Six new asymmetric thiocarbonohydrazones 3a-3f were synthesized from following steps： firstly hydrazine hydrate reacted with carbon disulfide to form thiocarbonohydrazide （1） under microwave irradiation. Then compo...Six new asymmetric thiocarbonohydrazones 3a-3f were synthesized from following steps： firstly hydrazine hydrate reacted with carbon disulfide to form thiocarbonohydrazide （1） under microwave irradiation. Then compound （1） reacted with ketone and different aldehydes step by step to give 3a-3f with excellent yields under solvent-free conditions using microwave irradiation. Their structures have been determined by elemental analysis, IR, MS and ^1H NMR data. 2009 Qing Han Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
A series of ligands,HL1（2-acetylpyridine thiosemicarbazone）,H2L2（bis（2-acetyl-pyridine） thiocarbonohydrazone） and H2L3（bis（imidazole-2-carboxaldehyde） thiocarbonohydrazone） was synthesized.H2L2 and H2L3 were...A series of ligands,HL1（2-acetylpyridine thiosemicarbazone）,H2L2（bis（2-acetyl-pyridine） thiocarbonohydrazone） and H2L3（bis（imidazole-2-carboxaldehyde） thiocarbonohydrazone） was synthesized.H2L2 and H2L3 were characterized by elemental analysis,IR spectra and single-crystal X-ray diffraction studies.Hydrogen bonds link different components to stabilize the crystal structure in the two ligands.To comprehend the structure-activity relationship well,the three ligands are all tested against human K562 leucocythemia cell line with IC50 analysis.Different substituent groups on the ligands show different levels of antitumor activity.By comparison with the other species studied,H2L2 with thiocarbonohydrazone along with 2-acetylpyridine is the most active compound with IC50 = 2.48 μM.展开更多
基金the Natural Science Foundation of Southwest University for Nationalities (No.08NQZ002) for financial support.
文摘Six new asymmetric thiocarbonohydrazones 3a-3f were synthesized from following steps： firstly hydrazine hydrate reacted with carbon disulfide to form thiocarbonohydrazide （1） under microwave irradiation. Then compound （1） reacted with ketone and different aldehydes step by step to give 3a-3f with excellent yields under solvent-free conditions using microwave irradiation. Their structures have been determined by elemental analysis, IR, MS and ^1H NMR data. 2009 Qing Han Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金supported by the Natural Science Foundation of Henan Province,the Natural Science Foundation of Educational Department of Henan Province (2010B150003)China Postdoctoral Science Foundation (20090460847)
文摘A series of ligands,HL1（2-acetylpyridine thiosemicarbazone）,H2L2（bis（2-acetyl-pyridine） thiocarbonohydrazone） and H2L3（bis（imidazole-2-carboxaldehyde） thiocarbonohydrazone） was synthesized.H2L2 and H2L3 were characterized by elemental analysis,IR spectra and single-crystal X-ray diffraction studies.Hydrogen bonds link different components to stabilize the crystal structure in the two ligands.To comprehend the structure-activity relationship well,the three ligands are all tested against human K562 leucocythemia cell line with IC50 analysis.Different substituent groups on the ligands show different levels of antitumor activity.By comparison with the other species studied,H2L2 with thiocarbonohydrazone along with 2-acetylpyridine is the most active compound with IC50 = 2.48 μM.
