Objective:To observe the efficacy of pentoxifylline+thioctic acid in the treatment of patients with painful diabetic peripheral neuropathy(PDPN).Methods:70 patients with PDPN admitted from October 2019 to October 2022...Objective:To observe the efficacy of pentoxifylline+thioctic acid in the treatment of patients with painful diabetic peripheral neuropathy(PDPN).Methods:70 patients with PDPN admitted from October 2019 to October 2022 were selected and randomly grouped,with pentoxifylline+thioctic acid treatment in Group A and thioctic acid treatment in Group B,and the treatment efficacy was compared.Results:The treatment efficacy in Group A was higher than that of Group B,P<0.05;the points of each symptom of PDPN in Group A were lower than that of Group B,P<0.05;the C-reactive protein and electromyography indexes of PDPN patients in Group A were better than that of Group B,P<0.05.Conclusion:PDPN patients treated with pentoxifylline+thioctic acid can optimize nerve function,inhibit inflammation progression,and reduce PDPN symptoms,which is an efficient and feasible treatment option.展开更多
AIM: To detect whether the combination of vincamine, thioctic acid and lutein will improve the retina and optic nerve functions in cases of an opaque media with an optic nerve and/or a retinal defect or not.METHODS: T...AIM: To detect whether the combination of vincamine, thioctic acid and lutein will improve the retina and optic nerve functions in cases of an opaque media with an optic nerve and/or a retinal defect or not.METHODS: Totally 2000 patients(2000 eyes) of corneal opacities with defects in the optic nerve or/and the retinal functions were studied. Every patient received three types of drugs: thioctic acid with cyanocobalamine, vincamine, and lutein. The drugs were given daily for 3-12 mo according to patient’s responses. Full field flash electroretinogram(ERG) and flash visual evoked potential(VEP) were done before treatment and at 1, 3, 6, and 12 mo sequentially. Patients were followed up for 12 mo.RESULTS: In the 2000 eyes, 1000 eyes had both moderate optic nerve and retinal function defects;and 840 eyes out of the 1000 improved with the medical treatment. Another 500 eyes out of the 2000 eyes had extinguished retinal function with normal optic nerve function and only 125 eyes of them improved. The 290 out of the 2000 eyes had severe defects in optic nerve with normal retinal function and 130 of them improved. Another 210 eyes have mild optic nerve and retinal function defects and 194 improved.CONCLUSION: The combination of vincamine, thioctic acid with cyanocobalamine, and lutein improved both retina and optic nerve functions mainly in mild and moderate defect than in severe cases.展开更多
45 female patients with polycystic ovary syndrome took thioctic acid (Thioctacid-HR), 600 mg (n = 25) or high protein diet (n = 20). Fast insulin and glucose stimulus insulin were investigated before and after 3 month...45 female patients with polycystic ovary syndrome took thioctic acid (Thioctacid-HR), 600 mg (n = 25) or high protein diet (n = 20). Fast insulin and glucose stimulus insulin were investigated before and after 3 months taken treatment. The use of thioctic acid, 600 mg is a new effective pathogenetics therapy of polycystic ovary syndrome on influence of hyperinsulinemia, HOMA-IR index and ovary volume in female patients with polycystic ovary syndrome.展开更多
Okadaic acid： Okadaic acid （OKA）, a polyether （C38 fatty acid） toxin, is a potent and selective inhibitor of protein phosphatase, PP1 and protein phosphatase 2A （PP2A）. It is mainly extracted from a black spong...Okadaic acid： Okadaic acid （OKA）, a polyether （C38 fatty acid） toxin, is a potent and selective inhibitor of protein phosphatase, PP1 and protein phosphatase 2A （PP2A）. It is mainly extracted from a black sponge Hallichondria okadaii and has been suggested to play a potent probe for studying the various molecular, cellular, biochemical and mechanism of neurotoxicity. It is known as a selective and potent in- hibitor of serine/threonine phosphatases 1 and 2A induces hyperphosphorylation