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Effect of two-step solid solution on microstructure andδphase precipitation of Inconel 718 alloy
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作者 Enyu Liu Qingshuang Ma +5 位作者 Xintong Li Aoxue Gao Jing Bai Liming Yu Qiuzhi Gao Huijun Li 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第10期2199-2207,共9页
Inconel 718 is the most popular nickel-based superalloy and is extensively used in aerospace,automotive,and energy indus-tries owing to its extraordinary thermomechanical properties.The effects of different two-step s... Inconel 718 is the most popular nickel-based superalloy and is extensively used in aerospace,automotive,and energy indus-tries owing to its extraordinary thermomechanical properties.The effects of different two-step solid solution treatments on microstructure andδphase precipitation of Inconel 718 alloy were studied,and the transformation mechanism fromγ″metastable phase toδphase was clarified.The precipitates were statistically analyzed by X-ray diffractometry.The results show that theδphase content firstly increased,and then decreased with the temperature of the second-step solid solution.The changes in microstructure andδphase were studied by scanning electron microscopy and transmission electron microscopy.An intragranularδphase formed in Inconel 718 alloy at the second-[100]_(δ)[011]γ step solid solution temperature of 925℃,and its orientation relationship withγmatrix was determined as//and(010)_(δ)//(111)γ.Furthermore,the Vickers hardness of different heat treatment samples was measured,and the sample treated by second-step solid solution at 1010℃ reached the maximum hardness of HV 446.84. 展开更多
关键词 Inconel 718 alloy two-step solid solution treatment δphase γ″-δtransformation
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Dual-function protective layer for highly reversible Zn anode
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作者 Jiaming Li Hanhao Liang +6 位作者 Yini Long Xiao Yu Jiaqi Li Nan Li Junyi Han Jianglin Wang Zhanhong Yang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第11期12-23,共12页
The thermodynamic instability of zinc anodes in aqueous electrolytes leads to issues such as corrosion,hydrogen evolution reactions(HER), and dendrite growth, severely hindering the practical application of zinc-based... The thermodynamic instability of zinc anodes in aqueous electrolytes leads to issues such as corrosion,hydrogen evolution reactions(HER), and dendrite growth, severely hindering the practical application of zinc-based aqueous energy storage devices. To address these challenges, this work proposes a dualfunction zinc anode protective layer, composed of Zn-Al-In layered double oxides(ILDO) by rationally designing Zn-Al layered double hydroxides(Zn-Al LDHs) for the first time. Differing from previous works on the LDHs coatings, firstly, the ILDO layer accelerates zinc-ion desolvation and also captures and anchors SO_(4)^(2-). Secondly, the in-situ formation of the Zn-In alloy phase effectively lowers the nucleation energy barrier, thereby regulating zinc nucleation. Consequently, the zinc anode with the ILDO protective layer demonstrates long-term stability exceeding 1900 h and low voltage hysteresis of 7.5 m V at 0.5 m A cm^(-2) and 0.5 m A h cm^(-2). Additionally, it significantly enhances the rate capability and cycling performance of Zn@ILDO//MnO_(2) full batteries and Zn@ILDO//activated carbon zinc-ion hybrid capacitors.This simple and effective dual-function protective layer strategy offers a promising approach for achieving high-performance zinc-ion batteries. 展开更多
关键词 Protection layer Zn-Al-In layered double oxide Captures and anchors SO_(4)^(2-) Zn-In alloy phase Zn metal anode
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Research on a New Control Strategy of Three Phase Inverter for Unbalanced Loads
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作者 Wenhua HU Weiming Ma Chunxi LIU 《Journal of Electromagnetic Analysis and Applications》 2010年第1期39-44,共6页
