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A Cognitive Science Framework for the Analysis of Knowledge-Based Systems
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作者 Feng Shan (Department of Automatic Control Engineering, Huazhong University of Science and Technology, Wuhan,Hubei, 430074 PRC) 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1994年第2期60-67,共8页
The paper presents a cognitive science framework for the analysis of knowledge-based systems,including people, media. simulation and expert systems, resulting in a practical model for the procedures ofknowledge engine... The paper presents a cognitive science framework for the analysis of knowledge-based systems,including people, media. simulation and expert systems, resulting in a practical model for the procedures ofknowledge engineering. Starting with the construct of a social organization model driven by anticipationand thed differentiating this into pesonal scientists with diverse relations to people and their internal andexternal communication, it provides powerful and general model of society. people, and the roles of peoplein society. This model extends naturally ic the role of conventional media in the knowledge processes ofsociety and the new roles of computer-based simulation and expert systems. In particular it provides amodel of knowledge transfer that enables the processes of knowledge engineering to be analyzed andautomated. 展开更多
关键词 cognitive modeling Knowledge-based systems Knowledge engineering Communal scientist Media.
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Research on Cognitive Cooperation in Multi-Agent Systems
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作者 SUN Juan DOU Wan-chun 《Wuhan University Journal of Natural Sciences》 EI CAS 2006年第1期278-282,共5页
The accomplishment of a complex problem usually involves cooperation between participators with different knowledge background concerned. This paper identifies interdependency between different sub problems (through ... The accomplishment of a complex problem usually involves cooperation between participators with different knowledge background concerned. This paper identifies interdependency between different sub problems (through problem decomposition) as the major factor that influences cooperative relations in multi-Agent systems, based on which we propose an efficient means to measure cooperation coefficient (degree) between different Agents. Then cognitive cooperation between Agents is analyzed which aims at collecting the wisdom of the cognitive community for a systematic solution to the overall problem. 展开更多
关键词 multi-Agent systems cognitive cooperation knowledge flow
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Relay Selection and Power Allocation in Amplify-and-Forward Cognitive Radio Systems Based on Spectrum Sharing
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作者 Daqian Zhao Zhizhong Zhang Fang Cheng 《Communications and Network》 2013年第3期380-385,共6页
In this paper, we consider a spectrum sharing scheme that is a joint optimization of relay selection and power allocation at the secondary transmitter, which aims to achieve the maximum possible throughput for the sec... In this paper, we consider a spectrum sharing scheme that is a joint optimization of relay selection and power allocation at the secondary transmitter, which aims to achieve the maximum possible throughput for the secondary user. This paper considers the scenario where the primary user is incapable of supporting its target signal-to-noise ratio (SNR). More especially, the secondary transmitter tries to assist the primary user with achieving its target SNR by cooperative amplify-and-forward (AF) relaying with two-phase. By exhaustive search for all candidate secondary transmitters, an optimal secondary transmitter can be selected, which not only can satisfy the primary user’s target SNR, but also maximize the secondary user’s throughput. The optimal secondary transmitter acts as a relay for the primary user by allocating a part of its power to amplify-and-forward the primary signal over the primary user’s licensed spectrum bands. At the same time, as a reward, the optimal secondary transmitter uses the remaining power to transmit its own signal over the remaining licensed spectrum bands. Thus, the secondary user obtains the spectrum access opportunities. Besides, there is no interference between the primary user and the secondary user. We study the joint optimization of relay selection and power allocation such that the secondary user’s throughput is maximized on the condition that it satisfies the primary user’s target SNR. From the simulation, it is shown that the joint optimization of relay selection and power allocation provides a significant throughput gain compared with random relay selection with optimal power allocation (OPA) and random relay selection with water-filling power allocation (WPA). Moreover, the simulation results also shown that our spectrum sharing scheme obtains the win-win solution for the primary system and the secondary system. 展开更多