of tau in vitro and in vivo. It has been reported that Alzheimer＇s disease （AD） is a complex multi- factorial neurodegenerative disorder and hyperphosphor- ylated tau protein is a major pathological hallmark of AD. The reduced activity of phosphatases like, PP2A has been implicated in the brain of AD patients. OKA also induced inhibition of protein phosphatases cause neurofibrillary tangles （NFTs） like pathological changes and tau hyperphos- phorylation seen in AD pathology. Our and others reports inferred that OKA induces neurodegeneration along with tau hyperphosphorylation, GSK3β activation, oxidative stress, neuroinflammation and neurotoxicity which are char- acteristic of AD pathology （Figure 1）.展开更多
Electrochemical impedance spectroscopy was employed to investigate the permeation of electrolyte ions in thioctic acid self-assembled monolayer when its structure was changed by the interaction of copper ions. The ion...Electrochemical impedance spectroscopy was employed to investigate the permeation of electrolyte ions in thioctic acid self-assembled monolayer when its structure was changed by the interaction of copper ions. The ion permeation was evaluated by using relatively low excitation frequencies, 0.2 Hz to 1000 Hz, and quantified by an extra resistive component in the equivalent circuit (RSAM). The extent of ion permeation affected by the electrode potentials and the electrolyte concentration were investigated. The experimental results verified that RSAM decreased ~70% by interaction with copper ions and that RSAM increased ~2 - 3 times when the electrolyte concentration was decreased by 10 times. This analysis can be performed without addition of redox species.展开更多
Poly(disulfide)s have been widely used in flexible wearable electronics,smart materials,and drug delivery.The synthesis of poly(disulfide)s usually utilizes external stimuli or toxic initiators to promote the polymeri...Poly(disulfide)s have been widely used in flexible wearable electronics,smart materials,and drug delivery.The synthesis of poly(disulfide)s usually utilizes external stimuli or toxic initiators to promote the polymerization.Here,we indicated that the long-range electronic effect can significantly alter the reactivity of the disulfide group.Accordingly,we established deprotonation-promoted ring-opening polymerization of thioctic acid(TA)as a highly effective and simple method to synthesize poly(disulfide)s due to the long-range electronic effect and nucleophilic carboxylate.Without external stimuli and initiators,simple mixing of TA and deprotonation reagent,choline bicarbonate,in different ratios at room temperature rapidly produced a series of high molecular weight(up to 772 kDa)ionic liquid crystal poly(disulfide)s elastomers with room temperature self-healing ability,adjustable conductivity(2.39×10^(−2)∼0.28×10^(−2)S m^(−1)),degradability,biocompatibility,antibacterial property,and tissue-like softness(Young’s moduli ranging from 18.2±6.0 to 111.1±36.7 kPa).The experiments and density functional theory calculations also revealed the principle of long-range electronic effect to establish a new synthetic strategy of poly(disulfide)s with superior properties favorable for bioelectronics.展开更多
Elastomers with high strength and toughness,excellent self-healing properties,and biocompatibility have broad application prospects in wearable electronics and other fields,but preparing it remains a challenge.In this...Elastomers with high strength and toughness,excellent self-healing properties,and biocompatibility have broad application prospects in wearable electronics and other fields,but preparing it remains a challenge.In this work,we propose a highly adaptable strategy by introducing the small molecule crosslinking agent of triethanolamine(TEA)to the poly(thioctic acid)(PTA)chains and preparing the PAx Ey elastomers using a simple synthesis step.This strategy stabilizes the PTA chains by constructing multiple non-covalent cross-linked dynamic networks,endowing materials with excellent strength and toughness(tensile strength of 288 kPa,toughness of 278.2 kJ/m3),admirable self-healing properties(self-healing efficiency of 121.6%within 7 h at 70℃),and good biocompatibility.The PAx Ey elastomers can also be combined with MWNTs to become flexible strain sensors,which can be used to monitor human joint movements with high sensitivity,repeatable responses,and stability.展开更多
