Objective To assess the efficacy and safety of Yiqi Yangyin Huoxue therapy (YYHT) for the treatment of IgA nephropathy. Methods Databases articles about YYHT in treating IgAN patients were searched through February 20...Objective To assess the efficacy and safety of Yiqi Yangyin Huoxue therapy (YYHT) for the treatment of IgA nephropathy. Methods Databases articles about YYHT in treating IgAN patients were searched through February 2018. Comparisons were YYHT alone or YYHT in combination with western medicine as experimental intervention, and western medicine as the control. Randomized controlled trials (RCTs) were selected. Cochrane collaboration tool was used for assessing risk of bias to evaluate methodologies. RevMan 5.3 software was applied to analyze the data of included trials. Results A total of 21 studies involving 1473 patients were included. Meta-analysis results demonstrated that YYHT alone or YYHT in combination with western medicine were more efficacious than only western medicine in decreasing proteinuria [MD =-0.41, 95% CI (-0.53,-0.29), P < 0.00001] and the urine red blood cells [MD =-7.46, 95% CI (-9.28,-5.64), P < 0.00001]. There also showed improvement in the clinical total effective rate [OR = 2.78, 95% CI (2.14, 3.61), P < 0.00001] between the two groups. Some of the included trials did not report the adverse events. Conclusions Current evidence shows that YYHT can reduce proteinuria and urine red blood cells and improve the total efficacy rate. Since poor quality and publication bias of some included trials, more evidence-based medicine studies needed to define the role of YYHT in the treatment of IgAN.展开更多
Objective:To systematically evaluate the effect of Yiqi Wenyang Huoxue therapy in treating diabetic kidney disease(DKD)of stage III-IV.Method:The relevant literature was retrieved by computer from CNKI,Wanfang and VIP...Objective:To systematically evaluate the effect of Yiqi Wenyang Huoxue therapy in treating diabetic kidney disease(DKD)of stage III-IV.Method:The relevant literature was retrieved by computer from CNKI,Wanfang and VIP databases,CBM,PubMed,EMBase,Cochrane Library and Web of Science.Articles screening and data extraction were performed by two researchers separately and independently.The Meta-analysis was conducted with RevMan 5.3.Results:A total of 10 randomized controlled trials were collected,including 778 cases with DKD.Meta-analysis showed that the Yiqi Wenyang Huoxue Method combined with western medicine basic treatment could reduce 24hUTP[MD=-0.36,95%CI(-0.46,-0.26),P<0.00001],UAER[MD=-36.72,95%CI(-47.21,-26.23),P<0.00001],Scr[MD=-16.28,95%CI(-20.59,-11.97),P<0.00001],BUN[MD=-1.45,95%CI(-1.76,-1.14),P<0.00001],TC[MD=-0.64,95%CI(-1.07,-0.21),P=0.004].There was also a reduction in HbA1c[MD=-0.50,95%CI(-0.94,-0.05),P=0.03],but the difference is not significant.Conclusion:Based on the current evidence,for the treatment of DKD of stage III-IV,basic western medicine treatment combined with Yiqi Wenyang Huoxue method may better reduce urine protein,total cholesterol levels and improve renal function.The conclusion of this study needs to be further researched by high-quality studies,because that the quality of the included studies is generally low.展开更多
文摘Objective To assess the efficacy and safety of Yiqi Yangyin Huoxue therapy (YYHT) for the treatment of IgA nephropathy. Methods Databases articles about YYHT in treating IgAN patients were searched through February 2018. Comparisons were YYHT alone or YYHT in combination with western medicine as experimental intervention, and western medicine as the control. Randomized controlled trials (RCTs) were selected. Cochrane collaboration tool was used for assessing risk of bias to evaluate methodologies. RevMan 5.3 software was applied to analyze the data of included trials. Results A total of 21 studies involving 1473 patients were included. Meta-analysis results demonstrated that YYHT alone or YYHT in combination with western medicine were more efficacious than only western medicine in decreasing proteinuria [MD =-0.41, 95% CI (-0.53,-0.29), P < 0.00001] and the urine red blood cells [MD =-7.46, 95% CI (-9.28,-5.64), P < 0.00001]. There also showed improvement in the clinical total effective rate [OR = 2.78, 95% CI (2.14, 3.61), P < 0.00001] between the two groups. Some of the included trials did not report the adverse events. Conclusions Current evidence shows that YYHT can reduce proteinuria and urine red blood cells and improve the total efficacy rate. Since poor quality and publication bias of some included trials, more evidence-based medicine studies needed to define the role of YYHT in the treatment of IgAN.
基金National Natural Science Foundation of China(No.81973801)。
文摘Objective:To systematically evaluate the effect of Yiqi Wenyang Huoxue therapy in treating diabetic kidney disease(DKD)of stage III-IV.Method:The relevant literature was retrieved by computer from CNKI,Wanfang and VIP databases,CBM,PubMed,EMBase,Cochrane Library and Web of Science.Articles screening and data extraction were performed by two researchers separately and independently.The Meta-analysis was conducted with RevMan 5.3.Results:A total of 10 randomized controlled trials were collected,including 778 cases with DKD.Meta-analysis showed that the Yiqi Wenyang Huoxue Method combined with western medicine basic treatment could reduce 24hUTP[MD=-0.36,95%CI(-0.46,-0.26),P<0.00001],UAER[MD=-36.72,95%CI(-47.21,-26.23),P<0.00001],Scr[MD=-16.28,95%CI(-20.59,-11.97),P<0.00001],BUN[MD=-1.45,95%CI(-1.76,-1.14),P<0.00001],TC[MD=-0.64,95%CI(-1.07,-0.21),P=0.004].There was also a reduction in HbA1c[MD=-0.50,95%CI(-0.94,-0.05),P=0.03],but the difference is not significant.Conclusion:Based on the current evidence,for the treatment of DKD of stage III-IV,basic western medicine treatment combined with Yiqi Wenyang Huoxue method may better reduce urine protein,total cholesterol levels and improve renal function.The conclusion of this study needs to be further researched by high-quality studies,because that the quality of the included studies is generally low.