关键词 Spectrum SHARING Cooperative Communication RELAY Selection Power ALLOCATION THROUGHPUT Maxi-mum Ratio Combining cognitive Radio systems
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Improving Audit Judgment and Decision Making With Dual Systems Cognitive Model
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作者 Philip Yim Kwong Cheng 《Journal of Modern Accounting and Auditing》 2011年第10期1060-1069,共10页
This article proposes a dual system cognitive reasoning model to enhance audit judgment and decision making. The model is built on the fact that the total cognitive capacity of an individual comprises two systems of r... This article proposes a dual system cognitive reasoning model to enhance audit judgment and decision making. The model is built on the fact that the total cognitive capacity of an individual comprises two systems of reasoning--System 1 that is unconscious, associative, implicit, more emotional and less controlled, and so forth; and System 2 that is conscious, explicit, deliberate and rule-governed, and so forth. The benefits of the proposed model that integrates these two complementary and compensatory systems are first illustrated with an example in audit planning, and second explained how the model could overcome the deficiencies of heuristics specifically in an audit context. 展开更多
关键词 dual cognitive systems audit judgment and decision HEURISTICS
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A Fuzzy Expert System Architecture for Intelligent Tutoring Systems:A Cognitive Mapping Approach
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作者 Mohammad Hossein Fazel Zarandi Mahdi Khademian +1 位作者 Behrouz Minaei-Bidgoli Ismail Burhan Turksen 《Journal of Intelligent Learning Systems and Applications》 2012年第1期29-40,共12页
An Intelligent Tutoring System (ITS) is a computer based instruction tool that attempts to provide individualized instructions based on learner’s educational status. Advances in development of these systems have rose... An Intelligent Tutoring System (ITS) is a computer based instruction tool that attempts to provide individualized instructions based on learner’s educational status. Advances in development of these systems have rose and fell since their emergence. Perhaps the main reason for this is the absence of appropriate framework for ITS development. This paper proposes a framework for designing two main parts of ITSs. Besides development framework, the second main reason for lack of significant advances in ITS development is its development cost. In general, this cost for instructional material is quite high and it becomes more in ITS development. The proposed method can significantly reduce the development cost. The cost reduction mainly is because of characteristics of applied mapping techniques. These maps are human readable and easily understandable by people who are not aware of knowledge representation techniques. The proposed framework is implemented for a graduate course at a technical university in Asia. This experiment provides an individualized instruction which is the main designing purpose of the ITSs. 展开更多
关键词 Concept Mapping EXPERT and STUDENT Models Fuzzy cognitive MAPS Intelligent TUTORING systems EXPERT systems
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A New Control Strategy for Modeling Wind Energy Systems Using Fuzzy Cognitive Maps
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作者 Peter Groumpos Vaia Gkountroumani 《Journal of Energy and Power Engineering》 2014年第11期1859-1868,共10页
Wind energy is currently a fast-growing interdisciplinary field that encompasses many different branches of engineering and science. Modeling and controlling wind energy systems are difficult and challenging problems.... Wind energy is currently a fast-growing interdisciplinary field that encompasses many different branches of engineering and science. Modeling and controlling wind energy systems are difficult and challenging problems. The basic structure of wind turbines and some wind control system methods are briefly reviewed. The need for using advanced theories from fuzzy and intelligent systems in studying wind energy systems is identified and justified. FCMs (fuzzy cognitive maps) are used to model wind energy systems. Simulation studies are performed and obtained results are discussed. A new mathematical approach has been proposed to model dynamical complex systems, the DYFUKN (dynamic fuzzy knowledge networks). Many open problems in the areas of modeling and controlling wind energy systems are outlined. 展开更多
关键词 MODELING CONTROL energy systems wind generators fuzzy cognitive maps.
