Tool Positioning Algorithm Based on Smooth Tool Paths for 5-axis Machining of Sculptured Surfaces

The current research of the 5-axis tool positioning algorithm mainly focuses on searching the local optimal tool position without gouging and interference at a cutter contact（CC） point,while not considering the smoothness and continuity of a whole tool path.When the surface curvature varies significantly,a local abrupt change of tool paths will happen.The abrupt change has a great influence on surface machining quality.In order to keep generated tool paths smooth and continuous,a five-axis tool positioning algorithm based on smooth tool paths is presented.Firstly,the inclination angle,the tilt angle and offset distance of the tool at a CC point are used as design variables,and the machining strip width is used as an objective function,an optimization model of a local tool positioning algorithm is thus established.Then,a vector equation of tool path is derived by using the above optimization model.By analyzing the equation,the main factors affecting the tool path quality are obtained.Finally,a new tool position optimization model is established,and the detailed process of tool position optimization is also given.An experiment is conducted to machine an aircraft turbine blade by using the proposed algorithm on a 5-axis blade grinding machine,and the machined blade surface is measured with a coordinate measuring machine（CMM）.Experimental and measured results show that the proposed algorithm can ensure tool paths are smooth and continuous,improve the tool path quality,avoid the local abrupt change of tool paths,and enhance machining quality and machining efficiency of sculptured surfaces.

Laser Interferometer Based Measurement for Positioning Error Compensation in Cartesian Multi-Axis Systems

Accuracy is one of the most important key indices to evaluate multi-axis systems’ (MAS’s) characteristics and performances. The accuracy of MAS’s such as machine tools, measuring machines and robots is adversely affected by various error sources, including geometric imperfections, thermal deformations, load effects, and dynamic disturbances. The increasing demand for higher dimensional accuracy in various industrial applications has created the need to develop cost-effective methods for enhancing the overall performance of these mechanisms. Improving the accuracy of a MAS by upgrading the physical structure would lead to an exponential increase in manufacturing costs without totally eliminating geometrical deviations and thermal deformations of MAS components. Hence, the idea of reducing MAS’s error by a software-based alternative approach to provide real-time prediction and correction of geometric and thermally induced errors is considered a strategic step toward achieving the full potential of the MAS. This paper presents a structured approach designed to improve the accuracy of Cartesian MAS’s through software error compensation. Four steps are required to develop and implement this approach: (i) measurement of error components using a multidimensional laser interferometer system, (ii) tridimensional volumetric error mapping using rigid body kinematics, (iii) volumetric error prediction via an artificial neural network model, and finally (iv) implementation of the on-line error compensation. An illustrative example using a bridge type coordinate measuring machine is presented.

Postoperative Mechanical Axis Alignment and Components Position after Conventional and Patient-Specific Total Knee Arthroplasty

Introduction: Accurate postoperative alignment and implant positioning are determinant factors for successful total knee arthroplasty (TKA). Patient-specific template (PST) is a technique that uses computer technology for the planning, deigning and production of cutting guides. This study aims to compare PST to conventional technique in terms of mechanical axis alignment and component positioning. Patients and method: 109 TKA were performed for 78 patients in 2 groups. Group A included 69 conventional TKA in 55 patients and Group B included 40 patient-specific TKA in 23 patient. Postoperative long-film X-rays were done for all patients to observe the mechanical axis, anatomical axis, lateral distal femoral mechanical angle and medial proximal tibial angle. Results: No statistically significant difference was found between the two groups regarding alignment or component positioning. Conclusion: Both techniques have shown similar results in restoring the mechanical axis and alignment after TKA. However, PST had the advantages of reduced blood loss and shorter operative time.

circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis

Human adipose-derived stem cells(hASCs)are a promising cell type for bone tissue regeneration.Circular RNAs(circRNAs)have been shown to play a critical role in regulating various cell differentiation and involve in mesenchymal stem cell osteogenesis.However,how circRNAs regulate hASCs in osteogenesis is still unclear.Herein,we found circ_0003204 was significantly downregulated during osteogenic differentiation of hASCs.Knockdown of circ_0003204 by si RNA or overexpression by lentivirus confirmed circ_0003204 could negatively regulate the osteogenic differentiation of hASCs.We performed dual-luciferase reporting assay and rescue experiments to verify circ_0003204 regulated osteogenic differentiation via sponging miR-370-3p.We predicted and confirmed that miR-370-3p had targets in the 3′-UTR of HDAC4 m RNA.The following rescue experiments indicated that circ_0003204 regulated the osteogenic differentiation of hASCs via miR-370-3p/HDAC4 axis.Subsequent in vivo experiments showed the silencing of circ_0003204 increased the bone formation and promoted the expression of osteogenic-related proteins in a mouse bone defect model,while overexpression of circ_0003204 inhibited bone defect repair.Our findings indicated that circ_0003204 might be a promising target to promote the efficacy of hASCs in repairing bone defects.

