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IndRT-GCNets: Knowledge Reasoning with Independent Recurrent Temporal Graph Convolutional Representations
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作者 Yajing Ma Gulila Altenbek Yingxia Yu 《Computers, Materials & Continua》 SCIE EI 2024年第1期695-712,共18页
Due to the structural dependencies among concurrent events in the knowledge graph and the substantial amount of sequential correlation information carried by temporally adjacent events,we propose an Independent Recurr... Due to the structural dependencies among concurrent events in the knowledge graph and the substantial amount of sequential correlation information carried by temporally adjacent events,we propose an Independent Recurrent Temporal Graph Convolution Networks(IndRT-GCNets)framework to efficiently and accurately capture event attribute information.The framework models the knowledge graph sequences to learn the evolutionary represen-tations of entities and relations within each period.Firstly,by utilizing the temporal graph convolution module in the evolutionary representation unit,the framework captures the structural dependency relationships within the knowledge graph in each period.Meanwhile,to achieve better event representation and establish effective correlations,an independent recurrent neural network is employed to implement auto-regressive modeling.Furthermore,static attributes of entities in the entity-relation events are constrained andmerged using a static graph constraint to obtain optimal entity representations.Finally,the evolution of entity and relation representations is utilized to predict events in the next subsequent step.On multiple real-world datasets such as Freebase13(FB13),Freebase 15k(FB15K),WordNet11(WN11),WordNet18(WN18),FB15K-237,WN18RR,YAGO3-10,and Nell-995,the results of multiple evaluation indicators show that our proposed IndRT-GCNets framework outperforms most existing models on knowledge reasoning tasks,which validates the effectiveness and robustness. 展开更多
关键词 Knowledge reasoning entity and relation representation structural dependency relationship evolutionary representation temporal graph convolution
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Learning Dual-Layer User Representation for Enhanced Item Recommendation
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作者 Fuxi Zhu Jin Xie Mohammed Alshahrani 《Computers, Materials & Continua》 SCIE EI 2024年第7期949-971,共23页
User representation learning is crucial for capturing different user preferences,but it is also critical challenging because user intentions are latent and dispersed in complex and different patterns of user-generated... User representation learning is crucial for capturing different user preferences,but it is also critical challenging because user intentions are latent and dispersed in complex and different patterns of user-generated data,and thus cannot be measured directly.Text-based data models can learn user representations by mining latent semantics,which is beneficial to enhancing the semantic function of user representations.However,these technologies only extract common features in historical records and cannot represent changes in user intentions.However,sequential feature can express the user’s interests and intentions that change time by time.But the sequential recommendation results based on the user representation of the item lack the interpretability of preference factors.To address these issues,we propose in this paper a novel model with Dual-Layer User Representation,named DLUR,where the user’s intention is learned based on two different layer representations.Specifically,the latent semantic layer adds an interactive layer based on Transformer to extract keywords and key sentences in the text and serve as a basis for interpretation.The sequence layer uses the Transformer model to encode the user’s preference intention to clarify changes in the user’s intention.Therefore,this dual-layer user mode is more comprehensive than a single text mode or sequence mode and can effectually improve the performance of recommendations.Our extensive experiments on five benchmark datasets demonstrate DLUR’s performance over state-of-the-art recommendation models.In addition,DLUR’s ability to explain recommendation results is also demonstrated through some specific cases. 展开更多
