This experiment was an attempt to use the soybean residue derived from the production of 'soy milk'. The residue contains about 18% protein, 70% caf bohydrates and 7.5% lipid as fish feed for reafing common ca...This experiment was an attempt to use the soybean residue derived from the production of 'soy milk'. The residue contains about 18% protein, 70% caf bohydrates and 7.5% lipid as fish feed for reafing common carp, Cyrinus carpto. There were 4 types of diets: (1)soybean residue, (2 ) soybean residue digested with Papain, (3) soybean residue (64%)mixed with beef liver (34%) and (4) same mixture as (3) but digested with Papain. The results indicate that the percentage increase in weight and length of fish feeding with beef liver supplemented diets was higher than those feeding with soybean residue alone. This was possibly due to the fact that beef liver was able to supplement the nutrient deficiency in soybean. The two types of feeds (2 and 4) digested with Papain also yielded significantly better fish growth in terms of weight and length gains, than their counterparts without digestion. Furthermore, the water turbidity of the tanks added with digested feeds was significantly less, as papain was able to hyrolyse the protein substrates suspended in the water, and thus lowered the turbidity展开更多
Several groups in the USA have been working to de-velop a low chill apricot that would ripen its fruits veryearly in the season. Unfortunately, the cultivatcd apricothas been developed mainly from the high chilling Eu...Several groups in the USA have been working to de-velop a low chill apricot that would ripen its fruits veryearly in the season. Unfortunately, the cultivatcd apricothas been developed mainly from the high chilling Euro-pean group within the species Prunus armeniaca. Amongthe five groups within the apricot species, this is the mostrecently evolved and least variable (Bailey and展开更多
In this paper, the authors develop the earlier work of Chen Jiabin et al. (1986). In order to reduce spectral truncation errors, the reference atmosphere has been introduced in ECMWF model, and the spectrally-represen...In this paper, the authors develop the earlier work of Chen Jiabin et al. (1986). In order to reduce spectral truncation errors, the reference atmosphere has been introduced in ECMWF model, and the spectrally-represented variables, temperature, geopotential height and orography, are replaced by their deviations from the reference atmosphere. Two modified semi- implicit schemes have been proposed to alleviate the computational instability due to the introduction of reference atmosphere. Concerning the deviation of surface geopotential height from reference atmosphere, an exact computational formulation has been used instead of the approximate one in the earlier work. To re duce aliasing errors in the computations of the deviation of the surface geopotential height, a spectral fit has been used slightly to modify the original Gaussian grid-point values of orography.A series of experiments has been performed in order to assess the impact of the reference atmosphere on ECMWF medium- range forecasts at the resolution T21, T42 and T63. The results we have obtained reveal that the reference atmosphere introduced in ECMWF spectral model is generally beneficial to the mean statistical scores of 1000-200 hPa height 10-day forecasts over the globe. In the Southern Hemisphere, it is a clear improvement for T21, T42 and T63 throughout the 10-day forecast period. In the Northern Hemisphere, the impact of the reference atmos phere on anomaly correlation is positive for resolution T21, a very slightly damaging at T42 and almost neutral at T63 in the range of day 1 to day 4. Beyond the day 4 there is a clear improvement at all resolutions.展开更多
Parkinson＇s disease is a neurological disorder with distinct motor signs of resting tremor,akinesia and/or lead-pipe rigidity,together with non-motor symptoms of impaired smell,cognition and autonomic function.These ...Parkinson＇s disease is a neurological disorder with distinct motor signs of resting tremor,akinesia and/or lead-pipe rigidity,together with non-motor symptoms of impaired smell,cognition and autonomic function.These manifest after a major degeneration of neurones mainly within the brainstem,particularly among the dopaminergic neurones.展开更多
The biogenic monoamines dopamine （DA）, norepinephrine （NE） and serotonin （5-hydroxytryptamine, 5-HT） are major neuromodulators in the mammalian central nervous system （CNS）. DA containing neurons are found in ...The biogenic monoamines dopamine （DA）, norepinephrine （NE） and serotonin （5-hydroxytryptamine, 5-HT） are major neuromodulators in the mammalian central nervous system （CNS）. DA containing neurons are found in i） the mesolimbic system in which cell bodies in the ventral tegmental area （VTA） project axons into the amygdala, cortex, hippocampus and the nucleus accumbens; and ii） the nigrostriatal system in which cell bodies located in the substantia nigra pars compacta send their axons into the dorsolateral parts of the striatum （Bjorklund and Dunnett, 2007）. The central noradrenergic neurons are concentrated in distinct brainstem nuclei with the locus coeruleus （LC） being the most prominent nucleus which projects a diffusely arborizing axonal network to most areas of the CNS （Szabadi, 2013）.展开更多