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A Spectrum Occupancy Model for Primary Users in Cognitive Radio Systems
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作者 Yingying Cao Yiqian Zhao Haihua Li 《Journal of Computer and Communications》 2023年第11期78-86,共9页
There are abundant research results related to cognitive radio systems (CR systems), but using queueing models to portray CR systems is a new research trend. In this paper, a single-server retrial cognitive radio syst... There are abundant research results related to cognitive radio systems (CR systems), but using queueing models to portray CR systems is a new research trend. In this paper, a single-server retrial cognitive radio system with a linear retrial rate has been considered. The system has two types of users: primary users and secondary users. Secondary users have no effect on primary users because primary users have preemptive precedence. As a result, our purpose is to examine some performance indicators such as the expected queue length for primary users, the probability of the system being idle or occupied by a secondary user, and the probability of the system being busy. This paper begins by deriving the expressions for the generating functions based on the balance equations, so that we can calculate our goal conveniently. 展开更多
关键词 cognitive Radio system Retrial Queue RENEGING Stable-State Distribution
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Analysis of the Validity and Reliability of the Das-Naglieri CAS (Cognitive Assessment System)-Arabic Edition 被引量:1
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作者 Nazeh Natur 《Psychology Research》 2014年第7期525-540,共16页
关键词 评估系统 可靠性 CAS 阿拉伯语 语言翻译 以色列 学龄儿童 交叉验证
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Improving the Reliability of Unmanned Aircraft System Wireless Communications through Cognitive Radio Technology
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作者 Hector Reyes Naima Kaabouch 《Communications and Network》 2013年第3期225-230,共6页
Unmanned Aircraft System networks are a special type of networks where high speeds of the nodes, long distances and radio spectrum scarcity pose a number of challenges. In these networks, the strength of the transmitt... Unmanned Aircraft System networks are a special type of networks where high speeds of the nodes, long distances and radio spectrum scarcity pose a number of challenges. In these networks, the strength of the transmitted/received signals varies due to jamming, multipath propagation, and the changing distance among nodes. High speeds cause another problem, Doppler Effect, which produces a shifting of the central frequency of the signal at the receiver. In this paper we discuss a modular system based on cognitive to enhance the reliability of UAS networks. 展开更多
关键词 UAS INTELLIGENT Communication systems cognitive RADIO Reliability
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Investigation of system structure and information processing mechanism for cognitive skywave over-the-horizon radar 被引量:8
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作者 Xia Wu Jianwen Chen Kun Lu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第4期797-806,共10页
Based on the cognitive radar concept and the basic connotation of cognitive skywave over-the-horizon radar(SWOTHR), the system structure and information processingmechanism about cognitive SWOTHR are researched. Amo... Based on the cognitive radar concept and the basic connotation of cognitive skywave over-the-horizon radar(SWOTHR), the system structure and information processingmechanism about cognitive SWOTHR are researched. Amongthem, the hybrid network system architecture which is thedistributed configuration combining with the centralized cognition and its soft/hardware framework with the sense-detectionintegration are proposed, and the information processing framebased on the lens principle and its information processing flowwith receive-transmit joint adaption are designed, which buildand parse the work law for cognition and its self feedback adjustment with the lens focus model and five stages informationprocessing sequence. After that, the system simulation andthe performance analysis and comparison are provided, whichinitially proves the rationality and advantages of the proposedideas. Finally, four important development ideas of futureSWOTHR toward "high frequency intelligence information processing system" are discussed, which are scene information fusion, dynamic reconfigurable system, hierarchical and modulardesign, and sustainable development. Then the conclusion thatthe cognitive SWOTHR can cause the performance improvement is gotten. 展开更多
关键词 cognitive radar skywave over-the-horizon radar system structure intelligence information processing information fusion target detection
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A Hybrid Reconfigurable Antenna Design for Cognitive Radio System—Combination of Sensing and Reconfigurable Antennas
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作者 Yahya S. H. Khraisat Nedal Al-Tawalbeh +1 位作者 Imad A. Abdel-Hafez Ebrahim Shibly 《Journal of Electromagnetic Analysis and Applications》 2013年第8期328-332,共5页
This paper presents a modification of an existing cognitive antenna design which contains two antennas: one is a sensing that covers the band from 1 - 11 GHz and the other is a hybrid triangular reconfigurable antenna... This paper presents a modification of an existing cognitive antenna design which contains two antennas: one is a sensing that covers the band from 1 - 11 GHz and the other is a hybrid triangular reconfigurable antenna. Two antennas are combined together to create a new design which called Cognitive Antenna. The new shape of the reconfigurable antenna will affect the cognitive antenna so as to work at two different frequencies via rotation by 180°. At each rotation, the antenna takes single frequency from number of possible frequencies that sensing antenna would find. 展开更多