关键词 User representation latent semantic sequential feature INTERPRETABILITY
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C-CORE:Clustering by Code Representation to Prioritize Test Cases in Compiler Testing
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作者 Wei Zhou Xincong Jiang Chuan Qin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期2069-2093,共25页
Edge devices,due to their limited computational and storage resources,often require the use of compilers for program optimization.Therefore,ensuring the security and reliability of these compilers is of paramount impo... Edge devices,due to their limited computational and storage resources,often require the use of compilers for program optimization.Therefore,ensuring the security and reliability of these compilers is of paramount importance in the emerging field of edge AI.One widely used testing method for this purpose is fuzz testing,which detects bugs by inputting random test cases into the target program.However,this process consumes significant time and resources.To improve the efficiency of compiler fuzz testing,it is common practice to utilize test case prioritization techniques.Some researchers use machine learning to predict the code coverage of test cases,aiming to maximize the test capability for the target compiler by increasing the overall predicted coverage of the test cases.Nevertheless,these methods can only forecast the code coverage of the compiler at a specific optimization level,potentially missing many optimization-related bugs.In this paper,we introduce C-CORE(short for Clustering by Code Representation),the first framework to prioritize test cases according to their code representations,which are derived directly from the source codes.This approach avoids being limited to specific compiler states and extends to a broader range of compiler bugs.Specifically,we first train a scaled pre-trained programming language model to capture as many common features as possible from the test cases generated by a fuzzer.Using this pre-trained model,we then train two downstream models:one for predicting the likelihood of triggering a bug and another for identifying code representations associated with bugs.Subsequently,we cluster the test cases according to their code representations and select the highest-scoring test case from each cluster as the high-quality test case.This reduction in redundant testing cases leads to time savings.Comprehensive evaluation results reveal that code representations are better at distinguishing test capabilities,and C-CORE significantly enhances testing efficiency.Across four datasets,C-CORE increases the average of the percentage of faults detected(APFD)value by 0.16 to 0.31 and reduces test time by over 50% in 46% of cases.When compared to the best results from approaches using predicted code coverage,C-CORE improves the APFD value by 1.1% to 12.3% and achieves an overall time-saving of 159.1%. 展开更多
关键词 Compiler testing test case prioritization code representation
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HCRVD: A Vulnerability Detection System Based on CST-PDG Hierarchical Code Representation Learning
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作者 Zhihui Song Jinchen Xu +1 位作者 Kewei Li Zheng Shan 《Computers, Materials & Continua》 SCIE EI 2024年第6期4573-4601,共29页