One of the very important functions of three-phase inverter is to maintain the symmetric three-phase output voltage when the three-phase loads are unbalanced. Although the traditional symmetrical component decomposing... One of the very important functions of three-phase inverter is to maintain the symmetric three-phase output voltage when the three-phase loads are unbalanced. Although the traditional symmetrical component decomposing and superimpose theory can keep the voltage balance through compensating the positive-, negative- and zero-sequence components of the output voltage of inverter, however, this method is time-consuming and not suitable for control. Aiming at high power medium frequency inverter source, a P+Resonant (Proportion and Resonant) controller which ensured a balanced three phase output voltage under unbalanced load is proposed in this paper. The regulator was proved to be applicable to both three-phase three-wire system and three-phase four-wire system and developed two methods of realization. The simulation results verified that this method can suppressed effectively the output voltage distorted caused by the unbalanced load and attained a high quality voltage waveforms. 展开更多
关键词 THREE-phase INVERTER unbalanced Load the THREE-phase OUTPUT Voltage SYMMETRIC Medium Frequency P+Resonant CONTROLLER
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Phase evolution of plasma sprayed Al_2O_3-13%TiO_2 coatings derived from nanocrystalline powders 被引量:2
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作者 路学成 阎殿然 +3 位作者 杨勇 董艳春 何继宁 张建新 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第10期2951-2956,共6页
Commercial nanosized alumina and titania particles were selected as raw materials to prepare the blended slurry with composition of A1203-13%TiO2 (mass fraction), which were reconstituted into micrometer-sized granu... Commercial nanosized alumina and titania particles were selected as raw materials to prepare the blended slurry with composition of A1203-13%TiO2 (mass fraction), which were reconstituted into micrometer-sized granules by spray drying, subsequently sintering at different temperatures to form nanostructured feedstock for thermal spraying, and then A1203-13%TiO2 nanocoatings were deposited by plasma spraying. The evolution of morphology, microstructure, and phase transformation of the agglomerated powder and as-sprayed coatings were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results show that A1203 retains the same a phase as the raw material during sintering, while TiO2 changes from anatase to futile. During plasma spraying, some a-A1203 phases solidify to form metastable y-A1203, and the volume fraction of a-A1203 decreases as CPSP increases. However, peaks of the TiO2 phase are not observed from the as-sprayed coatings except for the coatings sprayed at the lower CPSP. As the CPSP increases, nanostructured TiO2 is dissolved easily in y-A1203 or z-A1203'TiO2 phase. After heat treatment, y-A1203 in the coatings transforms to a-A1203, and rutile is precipitated. 展开更多
关键词 A1203-13%TiO2 nanocrystalline powder NANOCOATINGS phase evolution
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基于改进NSGA-3和不平衡潮流的配电网相序优化 被引量:3
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作者 丁石川 崔康 +2 位作者 杭俊 王正风 鲍海波 《电力系统保护与控制》 EI CSCD 北大核心 2023年第3期46-55,共10页
低压配电网存在大量单相负荷,三相负荷不平衡会造成台区线路损耗增加,危害电网运行安全。提出一种基于历史数据的用户相序优化方法。使用台区用户的历史电压、电流数据构建台区不平衡潮流模型。针对台区一天内的运行状况建立用户节点电... 低压配电网存在大量单相负荷,三相负荷不平衡会造成台区线路损耗增加,危害电网运行安全。提出一种基于历史数据的用户相序优化方法。使用台区用户的历史电压、电流数据构建台区不平衡潮流模型。针对台区一天内的运行状况建立用户节点电压平均不平衡度最小、台区线路损耗最小和换相次数最小的目标函数。提出含有正态分布交叉算子(normal distribution crossover, NDX)的改进非支配遗传算法(non-dominated sorting genetic algorithm-3,NSGA-3),对用户节点的相序进行优化,以获得较好的种群分布并减少优化时间。然后从解集中选择最符合条件的一组解作为换相策略。最后以安徽省某配电台区实际用户数据为例,验证了所提方法可以有效地降低三相电压不平衡度,减小线路损耗。 展开更多
关键词 相序优化 台区三相不平衡 NSGA-3 不平衡潮流计算
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Synthesis and Solid Phase Extraction Performance Study of NNAL-specific Molecularly Imprinted Polymers Using Dummy Templates 被引量:2
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作者 张志丹 郑赛晶 +3 位作者 杨俊 王维妙 刘百战 朱晓兰 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2013年第3期361-368,I0004,共9页
Dummy molecularly imprinted polymers (DMIPs) for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) were produced using three structural analogues as dummy template molecules. The chosen analogues were 4-(a... Dummy molecularly imprinted polymers (DMIPs) for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) were produced using three structural analogues as dummy template molecules. The chosen analogues were 4-(acetymethylamino)-1-(3-pyridyl)-butanol, 4- (methylamino)-1-(3-pyridyl)-1-butanol, and 1-(3-pyridyl)-1,4,-butanediol. The molecular recognition characteristics of the produced polymers were evaluated by X-ray photoelec- tron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR). Interactions between NNAL and methacrylic acid should be cooperative hydrogen bonds while the ni- trogen atom of the pyridine ring and the oxygen atom of the nitroso