关键词 RECONFIGURABLE ANTENNA SENSING ANTENNA HYBRID COMBINATION cognitive Radio system
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The Effect of Brief, Low-Intensity Stretching Gymnastics on Autonomic Nervous System Activity and Cognitive Function
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作者 Hisashi Mitsuishi 《Health》 CAS 2022年第12期1274-1286,共13页
Purpose: Stretching exercise and gymnastics both have beneficial effects, such as improvement of autonomic nervous system activity and mood. Additionally, studies on the effects of exercise on cognitive function have ... Purpose: Stretching exercise and gymnastics both have beneficial effects, such as improvement of autonomic nervous system activity and mood. Additionally, studies on the effects of exercise on cognitive function have been conducted covering a wide range of age groups and have attracted much attention. However, conventional studies have set up programs with implementation times of 20 to 30 minutes. Therefore, shorter stretching programs are needed in order to fit them more easily into one’s free time. We examined the effects of a short 7-minute stretching gymnastics regime on the autonomic nervous system activity and cognitive function in 21 healthy participants. Methods: In this study, the participants performed a 10-minute cognitive task, followed by either Stretch Well Gymnastics, Stretch Band Gymnastics, or Radio Gymnastics sessions on different days. The participants then performed the cognitive task again. Heart rate was measured continuously throughout the experiment and we analyzed the heart rate variability. The cognitive tasks completed by all of the participants were evaluated for inhibitory control and cognitive flexibility. Results: A significant increase was shown in the sympathetic nerve activity during the Stretch Well Gymnastics, compared to the Radio Gymnastics and Stretch Band Gymnastics. Parasympathetic nerve levels were significantly increased after the gymnastics, compared to during the gymnastics, although there were no significant differences between any of the tasks. Additionally, in both the Stroop task and the number-Letter task, reaction times were faster in all of the sessions. In particular, the Stroop task showed the highest values for the Radio Gymnastics sessions, with marginally significantly lower scores for the Stretch Well Gymnastics sessions. Conclusion: The results showed that these heart rate variability responses supported the effects of autonomic activity associated with conventional low-intensity exercise. Additionally, stretching gymnastics for less than 10 minutes showed a positive effect on inhibitory function and cognitive flexibility. 展开更多
关键词 Stretching Gymnastics Autonomic Nervous system cognitive Function Stretch Well Gymnastics
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A Cognitive Memory-Augmented Network for Visual Anomaly Detection 被引量:7
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作者 Tian Wang Xing Xu +1 位作者 Fumin Shen Yang Yang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第7期1296-1307,共12页
With the rapid development of automated visual analysis,visual analysis systems have become a popular research topic in the field of computer vision and automated analysis.Visual analysis systems can assist humans to ... With the rapid development of automated visual analysis,visual analysis systems have become a popular research topic in the field of computer vision and automated analysis.Visual analysis systems can assist humans to detect anomalous events(e.g.,fighting,walking alone on the grass,etc).In general,the existing methods for visual anomaly detection are usually based on an autoencoder architecture,i.e.,reconstructing the current frame or predicting the future frame.Then,the reconstruction error is adopted as the evaluation metric to identify whether an input is abnormal or not.The flaws of the existing methods are that abnormal samples can also be reconstructed well.In this paper,inspired by the human memory ability,we propose a novel deep neural network(DNN)based model termed cognitive memory-augmented network(CMAN)for the visual anomaly detection problem.The proposed CMAN model assumes that the visual analysis system imitates humans to remember normal samples and then distinguishes abnormal events from the collected videos.Specifically,in the proposed CMAN model,we introduce a memory module that is able to simulate the memory capacity of humans and a density estimation network that can learn the data distribution.The reconstruction errors and the novelty scores are used to distinguish abnormal events from videos.In addition,we develop a two-step scheme to train the proposed model so that the proposed memory module and the density estimation network can cooperate to improve performance.Comprehensive experiments evaluated on various popular benchmarks show the superiority and effectiveness of the proposed CMAN model for visual anomaly detection comparing with the state-of-the-arts methods.The implementation code of our CMAN method can be accessed at https://github.com/CMANcode/CMAN_pytorch. 展开更多
关键词 cognitive computing density estimation MEMORY visual analysis systems visual anomaly detection.
