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Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests
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作者 HUANG Beixiu QIAO Sijia +2 位作者 CHEN Xulei LI Lihui QI Shengwen 《Journal of Mountain Science》 SCIE CSCD 2024年第1期182-199,共18页
The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong earthquakes.While extensive studies have individually explored the effect of active faults and strong earthquakes on dif... The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong earthquakes.While extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains unclear.This research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active fault.The prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation corridor.The results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)increased.The PGAs of different engineering structures were weakened by the fault rupture zone.Nevertheless,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic vibration.Additionally,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active faults.The findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor. 展开更多
关键词 dynamic response Engineering structure Sichuan-Tibet transportation corridor Active fault EARTHQUAKE model test
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Microstructure modeling and virtual test of asphalt mixture based on three-dimensional discrete element method 被引量:3
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作者 马涛 张德育 +2 位作者 张垚 赵永利 黄晓明 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第6期1525-1534,共10页
The objective of this work is to model the microstructure of asphalt mixture and build virtual test for asphalt mixture by using Particle Flow Code in three dimensions(PFC^(3D))based on three-dimensional discrete elem... The objective of this work is to model the microstructure of asphalt mixture and build virtual test for asphalt mixture by using Particle Flow Code in three dimensions(PFC^(3D))based on three-dimensional discrete element method.A randomly generating algorithm was proposed to capture the three-dimensional irregular shape of coarse aggregate.And then,modeling algorithm and method for graded aggregates were built.Based on the combination of modeling of coarse aggregates,asphalt mastic and air voids,three-dimensional virtual sample of asphalt mixture was modeled by using PFC^(3D).Virtual tests for penetration test of aggregate and uniaxial creep test of asphalt mixture were built and conducted by using PFC^(3D).By comparison of the testing results between virtual tests and actual laboratory tests,the validity of the microstructure modeling and virtual test built in this study was verified.Additionally,compared with laboratory test,the virtual test is easier to conduct and has less variability.It is proved that microstructure modeling and virtual test based on three-dimensional discrete element method is a promising way to conduct research of asphalt mixture. 展开更多
关键词 asphalt mixture microstructure modeling virtual test discrete element method three-dimensional method
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Science Letters:Dynamic concision for three-dimensional reconstruction of human organ built with virtual reality modelling language (VRML) 被引量:3
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作者 禹正杨 郑树森 +2 位作者 陈雷霆 何晓乾 王建军 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2005年第7期611-616,共6页
This research studies the process of 3D reconstruction and dynamic concision based on 2D medical digital images using virtual reality modelling language (VRML) and JavaScript language, with a focus on how to realize t... This research studies the process of 3D reconstruction and dynamic concision based on 2D medical digital images using virtual reality modelling language (VRML) and JavaScript language, with a focus on how to realize the dynamic concision of 3D medical model with script node and sensor node in VRML. The 3D reconstruction and concision of body internal organs can be built with such high quality that they are better than those obtained from the traditional methods. With the function of dynamic concision, the VRML browser can offer better windows for man-computer interaction in real-time environment than ever before. 3D reconstruction and dynamic concision with VRML can be used to meet the requirement for the medical observation of 3D reconstruction and have a promising prospect in the fields of medical imaging. 展开更多
关键词 Virtual Reality modelling Language (VRML) Direct texture mapping three-dimensional reconstruction dynamic concision
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Three-Dimensional Model Test for Port Engineering with Multi-Directional Waves 被引量:1
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作者 Yu Yuxiu Liu Shuxue Professor, State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology (DUT), Dalian 116024 Assistant Researcher, State Key Laboratory of Coastal and Offshore Engineering, DUT, Dalian 116024 《China Ocean Engineering》 SCIE EI 1994年第1期51-66,共16页
-The necessity of using irregular waves, especially multi- directional waves to conduct three-dimensional model tests for port engineering and the test method are described in this paper through an example of model te... -The necessity of using irregular waves, especially multi- directional waves to conduct three-dimensional model tests for port engineering and the test method are described in this paper through an example of model test for a port. The test results show that a deep navigation channel has a large effect on the waves in front of the breakwater near the port entrance and on the wave condition in the port. 展开更多
