Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which pro...Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which provides valuable references for the in-depth study of overall aging.According to the Qi-collateral theory in traditional Chinese medicine,essence is the origin of life;Qi is the driving force of life;and spirit is the embodiment of life.This theory interprets key scientific issues such as the formation of life,the driving force of life,the function of Zang-Fu organs,and the spirit and consciousness.Furthermore,it reveals the key mechanism of aging.That is,the deficiency of kidney essence is the root of aging;the loss of vitality is the key of aging;and the depletion of body and spirit is the manifestation of aging.Based on the experience of medical practitioners in the past dynasties,such as nourishing essence,black food tonifying the kidney,and supplementing essence with flesh-blood products,the treatment method of invigorating kidney and supplementing essence,harmonizing Yin and Yang,reinforcing the vitality,and nourishing the body and spirit was proposed.Furthermore,an innovative Chinese patent medicine,Bazi Bushen capsules,is developed,which exerts the antiaging effect by replenishing Qi,invigorating the spirit,and nourishing the body and spirit.Pharmacological and clinical studies have confirmed that this preparation has antiaging effects and are effective in the prevention and treatment of age-related diseases.Experimental studies have shown that Bazi Bushen capsules can delay the overall aging,reduce the DNAmethylation and extend the healthy life of naturally aging mice,mitigate the age-related cognitive dysfunction,improve neurological function,maintain redox homeostasis and telomere integrity,and inhibit apoptosis.Moreover,Bazi Bushen capsules can increase the dermal thickness and the collagen fiber and elastic fiber content to prevent skin aging.In addition,Bazi Bushen capsules can correct the lipid metabolism disorders and ameliorate multisystem age-related diseases such as osteoporosis in surgically induced menopausal rats.This article discusses the pathogenesis,treatment,and prescription of aging and the antiaging theory,aiming to provide a basis for delaying aging and preventing related diseases.展开更多
股骨头坏死(osteonecrosis of femoral head,ONFH)是目前骨科临床诊疗中的常见疑难病,“坏死-修复-塌陷-骨关节炎”是ONFH患者逐步演变的自然病理过程,文章基于《黄帝内经》中“邪之所凑,其气必虚”拟探析邪气、气虚在ONFH病因病机的重...股骨头坏死(osteonecrosis of femoral head,ONFH)是目前骨科临床诊疗中的常见疑难病,“坏死-修复-塌陷-骨关节炎”是ONFH患者逐步演变的自然病理过程,文章基于《黄帝内经》中“邪之所凑,其气必虚”拟探析邪气、气虚在ONFH病因病机的重要性,ONFH往往具有共同的“气虚”病机,气虚受邪,邪气隐伏,交织渐进引起血瘀络阻等气血络病疾患,因气虚血瘀络阻,以中气损伤为先,最终伤及五脏精气,五脏之伤,穷必及肾,伤及命门元气,晚期出现明显骨及软骨皲裂、塌陷的状况。因此,药酒浊邪隐伏于内,邪凑气虚,气血络病是ONFH的时空病机共线。在活血通络法基础上溯本求源,从气论治,兼顾“气虚”,于匡扶正气的基础上通补兼施,益气活血通络,可以更好地运用中医药为受ONFH疾病困扰的患者提供帮助,以冀为保髋提供新思路。展开更多
基金This study was supported by the Strategic Consulting Project of the Chinese Academy of Engineering-Strategic Research on Anti-aging Effects of Traditional Chinese Medicine(2022-XY-45)the Natural Science Foundation of Hebei Province of China(no.H2022106065)+1 种基金the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(no.2023172)the Scientific Research Project of Traditional Chinese Medicine Administration of Hebei Province(no.2023391).
文摘Aging,a complex and multisystem process,has increasingly become a hot issue of global concern.Traditional Chinese medicine has accumulated rich understanding of aging during thousands of years of development,which provides valuable references for the in-depth study of overall aging.According to the Qi-collateral theory in traditional Chinese medicine,essence is the origin of life;Qi is the driving force of life;and spirit is the embodiment of life.This theory interprets key scientific issues such as the formation of life,the driving force of life,the function of Zang-Fu organs,and the spirit and consciousness.Furthermore,it reveals the key mechanism of aging.That is,the deficiency of kidney essence is the root of aging;the loss of vitality is the key of aging;and the depletion of body and spirit is the manifestation of aging.Based on the experience of medical practitioners in the past dynasties,such as nourishing essence,black food tonifying the kidney,and supplementing essence with flesh-blood products,the treatment method of invigorating kidney and supplementing essence,harmonizing Yin and Yang,reinforcing the vitality,and nourishing the body and spirit was proposed.Furthermore,an innovative Chinese patent medicine,Bazi Bushen capsules,is developed,which exerts the antiaging effect by replenishing Qi,invigorating the spirit,and nourishing the body and spirit.Pharmacological and clinical studies have confirmed that this preparation has antiaging effects and are effective in the prevention and treatment of age-related diseases.Experimental studies have shown that Bazi Bushen capsules can delay the overall aging,reduce the DNAmethylation and extend the healthy life of naturally aging mice,mitigate the age-related cognitive dysfunction,improve neurological function,maintain redox homeostasis and telomere integrity,and inhibit apoptosis.Moreover,Bazi Bushen capsules can increase the dermal thickness and the collagen fiber and elastic fiber content to prevent skin aging.In addition,Bazi Bushen capsules can correct the lipid metabolism disorders and ameliorate multisystem age-related diseases such as osteoporosis in surgically induced menopausal rats.This article discusses the pathogenesis,treatment,and prescription of aging and the antiaging theory,aiming to provide a basis for delaying aging and preventing related diseases.
文摘股骨头坏死(osteonecrosis of femoral head,ONFH)是目前骨科临床诊疗中的常见疑难病,“坏死-修复-塌陷-骨关节炎”是ONFH患者逐步演变的自然病理过程,文章基于《黄帝内经》中“邪之所凑,其气必虚”拟探析邪气、气虚在ONFH病因病机的重要性,ONFH往往具有共同的“气虚”病机,气虚受邪,邪气隐伏,交织渐进引起血瘀络阻等气血络病疾患,因气虚血瘀络阻,以中气损伤为先,最终伤及五脏精气,五脏之伤,穷必及肾,伤及命门元气,晚期出现明显骨及软骨皲裂、塌陷的状况。因此,药酒浊邪隐伏于内,邪凑气虚,气血络病是ONFH的时空病机共线。在活血通络法基础上溯本求源,从气论治,兼顾“气虚”,于匡扶正气的基础上通补兼施,益气活血通络,可以更好地运用中医药为受ONFH疾病困扰的患者提供帮助,以冀为保髋提供新思路。
