medical University》 2022年第10期15-19,共5页
Objective:To study the effect of combination of acupuncture and medicine on the expression of ATP sensitive potassium channel related proteins Kir6.1 and Kir6.2 in rats with myocardial infarction,and to study the poss... Objective:To study the effect of combination of acupuncture and medicine on the expression of ATP sensitive potassium channel related proteins Kir6.1 and Kir6.2 in rats with myocardial infarction,and to study the possible mechanism of combination of acupuncture and medicine on the improvement of myocardial infarction,so as to provide experimental data basis for the development of new treatment methods for myocardial infarction.Methods:65 healthy male SD rats were randomly selected as the control group.The other rats were fed with high-fat food for three weeks.The rats in the control group were injected with normal saline subcutaneously,and the other rats were injected with isoproterenol hydrochloride in the same way.Through ECG comparison,40 successful Mi rats were randomly divided into model group,acupuncture group,western medicine group and acupuncture drug combination group,with 10 rats in each group.After the corresponding treatment,the ECG changes of rats in each group were observed,the pathological changes of rat cardiomyocytes were observed by HE staining,and the expression of ATP sensitive potassium channel(Kir6.1,Kir6.2)protein was detected by Western blot.Results:compared with the control group,40 experimental specimens in the experimental group showed significant changes in cardiomyocyte protein The expression of Kir6.1 and Kir6.2 increased,and the difference was statistically significant.After treatment,compared with the model group,the protein expression of Kir6.1 and Kir6.2 in cardiomyocytes of Western medicine group,acupuncture group and acupuncture drug combination group showed a downward trend,among which the decline degree of acupuncture drug combination group was the most obvious,and the difference was statistically significant.The decline degree of acupuncture group and Western medicine group was not significant,and there was no significant difference Conclusion:acupuncture combined with medicine has a significant effect on improving myocardial infarction in rats,which may be related to the expression of ATP sensitive potassium channel related proteins Kir6.1 and Kir6.2 in rat cardiomyocytes. 展开更多
关键词 Combination of acupuncture and traditional chinese medicine Miocardial infarction ATP sensitive potassium channel Kir6.1 KIR6.2
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An Analysis of Therapeutic Effect of Drug Acupoint Application in 209 Cases of Allergic Asthma 被引量:3
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作者 赖新生 李月梅 +2 位作者 范兆金 张家维 刘炳权 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2001年第2期122-126,共5页