Macroporous amino-carboxvlic chelating resin of acrylic acid series may concentrate trace rare earth in the presence of 0.1 mol/l α-hydroxy-isobutyric acid at pH 4.5.With 0.10 mol/l HCl as eluant rare earth may be el...Macroporous amino-carboxvlic chelating resin of acrylic acid series may concentrate trace rare earth in the presence of 0.1 mol/l α-hydroxy-isobutyric acid at pH 4.5.With 0.10 mol/l HCl as eluant rare earth may be eluted quantitatively and separated from Ca,Mg,Fe and Cu.This method is used to determine trace amount of rare earth in human hair,stone (in kidney and bladder),peanut,grape,strawberry,cucumber,pig liver and other biological samples.展开更多
Immunoconjugates are antibody-drug hybrid molecules which combine the exquisite selectivity or monoclonal antibodies with the potent toxicity of anticancer agents. A monoclonal antibody SZ39 against human brain glioma...Immunoconjugates are antibody-drug hybrid molecules which combine the exquisite selectivity or monoclonal antibodies with the potent toxicity of anticancer agents. A monoclonal antibody SZ39 against human brain gliomas was used as a drug carrier. Adriamycin (ADR) was bound covalently to SZ39 to form a SZ39-ADR conjugate. The cytotoxic activity of the SZ39-ADR conjugate was tested in vitro and demonstrated potent and specific killing of cells derived from a human malignant glioma. 50% inhibitory concentration (IC50) for SZ39-ADR to 'target' cells was 8.14×10-9 M. An index of specificity between 'target' and 'non-target' cells was calculated to be 88-fold. These data suggest that the SZ39-ADR may use as a potent and cell type-specific agent and is a likely candidate for the targeting chemotherapy of malignant gliotnas.展开更多
Athymic nude mice bearing subcutaneous and intracerebral human glioma xenografts were used to assess the therapeutic efficacy of monoclonal anti-body-adriamycin immunoconjugates against malignant gliomas in vivo. Immu...Athymic nude mice bearing subcutaneous and intracerebral human glioma xenografts were used to assess the therapeutic efficacy of monoclonal anti-body-adriamycin immunoconjugates against malignant gliomas in vivo. Immunoconjugates showed a significantly stronger antitumor effect with a T/C (treated/ control tumor volume) of 30% as compared with free drug (T/C of 84%). The targeting treatment with immunoconjugates significantly prolonged 54% of median survival time of nude mice. Side effects of immunoconjugates on the normal bone marrow and small intestines were much slighter than those of the free drug. The results of this study indicate that the use of monoclonal antibodies as carriers of anti-tumor agents may have many therapeutic advantages and potential for the treatment of brain gliomas.展开更多
On February 12,the Anhui ProvincialPeople’s Government made a decisionon the speeding up of the use of foreigncapital.The decision involved the followingseven aspects: 1.To seize the opportunity to reviseideology and...On February 12,the Anhui ProvincialPeople’s Government made a decisionon the speeding up of the use of foreigncapital.The decision involved the followingseven aspects: 1.To seize the opportunity to reviseideology and to open up a new situation formaking use of foreign capital.The decisionurges the various localities to seize the righttime to shift their focus to making good useof their own advantages,and improving thelocal investment climate and the quality ofservice in the light of their actual conditionsso as to absorb more foreign funds.Meanwhile,enterprises must be led to face the marketand to join equal competition so as to pushforward the use of foreign funds to a展开更多
Decision making to mitigate the effects of natural hazards is a complex undertaking fraught with uncertainty. Models to describe risks associated with natural hazards have proliferated in recent years. Concurrently, t...Decision making to mitigate the effects of natural hazards is a complex undertaking fraught with uncertainty. Models to describe risks associated with natural hazards have proliferated in recent years. Concurrently, there is a growing body of work focused on developing best practices for natural hazard modeling and to create structured evaluation criteria for complex environmental models. However, to our knowledge there has been less focus on the conditions where decision makers can confidently rely on results from these models. In this review we propose a preliminary set of conditions necessary for the appropriate application of modeled results to natural hazard decision making and provide relevant examples within US wildfire management programs.展开更多
The peripheral nervous system is a vital part of the body because it transfers information to coordinate all actions.Peripheral nerve injuries are detrimental to the proper function of this system and can cause loss o...The peripheral nervous system is a vital part of the body because it transfers information to coordinate all actions.Peripheral nerve injuries are detrimental to the proper function of this system and can cause loss of sense and movement.It is of utmost importance to research approaches to the treatment of peripheral nerve damage because such injuries can drastically change a person’s life,展开更多
The report sets out to summarize the past and current situation regarding the practice of biologicalcontrol inrelationtothe use and exchange of genetic resources relevant for BCAs.It considers the twomain categories o...The report sets out to summarize the past and current situation regarding the practice of biologicalcontrol inrelationtothe use and exchange of genetic resources relevant for BCAs.It considers the twomain categories of biological control:classical and augmentative.Allowing access to BCAs for use inanother country imposes no risk of liability to the source country.Local scientific knowledge abouthabitats,fauna andflora,can be展开更多