关键词 port engineering three-dimensional model test irregular waves multi-directional waves
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Three-Dimensional Nonlinear Dynamic Model and Macro Control of Real Estate
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作者 Dan Ma Shengwu Zhou Haojin Lv 《Intelligent Information Management》 2010年第5期325-328,共4页
In this paper, according to economics of real estate and macro-control theory, combine with the characteristics of the real estate market, macro-control of the real estate market is studied. After giving the dynamic m... In this paper, according to economics of real estate and macro-control theory, combine with the characteristics of the real estate market, macro-control of the real estate market is studied. After giving the dynamic model of three-dimensional nonlinear differential equations based on the total number of houses on the real estate business, the government’s averages housing investment funds and the standard price, systematically established the stability conditions of equilibrium point for this model. What’s more, through the use of extreme value analysis model, government funds have been invested in real estate business building devotion principles and the construction base of the real estate businessmen has also been estimated successfully. This provides the corresponding theoretical basis for government macro control policy-making. 展开更多
关键词 REAL ESTATE MACRO Control three-dimensional dynamic model EXTREME Value Analysis
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Method of Testing of Dynamic Forces on Digital Jet Elements 被引量:3
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作者 莫波 杨彩霞 《Journal of Beijing Institute of Technology》 EI CAS 2002年第4期393-396,共4页
Method of testing for dynamic output forces from jet elements is studied, the handwidth is large in testing with this method. By establishing a model of the test system and simulating it, principles of how inherent fe... Method of testing for dynamic output forces from jet elements is studied, the handwidth is large in testing with this method. By establishing a model of the test system and simulating it, principles of how inherent features of the test system affect the dynamic force test are found out. Thus a theoretical foundation is given for the design and error modification to the actual test system. 展开更多
关键词 digital jet element dynamic force test modelING error analysis
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Predicting the Dynamic Behavior of Asphalt Concrete Using Three-dimensional Discrete Element Method 被引量:4
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作者 陈俊 PAN Tongyan +2 位作者 CHEN Jingya HUANG Xiaoming LU Yang 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2012年第2期382-388,共7页
A user-defined three-dimensional (3D) discrete element model was presented to predict the dynamic modulus and phase angle of asphalt concrete (AC). The 3D discrete element method (DEM) model of AC was constructe... A user-defined three-dimensional (3D) discrete element model was presented to predict the dynamic modulus and phase angle of asphalt concrete (AC). The 3D discrete element method (DEM) model of AC was constructed employing a user-defined computer program developed using the "Fish" language in PFC3D. Important microstructural features of AC were modeled, including aggregate gradation, air voids and mastic. The irregular shape of aggregate particle was modeled using a clump of spheres. The developed model was validated through comparing with experimental measurements and then used to simulate the cyclic uniaxial compression test, based on which the dynamic modulus and phase angle were calculated from the output stress- strain relationship. The effects of air void content, aggregate stiffness and volumetric fraction on AC modulus were further investigated. The experimental results show that the 3D DEM model is able to accurately predict both dynamic modulus and phase angle of AC across a range of temperature and loading frequencies. The user- defined 3D model also demonstrated significant improvement over the general existing two-dimensional models. 展开更多
关键词 asphalt concrete dynamic modulus MICROMECHANICS discrete element method three-dimensional model uniaxial compression test
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Model tests on XCC-piled embankment under dynamic train load of high-speed railways 被引量:6
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作者 Niu Tingting Liu Hanlong +1 位作者 Ding Xuanming Zheng Changjie 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2018年第3期581-594,共14页