Both therapies of traditional crude herb moxibustion and drug acupoint application were used in 209 cases of allergic asthma to compare their long-term and short-term therapeutic effects and to analyze the relationshi... Both therapies of traditional crude herb moxibustion and drug acupoint application were used in 209 cases of allergic asthma to compare their long-term and short-term therapeutic effects and to analyze the relationship between clinic therapeutic effects of both therapies and differential types of the disease. The results showed that the short-term total effective rate in the group of drug acupoint application was higher than that in the group of traditional crude herb moxibustion, the therapeutic effects of drug acupoint application being closely related to differential types. Analysis also shows the best short-term therapeutic effect was in the type of heat in the lung while the poorest effect in the type of deficiency of the kidney-yang. 展开更多
关键词 acupuncture Points MOXIBUSTION ASTHMA Diagnosis Differential drugs chinese Herbal FEMALE Humans MALE Medicine chinese traditional
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Acupuncture, Moxibustion, and Combination Therapies for Insomnia 被引量:1
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作者 Jianguo Wen Quancheng Kan Yan Chen 《Chinese Medicine》 2016年第2期67-76,共10页
Insomnia, a common sleep disorder, affects general well-being, hastens the onset of other diseases, and impairs work performance. Hypnotic medications are efficacious in the short term but have obvious side effects. A... Insomnia, a common sleep disorder, affects general well-being, hastens the onset of other diseases, and impairs work performance. Hypnotic medications are efficacious in the short term but have obvious side effects. Acupuncture, often used to treat insomnia in traditional Chinese medicine (TCM), is considered to be beneficial in restoring the normal sleep-wake cycle by regulating and restoring the natural flow of qi (energy power). The three main TCM theories for treating insomnia by acupuncture are the tranquilization disturbance, zangfu disturbance (disequilibrium of internal organs), and imbalance of yin and yang theories. Moxibustion, another treatment for insomnia, is usually combined with acupuncture. Acupuncture and moxibustion with tuina (exercise massage), acupuncture with Chinese herbal injection, electroacupuncture, and acupuncture with medication or psychotherapy are other interventions. Some acupuncture-based methods such as needle-rolling acupuncture, auricular acupoint plaster therapy, phlebotomy, and acupoint catgut-embedding therapy are used as well. Although most clinical trials have shown that acupuncture and its combination therapies are significantly effective in insomnia, the beneficial effects may have been overvalued, because of small sample size, nonstrict inclusion and exclusion criteria, flawed methodology, short follow-up, or nonstandardized evaluation. Therefore, clinical studies of high methodological quality are needed to verify the efficacy of acupuncture, moxibustion, and other combination therapies in insomnia. 展开更多
关键词 traditional chinese Medicine acupuncture MOXIBUSTION Auricular Acupoint Combination therapy
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Application of the Drugs for Expelling the Pathogenic Wind in Treatment of Chronic Diarrhea
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作者 王奎平 周永生 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2003年第4期264-266,共3页
