Connected vehicle (CV) trajectory data provides practitioners with opportunities to assess traffic signal performance with no investment in detection or communication infrastructure. With over 500 billion trajectory r...Connected vehicle (CV) trajectory data provides practitioners with opportunities to assess traffic signal performance with no investment in detection or communication infrastructure. With over 500 billion trajectory records generated each month in the United States, operations can be evaluated virtually at any of the over 400,000 traffic signals in the nation. The manual intersection mapping required to generate accurate movement-level trajectory-based performance estimations is the most time-consuming aspect of using CV data to evaluate traffic signal operations. Various studies have utilized vehicle location data to update and create maps;however, most proposed mapping techniques focus on the identification of roadway characteristics that facilitate vehicle navigation and not on the scaling of traffic signal performance measures. This paper presents a technique that uses commercial CV trajectory and open-source OpenStreetMap (OSM) data to automatically map intersection centers and approach areas of interest to estimate signal performance. OSM traffic signal tags are processed to obtain intersection centers. CV data is then used to extract intersection geometry characteristics surrounding the intersection. To demonstrate the proposed technique, intersection geometry is mapped at 500 locations from which trajectory-based traffic signal performance measures are estimated. The results are compared to those obtained from manual geometry definitions. Statistical tests found that at a 99% confidence level, upstream-focused performance estimations are strongly correlated between both methodologies. The presented technique will aid agencies in scaling traffic signal assessment as it significantly reduces the amount of manual labor required.展开更多
This contribution describes the use of chromatic techniques for quantifying signatures of partial discharges(PD).A brief description of the basis of chromatic monitoring is given along with explanations of how the app...This contribution describes the use of chromatic techniques for quantifying signatures of partial discharges(PD).A brief description of the basis of chromatic monitoring is given along with explanations of how the approach may be applied for addressing signals produced by PDs.Laboratory test data from several sources for different types of PDs,operating conditions and geometries have been subjected to the chromatic procedures.These include a point-plane gap,a sphere in a liquid and treeing in a cable.Chromatic changes in PD signals have been investigated as a function of the amplitude of the alternating voltage producing the PD,the time duration before full electrical breakdown and for different forms of PDs.Results of the chromatic processing of these data are presented in the form of a number of chromatic maps relating to different quarter cycles of the alternating voltage producing the PDs.The results show the potential of the chromatic techniques for indicating the likelihood of full electrical breakdown and for distinguishing between certain forms of PDs.A summary of the chromatic processing procedures is presented for producing chromatic maps and for adaptation in further exploring PD signal features.展开更多
In the future the fifth generation( 5 G) communication systems,channel models may be very complicated and it is difficult to calculate equivalent signal to interference plus noise ratio( SINR)of a random fading channe...In the future the fifth generation( 5 G) communication systems,channel models may be very complicated and it is difficult to calculate equivalent signal to interference plus noise ratio( SINR)of a random fading channel. Therefore,methods for the calculation of equivalent SINR of a random fading channel are very necessary.In this paper,an enhanced algorithm on the exponential effective SINR mapping( EESM) model for random fading channels was proposed. First, the optimal adjustment parameters of typical channel fading models including extended pedestrian A( EPA)model,extended vehicular A( EVA) model and extended typical urban( ETU) model were obtained by simulation. Then the proposed solution was used to actualize channel classification according to the maximum multipath delay and the average power of the random channel. The solution can determine the typical channel closest to random channel for obtaining the optimal adjustment value of EESM. The evaluation results indicate that the proposed one can improve the whole system throughput significantly and meanwhile the accuracy of the link prediction algorithm is also guaranteed.展开更多
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve...The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the known characteristics and components of the p38 pathway along with the mechanism and consequences of p38 activation. We focus on the role of p38 as a signal transduction mediator and examine the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types. Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38.展开更多