group in NNAL are two of the hydrogen-bond acceptors. It was further demonstrated that DMIP synthesized by 4-(acetymethylamino)-1-(3-pyridyl)-butanol had the best binding performance by XPS and FT-IR. Then dummy molecularly imprinted solid phase extraction (DMISPE) was developed for the determination of the analyte using the hit polymer as the sorbing material. Under optimal conditions, the recovery of NNAL dissolved in standard solution reached 93%. And the investigated polymer exhibited much higher binding of NNAL when nicotine was acted as the competitive molecule. Also the proposed method was applied to the measurement of NNAL spiked in blank urine samples with recoveries ranging from 87.2% to 101.2%. 展开更多
关键词 Molecularly imprinted polymer Dummy template 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol Solid phase extraction
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Modification and refinement mechanism of Mg_2Si phase in Sr-containing AZ61-0.7Si magnesium alloy 被引量:7
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作者 Yang Mingbo Shen Jia 《China Foundry》 SCIE CAS 2009年第1期37-42,共6页
The effect of Sr on modification and refinement of the Mg 2 Si phase in an AZ61-0.7Si magnesium alloy has been investigated and analyzed.The results indicate that Sr can effectively modify and refine the Chinese-scrip... The effect of Sr on modification and refinement of the Mg 2 Si phase in an AZ61-0.7Si magnesium alloy has been investigated and analyzed.The results indicate that Sr can effectively modify and refine the Chinese-script shaped Mg2Si phase in the AZ61-0.7Si alloy.By adding 0.06wt.%-0.12wt.%Sr to AZ61-0.7Si alloy,the Mg2Si phase in the alloy can be changed from the initial coarse Chinese-script shape to fine granule and/or irregular polygonal shapes.Accordingly,the Sr-containing AZ61-0.7Si alloy exhibits higher tensile and creep properties than the AZ61-0.7Si alloy without Sr modification.The mechanism on modification and refinement of the Mg2Si phase in Sr-containing AZ61-0.7Si alloy is possibly related to the following two aspects:(1)adding Sr may form the Al4Sr phase which can serve as the heterogeneous nucleus for the Mg2Si particles and/or(2)adding Sr may lower the onset crystallizing temperature and increase the undercooling level. 展开更多
关键词 AZ61-0.7Si magnesium alloy SR Mg2Si phase modification and refinement
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A Phase II Study of Antineoplastons A10 and AS2-1 in Children with High-Grade Glioma. Final Report (Protocol BT-06), and Review of Recent Trials 被引量:8
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作者 Stanislaw R. Burzynski Tomasz J. Janicki +1 位作者 Gregory S. Burzynski Ania Marszalek 《Journal of Cancer Therapy》 2014年第6期565-577,共13页
Standard treatment for high-grade glioma involves surgical resection followed by radiation therapy and temozolomide. Unfortunately, there are no standard treatment recommendations after recurrence and new therapies ar... Standard treatment for high-grade glioma involves surgical resection followed by radiation therapy and temozolomide. Unfortunately, there are no standard treatment recommendations after recurrence and new therapies are needed for patients whose tumor recurs after first-line treatment. This single-arm, two-stage, interventional Phase II study evaluated the efficacy and safety of a combination of antineoplastons A10 and AS2-1. Nineteen patients were enrolled in the study (safety population), but fifteen patients with a median age of 9.4 years who met eligibility criteria were evaluated. The majority of subjects (12/15) were Caucasian and 8/15 (53%) were female. More than half (53%) of patients were diagnosed with glioblastoma and 33% with anaplastic astrocytoma. All patients had failed standard therapy including surgery, radiation, and chemotherapy. Antineoplastons were administered intravenously every four hours (median dose of A10 6.9 g/kg/d and AS2-1 0.30 g/kg/d) until objective response was documented and thereafter for a further 8 months. Clinical evaluations were performed every 8 weeks. All patients enrolled in the study were included in the safety analysis but only patients fulfilling the inclusion criteria were included in the efficacy evaluation. The duration of treatment with antineoplastons ranged from 2 weeks to 120 weeks. A complete response was documented in 2/15 (13%), partial response in 2/15 (13%), stable disease in 3/15 (20%). Progression-free survival at six months was 47% and overall survival (OS) at one year was 33.3%. One patient (6.7%) survived 10 years from treatment start. A small group of patients suffered reversible Grade 3 and 4 toxicities including hypernatremia 2/19 (11%) and decrease of neutrophils 1/19 (5%). There were no chronic toxicities. There was improvement of quality of life in patients who had objective response. It is concluded that antineoplastons show efficacy with an acceptable profile in this cohort of patients with recurrent high-grade glioma. 展开更多