With the fast generation of electronic waste(e-waste)and the increasing depletion of metal resources,“urban mining”that can selectively recover gold from secondary resources has attracted great interest.Construction...With the fast generation of electronic waste(e-waste)and the increasing depletion of metal resources,“urban mining”that can selectively recover gold from secondary resources has attracted great interest.Construction of materials with high extraction capacity and satisfying selectivity in complex aqueous-based matrices still remains challenging.Here,a novel metal-organic framework/polymer composite(Fe-BTC/poly(thioctic acid),denoted as Fe-BTC/pTA)has been newly synthesized and applied for selective gold recovery in different matrices(river water,seawater,and leaching solution of e-waste).Benefiting from the high specific surface area and suitable pore sizes as well as the rational design of active sites,the composite exhibits high adsorption capacity(920 mg/g),high removal efficiency(>99%),fast kinetics(below 0.1 ppb within 10 min),and good applicability in complex matrices,which are better than those of most reported sulfur-containing adsorbents.Solid-state metallic gold with high purity can be effectively enriched due to the high recyclability and long-term stability of the composite.The material after adsorption can be further applied as a heterogeneous catalyst for water remediation due to the in situ generated gold nanoparticles by the redox reaction between Au(III)ions and the S-containing groups in the composites.展开更多
Ventral globus pallidus-injured rats by kainic acid(10 mg) were used to derter-mine the monoamine levels in four different brain regions.In this model,a great decrease of NE con-centration was observed in both hippoca...Ventral globus pallidus-injured rats by kainic acid(10 mg) were used to derter-mine the monoamine levels in four different brain regions.In this model,a great decrease of NE con-centration was observed in both hippocampus and frontal cortex compared with nonnal contro.This result hints that a damage of noradrenergic neurons in this model has occurred. DA concentrations in the four brain zones after kainic acid injection were all reduced, but only in the frontal cortex and striatum the pronounced reductions were discovered while DA turnover rates in frontal cortex, stria-tum and meddullapons were significantly reduced. These results revealed a DA metabolic disorder occurring in these regions.However,5-HT concentrations as well as DBH activity, expressed by ratio of NE/DA,showed no marked difference in this model. In our study it is found that the changes of monoamine levels in this model basically reflect those discovered in AD patients.展开更多
目的探究高压氧联合硫辛酸治疗糖尿病足的临床疗效。方法选取2020年5月至2022年5月河南省人民医院豫东分院收治的92例糖尿病足患者作为研究对象,按照不同治疗方法将其分为观察组(32例)、对照组(30例)和空白组(30例)。观察组患者在常规...目的探究高压氧联合硫辛酸治疗糖尿病足的临床疗效。方法选取2020年5月至2022年5月河南省人民医院豫东分院收治的92例糖尿病足患者作为研究对象,按照不同治疗方法将其分为观察组(32例)、对照组(30例)和空白组(30例)。观察组患者在常规治疗的基础上行高压氧联合硫辛酸治疗,对照组患者在常规治疗的基础上单纯行硫辛酸治疗,空白组患者单纯行常规治疗,对比观察3组患者临床疗效、血糖相关指标及血管功能相关因子水平与踝肱指数。结果治疗4周后,3组患者临床疗效对比,观察组明显优于空白组(Z=-2.429,P=0.015),而观察组与对照组以及对照组与空白组间无明显差异(Z=-1.415、-1.299,P=0.157、0.194)。治疗4周后,3组患者空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbAlc)水平对比,观察组均明显低于空白组(q=6.574、6.162、6.339,P均<0.001),而观察组与对照组以及对照组与空白组间无明显差异(FBG:q=3.310、3.213,P=0.055、0.065;2 h PBG:q=2.840、3.270,P=0.116、0.059;HbAlc:q=3.230、3.059,P=0.063、0.083);3组患者血清内皮素(ET)水平对比,观察组明显低于对照组与空白组(q=3.443、6.630,P=0.044、P<0.001),而对照组与空白组间无明显差异(q=3.137,P=0.074);3组患者血清降钙素基因相关肽(CGRP)、血管内皮生长因子(VEGF)水平对比,观察组均明显高于对照组与空白组(CGRP:q=3.491、6.883,P=0.041、P<0.001;VEGF:q=3.467、6.636,P=0.042、P<0.001),而对照组与空白组间无明显差异(q=3.339、2.851,P=0.053、0.114)。治疗4周后,3组患者踝肱指数对比,观察组明显高于对照组与空白组(q=3.947、7.330,P=0.018、P<0.001),而对照组与空白组间无明显差异(q=3.330,P=0.054)。结论高压氧联合硫辛酸治疗糖尿病足,有助于控制血糖水平、改善血管内皮功能及下肢血管病变程度,提高治疗效果,临床推广价值较高。展开更多