LINC00609 inhibits A549 cells progression through the regulation of miR-128-3p/RND3 axis

Background:Long-chain non-coding RNA(lncRNA)LINC00609 is a potential tumor suppressor,but the mechanism of action in non-small cell lung cancer(NSCLC)is yet to be understood.Objectives:The effects of LINC00609 on A549 cell proliferation,apoptosis,and cell cycle arrest were investigated.Methods:The LINC00609 levels in NSCLC and normal tissues were analyzed by bioinformatics.Expressions of LINC00609,miR-128-3p,and Rho family GTPase 3(RND3)in NSCLC cells(A549)were determined by qRT-PCR.Bioinformatics analysis predicted target genes and dual-luciferase reporter assays to ensure that LINC00609 targeted miR-128-3p and miR-128-3p targeted RND3.The proliferation of cells was determined using EDU and CCK-8.Flow cytometry was used to evaluate cell apoptosis rate and cell cycle.The western blotting assay identified proteins related to proliferation and apoptosis.Results:In NSCLC tissues,LINC00609 was expressed in low levels,while its high expression was associated with a higher survival rate.LINC00609 affected cell proliferation,apoptosis,cell cycle arrest,and expression of related proteins.Dual-luciferase reporter assay showed that LINC00609 binds specifically to miR-128-3p,and miR-128-3p binds to RND3.MiR-128-3p overexpression could neutralize the effects of LINC00609.A siRNA targeting RND3 could reverse the effect of the miR-128-3p inhibitor.Silencing RND3 resulted in a decrease in apoptosis rate and the number of cells in the S-phase and an increase in the number of cells in the G1-phase.Furthermore,phosphorylation levels of the AKT protein and mTOR protein,and Bcl2 expression,increased;however,the expression of RND3,Bax,and caspase3 decreased.Conclusions:LINC00609 regulated miR-128-3p/RND3 axis to modulate A549 cell proliferation,apoptosis,and cell cycle arrest.In the case of NSCLC,LINC00609 could be a potential target for therapy.

The Electric-Field Controllable Non-Volatile 35° Rotation of Magnetic Easy Axis in Magnetoelectric CoFeB/(001)-Cut Pb(Mg_(1/3)Nb_(2/3))O_3-25%PbTiO_3 Heterostructure

Using in situ electric-field-modulated anisotropic magnetoresistance measurement, a large reversible and non- volatile in-plane rotation of magnetic easy axis of -35° between the positive and negative electrical poling states is demonstrated in C040Fe40B20//（001）-cut Pb（Mgl/3Nb2/3）O3-25PbTiO3 （PMN-PT）. The specific magneto- electric coupling mechanism therein is experimentally verified to be related to the synchronous in-plane strain rotation induced by 109° ferroelastic domain switching in the （001）-cut PMN-PT substrate.

Studies on Performance of Distributed Vertical Axis Wind Turbine under Building Turbulence

As a part of the new energy development trend,distributed power generation may fully utilize a variety of decentralized energy sources.Buildings close to the installation location,besides,may have a considerable impact on the wind turbines’operation.Using a combined vertical axis wind turbine with an S-shaped lift outer blade and-shaped drag inner blade,this paper investigates how a novel type of upstream wall interacts with the incident wind at various speeds,the influence region of the turbulent vortex,and performance variation.The results demonstrate that the building’s turbulence affects the wind’s horizontal and vertical direction,as well as its speed,in downstreamplaces.The wall’s effect on wind speed changing in the downstreamarea is thoroughly investigated.It turns out that while choosing an installation location,disturbing flow areas or low disturbing flow zones should be avoided to have the least impact on wind turbine performance.

Definition and expression of non-symmetric physical properties in space for uniaxial crystals

The anisotropic physical property is the most noteworthy feature of crystals.In this paper,the subscript change method is used to analyze the sign changes of different tensors describing physical properties in uniaxial crystals.The distribution of some physical properties in special point groups exhibits non-symmetry in eight quadrants,which should attract the attention of crystal research.The difference between the crystallographic and physical coordinate systems and the lack of crystal symmetry operations are considered to be the origins of the non-symmetry.To avoid ambiguities and difficulties in characterizing and applying crystal physical properties,eight quadrants in space should be clarified.Hence,we proposed the use of piezoelectric properties to define the positive direction of the optical coordinate axis prior to the research and applications of optical properties.