关键词 Antineoplastons A10 and AS2-1 GLIOBLASTOMA phase II Clinical TRIAL RECURRENT GLIOMA
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A Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients with Recurrent Glioblastoma Multiforme: Final Report (Protocol BT-21) 被引量:10
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作者 Stanislaw R. Burzynski Tomasz J. Janicki Gregory S. Burzynski 《Journal of Cancer Therapy》 2014年第10期946-956,共11页
Treatment of recurrent glioblastoma multiforme (RGBM) creates one of the most difficult challenges to neuro-oncology. The purpose of this study is to evaluate the outcome of adults with high-grade glioma with special ... Treatment of recurrent glioblastoma multiforme (RGBM) creates one of the most difficult challenges to neuro-oncology. The purpose of this study is to evaluate the outcome of adults with high-grade glioma with special attention to RGBM patients treated with Antineoplastons (ANP) A10 and AS2-1 injections. The study was conducted according to Protocol BT-21, which accrued patients who failed standard radiation therapy (RT) and chemotherapy. There were 40 candidates registered in the study. Among the intent-to-treat (ITT) population, there were 30 cases of RGBM that progressed during and after prior treatment, 4 patients with anaplastic astrocytoma (AA), 1 with anaplastic mixed glioma (AMG), and 5 with persistent GBM. The aim of this paper is to evaluate the responses, survival and toxicity of all 40 patients, the efficacy in 30 patients with RGBM, and in 24 patients with RGBM who received at least 28 days of ANP (ERGBM). All RGBM patients were treated before with RT and chemotherapy, except one patient who only had surgery (patient refused radiation). In this group, 63% had one recurrence, 30% had two recurrences, and 7% had three recurrences. The median duration of ANP and ITT was 12 weeks and the median dosage of ANP A10 was 6.52 g/kg/d and ANP AS2-1 was 0.23 g/kg/d. Responses were assessed by gadolinium-enhanced magnetic resonance imaging (MRI) repeated every eight weeks. In the ITT population, objective responses (ORs) were determined in 10% of cases (complete response—CR, and partial response—PR in 5% each). Progression-free survival (PFS) in ITT at six months was 17.5%. Overall survival (OS) was 28.3% at one year, 2.6% at two years, five and ten years. In the RGBM population, objective responses (ORs) were determined in 13.3% of cases (CR and PR in 6.7% each). PFS in RGBM at six months was 16.7%. OS was 34.7% at one year, 3.47% at two years, five?and ten years. In the ERGBM population, ORs were determined in 16.7% of cases (CR and PR in?8.3% each). PFS in ERGBM at six months was 20.8%, OS was 39.3% at one year, 4.4% at two years, five and ten years. The treatment was well-tolerated with reversible Grades 3 and 4 toxicity in 17.5% of patients (7 patients who experienced multiple toxicities) and no chronic toxicity. In conclusion, the study reached efficacy endpoint. ANP is well-tolerated and compares favorably to the current treatment for RGBM. 展开更多
关键词 Antineoplastons A10 and AS2-1 RECURRENT GLIOBLASTOMA MULTIFORME phase II Clinical TRIAL Survival in GLIOBLASTOMA
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Thermodynamic modeling and phase diagram prediction of salt lake brine systemsⅡ.Aqueous Li^(+)-Na^(+)-K^(+)-SO_(4)^(2-) and its subsystems 被引量:7
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作者 Huan Zhou Peng Wu +3 位作者 Wenxuan Li Xingfan Wang Kuo Zhou Qing Hao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第6期134-149,共16页
