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Theory,technology and practice of shale gas three-dimensional development:A case study of Fuling shale gas field in Sichuan Basin,SW China 被引量:2
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作者 SUN Huanquan CAI Xunyu +5 位作者 HU Degao LU Zhiyong ZHAO Peirong ZHENG Aiwei LI Jiqing WANG Haitao 《Petroleum Exploration and Development》 SCIE 2023年第3期651-664,共14页
In the Jiaoshiba block of the Fuling shale gas field,the employed reserves and recovery factor by primary well pattern are low,no obvious barrier is found in the development layer series,and layered development is dif... In the Jiaoshiba block of the Fuling shale gas field,the employed reserves and recovery factor by primary well pattern are low,no obvious barrier is found in the development layer series,and layered development is difficult.Based on the understanding of the main factors controlling shale gas enrichment and high production,the theory and technology of shale gas three-dimensional development,such as fine description and modeling of shale gas reservoir,optimization of three-dimensional development strategy,highly efficient drilling with dense well pattern,precision fracturing and real-time control,are discussed.Three-dimensional development refers to the application of optimal and fast drilling and volume fracturing technologies,depending upon the sedimentary characteristics,reservoir characteristics and sweet spot distribution of shale gas,to form"artificial gas reservoir"in a multidimensional space,so as to maximize the employed reserves,recovery factor and yield rate of shale gas development.In the research on shale gas three-dimensional development,the geological+engineering sweet spot description is fundamental,the collaborative optimization of natural fractures and artificial fractures is critical,and the improvement of speed and efficiency in drilling and fracturing engineering is the guarantee.Through the implementation of three-dimensional development,the overall recovery factor in the Jiaoshiba block has increased from 12.6%to 23.3%,providing an important support for the continuous and stable production of the Fuling shale gas field. 展开更多
关键词 shale gas three-dimensional development Fuling shale gas field Sichuan Basin fine reservoir description precision fracturing recoveryfactor
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Study of the geomagnetic field's regional gradients in Chinese continent using three-dimensional surface Spline model
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作者 Yan Feng YiJun Li +3 位作者 JinYan Zhang Shuang Liu Abbas Nasir Ya Huang 《Earth and Planetary Physics》 EI CSCD 2023年第1期74-83,共10页
We combined domestic ground-based and satellite magnetic measurements to create a regional three-dimensional surface Spline(3DSS)gradient model of the main geomagnetic field over the Chinese continent.To improve the p... We combined domestic ground-based and satellite magnetic measurements to create a regional three-dimensional surface Spline(3DSS)gradient model of the main geomagnetic field over the Chinese continent.To improve the precision of the model,we considered the data gap between the ground and satellite data.We compared and analyzed the results of the Taylor polynomial,surface Spline,and CHAOS-6(the CHAMP,?rsted and SAC-C model of Earth’s magnetic field)gradient models.Results showed that the gradients in the south-north and east-west directions of the four models were consistent.The 3DSS model was able to express not only gradients at different altitudes,but also average gradients inside the research area.The two Spline models were able to capture more information on gradient anomalies than were the fitted models.Strong local anomalies were observed in northern Xinjiang,Beijing,and the junction area between Jiangsu and Zhejiang,and the total intensity F decreased whereas the altitude increased.The gradient decreased by 21.69%in the south-north direction and increased by 11.78%in the east-west direction.In addition,the altitude gradient turned from negative to positive while the altitude increased.The Spline model and the two fitted models differed mainly in the field sources they expressed and the modeling theory. 展开更多
关键词 geomagnetic field main field gradients regional model three-dimensional modeling
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Geodetic constraints on contemporary three-dimensional crustal deformation in the Laji Shan—Jishi Shan tectonic belt 被引量:1
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作者 Wenquan Zhuang Duxin Cui +2 位作者 Ming Hao Shangwu Song Zhangjun Li 《Geodesy and Geodynamics》 EI CSCD 2023年第6期589-596,共8页
The Laji Shan—Jishi Shan tectonic belt(LJTB),located in the southern part of the northeastern Tibetan Plateau(NETP),is a tectonic window to reveal regional tectonic deformation in the NETP.However,its kinematics in t... The Laji Shan—Jishi Shan tectonic belt(LJTB),located in the southern part of the northeastern Tibetan Plateau(NETP),is a tectonic window to reveal regional tectonic deformation in the NETP.However,its kinematics in the Holocene remains controversial.We obtain the latest and dense horizontal velocity field based on data collected from our newly constructed and existing GNSS stations.Combined with fault kinematics from geologic observations,we analyze the crustal deformation characteristics along the LJTB.The results show that:(1)The Laji Shan fault(LJF)is inactive,and the northwest-oriented Jishi Shan fault(JSF)exhibits a significant dextral and thrust slip.(2)The transpression along the arc-shaped LJTB accommodates deformation transformation between the dextral Riyue Shan fault and the sinistral west Qinling fault.(3)With the continuous pushing of the Indian plate,internal strains in the Tibetan Plateau are continuously transferred in the northeast via the LJTB as they are gradually dissipated near the LJTB and translated into significant crustal uplift in these regions. 展开更多