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Towards a Theoretical Framework of Autonomous Systems Underpinned by Intelligence and Systems Sciences 被引量:2
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作者 Yingxu Wang Ming Hou +5 位作者 Konstantinos NPlataniotis Sam Kwong Henry Leung Edward Tunstel Imre JRudas Ljiljana Trajkovic 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第1期52-63,共12页
Autonomous systems are an emerging AI technology functioning without human intervention underpinned by the latest advances in intelligence,cognition,computer,and systems sciences.This paper explores the intelligent an... Autonomous systems are an emerging AI technology functioning without human intervention underpinned by the latest advances in intelligence,cognition,computer,and systems sciences.This paper explores the intelligent and mathematical foundations of autonomous systems.It focuses on structural and behavioral properties that constitute the intelligent power of autonomous systems.It explains how system intelligence aggregates from reflexive,imperative,adaptive intelligence to autonomous and cognitive intelligence.A hierarchical intelligence model(HIM)is introduced to elaborate the evolution of human and system intelligence as an inductive process.The properties of system autonomy are formally analyzed towards a wide range of applications in computational intelligence and systems engineering.Emerging paradigms of autonomous systems including brain-inspired systems,cognitive robots,and autonomous knowledge learning systems are described.Advances in autonomous systems will pave a way towards highly intelligent machines for augmenting human capabilities. 展开更多
关键词 Autonomous systems(AS) cognitive systems computational intelligence engineering paradigms intelligence science intelligent mathematics
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IDSS: Designing to Extend the Cognitive Limits 被引量:1
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作者 Feng, Shan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1993年第1期33-44,共12页
The paper presents the conceptual and operational basis of the creation of IDSS based on our recent research experience. In this paper, an intelligent decision support system, IDSS is defined as: any interactive syste... The paper presents the conceptual and operational basis of the creation of IDSS based on our recent research experience. In this paper, an intelligent decision support system, IDSS is defined as: any interactive system that is specially designed to improve the decision making of its user by extending the user's cognitive decision making abilities. As a result, this view of man-machine joint cognitive system stresses the need to use computational technology to aid the user in the decision making process. And the human's role is to achieve total systems's objectives. The paper outlines the designing procedure in successive steps. First, the decision maker's cognitive needs for decision support are identified. Second, the computationally realizable support functions are defined that could be provided by IDSS. Then, the specific techniques that would best fill the decision needs are discussed. And finally, for system implementation the modern computational technology infrastructure is emphasized. 展开更多
关键词 Artificial intelligence cognitive systems Computational methods Computer architecture Decision theory Information science Information theory Interactive computer systems Knowledge based systems Man machine systems systems engineering
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Anderson's Cognitive Theory and Learning Strategy Studies in Second Language Acquisition 被引量:9
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作者 Lu Wenpeng (Foreign Languages department, Northwest Normal University, Lanzhou, 730070, China) 《兰州大学学报(社会科学版)》 CSSCI 北大核心 2000年第S1期228-231,共4页
Second language acquisition can not be understood without addressing the interaction between language and cognition. Cognitive theory can extend to describe learning strategies as complex cognitive skills. Theoretical... Second language acquisition can not be understood without addressing the interaction between language and cognition. Cognitive theory can extend to describe learning strategies as complex cognitive skills. Theoretical developments in Anderson’s production systems cover a broader range of behavior than other theories, including comprehension and production of oral and written texts as well as comprehension, problem solving, and verbal learning.Thus Anderson’s cognitive theory can be served as a rationale for learning strategy studies in second language acquisition. 展开更多
关键词 Anderson’s cognitive theory Anderson’s production systems learning strategy studies second language acquisition
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Cognitive Software Engineering: A Research Framework and Roadmap 被引量:1
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作者 Zohair Chentouf 《Journal of Software Engineering and Applications》 2014年第6期530-539,共10页
The work of software engineers is inherently cognitive. Integral to their duties is understanding and developing several artifacts. Each one is based on a specific model and a given level of abstraction. What distingu... The work of software engineers is inherently cognitive. Integral to their duties is understanding and developing several artifacts. Each one is based on a specific model and a given level of abstraction. What distinguishes Software Engineering is the logical complexity of some artifacts (especially programs), the high dependency among them, and the fact that the success of the software project also depends on the human and social factors, which characterize the engineers as individuals and as a group. The complexity of the daily tasks within a software development team motivates the investigation on the relevance of automating the software professionals’ cognitive processes in order to make their work easier and more efficient. The success of this endeavor is expected to emerge as Cognitive Software Engineering. For this aim, the present article suggests a research framework and roadmap, which build on the current state of the art. Some future directions in the Cognitive Software Engineering are presented. 展开更多