It is still a challenging task to accurately and temperature-continuously express the thermodynamic properties and phase equilibrium behaviors of the salt-lake brine with multi-component,multitemperature and high conc... It is still a challenging task to accurately and temperature-continuously express the thermodynamic properties and phase equilibrium behaviors of the salt-lake brine with multi-component,multitemperature and high concentration.The essential subsystem of sulfate type brine,aqueous Li^(+)-Na^(+)-K^(+)-SO_(4)^(2-) and its subsystems across a temperature range from 250 K to 643 K are investigated with the improved comprehensive thermodynamic model.Liquid parameters(Δg_(IJ),Δh_(IJ),and ΔC_(p,IJ))associated with the contributions of Gibbs energy,enthalpy,and heat capacity to the binary interaction parameters,i.e.the temperature coefficients of eNRTL parameters formulated with a Gibbs Helmholtz expression,are determined via multi-objective optimization method.The solid constantsΔ_(f)G_(k)°^((298.15))andΔ_(f)H_(k)°^((298.15))of11 solid species occurred in the quaternary system are rebuilt from multi-temperature solubilities.The modeling results show the accurate representation of(1)solution properties and binary phase diagram at temperature ranges from eutectic points to 643 K;(2)isothermal phase diagrams for Li_(2)SO_(4)-Na_(2)SO_(4)-H_(2)O,Li_(2)SO_(4)-K_(2)SO_(4)-H_(2)O and Na_(2)SO_(4)-K_(2)SO_(4)-H_(2)O ternary systems.The predicted results of complete structure and polythermal phase diagram of ternary systems and the isothermal phase diagrams of quaternary system excellently match with the experimental data. 展开更多
关键词 Aqueous electrolytes Comprehensive thermodynamic model Aqueous Li^(+)-Na^(+)-K^(+)-SO_(4)^(2-) phase diagram Thermodynamic properties
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A Phase II Study of Antineoplastons A10 and AS2-1 in Children with Recurrent, Refractory or Progressive Primary Brain Tumors—Final Report (Protocol BT-22) 被引量:11
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作者 Stanislaw R. Burzynski Tomasz J. Janicki +2 位作者 Gregory S. Burzynski Ania Marszalek Sheldon Brookman 《Journal of Cancer Therapy》 2014年第10期977-988,共12页
Primary malignant brain tumors are a leading cause of cancer-related death in children. This Phase II study evaluated the efficacy and safety of Antineoplastons A10 and AS2-1 (ANP) in children who developed progressio... Primary malignant brain tumors are a leading cause of cancer-related death in children. This Phase II study evaluated the efficacy and safety of Antineoplastons A10 and AS2-1 (ANP) in children who developed progression during standard treatment. A total of 43 children were recruited to the study, but only 41 met eligibility criteria. There were twelve cases of glioblastoma multiforme (GBM), eight anaplastic astrocytomas (AA), twelve diffuse intrinsic pontine gliomas (DIPG), three supertentorial primitive neuroectodermal tumors (sPNET), three cases of medulloblastoma and one case each of anaplastic ependymoma (AE), atypical teratoid rhabdoid tumor (AT/RT), and disseminated pilocytic astrocytoma (PAD). ANP was administered intravenously daily every four hours (median dose of A10 8.74 g/kg/d and AS2-1 0.35 g/kg/d), until objective response (OR) was documented, and then a further eight months. All enrolled patients were included in safety, but only eligible patients in the efficacy evaluation. A total of 12.2% of patients obtained OR;2.4% complete response (CR) and 9.8% partial response (PR). Stable disease (SD) was determined in 17.1% and progressive disease (PD) in 43.9% of cases. There were 26.8% of nonevaluable (NE) cases due to premature discontinuation. Out of five OR cases, four patients were diagnosed with recurrent DIPG and one with recurrent AA. Median progression-free survival (PFS) was 2.5 months. Median overall survival was 4.8 months. OS at 6 months was 46.3%, one year was 12.2%, and 4.8% at two, five, and ten years. The longest survivor is a patient diagnosed with DIPG and gliosarcoma who remains alive more than 15 years. A group of eleven patients reported grade 3 and 4 toxicity including hypernatremia in eight cases, somnolence in two cases, and hypokalemia in one case. There were no chronic toxicities, and the quality of life was very good. The largest group of patients were represented by DIPG, GBM, and AA. The best results were obtained in the DIPG and AA groups. In the DIPG group, CR was in 8.3%, PR was 25%, median PFS was 4.8 months, median OS was 6.1 months, and OS at 6 months was 58.3%, at one year 25%, and 8.3% at two, five, and ten years. In the AA group, PR was 12.5%, median PFS was 3.7 months, median OS was 4.7 months, and OS at 6 months was 37.5%, and 12.5%, at one, two, five, and ten years. In conclusion, antineoplastons showed efficacy and acceptable toxicity in patients with recurrent, refractory or progressive primary brain tumors. 展开更多
关键词 Anaplastic Astrocytoma Antineoplastons A10 and AS2-1 Brainstem GLIOMA Diffuse Intrinsic PONTINE GLIOMA (DIPG) GLIOSARCOMA phase II Clinical Trial RECURRENT GLIOMA