Prior studies have demonstrated that deep learning-based approaches can enhance the performance of source code vulnerability detection by training neural networks to learn vulnerability patterns in code representation... Prior studies have demonstrated that deep learning-based approaches can enhance the performance of source code vulnerability detection by training neural networks to learn vulnerability patterns in code representations.However,due to limitations in code representation and neural network design,the validity and practicality of the model still need to be improved.Additionally,due to differences in programming languages,most methods lack cross-language detection generality.To address these issues,in this paper,we analyze the shortcomings of previous code representations and neural networks.We propose a novel hierarchical code representation that combines Concrete Syntax Trees(CST)with Program Dependence Graphs(PDG).Furthermore,we introduce a Tree-Graph-Gated-Attention(TGGA)network based on gated recurrent units and attention mechanisms to build a Hierarchical Code Representation learning-based Vulnerability Detection(HCRVD)system.This system enables cross-language vulnerability detection at the function-level.The experiments show that HCRVD surpasses many competitors in vulnerability detection capabilities.It benefits from the hierarchical code representation learning method,and outperforms baseline in cross-language vulnerability detection by 9.772%and 11.819%in the C/C++and Java datasets,respectively.Moreover,HCRVD has certain ability to detect vulnerabilities in unknown programming languages and is useful in real open-source projects.HCRVD shows good validity,generality and practicality. 展开更多
关键词 Vulnerability detection deep learning CST-PDG code representation tree-graph-gated-attention network CROSS-LANGUAGE
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Oxygen Reduction Reaction Activity of Fe-based Dual-Atom Catalysts with Different Local Configurations via Graph Neural Representation
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作者 Xueqian Xia Zengying Ma Yucheng Huang 《Chinese Journal of Chemical Physics》 SCIE EI CAS CSCD 2024年第5期599-604,I0038-I0040,I0099,共10页
The performance of proton exchange membrane fuel cells depends heavily on the oxygen reduction reaction(ORR)at the cathode,for which platinum-based catalysts are currently the standard.The high cost and limited availa... The performance of proton exchange membrane fuel cells depends heavily on the oxygen reduction reaction(ORR)at the cathode,for which platinum-based catalysts are currently the standard.The high cost and limited availability of platinum have driven the search for alternative catalysts.While FeN4 single-atom catalysts have shown promising potential,their ORR activity needs to be further enhanced.In contrast,dual-atom catalysts(DACs)offer not only higher metal loading but also the ability to break the ORR scaling relations.However,the diverse local structures and tunable coordination environments of DACs create a vast chemical space,making large-scale computational screening challenging.In this study,we developed a graph neural network(GNN)-based framework to predict the ORR activity of Fe-based DACs,effectively addressing the challenges posed by variations in local catalyst structures.Our model,trained on a dataset of 180 catalysts,accurately predicted the Gibbs free energy of ORR intermediates and overpotentials,and identified 32 DACs with superior catalytic activity compared to FeN4 SAC.This approach not only advances the design of high-performance DACs,but also offers a powerful computational tool that can significantly reduce the time and cost of catalyst development,thereby accelerating the commercialization of fuel cell technologies. 展开更多
关键词 Oxygen reduction reaction Dual-atom catalyst Graph neural representation Density functional theory Artificial intelligence
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Representations of Hom-Jacobi-Jordan Algebras
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作者 LIU Zhiqing ZHANG Xiufu 《湖州师范学院学报》 2024年第10期7-13,共7页