In this research the fault parameters causing the September 27, 2010 Kazeron Earthquake with a magnitude of MW = 5.8 (BHRC) were determined using the random finite fault method. The parameters were recorded by 27 acce...In this research the fault parameters causing the September 27, 2010 Kazeron Earthquake with a magnitude of MW = 5.8 (BHRC) were determined using the random finite fault method. The parameters were recorded by 27 accelerometer stations. Simulation of strong ground motion is very useful for areas about which little information and data are available. Considering the distribution of earthquake records and the existing relationships, for the fault plane causing the September 27, 2010 Kazeron Earthquake the length of the fault along the strike direction and the width of the fault along the dip direction were determined to be 10 km and 7 km, respectively. Moreover, 10 elements were assumed along the length and 7 were assumed along the width of the plane. Research results indicated that the epicenter of the earthquake had a geographic coordination of 29.88N - 51.77E, which complied with the results reported by the Institute of Geophysics Tehran University (IGTU). In addition, the strike and dip measured for the fault causing the Kazeron Earthquake were 27 and 50 degrees, respectively. Therefore, the causing fault was almost parallel to and coincident with the fault. There are magnetic discontinuities on the analytical signal map with a north-south strike followed by a northwest-southeast strike. The discontinuities are consistent with the trend of Kazeron fault but are several kilometers away from it. Therefore, they show the fault depth at a distance of 12 km from the fault surface.展开更多
Filamentous fungi employ conserved eukaryotic signaling pathway to detect and respond to environmental signals, including the presence of the host. Genetic experiment in which a particular signaling protein is lost, o...Filamentous fungi employ conserved eukaryotic signaling pathway to detect and respond to environmental signals, including the presence of the host. Genetic experiment in which a particular signaling protein is lost, or its activity enhanced, have defined some of the function of heterotrimeric G proteins and MAP kinases in development and virulence. A hallmark of these studies is that orthologs in different species may have different functions. Antagonistic fungal-fungal interactions form the basis for biological control of plant disease. These interactions may employ novel modes of regulation by conserved signaling elements. Tag1, a G protein α subunit of Trichoderma. atroviride belonging to fungal Gi class, is involved in repression of sporulation and hyphal coiling(1). Deletion of ortholog of this gene, TgaA, in Trichoderma (Gliocladium) virens, however, did not affect sporulation and growth, yet tgaA mutants are unable to parasitize S. rolfsii sclerotia(2). Mutation of a second G α subunit gene is now under study. TmkA, a MAPK gene of T. virens, is involved in biocontrol properties and repression of conidiation(3). Using suppression-subtraction hybridization and other approaches, we are beginning to identify additional elements of the signaling cascades and their downsteam targets. The role of G protein and MAPK genes are sometimes specific to a particular host fungus or to parasitism of mycelia or sclerotia(2,3). Also of relevance to biocontrol, signal transduction pathway provide a means to alter the balance between sporulation, mycelial growth and hyphal coiling.展开更多
文摘Connected vehicle (CV) trajectory data provides practitioners with opportunities to assess traffic signal performance with no investment in detection or communication infrastructure. With over 500 billion trajectory records generated each month in the United States, operations can be evaluated virtually at any of the over 400,000 traffic signals in the nation. The manual intersection mapping required to generate accurate movement-level trajectory-based performance estimations is the most time-consuming aspect of using CV data to evaluate traffic signal operations. Various studies have utilized vehicle location data to update and create maps;however, most proposed mapping techniques focus on the identification of roadway characteristics that facilitate vehicle navigation and not on the scaling of traffic signal performance measures. This paper presents a technique that uses commercial CV trajectory and open-source OpenStreetMap (OSM) data to automatically map intersection centers and approach areas of interest to estimate signal performance. OSM traffic signal tags are processed to obtain intersection centers. CV data is then used to extract intersection geometry characteristics surrounding the intersection. To demonstrate the proposed technique, intersection geometry is mapped at 500 locations from which trajectory-based traffic signal performance measures are estimated. The results are compared to those obtained from manual geometry definitions. Statistical tests found that at a 99% confidence level, upstream-focused performance estimations are strongly correlated between both methodologies. The presented technique will aid agencies in scaling traffic signal assessment as it significantly reduces the amount of manual labor required.
文摘This contribution describes the use of chromatic techniques for quantifying signatures of partial discharges(PD).A brief description of the basis of chromatic monitoring is given along with explanations of how the approach may be applied for addressing signals produced by PDs.Laboratory test data from several sources for different types of PDs,operating conditions and geometries have been subjected to the chromatic procedures.These include a point-plane gap,a sphere in a liquid and treeing in a cable.Chromatic changes in PD signals have been investigated as a function of the amplitude of the alternating voltage producing the PD,the time duration before full electrical breakdown and for different forms of PDs.Results of the chromatic processing of these data are presented in the form of a number of chromatic maps relating to different quarter cycles of the alternating voltage producing the PDs.The results show the potential of the chromatic techniques for indicating the likelihood of full electrical breakdown and for distinguishing between certain forms of PDs.A summary of the chromatic processing procedures is presented for producing chromatic maps and for adaptation in further exploring PD signal features.