Chronic diarrhea can be divided into four types:retention of dampness leading to blockage of qi,invasion of the intestines by pathogenic wind,damp-retention due to deficiency of the spleen, andstagnation of the liver-... Chronic diarrhea can be divided into four types:retention of dampness leading to blockage of qi,invasion of the intestines by pathogenic wind,damp-retention due to deficiency of the spleen, andstagnation of the liver-qi with deficiency of thespleen. 展开更多
关键词 PHYTOtheRAPY ADULT Chronic Disease Diagnosis Differential DIARRHEA drug Combinations drugs chinese Herbal Female Humans Male Medicine chinese traditional Middle Aged
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Juvenile Myasthenia Laryngis Treated by Acupuncture and TCM Medication
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作者 谢强 杨淑荣 +1 位作者 李唯刚 毛树章 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2003年第4期280-281,共2页
Myasthenia laryngis, or laryngoparalysis, oftenoccurs in juvenile teachers, actors or actresses, andmusical school students.
关键词 acupuncture therapy PHYTOtheRAPY ADOLESCENT Adult combined Modality therapy drugs chinese Herbal Female Humans LARYNGITIS Male Voice Disorders
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Clinical Observation on Treatment of Acquired Paralytic Strabismus by Acupuncture Plus Oral Administration of Chinese Herbs
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作者 元旭红 周永生 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2003年第3期188-190,共3页
From June 1996 to June 2002, the author treated 38 cases of acquired paralytic strabismus by acupuncture plus oral administration of Zheng Rong Tang (正容汤), with another 38 cases of acquired paralytic strabismus tre... From June 1996 to June 2002, the author treated 38 cases of acquired paralytic strabismus by acupuncture plus oral administration of Zheng Rong Tang (正容汤), with another 38 cases of acquired paralytic strabismus treated only with oral administration of Chinese herbs as the controls. The results are reported as follows. 展开更多
关键词 acupuncture therapy PHYTOtheRAPY Administration Oral combined Modality therapy drugs chinese Herbal OPHTHALMOPLEGIA STRABISMUS
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医疗机构基于“三结合”中药新药研发及管理体系的构建
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作者 路遥 申琳 +3 位作者 鲁雨荍 刘殿娜 王乐 陈旭 《中国药事》 CAS 2024年第2期147-151,共5页
目的:在中药审评审批制度改革的政策背景下,围绕医疗机构,探索中医药理论、人用经验和临床试验相结合(简称“三结合”)的审评证据体系落地举措,为医疗机构中药制剂及中药新药研发提供参考。方法:根据“三结合”审评证据体系下中药新药... 目的:在中药审评审批制度改革的政策背景下,围绕医疗机构,探索中医药理论、人用经验和临床试验相结合(简称“三结合”)的审评证据体系落地举措,为医疗机构中药制剂及中药新药研发提供参考。方法:根据“三结合”审评证据体系下中药新药研发的相关要求,从机构层面加强人用经验研究相关配套建设,从管理层面搭建中药研发、成果转化服务平台,从临床层面规范开展人用经验研究,构建医疗机构中药新药研发及管理体系。结果:医疗机构中药新药研发及管理体系的构建,有助于将临床诊疗数据转变为支持中药新药注册的人用经验证据,通过提高中药研发水平促进中药新药转化。结论:在医疗机构构建基于“三结合”的中药新药研发及管理体系,是“三结合”审评证据体系落地、政策引导研发实践的路径之一。 展开更多
关键词 “三结合”审评证据体系 人用经验 医疗机构 中药新药研发 中药新药转化 医疗机构中药制剂
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韦企平从肝论治原发性闭角型青光眼经验 被引量:1
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作者 曹琳琳 王妍 +2 位作者 夏燕婷 廖良 韦企平 《中国中医眼科杂志》 2024年第5期429-433,437,共6页
原发性闭角型青光眼(PACG)是临床最常见的致盲眼病之一。若眼压控制不佳,常可造成视神经萎缩,导致视力下降、视野缺损,最终失明。西医认为其主要是由于眼前房角部的解剖结构异常或功能障碍,导致房水排出受阻,进而引起眼内压增高。中医... 原发性闭角型青光眼(PACG)是临床最常见的致盲眼病之一。若眼压控制不佳,常可造成视神经萎缩,导致视力下降、视野缺损,最终失明。西医认为其主要是由于眼前房角部的解剖结构异常或功能障碍,导致房水排出受阻,进而引起眼内压增高。中医学则将本病病因病机归咎于肝火上炎、痰火郁结、肝肾阴虚以及饮邪上犯等因素。这些因素共同作用,引起气血失和、气滞血瘀,从而导致目中玄府闭塞及神水瘀滞,发为PACG。韦企平擅长中西医结合治疗不同发病阶段的PACG,对其病因病机和辨证论治有独到见解,主张本病应从肝论治,在控制眼压的基础上,重视全身辨证论治,采用针药结合治疗PACG导致的视神经萎缩。 展开更多