Remote positioning system based on GPS/GPRS

Considering the need of target positioning,a remote positioning system is designed based on global positioning system(GPS)and general packet radio service(GPRS);The data collection terminal is based on microcontroller unit(MCU)PIC24FV301.It uses GPRS network to create wireless link and transmits GPS source information which is collected by LEA-5H board to monitor center on the Internet.The monitor center obtains the target information through processing and analysis of the calculated data.Actual operation results indicate that the designed system has excellent performance and achieves the goal of the remote location.

采用间接测量法对平面3-RPR机构进行运动学标定的仿真

采用间接测量对平面机构进行标定时 ,需要引进标准测量参照物 ,但参照物本身仍可能存在一定的尺寸误差 ;另外间接测量时要不断变换标准测量参照物的位置 ,又会引进位置误差。为便于解决实际问题 ,使研究更具可操作性 ,将上述误差和待标定的机构结构误差一起考虑对机构进行了标定仿真 ,同时在仿真过程中采用矩阵重构的方法来解决测量误差扰动的问题 ,避免了大规模的空间寻优。仿真结果表明 。

繁荣、失落与回归--从海河的变迁剖析天津城市空间形态的变迁

通过对天津市城市建设史与城市空间发展格局的分析与比较,剖析了海河作为天津城市的母亲河对天津城市发展的影响与作用,论述了海河与城市的关系的变化发展过程和对城市滨水区的价值认知。

基于“点-轴系统”理论的西安地区空间关系定位

将“点-轴系统”理论应用于西安地区,分别进行“点”的开发与“轴”的开发,提出了“四极三轴”的西安地区空间框架结构,构造出集中与分散相协调的空间结构体系,达到有效疏散过度集中的西安城市人口与产业的目的。在空间影响尺度、产业及功能地位上,“四极三轴”各有侧重。

短链脂肪酸-酰化淀粉对小鼠抑郁样行为的缓解及机制

大量研究证实“微生物-肠-脑轴”在抑郁症的发生发展中发挥重要作用,而肠道微生物产生的短链脂肪酸(short chain fatty acids,SCFAs),更是参与神经调控作用的关键分子。该研究首次采用SCFA-酰化淀粉在大肠定点释放5类短链脂肪酸,探究其对慢性应激诱导的抑郁症状的缓解及机制。以雄性C57BL/6 J小鼠为研究对象,通过为期5周的慢性不可预知温和应激构建抑郁小鼠模型,通过旷场实验、高架十字迷宫实验和强迫游泳实验对小鼠的抑郁样行为进行评价。同时对小鼠应激激素、神经递质水平及相关酶的表达水平进行检测。结果显示,乙酸、异丁酸和丁酸能在不同程度上减轻小鼠抑郁样行为,其可能机制与SCFAs修复下丘脑-垂体-肾上腺轴反馈调节障碍、恢复5-羟色胺的正常代谢相关。该研究为抑郁症的营养干预提供了新的理论依据。

转台-摆头式五轴机床几何误差测量及辨识

为降低转动轴几何误差对转台-摆头式五轴机床精度的影响,提出了基于球杆仪的位置无关几何误差测量和辨识方法。基于多体系统理论及齐次坐标变换方法建立了转台-摆头式五轴机床位置无关几何误差模型,依据旋转轴不同运动状态下的几何误差影响因素建立基于圆轨迹的四种测量模式,并实现10项位置无关几何误差的辨识。利用所建立的几何误差模型进行数值模拟,确定转动轴的10项位置无关几何误差对测量轨迹的影响。最后,采用误差补偿的形式实验验证所提出的测量及辨识方法的有效性,将位置无关几何误差补偿前后的测量轨迹进行比较。误差补偿后10项位置无关几何误差的平均补偿率为70.4%,最大补偿率达到88.4%,实验结果表明所提出的建模和辨识方法可用于转台-摆头式五轴机床转动轴精度检测,同时可为机床精度评价及几何精度提升提供依据。

THE FEKETE-SZEG PROBLEM FOR CLOSE-TO-CONVEX FUNCTIONS WITH RESPECT TO THE KOEBE FUNCTION

An analytic function f in the unit disk D ：= {z ∈ C ： ｜z｜ 〈 1}, standardly normalized, is called close-to-convex with respect to the Koebe function k（z） ：= z/（1-z）2, z ∈ D, if there exists δ ∈ （-π/2,π/2） such that Re {eiδ（1-z）2f′（z）} 〉 0, z ∈ D. For the class C（k） of all close-to-convex functions with respect to k, related to the class of functions convex in the positive direction of the imaginary axis, the Fekete-Szego problem is studied.