关键词 SOFTWARE ENGINEERING cognitive systems CASE TOOLS cognitive SOFTWARE ENGINEERING
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Contribution to Enterprise Intelligent Systems Architecture: Assumptions, Expectations and a Proposal
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作者 Abdessamad Mouzoune 《Intelligent Information Management》 2012年第6期311-318,共8页
Currently, enterprise intelligent systems are built without expressed assumptions likely to enable harmonizing the field and correctly attributing the intelligence label to enterprise systems within the way they are b... Currently, enterprise intelligent systems are built without expressed assumptions likely to enable harmonizing the field and correctly attributing the intelligence label to enterprise systems within the way they are built. In the present paper we propose three base assumptions for an enterprise intelligent system architecture as related to 1) Cognitive Enterprise, 2) Embodied Cognition and 3) Agent Paradigm. The aim is to open up possibility to deal with intelligence at the early stages of enterprise architecture and related disciplines such as system engineering and software development. In addi-tion, we suggest possible expectations from Enterprise Intelligent Systems Architecture and propose an architectural frame based on the cognitive architecture CogAff. Compared with similar works, we noted differences in the fact that our work takes into consideration the cognitive aspect of the firm and the general aspect of intelligence. 展开更多
关键词 ENTERPRISE Intelligent systems ARCHITECTURE cognitive ENTERPRISE EMBODIED cognitION Agent PARADIGM CogAff
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Peer selecting model based on FCM for wireless distributed P2P files sharing systems
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作者 李曦 纪红 郑瑞明 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2010年第5期593-599,共7页
IIn order to improve the performance of wireless distributed peer-to-peer(P2P)files sharing systems,a general system architecture and a novel peer selecting model based on fuzzy cognitive maps(FCM)are proposed in this... IIn order to improve the performance of wireless distributed peer-to-peer(P2P)files sharing systems,a general system architecture and a novel peer selecting model based on fuzzy cognitive maps(FCM)are proposed in this paper.The new model provides an effective approach on choosing an optimal peer from several resource discovering results for the best file transfer.Compared with the traditional min-hops scheme that uses hops as the only selecting criterion,the proposed model uses FCM to investigate the complex relationships among various relative factors in wireless environments and gives an overall evaluation score on the candidate.It also has strong scalability for being independent of specified P2P resource discovering protocols.Furthermore,a complete implementation is explained in concrete modules.The simulation results show that the proposed model is effective and feasible compared with min-hops scheme,with the success transfer rate increased by at least 20% and transfer time improved as high as 34%. 展开更多
关键词 wireless P2P files sharing systems peer selecting model fuzzy cognitive maps
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Kai Xin San ameliorates scopolamine-induced cognitive dysfunction 被引量:12
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作者 Yu-Min Xu Xin-Chen Wang +12 位作者 Ting-Ting Xu Hong-Ying Li Shang-Yan Hei Na-Chuan Luo Hong Wang Wei Zhao Shu-Huan Fang Yun-Bo Chen Li Guan Yong-Qi Fang Shi-Jie Zhang Qi Wang Wei-Xiong Liang 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第5期794-804,共11页
Kai Xin San(KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this s... Kai Xin San(KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this study, 72 specific-pathogen-free male Kunming mice aged 8 weeks were randomly divided into a vehicle control group, scopolamine group, low-dose KXS group, moderate-dose KXS group, high-dose KXS group, and positive control group. Except for the vehicle control group and scopolamine groups(which received physiological saline), the doses of KXS(0.7, 1.4 and 2.8 g/kg per day) and donepezil(3 mg/kg per day) were gastrointestinally administered once daily for 2 weeks. On day 8 after intragastric treatment, the behavioral tests were carried out. Scopolamine group and intervention groups received scopolamine 3 mg/kg per day through intraperitoneal injection. The effects of KXS on spatial learning and memory, pathological changes of brain tissue, expression of apoptosis factors, oxidative stress injury factors, synapse-associated protein, and cholinergic neurotransmitter were measured. The results confirmed the following.(1) KXS shortened the escape latency and increased residence time in the target quadrant and the number of platform crossings in the Morris water maze.(2) KXS increased the percentage of alternations between the labyrinth arms in the mice of KXS groups in the Y-maze.(3) Nissl and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining revealed that KXS promoted the production of Nissl bodies and inhibited the formation of apoptotic bodies.(4) Western blot assay showed that KXS up-regulated the expression of anti-apoptotic protein Bcl-2 and inhibited the expression of pro-apoptotic protein Bax. KXS up-regulated the expression of postsynaptic density 95, synaptophysin, and brain-derived neurotrophic factor in the cerebral cortex and hippocampus.(5) KXS increased the level and activity of choline acetyltransferase, acetylcholine, superoxide dismutase, and glutathione peroxidase, and reduced the level and activity of acetyl cholinesterase, reactive oxygen species, and malondialdehyde through acting on the cholinergic system and reducing oxidative stress damage. These results indicate that KXS plays a neuroprotective role and improves cognitive function through reducing apoptosis and oxidative stress, and regulating synapse-associated protein and cholinergic neurotransmitters. 展开更多
关键词 Kai Xin SAN cognitive DYSFUNCTION SCOPOLAMINE hydrobromide neuroprotection oxidative stress SYNAPTIC DYSFUNCTION apoptosis CHOLINERGIC system DYSFUNCTION DONEPEZIL neural regeneration
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