关键词 原发性闭角型青光眼 中西医结合 韦企平 针药并用
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中药联合抗肿瘤血管生成药物治疗非小细胞肺癌的研究进展 被引量:1
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作者 刘宝生 周秀丽 +3 位作者 朱彦 刘丽红 于泽胜 王振华 《基层中医药》 2024年第2期112-118,共7页
非小细胞肺癌(NSCLC)是肺癌最为常见的一种病理类型,一半以上的患者确诊时即为进展期肺癌,患者生存期较短。抗肿瘤血管生成药物是目前治疗非小细胞肺癌的重要靶向药物,其临床疗效已获得临床认可,但仍存在耐药性及毒副作用不可耐受的局限... 非小细胞肺癌(NSCLC)是肺癌最为常见的一种病理类型,一半以上的患者确诊时即为进展期肺癌,患者生存期较短。抗肿瘤血管生成药物是目前治疗非小细胞肺癌的重要靶向药物,其临床疗效已获得临床认可,但仍存在耐药性及毒副作用不可耐受的局限性,而中药辨证论治及减毒增效的优点,可减轻药物的不良反应,并提高临床疗效,已成为中西医结合治疗非小细胞肺癌的重要方向。本文主要通过检索2010年1月—2023年6月中国知网、万方、维普及PubMed等数据库中的相关文献,总结近年来不同中药联合各类抗肿瘤血管生成药物治疗NSCLC的相关研究,试从不同角度探讨治疗NSCLC的新思路。 展开更多
关键词 非小细胞肺癌 中药 抗肿瘤血管生成药物 联合治疗
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蒽环类药物心脏毒性的中西药防治策略
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作者 钱俊 张淑敏 +3 位作者 仇慧鑫 刘思彤 邓雁如 舒乐新 《世界科学技术-中医药现代化》 CSCD 北大核心 2024年第7期1706-1714,共9页
蒽环类药物的心脏毒性对其临床使用造成极大限制,为探究蒽环类心脏毒性的规律及中西药防治策略,本文通过文献检索对蒽环类药物心脏毒性的发生机制和防治药物进行了归纳总结,其机制可分氧化应激、炎性反应、心肌细胞自噬以及DNA损伤4大... 蒽环类药物的心脏毒性对其临床使用造成极大限制,为探究蒽环类心脏毒性的规律及中西药防治策略,本文通过文献检索对蒽环类药物心脏毒性的发生机制和防治药物进行了归纳总结,其机制可分氧化应激、炎性反应、心肌细胞自噬以及DNA损伤4大类。防治药物西药以右丙亚胺、ACEI、ARB等为主,中药可分为单药、经方及中成药。在此基础上,对联合用药防治心脏毒性进行了讨论,介绍了西药、中药及中西药联合应用的理论依据及研究现状,结果表明其具有良好的可行性和安全性,可为临床上蒽环类化疗药物心脏毒性的防治策略研究提供参考。 展开更多
关键词 蒽环类药物 心脏毒性 防治策略 西药 中药 联合用药
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5-氨基水杨酸口服制剂及联合中药在炎症性肠病治疗中的应用
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作者 程燕 颜冬梅 +1 位作者 李飞 朱卫丰 《中国现代中药》 CAS 2024年第8期1420-1431,共12页
5-氨基水杨酸(5-ASA)是1种从中药柳树皮中分离提纯得到的天然抗炎活性成分水杨酸的衍生物,别名阿米诺水杨酸、美沙拉嗪,是临床治疗炎症性肠病(IBD)并预防其复发的一线药物。尽管目前莎尔福(Salofalk)、亚沙可(Asacol)和潘他沙(Pentasa)... 5-氨基水杨酸(5-ASA)是1种从中药柳树皮中分离提纯得到的天然抗炎活性成分水杨酸的衍生物,别名阿米诺水杨酸、美沙拉嗪,是临床治疗炎症性肠病(IBD)并预防其复发的一线药物。尽管目前莎尔福(Salofalk)、亚沙可(Asacol)和潘他沙(Pentasa)等5-ASA口服结肠靶向制剂已广泛用于IBD的临床治疗,但仍存在在小肠提前释药和受胃肠道生理状态影响显著等制剂缺陷、对克罗恩病和重度溃疡性结肠炎(UC)治疗效果不佳等临床未满足的需求,以及减少UC患者黏膜菌群多样性、长期使用增加用药风险和降低患者服药依从性等问题。开发硅胶纳米粒、水凝胶等新型递药载体,基于pH依赖、时滞控制和菌群/酶触发等多机制结合释药原理设计新型口服结肠靶向制剂从而解决制剂缺陷问题,提高5-ASA疗效和患者服药耐受性、依从性是目前制剂研究的重点。此外,5-ASA口服制剂联合中药保留灌肠、中药口服制剂和注射液等治疗IBD可发挥协同抗炎作用,实现增效减毒目的。对5-ASA口服制剂品种、近年来新型制剂和递药载体的研究进展,以及与中药联用的临床应用和研究现状等进行综述,为5-ASA口服制剂的剂型改造、载体材料研究和临床用药等提供参考。 展开更多
关键词 5-氨基水杨酸 口服结肠靶向制剂 递药载体 联合中药 炎症性肠病
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针药结合治疗卵巢储备功能减退Meta分析
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作者 陶鑫悦 赵越梦 +3 位作者 郑小艳 李怡婷 黄蕾 杨洁 《亚太传统医药》 2024年第6期167-173,共7页
目的:通过评估针灸结合中药治疗卵巢储备功能减退的疗效,以期获得更有效的治疗方法。方法:检索Cochrane Library、Embase、PubMed、国家生物医疗文献(China Biology Medicine,CBM)、国家知识基础设施数据库(China National Knowledge In... 目的:通过评估针灸结合中药治疗卵巢储备功能减退的疗效,以期获得更有效的治疗方法。方法:检索Cochrane Library、Embase、PubMed、国家生物医疗文献(China Biology Medicine,CBM)、国家知识基础设施数据库(China National Knowledge Infrastructure,CNKI)、维普(China Science and Technology Journal Database),VIP和万方(WanFang Database),检索时间为建库至2023年1月,收集到7个采用针药结合方法改善卵巢储备功能的随机对照试验。经过2位研究人员的评估与审核,采用Review Manager 5.3分析工具,从174篇有效文章中,筛选出23项RCT,将1 635位DOR患者纳入研究。结果:针药结合治疗卵巢储备功能减退有效率远高于单纯西药或单纯中药治疗[RR=1.17,95%CI(1.12~1.23),P<0.01,I^(2)=26%]。针药结合治疗卵巢储备功能减退患者血清FSH水平优于单纯西药或单纯中药治疗[SMD=-0.93,95%CI(-1.04~-0.38),P<0.01]。结论:针药结合治疗卵巢储备功能减退比单独使用西药或单独使用中药具有更好的疗效。但该Meta分析存在纳入的文献质量较低、亚组分析异质性偏大等问题,研究结论有待更大样本量的高质量RCT验证。 展开更多
关键词 卵巢储备功能减退 针药结合 针灸 中药 META分析 随机对照试验
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