Some relationships between the representation of Hom-Jacobi-Jordan algebra and that of Jacobi-Jordan algebra are studied.Moreover,by using the notion ofαk-anti-derivation,a property theorem of multiplicative Hom-Jaco... Some relationships between the representation of Hom-Jacobi-Jordan algebra and that of Jacobi-Jordan algebra are studied.Moreover,by using the notion ofαk-anti-derivation,a property theorem of multiplicative Hom-Jacobi-Jordan algebras is also given. 展开更多
关键词 Jacobi-Jordan algebra Hom-Jacobi-Jordan algebra representation anti-derivation
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Wigner function of optical cumulant operator and its dissipation in thermo-entangled state representation
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作者 张科 李兰兰 范洪义 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期205-210,共6页
To conveniently calculate the Wigner function of the optical cumulant operator and its dissipation evolution in a thermal environment, in this paper, the thermo-entangled state representation is introduced to derive t... To conveniently calculate the Wigner function of the optical cumulant operator and its dissipation evolution in a thermal environment, in this paper, the thermo-entangled state representation is introduced to derive the general evolution formula of the Wigner function, and its relation to Weyl correspondence is also discussed. The method of integration within the ordered product of operators is essential to our discussion. 展开更多
关键词 Wigner function optical cumulant operator dissipation evolution thermo-entangled state representation integration within ordered product of operators
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Efficient simulation of spatially correlated non-stationary ground motions by wavelet-packet algorithm and spectral representation method
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作者 Ji Kun Cao Xuyang +1 位作者 Wang Suyang Wen Ruizhi 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第4期799-814,共16页
Although the classical spectral representation method(SRM)has been widely used in the generation of spatially varying ground motions,there are still challenges in efficient simulation of the non-stationary stochastic ... Although the classical spectral representation method(SRM)has been widely used in the generation of spatially varying ground motions,there are still challenges in efficient simulation of the non-stationary stochastic vector process in practice.The first problem is the inherent limitation and inflexibility of the deterministic time/frequency modulation function.Another difficulty is the estimation of evolutionary power spectral density(EPSD)with quite a few samples.To tackle these problems,the wavelet packet transform(WPT)algorithm is utilized to build a time-varying spectrum of seed recording which describes the energy distribution in the time-frequency domain.The time-varying spectrum is proven to preserve the time and frequency marginal property as theoretical EPSD will do for the stationary process.For the simulation of spatially varying ground motions,the auto-EPSD for all locations is directly estimated using the time-varying spectrum of seed recording rather than matching predefined EPSD models.Then the constructed spectral matrix is incorporated in SRM to simulate spatially varying non-stationary ground motions using efficient Cholesky decomposition techniques.In addition to a good match with the target coherency model,two numerical examples indicate that the generated time histories retain the physical properties of the prescribed seed recording,including waveform,temporal/spectral non-stationarity,normalized energy buildup,and significant duration. 展开更多
关键词 non-stationarity time-varying spectrum wavelet packet transform(WPT) spectral representation method(SRM) response spectrum spatially varying recordings
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Localization in modified polar representation: hybrid measurements and closed-form solution
