AIM To confirm the therapeutic effect of Zijin capsule on liver fibrosis in rat model. METHODS Model group: bovine serum albumin (BSA) Freund′s incomplete adjuvant 0 5ml was injected subdermally at d 1, d ...AIM To confirm the therapeutic effect of Zijin capsule on liver fibrosis in rat model. METHODS Model group: bovine serum albumin (BSA) Freund′s incomplete adjuvant 0 5ml was injected subdermally at d 1, d 15 , d 22 , d 29 and d 36 for primary sensitization. Seven days after the fifth injection, BSA antibody in the serum was detected by double agar diffusion method. Normal saline of 0 4ml was injected through cauda vein to BSA antibody positive rat twice a week for fifteen times. Traditional Chinese medicine (TCM) decoction group and Zijin capsule group: In the attack injection period, Chinese medicinal decoction or Zijin capsule was given ig, the others were the same as in the model group. NS was used in the control group. The collagen content of rat liver was determined by Bergman′s method and expressed as ±s . The liver pathological changes were divided into four grades and expressed as the avarage of the total rank sum. RESULTS The collagen content (mg/g) of the liver in the control group (7 2±1 9) was significantly lower than that in the other groups; it was higher in the model group (31 7±16 6) than that in the two therapeutic groups; and lower in Zijin capsule group (9 7±2 8) than that in the TCM decoction group (11 5±5 3). The pathological changes were more aggravated in the model group (37 4) than those in the two therapeutic groups; and more severe in the TCM decoction group (30.2) than in the Zijin capsule group (22.9) CONCLUSION The therapeutic effect of Zijin capsule on the model was confirmed.展开更多
文摘AIM To confirm the therapeutic effect of Zijin capsule on liver fibrosis in rat model. METHODS Model group: bovine serum albumin (BSA) Freund′s incomplete adjuvant 0 5ml was injected subdermally at d 1, d 15 , d 22 , d 29 and d 36 for primary sensitization. Seven days after the fifth injection, BSA antibody in the serum was detected by double agar diffusion method. Normal saline of 0 4ml was injected through cauda vein to BSA antibody positive rat twice a week for fifteen times. Traditional Chinese medicine (TCM) decoction group and Zijin capsule group: In the attack injection period, Chinese medicinal decoction or Zijin capsule was given ig, the others were the same as in the model group. NS was used in the control group. The collagen content of rat liver was determined by Bergman′s method and expressed as ±s . The liver pathological changes were divided into four grades and expressed as the avarage of the total rank sum. RESULTS The collagen content (mg/g) of the liver in the control group (7 2±1 9) was significantly lower than that in the other groups; it was higher in the model group (31 7±16 6) than that in the two therapeutic groups; and lower in Zijin capsule group (9 7±2 8) than that in the TCM decoction group (11 5±5 3). The pathological changes were more aggravated in the model group (37 4) than those in the two therapeutic groups; and more severe in the TCM decoction group (30.2) than in the Zijin capsule group (22.9) CONCLUSION The therapeutic effect of Zijin capsule on the model was confirmed.
文摘目的系统评价中西医结合治疗输卵管阻塞性不孕症的有效性和安全性。方法计算机检索Pub Med、EMBase、Cochrane图书馆对照试验资料库、中国期刊全文数据库(CNKI)、中国生物医学文献服务系统(CBM)、维普信息资源系统(VIP)中关于中西医结合治疗输卵管阻塞性不孕症有效性和安全性的文献。检索时间均为建库至2014年5月。采用Rev Man 5.1统计软件对符合纳入及排除标准的文献进行统计学分析。结果共纳入文献19篇,共计患者数2 503例。Meta分析结果显示:中西医治疗组和西医治疗组的妊娠率比较,差异有统计学意义〔OR(95%CI)=1.42(1.30,1.56),P<0.01〕;非腹腔镜手术亚组中,两组妊娠率比较,差异有统计学意义〔OR(95%CI)=1.47(1.30,1.66),P<0.01〕;腹腔镜手术亚组中,两组妊娠率比较,差异有统计学意义〔OR(95%CI)=1.36(1.18,1.56),P<0.01〕。中西医治疗组和西医治疗组的总有效率比较,差异有统计学意义〔RR(95%CI)=1.39(1.29,1.50),P<0.01〕;非腹腔镜手术亚组中,两组总有效率比较,差异有统计学意义〔RR(95%CI)=1.41(1.29,1.55),P<0.01〕;腹腔镜手术亚组中,两组总有效率比较,差异有统计学意义〔RR(95%CI)=1.34(1.16,1.54),P<0.01〕。中西医治疗组和西医治疗组的输卵管再通率比较,差异有统计学意义〔RR(95%CI)=1.34(1.20,1.50),P<0.01〕。中西医治疗组和西医治疗组的异位妊娠率比较,差异有统计学意义〔OR(95%CI)=0.32(0.15,0.68),P<0.01〕;非腹腔镜手术亚组中,两组异位妊娠率比较,差异有统计学意义〔OR(95%CI)=0.23(0.08,0.68),P<0.01〕。中西医治疗组和西医治疗组的术后再粘连率比较,差异有统计学意义〔RR(95%CI)=0.38(0.25,0.59),P<0.01〕。仅有3篇文献对患者治疗期间的不良反应进行了描述,且不良反应症状均较轻,休息后可自行缓解。结论与单纯西医治疗相比,中西医结合治疗可以提高输卵管阻塞性不孕症患者的妊娠率、总有效率及输卵管再通率,降低其术后再粘连率和非腹腔镜手术治疗患者的异位妊娠率,不良反应较少,有效性和安全性较高。