Advertisements must bring a certain product to the attention of potential buyers. Further, they must stress its qualities in the most attractive way clearly outline the reason for buying it, and leave a memorable echo...Advertisements must bring a certain product to the attention of potential buyers. Further, they must stress its qualities in the most attractive way clearly outline the reason for buying it, and leave a memorable echo of what has been said ringing in the reader’s or listener’s mind. Therefore, the wording of an advertisement must have immediate impact and rapid persuasion.展开更多
On March 13th,Reuters reported that the long run version of Tesla Model 3 will use permanent magnet motors.One of the materials for this type of motor is rare earth metal neodymium,which will further increase the supp...On March 13th,Reuters reported that the long run version of Tesla Model 3 will use permanent magnet motors.One of the materials for this type of motor is rare earth metal neodymium,which will further increase the supply pressure of neodymium.Governments around the world are committed to reducing the harmful emissions produced by fossil fuel cars,pushing up demand for electric vehicles展开更多
文摘This experiment was an attempt to use the soybean residue derived from the production of 'soy milk'. The residue contains about 18% protein, 70% caf bohydrates and 7.5% lipid as fish feed for reafing common carp, Cyrinus carpto. There were 4 types of diets: (1)soybean residue, (2 ) soybean residue digested with Papain, (3) soybean residue (64%)mixed with beef liver (34%) and (4) same mixture as (3) but digested with Papain. The results indicate that the percentage increase in weight and length of fish feeding with beef liver supplemented diets was higher than those feeding with soybean residue alone. This was possibly due to the fact that beef liver was able to supplement the nutrient deficiency in soybean. The two types of feeds (2 and 4) digested with Papain also yielded significantly better fish growth in terms of weight and length gains, than their counterparts without digestion. Furthermore, the water turbidity of the tanks added with digested feeds was significantly less, as papain was able to hyrolyse the protein substrates suspended in the water, and thus lowered the turbidity
文摘Several groups in the USA have been working to de-velop a low chill apricot that would ripen its fruits veryearly in the season. Unfortunately, the cultivatcd apricothas been developed mainly from the high chilling Euro-pean group within the species Prunus armeniaca. Amongthe five groups within the apricot species, this is the mostrecently evolved and least variable (Bailey and
文摘In this paper, the authors develop the earlier work of Chen Jiabin et al. (1986). In order to reduce spectral truncation errors, the reference atmosphere has been introduced in ECMWF model, and the spectrally-represented variables, temperature, geopotential height and orography, are replaced by their deviations from the reference atmosphere. Two modified semi- implicit schemes have been proposed to alleviate the computational instability due to the introduction of reference atmosphere. Concerning the deviation of surface geopotential height from reference atmosphere, an exact computational formulation has been used instead of the approximate one in the earlier work. To re duce aliasing errors in the computations of the deviation of the surface geopotential height, a spectral fit has been used slightly to modify the original Gaussian grid-point values of orography.A series of experiments has been performed in order to assess the impact of the reference atmosphere on ECMWF medium- range forecasts at the resolution T21, T42 and T63. The results we have obtained reveal that the reference atmosphere introduced in ECMWF spectral model is generally beneficial to the mean statistical scores of 1000-200 hPa height 10-day forecasts over the globe. In the Southern Hemisphere, it is a clear improvement for T21, T42 and T63 throughout the 10-day forecast period. In the Northern Hemisphere, the impact of the reference atmos phere on anomaly correlation is positive for resolution T21, a very slightly damaging at T42 and almost neutral at T63 in the range of day 1 to day 4. Beyond the day 4 there is a clear improvement at all resolutions.
文摘Parkinson＇s disease is a neurological disorder with distinct motor signs of resting tremor,akinesia and/or lead-pipe rigidity,together with non-motor symptoms of impaired smell,cognition and autonomic function.These manifest after a major degeneration of neurones mainly within the brainstem,particularly among the dopaminergic neurones.
基金supported by the Deutsche Forschungsgemeinschaft(SFB636)to PS and FM
文摘The biogenic monoamines dopamine （DA）, norepinephrine （NE） and serotonin （5-hydroxytryptamine, 5-HT） are major neuromodulators in the mammalian central nervous system （CNS）. DA containing neurons are found in i） the mesolimbic system in which cell bodies in the ventral tegmental area （VTA） project axons into the amygdala, cortex, hippocampus and the nucleus accumbens; and ii） the nigrostriatal system in which cell bodies located in the substantia nigra pars compacta send their axons into the dorsolateral parts of the striatum （Bjorklund and Dunnett, 2007）. The central noradrenergic neurons are concentrated in distinct brainstem nuclei with the locus coeruleus （LC） being the most prominent nucleus which projects a diffusely arborizing axonal network to most areas of the CNS （Szabadi, 2013）.