文摘Objective:To observe the efficacy of pentoxifylline+thioctic acid in the treatment of patients with painful diabetic peripheral neuropathy(PDPN).Methods:70 patients with PDPN admitted from October 2019 to October 2022 were selected and randomly grouped,with pentoxifylline+thioctic acid treatment in Group A and thioctic acid treatment in Group B,and the treatment efficacy was compared.Results:The treatment efficacy in Group A was higher than that of Group B,P<0.05;the points of each symptom of PDPN in Group A were lower than that of Group B,P<0.05;the C-reactive protein and electromyography indexes of PDPN patients in Group A were better than that of Group B,P<0.05.Conclusion:PDPN patients treated with pentoxifylline+thioctic acid can optimize nerve function,inhibit inflammation progression,and reduce PDPN symptoms,which is an efficient and feasible treatment option.
文摘AIM: To detect whether the combination of vincamine, thioctic acid and lutein will improve the retina and optic nerve functions in cases of an opaque media with an optic nerve and/or a retinal defect or not.METHODS: Totally 2000 patients(2000 eyes) of corneal opacities with defects in the optic nerve or/and the retinal functions were studied. Every patient received three types of drugs: thioctic acid with cyanocobalamine, vincamine, and lutein. The drugs were given daily for 3-12 mo according to patient’s responses. Full field flash electroretinogram(ERG) and flash visual evoked potential(VEP) were done before treatment and at 1, 3, 6, and 12 mo sequentially. Patients were followed up for 12 mo.RESULTS: In the 2000 eyes, 1000 eyes had both moderate optic nerve and retinal function defects;and 840 eyes out of the 1000 improved with the medical treatment. Another 500 eyes out of the 2000 eyes had extinguished retinal function with normal optic nerve function and only 125 eyes of them improved. The 290 out of the 2000 eyes had severe defects in optic nerve with normal retinal function and 130 of them improved. Another 210 eyes have mild optic nerve and retinal function defects and 194 improved.CONCLUSION: The combination of vincamine, thioctic acid with cyanocobalamine, and lutein improved both retina and optic nerve functions mainly in mild and moderate defect than in severe cases.
文摘45 female patients with polycystic ovary syndrome took thioctic acid (Thioctacid-HR), 600 mg (n = 25) or high protein diet (n = 20). Fast insulin and glucose stimulus insulin were investigated before and after 3 months taken treatment. The use of thioctic acid, 600 mg is a new effective pathogenetics therapy of polycystic ovary syndrome on influence of hyperinsulinemia, HOMA-IR index and ovary volume in female patients with polycystic ovary syndrome.
基金supported in part by Council of Scientific and Industrial Research(CSIR),IndiaNational Institute of Health,USA
文摘Okadaic acid： Okadaic acid （OKA）, a polyether （C38 fatty acid） toxin, is a potent and selective inhibitor of protein phosphatase, PP1 and protein phosphatase 2A （PP2A）. It is mainly extracted from a black sponge Hallichondria okadaii and has been suggested to play a potent probe for studying the various molecular, cellular, biochemical and mechanism of neurotoxicity. It is known as a selective and potent in- hibitor of serine/threonine phosphatases 1 and 2A induces hyperphosphorylation of tau in vitro and in vivo. It has been reported that Alzheimer＇s disease （AD） is a complex multi- factorial neurodegenerative disorder and hyperphosphor- ylated tau protein is a major pathological hallmark of AD. The reduced activity of phosphatases like, PP2A has been implicated in the brain of AD patients. OKA also induced inhibition of protein phosphatases cause neurofibrillary tangles （NFTs） like pathological changes and tau hyperphos- phorylation seen in AD pathology. Our and others reports inferred that OKA induces neurodegeneration along with tau hyperphosphorylation, GSK3β activation, oxidative stress, neuroinflammation and neurotoxicity which are char- acteristic of AD pathology （Figure 1）.