Piled embankments,which offer many advantages,are increasingly popular in construction of high-speed railways in China.Although the performance of piled embankment under static loading is well-known,the behavior under... Piled embankments,which offer many advantages,are increasingly popular in construction of high-speed railways in China.Although the performance of piled embankment under static loading is well-known,the behavior under the dynamic train load of a high-speed railway is not yet understood.In light of this,a heavily instrumented piled embankment model was set up,and a model test was carried out,in which a servo-hydraulic actuator outputting M-shaped waves was adopted to simulate the process of a running train.Earth pressure,settlement,strain in the geogrid and pile and excess pore water pressure were measured.The results show that the soil arching height under the dynamic train load of a high-speed railway is shorter than under static loading.The growth trend for accumulated settlement slowed down after long-term vibration although there was still a tendency for it to increase.Accumulated geogrid strain has an increasing tendency after long-term vibration.The closer the embankment edge,the greater the geogrid strain over the subsoil.Strains in the pile were smaller under dynamic train loads,and their distribution was different from that under static loading.At the same elevation,excess pore water pressure under the track slab was greater than that under the embankment shoulder. 展开更多
关键词 piled embankment model test dynamic train load of high-speed railways XCC-pile M-shaped wave
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Study on Model Tests and Hydrodynamic Force Models for Free Spanning Submarine Pipelines Subjected to Earthquakes 被引量:3
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作者 李明高 李昕 +2 位作者 董汝博 周晶 关炯 《China Ocean Engineering》 SCIE EI 2010年第2期305-320,共16页
A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model ... A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model tests are carried out to consider the effects of exciting wave directions and types. Based on the experimental results, two hydrodynamic force models derived from Morisen equation and Wake model are presented respectively. By use of hydrodynamic force models suitable for free spanning submarine pipelines under earthquakes, diseretized equations of motion are obtained and finite element models are established to analyze dynamic response of free spanning submarine pipeline subjected to multi-support seismic excitations. The comparison of numerical results with experimental results shows that the improved Morison and Wake hydrodynamic force models could satisfactorily predict dynamic response on the free spanning submarine pipelines subjected to earthquakes. 展开更多
关键词 free spanning submarine pipelines model tests hydrodynamic force models dynamic response analysis earthquke
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Physical model test and application of 3D printing rock-like specimens to laminated rock tunnels
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作者 Yun Tian Weizhong Chen +3 位作者 Hongming Tian Xiaoyun Shu Linkai He Man Huang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第11期4625-4637,共13页
Weak structural plane deformation is responsible for the non-uniform large deformation disasters in layered rock tunnels,resulting in steel arch distortion and secondary lining cracking.In this study,a servo biaxial t... Weak structural plane deformation is responsible for the non-uniform large deformation disasters in layered rock tunnels,resulting in steel arch distortion and secondary lining cracking.In this study,a servo biaxial testing system was employed to conduct physical modeling tests on layered rock tunnels with bedding planes of varying dip angles.The influence of structural anisotropy in layered rocks on the micro displacement and strain field of surrounding rocks was analyzed using digital image correlation(DIC)technology.The spatiotemporal evolution of non-uniform deformation of surrounding rocks was investigated,and numerical simulation was performed to verify the experimental results.The findings indicate that the displacement and strain field of the surrounding layered rocks are all maximized at the horizontal bedding planes and decrease linearly with the increasing dip angle.The failure of the layered surrounding rock with different dip angles occurs and extends along the bedding planes.Compressive strain failure occurs after excavation under high horizontal stress.This study provides significant theoretical support for the analysis,prediction,and control of non-uniform deformation of tunnel surrounding rocks. 展开更多
关键词 Bedding plane three-dimensional(3D)printing Physical model test Non-uniform deformation Digital imaging correlation(DIC)
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Dynamic Elastic Modulus of Cement Paste at Early Age based on Nondestructive Test and Multiscale Prediction Model 被引量:1
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作者 赵海涛 黄冬辉 +1 位作者 WANG Xiaojun CHEN Xudong 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2014年第2期321-328,共8页
This paper introduced a nondestructive testing method to evaluate the dynamic elastic modulus of cement paste. Moreover, the effect of water-cement ratio and conventional admixtures on the dynamic elastic modulus of c... This paper introduced a nondestructive testing method to evaluate the dynamic elastic modulus of cement paste. Moreover, the effect of water-cement ratio and conventional admixtures on the dynamic elastic modulus of cement paste was investigated, in which three kinds of admixtures were taken into account including viscosity modifying admixture (VMA), silica.fume (SF), and shrinkage-reducing admixture (SRA). The experimental results indicate that the dynamic elastic modulus of cement paste increases with decreasing water-cement ratio. The addition of SF increases the dynamic elastic modulus, however, the overdosage of VMA causes its reduction. SRA reduces the dynamic elastic modulus at early age without affecting it in later period. Finally, a multiscale micromechanics approach coupled with a hydration model CEMHYD3D and percolation theory is utilized to predict the elastic modulus of cement paste, and the predictive results by the model are in accordance with the experimental data. 展开更多