基金Institute of Nonlinear Science of Donghua University,China
文摘In the future the fifth generation( 5 G) communication systems,channel models may be very complicated and it is difficult to calculate equivalent signal to interference plus noise ratio( SINR)of a random fading channel. Therefore,methods for the calculation of equivalent SINR of a random fading channel are very necessary.In this paper,an enhanced algorithm on the exponential effective SINR mapping( EESM) model for random fading channels was proposed. First, the optimal adjustment parameters of typical channel fading models including extended pedestrian A( EPA)model,extended vehicular A( EVA) model and extended typical urban( ETU) model were obtained by simulation. Then the proposed solution was used to actualize channel classification according to the maximum multipath delay and the average power of the random channel. The solution can determine the typical channel closest to random channel for obtaining the optimal adjustment value of EESM. The evaluation results indicate that the proposed one can improve the whole system throughput significantly and meanwhile the accuracy of the link prediction algorithm is also guaranteed.
文摘The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the known characteristics and components of the p38 pathway along with the mechanism and consequences of p38 activation. We focus on the role of p38 as a signal transduction mediator and examine the evidence linking p38 to inflammation, cell cycle, cell death, development, cell differentiation, senescence and tumorigenesis in specific cell types. Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38.
文摘In this research the fault parameters causing the September 27, 2010 Kazeron Earthquake with a magnitude of MW = 5.8 (BHRC) were determined using the random finite fault method. The parameters were recorded by 27 accelerometer stations. Simulation of strong ground motion is very useful for areas about which little information and data are available. Considering the distribution of earthquake records and the existing relationships, for the fault plane causing the September 27, 2010 Kazeron Earthquake the length of the fault along the strike direction and the width of the fault along the dip direction were determined to be 10 km and 7 km, respectively. Moreover, 10 elements were assumed along the length and 7 were assumed along the width of the plane. Research results indicated that the epicenter of the earthquake had a geographic coordination of 29.88N - 51.77E, which complied with the results reported by the Institute of Geophysics Tehran University (IGTU). In addition, the strike and dip measured for the fault causing the Kazeron Earthquake were 27 and 50 degrees, respectively. Therefore, the causing fault was almost parallel to and coincident with the fault. There are magnetic discontinuities on the analytical signal map with a north-south strike followed by a northwest-southeast strike. The discontinuities are consistent with the trend of Kazeron fault but are several kilometers away from it. Therefore, they show the fault depth at a distance of 12 km from the fault surface.
文摘Filamentous fungi employ conserved eukaryotic signaling pathway to detect and respond to environmental signals, including the presence of the host. Genetic experiment in which a particular signaling protein is lost, or its activity enhanced, have defined some of the function of heterotrimeric G proteins and MAP kinases in development and virulence. A hallmark of these studies is that orthologs in different species may have different functions. Antagonistic fungal-fungal interactions form the basis for biological control of plant disease. These interactions may employ novel modes of regulation by conserved signaling elements. Tag1, a G protein α subunit of Trichoderma. atroviride belonging to fungal Gi class, is involved in repression of sporulation and hyphal coiling(1). Deletion of ortholog of this gene, TgaA, in Trichoderma (Gliocladium) virens, however, did not affect sporulation and growth, yet tgaA mutants are unable to parasitize S. rolfsii sclerotia(2). Mutation of a second G α subunit gene is now under study. TmkA, a MAPK gene of T. virens, is involved in biocontrol properties and repression of conidiation(3). Using suppression-subtraction hybridization and other approaches, we are beginning to identify additional elements of the signaling cascades and their downsteam targets. The role of G protein and MAPK genes are sometimes specific to a particular host fungus or to parasitism of mycelia or sclerotia(2,3). Also of relevance to biocontrol, signal transduction pathway provide a means to alter the balance between sporulation, mycelial growth and hyphal coiling.
文摘目的 :探讨组蛋白去甲基化酶JMJD2B影响人结直肠癌细胞恶性表型所介导的信号通路。方法 :以RNA干扰技术靶向沉默人结直肠癌细胞HCT116和SW480中JMJD2B的表达,采用蛋白质印迹法检测人结直肠癌细胞ERK-MAPK信号通路的变化,并分别采用CCK-8、流式细胞分析检测细胞增殖和细胞周期分布、凋亡情况。结果:转染JMJD2B si RNA能特异性抑制JMJD2B的表达并导致ERK2表达下调,其磷酸化水平也降低,肿瘤细胞发生G2/M或G0/G1期阻滞,细胞凋亡比例增加,增殖显著受抑(P<0.05)。结论:抑制JMJD2B可通过阻断ERK-MAPK信号转导而抑制人结直肠癌细胞的恶性表型。