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A Phase II Study of Antineoplastons A10 and AS2-1 in Patients with Brainstem Gliomas. The Report on Non-Diffuse Intrinsic Pontine Glioma (Protocol BT-11) 被引量:3
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作者 Stanislaw R. Burzynski Tomasz J. Janicki +1 位作者 Gregory S. Burzynski Ania Marszalek 《Journal of Cancer Therapy》 2015年第4期334-344,共11页
Inoperable brainstem gliomas (BSG) are among the most difficult to treat malignancies. In the intent-to-treat (ITT) population of the BT-11 study for BSG, forty patients (median age 11.2 years old) were enrolled. Anti... Inoperable brainstem gliomas (BSG) are among the most difficult to treat malignancies. In the intent-to-treat (ITT) population of the BT-11 study for BSG, forty patients (median age 11.2 years old) were enrolled. Antineoplastons A10 and AS2-1 (ANP) were administered intravenously daily. The median daily dose of A10 was 8.70 g/kg/day and AS2-1 was 0.32 g/kg/day. Efficacy analyses were conducted in two subgroups: recurrent pediatric diffuse intrinsic pontine glioma (RPDIPG, N?= 17) and non-diffuse intrinsic pontine glioma (NDIPG, N?= 11). This paper reports the results of the study of the efficacy and safety of ANP in patients with NDIPG. The results in the RPDIPG group were reported before;complete response (CR) was 6%, partial response (PR) 23.5%, and stable disease (SD) 17.6%. One year overall survival (OS) was 29.4%, 2 years 11.8%, and 5, 10, and 15 years 6%. In the NDIPG group, there were 36% CR and 27.5% SD. OS at 1, 5, 10, and 15 years was 82%, 73%, 62%, and 50% correspondingly. There was only one serious adverse event (9%) reported in NDIPG represented by hypokalemia, Grade 4. The results suggest that ANP shows efficacy and an acceptable tolerability profile in patients with RPDIPG and NDIPG. 展开更多
关键词 Antineoplastons A10 and AS2-1 BRAINSTEM GLIOMA DIFFUSE Intrinsic PONTINE GLIOMA phase 2 Clinical Trial RECURRENT GLIOMA
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Synergistic Effect in Mixed Capillary Gas Chromatographic Stationap Phases Containing Heptakis(2,3,6-tri-o-pentyl)-β-cyclodextrin and Dibenzo-18-crown-6 被引量:1
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作者 Li Ming YUAN Ruo Nong FU +3 位作者 Xue Xian CHEN Shi Hong GUl Rong Ji DAI (Chemistry Department of Yunnan Normal University.Kunming 650092)(Department of Chemical Engineering.Beijing institute of Technology,BEijing 100081)(Solar Energy Research Institute ofyunna 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第3期223-226,共4页
used-silical capillary columns containing heptakis(2、3、6-tri-o-pentyl)-β-cyclodextrinand dibenzo-18-crown-6 were prepared.By studying the selectivity of mixed stationary phases forsome solute pairs.as well a... used-silical capillary columns containing heptakis(2、3、6-tri-o-pentyl)-β-cyclodextrinand dibenzo-18-crown-6 were prepared.By studying the selectivity of mixed stationary phases forsome solute pairs.as well as comparing with the heptakis(2.3、6-tri-O-pentyl)-β-cyclodextrin and thedibenzo-18-crown-6 used as individual stationary phase、the synergistic effects were observed.These effects were affected by the column temperature.mixed ratio and linear velocity of carrier gas. 展开更多
关键词 Gas chromatography mixed stationary phase synergistic effect heptakis(2.3.6-tri-o-pentyl)-β-cyclodextrin DIBENZO-18-CROWN-6
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A Phase II Study of Antineoplastons A10 and AS2-1 in Children with Low-Grade Astrocytomas—Final Report (Protocol BT-13) 被引量:1
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作者 Stanislaw R. Burzynski Tomasz J. Janicki Gregory S. Burzynski 《Journal of Cancer Therapy》 2016年第12期837-850,共14页
Nonresectable Low-Grade Astrocytomas (LGA) can compromise function and threaten life. For the majority of patients, the most appropriate strategy is initial chemotherapy followed by Radiation Therapy (RT). Since curat... Nonresectable Low-Grade Astrocytomas (LGA) can compromise function and threaten life. For the majority of patients, the most appropriate strategy is initial chemotherapy followed by Radiation Therapy (RT). Since curative treatment is not available for most of these patients, it is reasonable to conduct clinical studies to evaluate new agents. This Phase II study evaluates efficacy and safety of Antineoplastons A10 and AS2-1 (ANP) in LGA. Sixteen children diagnosed with LGA were treated. They included 12 males and 4 females, ages 1.6 - 17.4 years (median 10.6). Efficacy was evaluated