关键词 dynamic elastic modulus nondestructive test viscosity modifying admixture silica fume shrinkage-reducing admixture multiscale model
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High-frequency interference waves in low strain dynamic testing of X-section concrete piles 被引量:1
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作者 Qu Liming Fan Yuming +2 位作者 Ding Xuanming Yang Changwei Zhang Yanling 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2021年第4期877-885,共9页
Stress waves propagate along vertical,radial and circumferential directions when a non-uniformly distributed load is applied at one end of a three-dimensional shaft.As a result,the receiving signals are usually mixed ... Stress waves propagate along vertical,radial and circumferential directions when a non-uniformly distributed load is applied at one end of a three-dimensional shaft.As a result,the receiving signals are usually mixed with undesired interference components,often featuring as high-frequency fluctuations.Previous studies have revealed that sectional geometry(shape and size)greatly affects the high-frequency interference.In this study,low strain dynamic testing on full-scale X-section concrete is conducted in order to investigate the influences of high-frequency interference on velocity responses at the pile head.Emphasis is placed on the frequency and peak value of interference waves at various receiving points.Additionally,the effects of the geometrical,and mechanical properties of the pile shaft on high-frequency interference are elaborated on through the three-dimensional finite element method.The results show that the measured wave is obscured by interference waves superposed by two types of high-frequency components.The modulus and cross-sectional area are contributing factors to the frequency and peak value of the interference waves.On the other hand,the position with the least interference is determined,to some extent,by the accurate shape of the X-section. 展开更多
关键词 low strain dynamic testing X-section concrete pile high-frequency interference full-scale model test finite element method
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Dynamic stress accumulation model of granite residual soil under cyclic loading based on small-size creep tests 被引量:1
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作者 TANG Lian-sheng ZHAO Zhan-lun +2 位作者 CHEN Hao-kun WU Yan-ping ZENG Yu-chao 《Journal of Central South University》 SCIE EI CAS CSCD 2019年第3期728-742,共15页
The creep behaviors of granite residual soil with pre-stress of 100 kPa was investigated by a series of small size creep tests. Three different types of strain curves were obtained at different stress levels. Based on... The creep behaviors of granite residual soil with pre-stress of 100 kPa was investigated by a series of small size creep tests. Three different types of strain curves were obtained at different stress levels. Based on creep characteristics of the granite residual soil under different stress levels, a creep model of the granite residual soil was established by rheological theory, and related parameters of the model were determined according to the experimental data at the same time. Further on, based on the established creep model, a theoretical model of dynamic stress accumulation in the granite residual soil under cyclic loading was deduced. It is found that there is a threshold of dynamic stress accumulation in this theoretical model. The dynamic stress accumulation laws of the granite residual soil are different under different cyclic loading stress. Finally, with the dynamic stress accumulation laws in the small-size samples of granite residual soil under different cycle loading studied and the experimental results comparing with the theoretical results, it verifies the validity of the theoretical model. 展开更多
关键词 granite residual soil creep tests dynamic stress accumulation model
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Tire Dynamics Modeling Method Based on Rapid Test Method 被引量:1
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作者 Dang Lu Lei Lu +2 位作者 Haidong Wu Wei Wang Manyi Lv 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2020年第6期228-237,共10页