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作者 CONG Xunchao SUN Yimao +2 位作者 YANG Yanbing ZHANG Lei CHEN Liangyin 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期575-588,共14页
Classical localization methods use Cartesian or Polar coordinates, which require a priori range information to determine whether to estimate position or to only find bearings. The modified polar representation (MPR) u... Classical localization methods use Cartesian or Polar coordinates, which require a priori range information to determine whether to estimate position or to only find bearings. The modified polar representation (MPR) unifies near-field and farfield models, alleviating the thresholding effect. Current localization methods in MPR based on the angle of arrival (AOA) and time difference of arrival (TDOA) measurements resort to semidefinite relaxation (SDR) and Gauss-Newton iteration, which are computationally complex and face the possible diverge problem. This paper formulates a pseudo linear equation between the measurements and the unknown MPR position,which leads to a closed-form solution for the hybrid TDOA-AOA localization problem, namely hybrid constrained optimization(HCO). HCO attains Cramér-Rao bound (CRB)-level accuracy for mild Gaussian noise. Compared with the existing closed-form solutions for the hybrid TDOA-AOA case, HCO provides comparable performance to the hybrid generalized trust region subproblem (HGTRS) solution and is better than the hybrid successive unconstrained minimization (HSUM) solution in large noise region. Its computational complexity is lower than that of HGTRS. Simulations validate the performance of HCO achieves the CRB that the maximum likelihood estimator (MLE) attains if the noise is small, but the MLE deviates from CRB earlier. 展开更多
关键词 LOCALIZATION modified polar representation time difference of arrival(TDOA) angle of arrival(AOA) closed-form solution
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GNN Representation Learning and Multi-Objective Variable Neighborhood Search Algorithm for Wind Farm Layout Optimization
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作者 Yingchao Li JianbinWang HaibinWang 《Energy Engineering》 EI 2024年第4期1049-1065,共17页
With the increasing demand for electrical services,wind farm layout optimization has been one of the biggest challenges that we have to deal with.Despite the promising performance of the heuristic algorithm on the rou... With the increasing demand for electrical services,wind farm layout optimization has been one of the biggest challenges that we have to deal with.Despite the promising performance of the heuristic algorithm on the route network design problem,the expressive capability and search performance of the algorithm on multi-objective problems remain unexplored.In this paper,the wind farm layout optimization problem is defined.Then,a multi-objective algorithm based on Graph Neural Network(GNN)and Variable Neighborhood Search(VNS)algorithm is proposed.GNN provides the basis representations for the following search algorithm so that the expressiveness and search accuracy of the algorithm can be improved.The multi-objective VNS algorithm is put forward by combining it with the multi-objective optimization algorithm to solve the problem with multiple objectives.The proposed algorithm is applied to the 18-node simulation example to evaluate the feasibility and practicality of the developed optimization strategy.The experiment on the simulation example shows that the proposed algorithm yields a reduction of 6.1% in Point of Common Coupling(PCC)over the current state-of-the-art algorithm,which means that the proposed algorithm designs a layout that improves the quality of the power supply by 6.1%at the same cost.The ablation experiments show that the proposed algorithm improves the power quality by more than 8.6% and 7.8% compared to both the original VNS algorithm and the multi-objective VNS algorithm. 展开更多