文摘Electrochemical impedance spectroscopy was employed to investigate the permeation of electrolyte ions in thioctic acid self-assembled monolayer when its structure was changed by the interaction of copper ions. The ion permeation was evaluated by using relatively low excitation frequencies, 0.2 Hz to 1000 Hz, and quantified by an extra resistive component in the equivalent circuit (RSAM). The extent of ion permeation affected by the electrode potentials and the electrolyte concentration were investigated. The experimental results verified that RSAM decreased ~70% by interaction with copper ions and that RSAM increased ~2 - 3 times when the electrolyte concentration was decreased by 10 times. This analysis can be performed without addition of redox species.
基金supported by the National Key Research and Development Program of China(grant nos.2021YFC2101800 and 2021YFC2400802)the National Natural Science Foundation of China(grantnos.52173117 and 21991123)+5 种基金Belt&Road Young Scientist Exchanges Project of Science and Technology Commission Foundation of Shanghai(grant no.20520741000)Ningbo 2025 Science and Technology Major Project(grant no.2019B10068)the Natural Science Foundation of Shanghai(grant no.20ZR1402500)Science and Technology Commission of Shanghai Municipality(grant nos.20DZ2254900and 20DZ2270800)the Fundamental Research Funds for the Central Universities,DHU Distinguished Young Professor Program(grant no.LZA2019001)the Biomedical Engineering fund of Shanghai Jiao Tong University(grant no.YG2021GD04).
文摘Poly(disulfide)s have been widely used in flexible wearable electronics,smart materials,and drug delivery.The synthesis of poly(disulfide)s usually utilizes external stimuli or toxic initiators to promote the polymerization.Here,we indicated that the long-range electronic effect can significantly alter the reactivity of the disulfide group.Accordingly,we established deprotonation-promoted ring-opening polymerization of thioctic acid(TA)as a highly effective and simple method to synthesize poly(disulfide)s due to the long-range electronic effect and nucleophilic carboxylate.Without external stimuli and initiators,simple mixing of TA and deprotonation reagent,choline bicarbonate,in different ratios at room temperature rapidly produced a series of high molecular weight(up to 772 kDa)ionic liquid crystal poly(disulfide)s elastomers with room temperature self-healing ability,adjustable conductivity(2.39×10^(−2)∼0.28×10^(−2)S m^(−1)),degradability,biocompatibility,antibacterial property,and tissue-like softness(Young’s moduli ranging from 18.2±6.0 to 111.1±36.7 kPa).The experiments and density functional theory calculations also revealed the principle of long-range electronic effect to establish a new synthetic strategy of poly(disulfide)s with superior properties favorable for bioelectronics.
基金supported by the National Natural Science Foundation of China(No.52073099)the Guangdong Basic and Applied Basic Research Foundation(No.2024A1515010847)the Guangdong Project of R&D Plan in Key Areas(No.2020B010180001)。
文摘Elastomers with high strength and toughness,excellent self-healing properties,and biocompatibility have broad application prospects in wearable electronics and other fields,but preparing it remains a challenge.In this work,we propose a highly adaptable strategy by introducing the small molecule crosslinking agent of triethanolamine(TEA)to the poly(thioctic acid)(PTA)chains and preparing the PAx Ey elastomers using a simple synthesis step.This strategy stabilizes the PTA chains by constructing multiple non-covalent cross-linked dynamic networks,endowing materials with excellent strength and toughness(tensile strength of 288 kPa,toughness of 278.2 kJ/m3),admirable self-healing properties(self-healing efficiency of 121.6%within 7 h at 70℃),and good biocompatibility.The PAx Ey elastomers can also be combined with MWNTs to become flexible strain sensors,which can be used to monitor human joint movements with high sensitivity,repeatable responses,and stability.
基金support from the National Natural Science Foundation of China(Nos.22078274,22373080,and 21903066)the President Fund of Xiamen University(No.20720210046).