Combined with the tire dynamics theoretical model,a rapid test method to obtain tire lateral and longitudinal both steady-state and transient characteristics only based on the tire quasi-steady-state test results is p... Combined with the tire dynamics theoretical model,a rapid test method to obtain tire lateral and longitudinal both steady-state and transient characteristics only based on the tire quasi-steady-state test results is proposed.For steady state data extraction,the test time of the rapid test method is half that of the conventional test method.For transient tire characteristics the rapid test method omits the traditional tire test totally.At the mean time the accuracy of the two method is much closed.The rapid test method is explained theoretically and the test process is designed.The key parameters of tire are extracted and the comparison is made between rapid test and traditional test method.The result show that the identification accuracy based on the rapid test method is almost equal to the accuracy of the conventional one.Then,the heat generated during the rapid test method and that generated during the conventional test are calculated separately.The comparison shows that the heat generated during the rapid test is much smaller than the heat generated during the conventional test process.This benefits to the reduction of tire wear and the consistency of test results.Finally,it can be concluded that the fast test method can efficiently,accurately and energy-efficiently measure the steady-state and transient characteristics of the tire. 展开更多
关键词 Tire dynamics modeling Rapid test method Tire steady-state and transient characteristics Identificationof tire characteristics parameterg
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Establishmen and vertification of an improved similitude law for dynamic ice force model test
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作者 柳春光 贾玲玲 齐念 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2010年第6期853-857,共5页
To study the similitude laws for dynamic ice force model test which is a hot problem in ice mechanics.In this paper,a new modified similitude law for dynamic ice force model test is proposed based on ice-induced virbr... To study the similitude laws for dynamic ice force model test which is a hot problem in ice mechanics.In this paper,a new modified similitude law for dynamic ice force model test is proposed based on ice-induced virbration theory and two reasonable assumptions.And the new law is vertified with an ice-induced pier virbration example.The numerical calculation results show that,firstly,the error of frequency factor between test value and theory value is small as well as that of displacement and velocity;Secondly,the time scale completely meet the similitude relation,the waveforms anastomotic well,and the phenomenon of offset and omit do not occur;Thirdly,as the damping ratio between prototype and model is nearly equal,the improved similitude law will still be applied.Therefore,the new modified similitude law is feasible to study dynamic ice force model test and can provide reference for the ice mechanics. 展开更多
关键词 MODIFIED references laws dynamic ice force model test
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Numerical and Experimental Analysis of the Hydrodynamic Performance of a Three-Dimensional Finite-Length Rotating Cylinder
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作者 Wei Wang Yuwei Wang +3 位作者 Dagang Zhao Yongjie Pang Chunyu Guo Yifan Wang 《Journal of Marine Science and Application》 CSCD 2020年第3期388-397,共10页
The hydrodynamic performance of a three-dimensional finite-length rotating cylinder is studied by means of a physical tank and numerical simulation.First,according to the identified influencing factors,a hydrodynamic ... The hydrodynamic performance of a three-dimensional finite-length rotating cylinder is studied by means of a physical tank and numerical simulation.First,according to the identified influencing factors,a hydrodynamic performance test of the rotating cylinder was carried out in a circulating water tank.In order to explore the changing law of hydrodynamic performance with these factors,a particle image velocimetry device was used to monitor the flow field.Subsequently,a computational field dynamics numerical simulation method was used to simulate the flow field,followed by an analysis of the effects of speed ratio,Reynolds number,and aspect ratio on the flow field.The results show that the lift coefficient and drag coefficient of the cylinder increase first and then decrease with the increase of the rotational speed ratio.The trend of numerical simulation and experimental results is similar. 展开更多
关键词 Rotating cylinder Magnus Rotational speed ratio Aspect ratio Computational field dynamics model test
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In-situ three-dimensional visualization of dynamic tension deformation in ferrite stainless steels
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作者 ZHANG Zhixia BI Hongyun LI Xin 《Baosteel Technical Research》 CAS 2013年第4期56-61,共6页
An improved three-dimensional (3-D) experimental visualization methodology is presented tor evaluating the fracture mechanisms of ferritic stainless steels by in-situ tensile testing with an environmental scanning e... An improved three-dimensional (3-D) experimental visualization methodology is presented tor evaluating the fracture mechanisms of ferritic stainless steels by in-situ tensile testing with an environmental scanning electron microscope (ESEM). The samples were machined with a radial notched shape and a sloped surface. Both planar surface deformation and sloping surface deformation-induced microvoids were observed during dynamic tension experiments, where a greater amount of information could be obtained from the sloping surface. The results showed that microvoids formed at the grain boundaries of highly elongated large grains. The microvoids nucleated in the severely deformed regions grew nearly parallel to the tensile axis, predominantly along the grain boundaries. The microvoids nucleated at the interface of particles and the matrix did not propagate due to the high plasticity of the matrix. The large microvoids propagated and showed a zigzag shape along the grain boundaries,seemingly a consequence of the fracture of the slip bands caused by dislocation pile-ups. The final failure took place due to the reduction of the load-beating area. 展开更多