关键词 Laji Shan-Jishi Shan tectonic belt three-dimensional crustal deformation Fault slip rate GNSS Velocity field
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A contrastive study on the influences of radial and three-dimensional satellite gravity gradiometry on the accuracy of the Earth's gravitational field recovery 被引量:5
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作者 郑伟 许厚泽 +1 位作者 钟敏 员美娟 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第10期577-584,共8页
The accuracy of the Earth's gravitational field measured from the gravity field and steady-state ocean circulation explorer(GOCE),up to 250 degrees,influenced by the radial gravity gradient V zz and three-dimension... The accuracy of the Earth's gravitational field measured from the gravity field and steady-state ocean circulation explorer(GOCE),up to 250 degrees,influenced by the radial gravity gradient V zz and three-dimensional gravity gradient V ij from the satellite gravity gradiometry(SGG) are contrastively demonstrated based on the analytical error model and numerical simulation,respectively.Firstly,the new analytical error model of the cumulative geoid height,influenced by the radial gravity gradient V zz and three-dimensional gravity gradient V ij are established,respectively.In 250 degrees,the GOCE cumulative geoid height error measured by the radial gravity gradient V zz is about 2 1/2 times higher than that measured by the three-dimensional gravity gradient V ij.Secondly,the Earth's gravitational field from GOCE completely up to 250 degrees is recovered using the radial gravity gradient V zz and three-dimensional gravity gradient V ij by numerical simulation,respectively.The study results show that when the measurement error of the gravity gradient is 3×10 12 /s 2,the cumulative geoid height errors using the radial gravity gradient V zz and three-dimensional gravity gradient V ij are 12.319 cm and 9.295 cm at 250 degrees,respectively.The accuracy of the cumulative geoid height using the three-dimensional gravity gradient V ij is improved by 30%-40% on average compared with that using the radial gravity gradient V zz in 250 degrees.Finally,by mutual verification of the analytical error model and numerical simulation,the orders of magnitude from the accuracies of the Earth's gravitational field recovery make no substantial differences based on the radial and three-dimensional gravity gradients,respectively.Therefore,it is feasible to develop in advance a radial cold-atom interferometric gradiometer with a measurement accuracy of 10 13 /s 2-10 15 /s 2 for precisely producing the next-generation GOCE Follow-On Earth gravity field model with a high spatial resolution. 展开更多
关键词 GOCE GOCE Follow-On radial and three-dimensional gravity gradients satellite gravity gradiometry Earth's gravitational field
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Three-Dimensional Analytical Modeling of Axial-Flux Permanent Magnet Drivers
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作者 Wenhui Li Dazhi Wang +3 位作者 Shuo Cao Deshan Kong Sihan Wang Zhong Hua 《Computers, Materials & Continua》 SCIE EI 2023年第4期259-276,共18页
In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare co... In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers. 展开更多
关键词 three-dimensional analytical modeling cylindrical coordinates magnetic field distribution parameter sensitivity analysis performance measurement
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Risk Assessment of Coal Mine Water Hazard Based on Three-Dimensional Model of Geology and Underground Space 被引量:1
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作者 Kai Zhang~1,Ming Huang~1,Bin Tang~2,Fan Cui~1 1.Laboratory of Coal Resources and Mine Safety,China University of Mining and Technology,Beijing 100083,China. 2.China Water Investment Co.Ltd,Beijing 100053,China 《地学前缘》 EI CAS CSCD 北大核心 2009年第S1期279-279,共1页
Mine safety have top-five disasters,which including the water,gas,fire,dust and geological dynamic disaster.The coal mine water disaster is one of the important factors which restricted the development of China’s coa... Mine safety have top-five disasters,which including the water,gas,fire,dust and geological dynamic disaster.The coal mine water disaster is one of the important factors which restricted the development of China’s coal production.It is showed by statistics that 60%of mine accidents are affected by groundwater,which not only result in the production losses,casualties and a variety of 展开更多
关键词 DISASTER risk assessment three-dimensional model of GEOLOGY and UNDERGROUND space emergency RESCUE
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Three-dimensional Holographic Vector of Atomic Interaction Field(3D-HoVAIF) for the QSPR/QSAR of Polychlorinated Naphthalenes 被引量:1
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作者 李正华 陈刚 +3 位作者 陈志涛 夏之宁 程凡圣 陈华 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2012年第3期345-352,共8页
Three-dimensional holographic vector of atomic interaction field(3D-HoVAIF) is used to describe the chemical structures of polychlorinated naphthalenes(PCNs).After variable screening by stepwise multiple regressio... Three-dimensional holographic vector of atomic interaction field(3D-HoVAIF) is used to describe the chemical structures of polychlorinated naphthalenes(PCNs).After variable screening by stepwise multiple regression(SMR) technique,the liner relationships between gas-chromatographic relative retention time(RRT),298 K supercooled liquid pressures(logPL),n-octanol/air partition coefficient(logKOA),n-octanol/water partition coefficient(logKOW),aqueous solubilities(logSW),relative in vitro potency values(-logEROD) of PCNs and 3D-HoVAIF descriptors have been established by partial least-square(PLS) regression.The result shows that the 3D-HoVAIF descriptors can be well used to express the quantitative structure-property(activity) relationships of PCNs.Predictive capability of the models has also been demonstrated by leave-one-out cross-validation.Moreover,the predicted values have been presented for those PCNs which are lack of experimentally physico-chemical properties and biological activity by the optimum models. 展开更多
