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Thermomineral water promotes axonal sprouting but does not reduce glial scar formation in a mouse model of spinal cord injury
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作者 Dubravka Aleksi? Milan Aksi? +3 位作者 Nevena Divac Vidosava Radonji? Branislav Filipovi? Igor Jakov?evski 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第24期2174-2181,共8页
Thermomineral water from the Atomic Spa Gornja Trepca has been used for a century in the treatment of neurologic disease. The thermomineral water contains microelements, including lithium and magnesium, which show neu... Thermomineral water from the Atomic Spa Gornja Trepca has been used for a century in the treatment of neurologic disease. The thermomineral water contains microelements, including lithium and magnesium, which show neural regeneration-promoting effects after central nervous system injury. In this study, we investigated the effects of oral intake of thermomineral water from the Atomic Spa Gornja Trepca on nerve regeneration in a 3-month-old mouse model of spinal cord injury. The mice receiving oral intake of thermomineral water showed better locomotor recovery than those without administration of thermomineral water at 8 and 12 weeks after lower thoracic spinal cord compression. At 12 weeks after injury, sprouting of catecholaminergic axons was better in mice that drank thermomineral water than in those without administration of thermomineral water, but there was no difference in glial reaction to injury between mice with and without administration of thermomineral water. These findings suggest that thermomineral water can promote the nerve regeneration but cannot reduce glial scar formation in a mouse model of spinal cord injury. 展开更多
关键词 astrocyte scar catecholaminergic innervations lithium MAGNESIUM thermomineral water locomotor recovery MICROGLIA neuroprotection MAGNESIUM spinal cord injury nerve regeneration
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Possibilities of geophysical methods application in defining future resources of mineral and thermomineral water
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《Global Geology》 1998年第1期110-110,共1页
关键词 Possibilities of geophysical methods application in defining future resources of mineral and thermomineral water
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