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Crystal and Molecular Structure of N-Isopropyl-O-(p-Chlorophenyl)-O'-(1,2:3,4-Di-O"-isopropylidene-α-D-galactopyranosyl) Thiophosphoramidate
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作者 Chen Xiao-Ru Chen Ru-Yu(State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071)Wang Ru-Ji Wang Hong-Gen(Central Laboratory,Nankai University,Tianjin 300071) 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 1995年第6期20-24,共5页
One pure isomer of the title compound was obtained,and its crystal structure was determined by single crystal X-ray diffraction analysis.C<sub>2</sub>1H<sub>3</sub>1ClNO<sub>7</sub>... One pure isomer of the title compound was obtained,and its crystal structure was determined by single crystal X-ray diffraction analysis.C<sub>2</sub>1H<sub>3</sub>1ClNO<sub>7</sub>PS,M<sub>r</sub>=507.97,triclinic,space group P1,crystal data:a=10.475 (4),b=11.165(3),c=12.484(2),α=76.65(2),β=81.05(2),γ=65.54(2)°,V=1290.1(7) 3,Z=2,D<sub>x</sub>=1.31 g/cm3,μ=3.22 cm-1,F(000)=536,the final R=0.073 and Rω=0. 083 for 2851 observed reflections[I≥3σ(I)].The configuration of the chiral phosphorus atom P(1) is R. 展开更多
关键词 galactopyranosyl thiophosphoramidate crystal structure antitumor Drug
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A NEW CONVENIENT SYNTHESIS OF S-ALKYL N,N-DIALKYL THIOPHOSPHORAMIDIC ACID DERIVATIVES
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作者 Chu Chi TANG Gui Ping WU Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071 《Chinese Chemical Letters》 SCIE CAS CSCD 1992年第8期593-594,共2页
The chlorination of O,O-dialkyl N,N-dialkyl thiophosphoramidates with phosphorus oxychloride proceeds with isomerization to give S-alkyl N,N-dialkyl thiophosphoramidochloridates,which react further with various nucleo... The chlorination of O,O-dialkyl N,N-dialkyl thiophosphoramidates with phosphorus oxychloride proceeds with isomerization to give S-alkyl N,N-dialkyl thiophosphoramidochloridates,which react further with various nucleophiles in the presence of base to give the title compounds. 展开更多
关键词 ACID A NEW CONVENIENT SYNTHESIS OF S-ALKYL N N-DIALKYL THIOPHOSPHORAMIDIC ACID DERIVATIVES
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Synthesis and Electrospray Ionization Mass Spectra of N-(1,3, 2-Dioxaphosphorinan-2-ylmethyl)thiophosphoramidates 被引量:5
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作者 苗志伟 傅翠蓉 +3 位作者 王彬 崔占伟 张建锋 陈茹玉 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2007年第9期1344-1348,共5页
N-(1,3,2-Dioxaphosphorinan-2-ylmethyl)thiophosphoramidates were synthesized and determined by NMR spectra and positive ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectro... N-(1,3,2-Dioxaphosphorinan-2-ylmethyl)thiophosphoramidates were synthesized and determined by NMR spectra and positive ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). The fragmentation pathways were investigated. The results show that these characteristic ions in ESI mass spectra are useful in the structural determination of N-(1,3,2-dioxaphosphorinan-2-ylmethyl)- thiophosphoramidates. 展开更多
关键词 ESI-MS N-(1 3 2-dioxaphosphorinan-2-ylmethyl)thiophosphoramidate CONJUGATE tandem mass spectrometry
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Synthesis and Novel Properties of Alkyl Thiophosphoramidate Derivatives of Nucleosides 被引量:1
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作者 苗志伟 付华 +3 位作者 涂光忠 刘海 韩波 赵玉芬 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2002年第5期492-496,共5页
Novel alkyl thiophosphoramidate derivatives of nucleoside analogues (5) have been prepared by phosphochloridothioate chemistry. O Isopropyl 2′,3′ O isopropylidene uridine 5′ yl N thiophosphoryl th... Novel alkyl thiophosphoramidate derivatives of nucleoside analogues (5) have been prepared by phosphochloridothioate chemistry. O Isopropyl 2′,3′ O isopropylidene uridine 5′ yl N thiophosphoryl threonine and serine methyl esters (5a and 5b) underwent the intramolecular catalyzed hydrolysis reaction. 展开更多
关键词 SYNTHESIS alkyl thiophosphoramidate nucleoside analogue hydrolysis reaction MECHANISM
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Studies on Synthesis and Intramolecular Catalyzed Hydrolysis of Thiophosphoramidate Derivatives of Nucleoside
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作者 苗志伟 付华 +3 位作者 冯玉萍 韩波 涂光忠 赵玉芬 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2002年第11期1434-1438,1134,共5页
Novel thiophosphoramidate derivatives of nucleoside analogue as membrane-soluble prodrugs of the bioactive free nucleotides have been prepared by thiophosphorylation reaction. 2′,3′-O, O′-Isopropylidene uridine-5′... Novel thiophosphoramidate derivatives of nucleoside analogue as membrane-soluble prodrugs of the bioactive free nucleotides have been prepared by thiophosphorylation reaction. 2′,3′-O, O′-Isopropylidene uridine-5′-yl N-thiophosphoryl serine and threonine methyl esters underwent the intramolecular catalyzed hydrolysis reaction. 展开更多
关键词 SYNTHESIS thiophosphoramidate nucleoside analogue hydrolysis reaction MECHANISM
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