in 16 patients. The majority of patients were previously treated, but 1 patient had stereotactic biopsy only. Out of the remaining 15 patients, 6 patients received chemotherapy, and 7 patients had surgery, and 2 patients received RT and chemotherapy after surgery. The patients received treatment with ANP administered daily every 4 hours (median dose of A10 was 7.71 g/kg/d and AS2-1 was 0.26 g/kg/d) until objective response or stable disease was documented and for 8 months thereafter. The duration of ANP IV ranged from 1.4 to 286 weeks with a median of 83 weeks. A complete response was documented in 25.0%, partial response in 12.5%, and stable disease in 37.5%. Overall survival was 67.7% at 5 years, and 54.2% at 10 and 15 years. Progression-free survival was 48.1%, 34.4% and 34.4% at 5, 10, and 15 years respectively. The treatment was associated with grade 3 or grade 4 Adverse Drug Experiences (ADE) in 6 patients. There were two hypernatremias of grade 4 (12%). Grade 3 ADE included urinary frequency (6%), fatigue (6%) and hypernatremia (6%). There were no chronic toxicities, and there was a high quality of survival. ANP shows efficacy with a very good toxicity profile in this cohort of children with low-grade astrocytoma. 展开更多
关键词 Antineoplastons A10 and AS2-1 ASTROCYTOMA Low-Grade Astrocytoma Low-Grade Glioma Pediatric Brain Tumors phase II Clinical Trial
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Solid-phase Synthesis of-Haloaldehydes from Polymer-supported 4-(Phenylseleno)morpholine
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作者 ShouRiSHENG LuLingWU XianHUANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第5期456-458,共3页
Polystyrene-supported 4-(phenylseleno)morpholine was synthesized and could be used as an efficient ?selenenylating agent for saturated aldehydes. ?Haloaldehydes were prepared by reaction of polystyrene-supported ?sel... Polystyrene-supported 4-(phenylseleno)morpholine was synthesized and could be used as an efficient ?selenenylating agent for saturated aldehydes. ?Haloaldehydes were prepared by reaction of polystyrene-supported ?selenoaldehydes with bromine or sulfuryl chloride in good yield and high purity. 展开更多
关键词 Solid phase organic synthesis (4-phenylseleno) morpholine -selenoaldehyde - haloaldehyde.
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X-ray diffraction study of effect of deposition conditions on α-β phase transition and stress evolution in sputter-deposited W coatings
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作者 王聪 Brault Pascal +2 位作者 Pineau Alain Plantin Pascale Thomann Anne-Lise 《Chinese Physics B》 SCIE EI CAS CSCD 2006年第2期432-436,共5页
Pure W and W-Cu-W trilayer coatings were deposited on an Fe substrate by d.c. magnetron sputtering. The α-β phase evolution, intragranular stress evolution in sputter-deposited W layer were investigated by x-ray dif... Pure W and W-Cu-W trilayer coatings were deposited on an Fe substrate by d.c. magnetron sputtering. The α-β phase evolution, intragranular stress evolution in sputter-deposited W layer were investigated by x-ray diffraction. They are directly related to the film microstructure, density and adhesion. Therefore, control of the film stress and phase component transition is essential for its applications. The phase component transition from β-W to α-W and intragranular stress evolution from tensile to compressive strongly depend on the deposition parameters and can be induced by lowering Ar pressure and rising target power. The compressively stressed films with α-W phase have a dense microstructure and high adhesion to Fe substrate. 展开更多
关键词 W coatings x-ray diffraction α-β phase component transition thin film stress
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Solid-Phase Stereoselective Synthesis of (E)-1, 2-Disubstituted Ethenes from Polymer-Sopported a-Selenoaldehydes
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作者 ShouRiSHENG LuLingWU XianHUANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第10期991-992,共2页
Reaction of polymer-supported a-selenoaldehydes with Grignard reagents afforded polymer-bound B-hydroxyalkyl selenides, which treated with thionyl chloride and triethylamine leading to (E)-1, 2-disubstituted ethenes i... Reaction of polymer-supported a-selenoaldehydes with Grignard reagents afforded polymer-bound B-hydroxyalkyl selenides, which treated with thionyl chloride and triethylamine leading to (E)-1, 2-disubstituted ethenes in good yield. 展开更多
关键词 Solid phase organic synthesis a-selenoaldehyde (E)-1 2-disubstituted ethene.