文摘With the fast generation of electronic waste(e-waste)and the increasing depletion of metal resources,“urban mining”that can selectively recover gold from secondary resources has attracted great interest.Construction of materials with high extraction capacity and satisfying selectivity in complex aqueous-based matrices still remains challenging.Here,a novel metal-organic framework/polymer composite(Fe-BTC/poly(thioctic acid),denoted as Fe-BTC/pTA)has been newly synthesized and applied for selective gold recovery in different matrices(river water,seawater,and leaching solution of e-waste).Benefiting from the high specific surface area and suitable pore sizes as well as the rational design of active sites,the composite exhibits high adsorption capacity(920 mg/g),high removal efficiency(>99%),fast kinetics(below 0.1 ppb within 10 min),and good applicability in complex matrices,which are better than those of most reported sulfur-containing adsorbents.Solid-state metallic gold with high purity can be effectively enriched due to the high recyclability and long-term stability of the composite.The material after adsorption can be further applied as a heterogeneous catalyst for water remediation due to the in situ generated gold nanoparticles by the redox reaction between Au(III)ions and the S-containing groups in the composites.
文摘Ventral globus pallidus-injured rats by kainic acid(10 mg) were used to derter-mine the monoamine levels in four different brain regions.In this model,a great decrease of NE con-centration was observed in both hippocampus and frontal cortex compared with nonnal contro.This result hints that a damage of noradrenergic neurons in this model has occurred. DA concentrations in the four brain zones after kainic acid injection were all reduced, but only in the frontal cortex and striatum the pronounced reductions were discovered while DA turnover rates in frontal cortex, stria-tum and meddullapons were significantly reduced. These results revealed a DA metabolic disorder occurring in these regions.However,5-HT concentrations as well as DBH activity, expressed by ratio of NE/DA,showed no marked difference in this model. In our study it is found that the changes of monoamine levels in this model basically reflect those discovered in AD patients.
文摘目的探究高压氧联合硫辛酸治疗糖尿病足的临床疗效。方法选取2020年5月至2022年5月河南省人民医院豫东分院收治的92例糖尿病足患者作为研究对象,按照不同治疗方法将其分为观察组(32例)、对照组(30例)和空白组(30例)。观察组患者在常规治疗的基础上行高压氧联合硫辛酸治疗,对照组患者在常规治疗的基础上单纯行硫辛酸治疗,空白组患者单纯行常规治疗,对比观察3组患者临床疗效、血糖相关指标及血管功能相关因子水平与踝肱指数。结果治疗4周后,3组患者临床疗效对比,观察组明显优于空白组(Z=-2.429,P=0.015),而观察组与对照组以及对照组与空白组间无明显差异(Z=-1.415、-1.299,P=0.157、0.194)。治疗4周后,3组患者空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbAlc)水平对比,观察组均明显低于空白组(q=6.574、6.162、6.339,P均<0.001),而观察组与对照组以及对照组与空白组间无明显差异(FBG:q=3.310、3.213,P=0.055、0.065;2 h PBG:q=2.840、3.270,P=0.116、0.059;HbAlc:q=3.230、3.059,P=0.063、0.083);3组患者血清内皮素(ET)水平对比,观察组明显低于对照组与空白组(q=3.443、6.630,P=0.044、P<0.001),而对照组与空白组间无明显差异(q=3.137,P=0.074);3组患者血清降钙素基因相关肽(CGRP)、血管内皮生长因子(VEGF)水平对比,观察组均明显高于对照组与空白组(CGRP:q=3.491、6.883,P=0.041、P<0.001;VEGF:q=3.467、6.636,P=0.042、P<0.001),而对照组与空白组间无明显差异(q=3.339、2.851,P=0.053、0.114)。治疗4周后,3组患者踝肱指数对比,观察组明显高于对照组与空白组(q=3.947、7.330,P=0.018、P<0.001),而对照组与空白组间无明显差异(q=3.330,P=0.054)。结论高压氧联合硫辛酸治疗糖尿病足,有助于控制血糖水平、改善血管内皮功能及下肢血管病变程度,提高治疗效果,临床推广价值较高。