Indoor Positioning System Using Axis Alignment and Complementary IMUs for Robot Localization

An indoor positioning method for robots is presented to improve the precision of displacement measurement using only low-cost inertial measurement units(IMUs).Firstly,a high-fidelity displacement estimation for linear motion is proposed.A new robot motion model is designed as well as an axis alignment that only uses a single axis of the accelerometer.The integral error of velocity is eliminated by a new subsection calculation method.Two complementary IMUs are combined by assigning them different weights to obtain high accuracy displacement results.Secondly,an orientation estimation based on a fusion filter for the steering motion is proposed.Experiments show that the proposed method significantly improves the accuracy of linear motion measurement and is effective for the indoor positioning of a robot.

云海-2掩星探测资料在全球数值天气预报模式中的同化效果评估

本文基于T799L91全球数值天气预报模式及其四维变分同化系统,构建了云海-2掩星探测资料的同化流程,并以2019年7月开展了为期一个月的云海-2掩星探测资料同化预报试验。对东亚区域、北半球和南半球的同化预报结果评估表明:在全球数值天气预报模式中,同化云海-2掩星探测资料能够有效提高预报场的准确性,提高的幅度随着预报时效和预报日数的增加逐渐增大;在更长时效的72 h、120 h、168 h预报中,云海-2掩星探测资料与GPS(Global Positioning System)掩星探测资料的同化效果在中前期相当,在中后期,同化云海-2掩星探测资料逐渐优于GPS掩星探测资料;随着预报日数的增加,联合同化云海-2掩星探测资料和GPS掩星探测资料的优势逐步显现。

OUR-QGD型体部伽玛刀Y轴激光定位尺研制与临床应用

目的自行研制体部伽玛刀Y轴激光定位尺,使患者治疗计划在治疗设备上得以顺利实施。方法 Y轴激光定位尺由水平底座、刻度尺、滑动卡、激光笔及刻度指针组成,且操作简便易行。结果对照组50例治疗计划,Y轴方向有38例顺利通过治疗,通过率为76%;试验组50例治疗计划,Y轴方全部通过治疗,通过率为100%。结论使用体部伽玛刀Y轴激光定位尺定位,杜绝了治疗计划由于Y轴数值超出可行范围无法实施的情况,提高了工作效率、缩短了患者的治疗时间、确保治疗安全。

A concurrent optimization approach for energy efficient multiple axis positioning tasks

Automated production systems typically comprise numerous electrical servo drives,many of which conduct positioning motions,e.g.for handling or manipulation tasks.The power electronics of modern multi-axis systems often comprise coupled DC-links,enabling for internal exchange of recuperative brake energy.However,the motion sequences of manipulators are often commanded at maximum dynamics for minimum time motion,neglecting possible optimization potential,e.g.available idle time,leading to inefficient energy management.A robust trajectory optimization approach based on the particle swarm algorithm and well-established path planning methods is presented for the adaption of multi-axis positioning tasks with only two parameters per axis and positioning motion during system run-time.Experimental results prove that,depending on the positioning task and chosen optimization constraints,energy demands are distinctly reduced.The approach is applicable to diverse multi-axis configurations and enables for considerable energy savings without additional hardware invest.

Polynomial regression calculation of the Earth's position based on millisecond pulsar timing

Prior to achieving high precision navigation of a spacecraft using X-ray observations, a pulsar rotation model must be built and analysis of the precise posi- tion of the Earth should be performed using ground pulsar timing observations. We can simulate time-of-arrival ground observation data close to actual observed values before using pulsar timing observation data. Considering the correlation between the Earth＇s position and its short arc section of an orbit, we use polynomial regression to build the correlation. Regression coefficients can be calculated using the least square method, and a coordinate component series can also be obtained; that is, we can calcu- late Earth＇s position in the Barycentric Celestial Reference System according to pulse arrival time data and a precise pulsar rotation model. In order to set appropriate param- eters before the actual timing observations for Earth positioning, we can calculate the influence of the spatial distribution of pulsars on errors in the positioning result and the influence of error source variation on positioning by simulation. It is significant that the threshold values of the observation and systematic errors can be established before an actual observation occurs; namely, we can determine the observation mode with small errors and reject the observed data with big errors, thus improving the positioning result.