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Phase Composition Analysis of TiN-AI_2O_3Synthesized from Aluminum-containing Dross and Rutile by Aluminothermic Reductionnitridation Method
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作者 LIU Haitao MIN Xin +4 位作者 JI Haipeng XU Youguo FANG Minghao LIU Yangai HUANG Zhaohui 《China's Refractories》 CAS 2014年第3期40-43,共4页
TiN- Al2O3 composite powder was prepared by aluminothermic reduction- nitridation method with starting materials of aluminum-containing dross and rutile,and metallic aluminum in the aluminum-containing dross as reduce... TiN- Al2O3 composite powder was prepared by aluminothermic reduction- nitridation method with starting materials of aluminum-containing dross and rutile,and metallic aluminum in the aluminum-containing dross as reducer. The influences of synthesis temperature(600-1 400 ℃) and aluminum-containing dross addition(20% lower than theoretical value,theoretical value,20% higher than theoretical value,and 50% higher than theoretical value) on phase compositions and microstructure of the composites were investigated,and the reaction mechanism was analyzed. The results show that(1) TiN- Al2O3 composite powder can be synthesized under the experimental conditions; the main phases are TiN,α-Al2O3,a little bytownite,and MgAl2O4;(2)enhancing synthesis temperature or increasing aluminumcontaining dross addition favors the reaction of aluminothermic reduction- nitridation;(3) in the synthesized products,α-Al2O3 is platy or columnar; TiN is sub-micron granular,which reinforces and toughens the composite. 展开更多
关键词 aluminum-containing dross futile alumi-nothermic reduction - nitridation titanium nitride -alurnina composite powder phase compositions
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Residue Upgrading in Slurry Phase over Ultra-fine NiMo/γ-Al_2O_3 Catalyst
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作者 Tong Fengya Yang Qinghe +2 位作者 Li Dadong Dai Lishun Deng Zhonghuo 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2015年第3期1-6,共6页
In this article, residual oil hydroconversion was studied in slurry phase in the presence of fine solid Ni Mo/γ-Al2O3 catalyst and the effects of operating conditions were carefully studied. The results showed that r... In this article, residual oil hydroconversion was studied in slurry phase in the presence of fine solid Ni Mo/γ-Al2O3 catalyst and the effects of operating conditions were carefully studied. The results showed that residue conversion was only affected by the reaction temperature and reaction time. The coke yield increased with a higher reaction temperature, a bigger catalyst particle size, a longer reaction time, a lower initial hydrogen pressure and a lower catalyst concentration. Heteroatoms removal rate increased with a higher reaction temperature, a longer reaction time, a higher initial hydrogen pressure, a higher catalyst concentration, and a smaller catalyst particle size. The role of catalyst in the slurry bed technology was discussed and its function could be stated as follows: the metal was applied to activate the hydrogen atoms for removing heteroatoms and saturating aromatics, while the support of the catalyst was used to prevent the mesophase coalescence for reducing coke formation. 展开更多
关键词 slurry phase residual oil NiMo/γ- Al2O3 UPGRADING mechanism
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CALCULATION OF PHASE DIAGRAM FOR PSEUDOBINARY GaAs-InAs
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作者 Qiao, Huan Shen, Jianyun Li,Guoxun(General Research Institute for Nonferrous Metals, Beijing 100088)Chatillon, C(Laboratoire de Thermodynamique et Physico-chimie Metallurgiques ENSEEG,BP75,38402 St.martin d′H eres, France) 《中国有色金属学会会刊:英文版》 CSCD 1994年第4期25-28,共4页
CALCULATIONOFPHASEDIAGRAMFORPSEUDOBINARYGaAs-InAs¥Qiao,Huan;Shen,Jianyun;Li,Guoxun(GeneralResearchInstitutef... CALCULATIONOFPHASEDIAGRAMFORPSEUDOBINARYGaAs-InAs¥Qiao,Huan;Shen,Jianyun;Li,Guoxun(GeneralResearchInstituteforNonferrousMetal... 展开更多
关键词 GaAs-InAs - COMPOUND calculation of phase DIAGRAM MISCIBILITY gap
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