关键词 GNN representation learning variable neighborhood search multi-objective optimization wind farm layout point of common coupling
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Multi-Modal Medical Image Fusion Based on Improved Parameter Adaptive PCNN and Latent Low-Rank Representation
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作者 Zirui Tang Xianchun Zhou 《Instrumentation》 2024年第2期53-63,共11页
Multimodal medical image fusion can help physicians provide more accurate treatment plans for patients, as unimodal images provide limited valid information. To address the insufficient ability of traditional medical ... Multimodal medical image fusion can help physicians provide more accurate treatment plans for patients, as unimodal images provide limited valid information. To address the insufficient ability of traditional medical image fusion solutions to protect image details and significant information, a new multimodality medical image fusion method(NSST-PAPCNNLatLRR) is proposed in this paper. Firstly, the high and low-frequency sub-band coefficients are obtained by decomposing the source image using NSST. Then, the latent low-rank representation algorithm is used to process the low-frequency sub-band coefficients;An improved PAPCNN algorithm is also proposed for the fusion of high-frequency sub-band coefficients. The improved PAPCNN model was based on the automatic setting of the parameters, and the optimal method was configured for the time decay factor αe. The experimental results show that, in comparison with the five mainstream fusion algorithms, the new algorithm has significantly improved the visual effect over the comparison algorithm,enhanced the ability to characterize important information in images, and further improved the ability to protect the detailed information;the new algorithm has achieved at least four firsts in six objective indexes. 展开更多
关键词 image fusion improved parameter adaptive pcnn non-subsampled shear-wave transform latent low-rank representation
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A FORMAL REPRESENTATION FOR FEATURE-BASED DESIGN 被引量:1
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作者 孙正兴 丁秋林 张福炎 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 1997年第1期37-46,共10页
Feature based design has been regarded as a promising approach for CAD/CAM integration.This paper aims to establish a domain independent representation formalism for feature based design in three aspects: formal re... Feature based design has been regarded as a promising approach for CAD/CAM integration.This paper aims to establish a domain independent representation formalism for feature based design in three aspects: formal representation,design process model and design algorithm.The implementing scheme and formal description of feature taxonomy,feature operator,feature model validation and feature transformation are given in the paper.The feature based design process model suited for either sequencial or concurrent engineering is proposed and its application to product structural design and process plan design is presented. Some general design algorithms for developing feature based design system are also addressed.The proposed scheme provides a formal methodology elementary for feature based design system development and operation in a structural way. 展开更多
关键词 CAD CAM product modelling design process feature based design representation formalism
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Representation Theory of Three-Dimensional Elliptical Crack Under Dynamic Loading
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作者 范天佑 《Journal of Beijing Institute of Technology》 EI CAS 2000年第2期138-141,共4页