文摘Macroporous amino-carboxvlic chelating resin of acrylic acid series may concentrate trace rare earth in the presence of 0.1 mol/l α-hydroxy-isobutyric acid at pH 4.5.With 0.10 mol/l HCl as eluant rare earth may be eluted quantitatively and separated from Ca,Mg,Fe and Cu.This method is used to determine trace amount of rare earth in human hair,stone (in kidney and bladder),peanut,grape,strawberry,cucumber,pig liver and other biological samples.
文摘Immunoconjugates are antibody-drug hybrid molecules which combine the exquisite selectivity or monoclonal antibodies with the potent toxicity of anticancer agents. A monoclonal antibody SZ39 against human brain gliomas was used as a drug carrier. Adriamycin (ADR) was bound covalently to SZ39 to form a SZ39-ADR conjugate. The cytotoxic activity of the SZ39-ADR conjugate was tested in vitro and demonstrated potent and specific killing of cells derived from a human malignant glioma. 50% inhibitory concentration (IC50) for SZ39-ADR to 'target' cells was 8.14×10-9 M. An index of specificity between 'target' and 'non-target' cells was calculated to be 88-fold. These data suggest that the SZ39-ADR may use as a potent and cell type-specific agent and is a likely candidate for the targeting chemotherapy of malignant gliotnas.
文摘Athymic nude mice bearing subcutaneous and intracerebral human glioma xenografts were used to assess the therapeutic efficacy of monoclonal anti-body-adriamycin immunoconjugates against malignant gliomas in vivo. Immunoconjugates showed a significantly stronger antitumor effect with a T/C (treated/ control tumor volume) of 30% as compared with free drug (T/C of 84%). The targeting treatment with immunoconjugates significantly prolonged 54% of median survival time of nude mice. Side effects of immunoconjugates on the normal bone marrow and small intestines were much slighter than those of the free drug. The results of this study indicate that the use of monoclonal antibodies as carriers of anti-tumor agents may have many therapeutic advantages and potential for the treatment of brain gliomas.
文摘On February 12,the Anhui ProvincialPeople’s Government made a decisionon the speeding up of the use of foreigncapital.The decision involved the followingseven aspects: 1.To seize the opportunity to reviseideology and to open up a new situation formaking use of foreign capital.The decisionurges the various localities to seize the righttime to shift their focus to making good useof their own advantages,and improving thelocal investment climate and the quality ofservice in the light of their actual conditionsso as to absorb more foreign funds.Meanwhile,enterprises must be led to face the marketand to join equal competition so as to pushforward the use of foreign funds to a
文摘Decision making to mitigate the effects of natural hazards is a complex undertaking fraught with uncertainty. Models to describe risks associated with natural hazards have proliferated in recent years. Concurrently, there is a growing body of work focused on developing best practices for natural hazard modeling and to create structured evaluation criteria for complex environmental models. However, to our knowledge there has been less focus on the conditions where decision makers can confidently rely on results from these models. In this review we propose a preliminary set of conditions necessary for the appropriate application of modeled results to natural hazard decision making and provide relevant examples within US wildfire management programs.
文摘The peripheral nervous system is a vital part of the body because it transfers information to coordinate all actions.Peripheral nerve injuries are detrimental to the proper function of this system and can cause loss of sense and movement.It is of utmost importance to research approaches to the treatment of peripheral nerve damage because such injuries can drastically change a person’s life,
文摘The report sets out to summarize the past and current situation regarding the practice of biologicalcontrol inrelationtothe use and exchange of genetic resources relevant for BCAs.It considers the twomain categories of biological control:classical and augmentative.Allowing access to BCAs for use inanother country imposes no risk of liability to the source country.Local scientific knowledge abouthabitats,fauna andflora,can be
文摘Advertisements must bring a certain product to the attention of potential buyers. Further, they must stress its qualities in the most attractive way clearly outline the reason for buying it, and leave a memorable echo of what has been said ringing in the reader’s or listener’s mind. Therefore, the wording of an advertisement must have immediate impact and rapid persuasion.
文摘On March 13th,Reuters reported that the long run version of Tesla Model 3 will use permanent magnet motors.One of the materials for this type of motor is rare earth metal neodymium,which will further increase the supply pressure of neodymium.Governments around the world are committed to reducing the harmful emissions produced by fossil fuel cars,pushing up demand for electric vehicles