关键词 three-dimensional (3-D) visualization MICROVOIDS in-situ dynamic tensile testing ferritic stainless steels
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Research on dynamic characteristics model test scheme for middle pylon of multi-pylon multi-span suspension bridges
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作者 Zhang Yufeng Zhang Dachang 《Engineering Sciences》 EI 2012年第3期64-71,共8页
Multi-pylon multi-span suspension bridge is a new type super flexible structure system, and the rigidity design of middle pylon is one of the main difficult technical issues. Due to the requirements of longitudinal ri... Multi-pylon multi-span suspension bridge is a new type super flexible structure system, and the rigidity design of middle pylon is one of the main difficult technical issues. Due to the requirements of longitudinal rigidity, the structural form and the corresponding foundation type of middle pylon are different from those of the ordinary steel pylon, and the complicated dynamic characteristics make the calculation quite difficult. In this article, exploration has been made in selection of similarity ratio and model materials, section simulation, restriction conditions simulation, fixing of mass blocks, fabrication scheme and testing method by taking into account different construction and working conditions such as restriction conditions and working environment of a three-pylon suspension bridge, to conduct the test experimental design of the dynamic behavior of the middle pylon, with the purpose to reveal its dynamic characteristics and make comparison and analysis with theoretical assumptions, to provide basis for anti-wind and anti-seismic design and reference for the design and research of three-pylon two-span suspension bridges in the future. 展开更多
关键词 multi-pylon multi-span suspension bridge middle pylon dynamic characteristics model test
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A model test system with a dynamic load device for geotechnical engineering in cold regions
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作者 ShuPing Zhao Wei Ma +1 位作者 GuiDe Jiao Fei Luo 《Research in Cold and Arid Regions》 2012年第2期115-120,共6页
A model test system with a dynamic load device for geotechnical engineering in cold regions is presented. This system consists of a model test tank, a refrigeration device and temperature controller, a dynamic load de... A model test system with a dynamic load device for geotechnical engineering in cold regions is presented. This system consists of a model test tank, a refrigeration device and temperature controller, a dynamic load device, together with sensors and data loggers for detecting stress, deformation, and temperature changes. The system can accommodate soil blocks up to 3 m in length, 2.5 m in width, and 1 m in height. The lowest temperature provided by the refrigeration device is -20 ℃. The maximum load provided by the dynamic load device is 100 kN and the vibration fi'equency of the dynamic load can range from 0.1 to 10 Hz. A number of waveforms, such as sine waves, rectangular waves, triangle waves, and other user-defined waves can be generated by the dynamic load device controller. 展开更多
关键词 model test system dynamic load device STRESS DEFORMATION temperature change
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Cosmetic Safety Evaluation Based on In Vitro Three-dimensional Reconstructed Human Epidermis(3D-RHE) Models
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作者 Xue Kong Wendan He +2 位作者 Pengju Nie Ying Tang Ding Cao 《China Detergent & Cosmetics》 2016年第2期49-54,共6页
Cosmetic safety evaluation employs a series of toxicological tests, on both qualitative and quantitative levels, to assess the potential risks for the daily use of selected cosmetic ingredients and final products. Tra... Cosmetic safety evaluation employs a series of toxicological tests, on both qualitative and quantitative levels, to assess the potential risks for the daily use of selected cosmetic ingredients and final products. Traditionally, safety evaluation of cosmetics uses animal tests. With the development of in vitro science and the 3R (Reduction, Replacement and Refinement) principle, three-dimensional reconstructed human epidermis (3D-RHE) models have been developed and widely applied in cosmetic safety evaluation. Reconstructed human skin models possess anatomy and metabolism biology similar to real human tissue. This paper reviews the current application of 3D-RHE models in the safety evaluation of skin irritation, eye irritation, phototoxicity and genotoxicity potential of cosmetic ingredients/formulas. The advantages and disadvantages of using skin models are also discussed, and comments and suggestions are given for its future development. 展开更多
关键词 three-dimensional reconstructed human epidermis models cosmetic safety in vitro tests alternative methods
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