The relation between the normal displacement on the surface of a dynamical elliptical crack and the normal stress over the crack surface was studied. The three dimensional elastodynamic equations and Fourier Laplace... The relation between the normal displacement on the surface of a dynamical elliptical crack and the normal stress over the crack surface was studied. The three dimensional elastodynamic equations and Fourier Laplace transforms are used. Based on the influence function and the inversion of integral transforms, one can find that if the distribution of normal displacement on the surface of a dynamic elliptical crack is a polynomial of degree n in x 1 and x 2 , then the normal pressure acting over the ellipse is also a polynomial P n(x 1,x 2) of the same degree in x 1 and x 2 . 展开更多
关键词 dynamic elliptical crack ELASTODYNAMICS integral transforms representation theory
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Inhomogeneous Differential Realization, Boson-Fermion Realization of OSP(2,1) Superalgebra and Its Representations
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作者 陈永清 《深圳信息职业技术学院学报》 2000年第2期80-85,共6页
Homogeneous and inhornogeneous differential realizations of the OSP(2,1)superalgebra on the spaces of homogeneous and inhomogeneous polynomials and the corresponding boson-fermioii realizations are studied.The new ind... Homogeneous and inhornogeneous differential realizations of the OSP(2,1)superalgebra on the spaces of homogeneous and inhomogeneous polynomials and the corresponding boson-fermioii realizations are studied.The new indecomposable and irreducible representations of the OSP(2,1)are given on subspaces and quotient spaces of the universal enveloping algebras of Heisenberg-Weyl superalgebra.All the finite dimensional irreducible representation of the OSP(2,1)superalgebra is naturally obtained as special cases. 展开更多
关键词 Lie SUPERALGEBRAS INHOMOGENEOUS DIFFERENTIAL REALIZATION BOSON-FERMION REALIZATION Irreducible representation
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基于“微生物-肠-脑轴”探讨补肾通腑方对APP/PS1小鼠肠道菌群及LPS/TLR4/NF-κB通路的影响
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作者 王旭 张杰 +2 位作者 赵敏 宋晓雨 段建平 《中国药理学通报》 CAS 北大核心 2025年第1期171-178,共8页
目的探讨补肾通腑方调控肠道菌群,改善阿尔茨海默病(Alzheimer’s disease,AD)模型小鼠学习记忆能力的作用机制。方法以APP/PS1小鼠为研究对象,给予补肾通腑方治疗8周,采用Morris水迷宫法观察小鼠空间学习记忆能力变化;16S rDNA检测小... 目的探讨补肾通腑方调控肠道菌群,改善阿尔茨海默病(Alzheimer’s disease,AD)模型小鼠学习记忆能力的作用机制。方法以APP/PS1小鼠为研究对象,给予补肾通腑方治疗8周,采用Morris水迷宫法观察小鼠空间学习记忆能力变化;16S rDNA检测小鼠肠道菌群丰度、多样性变化;HE染色观察海马病理形态学变化;免疫荧光检测海马区小胶质细胞活化情况;Western blot检测TLR4、NF-κB、IL-6等炎症因子表达。结果与模型组相比,补肾通腑方可以缩短AD模型小鼠逃避潜伏期、游泳路径,增加跨越平台次数(P<0.05),提升肠道菌群多样性,调节肠道菌群丰度,促进海马神经元细胞损伤修复,降低iNOS/Iba1共表达,提高Arg1/Iba1共表达(P<0.01),促进小胶质细胞从M1型向M2型转化,下调TLR4、NF-κB、IL-6等促炎因子的表达。结论补肾通腑方改善AD模型小鼠学习记忆能力的作用机制可能与调节肠道菌群介导的LPS/TLR4/NF-κB通路,从而抑制促炎型小胶质细胞活化、减轻中枢神经系统炎症、改善海马区神经元细胞损伤有关。 展开更多
关键词 阿尔茨海默病 补肾通腑方 肠道菌群 LPS/TLR4/NF-κB通路 16S rDNA 微生物--脑轴
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需求不确定下的两阶段应急物流选址-路径研究
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作者 王庆荣 王雪娜 +1 位作者 朱昌锋 李裕杰 《灾害学》 北大核心 2025年第1期160-166,共7页
针对灾后应急救援在需求不确定和资源受限方面的问题,以多级应急物流网络为背景,构建了一个需求不确定下的两阶段应急选址-路径规划模型。该模型以总成本最小和救援车辆运输总距离最短为目标,采用三角模糊数刻画受灾点的不确定需求,并... 针对灾后应急救援在需求不确定和资源受限方面的问题,以多级应急物流网络为背景,构建了一个需求不确定下的两阶段应急选址-路径规划模型。该模型以总成本最小和救援车辆运输总距离最短为目标,采用三角模糊数刻画受灾点的不确定需求,并采用基于可信性的模糊机会约束规划方法,以消除约束条件中的不确定参数。模型第一阶段调用Gurobi求解器,求解得到应急配送中心选址结果和对受灾点的分配方案;第二阶段将选址及分配结果作为输入进行路径规划,并提出一种改进的自适应遗传算法(IAGA)对算例进行求解。然后采用自适应遗传算法(AGA)与之对比,并进行灵敏度分析。结果表明:IAGA在目标值、收敛速度和运行时间等方面均优于AGA,证明了IAGA具有一定的可行性和有效性,且可以为决策者提供较优的应急选址-路径规划方案,从而提升灾后救援的效率。 展开更多
关键词 应急物流 选址-路径问题 Gurobi 模糊需求 改进的自适应遗传算法
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SPME-Arrow/GC-MS结合多元统计分析研究不同批次爆珠香精组分差异
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作者 刘琪 张华 +4 位作者 叶远青 刘昌泽 袁益来 廖惠云 吴君章 《分析测试学报》 CAS 北大核心 2025年第1期135-144,共10页
以箭型固相微萃取(SPME-Arrow)为样品萃取手段,通过优化萃取头种类、氯化钠添加量、萃取温度、平衡时间及萃取时间等条件,构建了高效鉴定爆珠香精中挥发性及半挥发性化合物的箭型固相微萃取结合气相色谱-质谱联用(SPME-Arrow/GC-MS)法... 以箭型固相微萃取(SPME-Arrow)为样品萃取手段,通过优化萃取头种类、氯化钠添加量、萃取温度、平衡时间及萃取时间等条件,构建了高效鉴定爆珠香精中挥发性及半挥发性化合物的箭型固相微萃取结合气相色谱-质谱联用(SPME-Arrow/GC-MS)法。采用该方法对不同批次爆珠香精进行分析,结合主成分分析(PCA)、正交偏最小二乘-判别分析(OPLS-DA)及显著性F检验等多元统计分析手段,筛选显著性差异成分。结果表明:最佳萃取条件为优选DVB/CAR/PDMS萃取头,添加2.0 g氯化钠,在60℃下平衡50 min,萃取时间为40 min;经谱库检索结合保留指数辅助定性,共鉴定出96种挥发性、半挥发性组分,目标物峰面积的日间相对标准偏差(RSD)小于10%的色谱峰数量占总峰数量的92.7%,表明方法的重复性较好;从不同批次爆珠香精中共筛选出17个潜在差异化合物,通过显著性检验,确定10种显著性差异化合物,分别为α-蒎烯、柠檬烯、桉叶油醇、异胡薄荷醇、薄荷酮(含异构体)、新异薄荷醇、乙酸新薄荷酯、三辛酸甘油酯和二辛酸单癸酸甘油酯。该法可有效区分不同批次爆珠样品的组分差异,具有客观真实、准确可靠、可视化强等特点,能够为爆珠产品质量检验提供技术支持。 展开更多
关键词 箭型固相微萃取 气相色谱-质谱联用 多元统计分析 爆珠香精 差异化合物
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法舒地尔缓解β-淀粉样蛋白1-42诱导的SH-SY5Y细胞凋亡
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作者 郭敏芳 张慧宇 +3 位作者 章培军 苏琴 贾思玮 尉杰忠 《中国组织工程研究》 CAS 北大核心 2025年第23期4939-4946,共8页
背景:法舒地尔对阿尔茨海默病小鼠脑内的线粒体动力学有调节作用,并且可以抑制神经炎症,但能否调节线粒体自噬和NLRP3炎症小体进而减轻β-淀粉样蛋白毒性尚不清楚。目的:探究法舒地尔对β-淀粉样蛋白1-42诱导的人源神经母细胞瘤细胞株SH... 背景:法舒地尔对阿尔茨海默病小鼠脑内的线粒体动力学有调节作用,并且可以抑制神经炎症,但能否调节线粒体自噬和NLRP3炎症小体进而减轻β-淀粉样蛋白毒性尚不清楚。目的:探究法舒地尔对β-淀粉样蛋白1-42诱导的人源神经母细胞瘤细胞株SH-SY5Y凋亡和线粒体自噬以及NLRP3炎症小体的调节作用。方法:将SH-SY5Y细胞接种于孔板内,细胞贴壁后分3组干预:对照组不加入任何药物,模型组加入20μmol/L β-淀粉样蛋白1-42,法舒地尔组同时加入20μmol/L β-淀粉样蛋白1-42与15 mg/L法舒地尔,干预24 h后,采用MTT法检测细胞活性,TUNEL染色检测细胞凋亡,qRT-PCR和Western blot检测凋亡相关蛋白表达,免疫荧光染色和Western blot检测线粒体自噬相关蛋白表达,免疫荧光染色和Western blot检测NLRP3炎症小体相关蛋白表达。结果与结论:(1)与对照组比较,模型组细胞活性降低、凋亡率升高(P<0.05);与模型组比较,法舒地尔组细胞活性升高、凋亡率降低(P<0.05);(2)qRT-PCR和Western blot检测结果显示,与对照组比较,模型组细胞Bax mRNA与蛋白表达升高(P<0.05),Bcl-2 mRNA与蛋白表达降低(P<0.05);与模型组比较,法舒地尔组细胞Bax mRNA与蛋白表达降低(P<0.05),Bcl-2 mRNA与蛋白表达升高(P<0.05);(3)免疫荧光染色和Western blot检测结果显示,与对照组相比,模型组细胞PINK1、帕金森病蛋白和LC3蛋白表达降低(P<0.05),p62蛋白表达升高(P<0.05);与模型组相比,法舒地尔组细胞PINK1、帕金森病蛋白和LC3蛋白表达升高(P<0.05),p62蛋白表达降低(P<0.05);(4)免疫荧光染色和Western blot检测结果显示,与对照组相比,模型组细胞NLRP3、ASC、Caspase-1和白细胞介素1β蛋白表达升高(P<0.05);与模型组相比,法舒地尔组细胞NLRP3、ASC、Caspase-1和白细胞介素1β蛋白表达降低(P<0.05);(5)结果表明,法舒地尔可以减轻β-淀粉样蛋白1-42诱导的SH-SY5Y细胞凋亡,其机制可能与激活线粒体自噬且抑制NLRP3炎症小体激活有关。 展开更多
关键词 法舒地尔 Β-淀粉样蛋白 神经细胞 细胞凋亡 线粒体自噬 炎症小体
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真武汤介导lncRNA NEAT1/miR-31-5p/IGFBP7分子轴抑制慢性心力衰竭进程的机制研究
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作者 宁小康 张迎 +1 位作者 周永学 张立 《陕西中医》 CAS 2025年第1期8-12,共5页
目的:探讨真武汤通过lncRNA NEAT1/miR-31-5p/IGFBP7分子轴抑制慢性心力衰竭(CHF)进程的机制。方法:将雄性SD大鼠分为对照组、模型组、阳性对照组和真武汤低、中、高剂量组,每组各10只。除对照组外,其余各组采用腹腔注射阿霉素的方法建... 目的:探讨真武汤通过lncRNA NEAT1/miR-31-5p/IGFBP7分子轴抑制慢性心力衰竭(CHF)进程的机制。方法:将雄性SD大鼠分为对照组、模型组、阳性对照组和真武汤低、中、高剂量组,每组各10只。除对照组外,其余各组采用腹腔注射阿霉素的方法建立CHF模型,阳性对照组给予美托洛尔灌胃,真武汤低、中、高剂量组给予真武汤(生药含量6、12、18 g/kg)灌胃。检测各组大鼠左心室射血分数(LVEF)、左心室短轴缩短率(LVFS),血清脑钠肽(BNP)水平,心脏体重比,心肌病理改变,心肌中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平及lncRNA NEAT1、miR-31-5p、IGFBP7表达水平。培养大鼠心肌H9c2细胞,采用双荧光素酶报告基因实验检测lncRNA NEAT1靶向miR-31-5p、miR-31-5p靶向IGFBP7。结果:与模型组比较,真武汤低、中、高剂量组的LVEF、LVFS增加,血清BNP水平降低(P<0.05);与模型组比较,真武汤低、中、高剂量组的心肌TNF-α、IL-1β、MDA水平降低,SOD水平增加(P<0.05);与模型组比较,真武汤低、中、高剂量组的心肌lncRNA NEAT1、IGFBP7表达降低,miR-31-5p表达增加(P<0.05)。H9c2心肌细胞中,lncRNA NEAT1靶向miR-31-5p、miR-31-5p靶向IGFBP7。结论:真武汤可能通过lncRNA NEAT1/miR-31-5p/IGFBP7分子轴改善CHF大鼠心功能并减轻炎症反应、氧化应激反应。 展开更多
关键词 慢性心力衰竭 真武汤 超氧化物歧化酶 miR-31-5p 丙二醛
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Computation of the Rational Representation for Solutions of High-dimensional Systems 被引量:3
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作者 TAN CHANG ZHANG SHU-GONG 《Communications in Mathematical Research》 CSCD 2010年第2期119-130,共12页
This paper deals with the representation of the solutions of a polynomial system, and concentrates on the high-dimensional case. Based on the rational univari- ate representation of zero-dimensional polynomial systems... This paper deals with the representation of the solutions of a polynomial system, and concentrates on the high-dimensional case. Based on the rational univari- ate representation of zero-dimensional polynomial systems, we give a new description called rational representation for the solutions of a high-dimensional polynomial sys- tem and propose an algorithm for computing it. By this way all the solutions of any high-dimensional polynomial system can be represented by a set of so-called rational- representation sets. 展开更多
关键词 rational univariate representation high-dimensional ideal maximally independent set rational representation irreducible component
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