关键词 polychlorinated naphthalenes three-dimensional holographic vector of atomic interaction field QSPR QSAR
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EXPERIMENTAL INVESTIGATION FOR THE EFFECT OF ROTATION ON THREE-DIMENSIONAL FLOW FIELD IN FILM-COOLED TURBINE 被引量:2
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作者 YUAN Feng ZHU Xiaocheng DU Zhaohui 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2007年第1期10-15,共6页
An experimental investigation of three-dimensional flow field in a film-cooled turbine model is carried out by using particle image velocimeter (PIV) in a low-speed wind tunnel. The effects of different blowing rati... An experimental investigation of three-dimensional flow field in a film-cooled turbine model is carried out by using particle image velocimeter (PIV) in a low-speed wind tunnel. The effects of different blowing ratios (M=1.5, 2) on the flow field are studied. The experimental results reveal the classical phenomena of the formation of kidney vortex pair and secondary flow in wake region behind the jet hole. And the changes of the kidney vortex pair and the wake at different locations away from the hole on the suction and pressure sides are also studied. Compared with the flow field in stationary cascade, there are centrifugal force and Coriolis force existing in the flow field of rotating turbine, and these forces bring the radial velocity in the jet flow. The effect of rotatien on the flow field of the pressure side is more distinct than that on the suction side from the measured flow fields in Y-Z plane and radial velocity contours. The increase of blowing ratio makes the kidney vortex pair and the secondary flow in the wake region stronger and makes the range of the wake region enlarged. 展开更多
关键词 Film-cooled turbine rotor PIV measurement Blowing ratio three-dimensional flow field
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Variational Reconstruction and Simulation Experiments of Sea Surface Wind Field for Ocean Data Buoy
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作者 LI Yunzhou HUANG Sixun +4 位作者 YAN Shen SUN Xuejin QI Suiping WANG Zhongqiu TANG Xiaoyu 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第3期577-582,共6页
The sea surface wind field is an important physical parameter in oceanography and meteorology.With the continuous refinement of numerical weather prediction,air-sea interface materials,energy exchange,and other studie... The sea surface wind field is an important physical parameter in oceanography and meteorology.With the continuous refinement of numerical weather prediction,air-sea interface materials,energy exchange,and other studies,three-dimensional(3D)wind field distribution at local locations on the sea surface must be measured accurately.The current in-situ observation of sea surface wind parameters is mainly achieved through the installation of wind sensors on ocean data buoys.However,the results obtained from this single-point measurement method cannot reflect wind field distribution in a vertical direction above the sea surface.Thus,the present paper proposes a theoretical framework for the optimal inversion of the 3D wind field structure variation in the area where the buoy is located.The variation analysis method is first used to reconstruct the wind field distribution at different heights of the buoy,after which theoretical analysis verification and numerical simulation experiments are conducted.The results indicate that the use of variational methods to reconstruct 3D wind fields is significantly effective in eliminating disturbance errors in observations,which also verifies the correctness of the theoretical analysis of this method.The findings of this article can provide a reference for the layout optimization design of wind measuring instruments in buoy observation systems and also provide theoretical guidance for the design of new observation buoys in the future. 展开更多
关键词 moored buoy three-dimensional wind field distribution variational analysis wind field reconstruction
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Three-Dimensional Stress Fields in Finite Thickness Plate with Hole Under Shear Load
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作者 戴隆超 王鑫伟 +1 位作者 龚俊杰 顾乡 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2014年第5期546-551,共6页
The theoretical solutions are obtained for the three-dimensional(3-D)stress field in an infinite isotropic elastic plate with a through-the-thickness circular hole subjected to shear load at far field by using Kane an... The theoretical solutions are obtained for the three-dimensional(3-D)stress field in an infinite isotropic elastic plate with a through-the-thickness circular hole subjected to shear load at far field by using Kane and Mindlin′s assumption based on the stress function method.Based on the present solutions,the characteristics of 3-D stress field are analyzed and the emphasis is placed on the effects of the plate thickness and Poisson′s ratio on the deviation of the present 3-D in-plane stress from the related plane stress solutions,the stress concentration and the out-of-plane constraint.The present solutions show that the stress concentration factor reaches its peak value of about 8.9% which is higher than that of the plane stress solutions.As expected,the out-of-plane stress constraint factor can reach 1on the surface of the hole when the plate is a very thick one. 展开更多
关键词 three-dimensional stress field through-the-thickness circular hole thickness effect stress concentration out-of-plane constraint
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Controlling Three-Dimensional Electron-Electron Correlation via Elliptically Polarized Intense Laser Field
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作者 郝建兴 郝小雷 +2 位作者 李卫东 胡师林 陈京 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第4期30-34,共5页
The three-dimensional electron-electron correlation in an elliptically polarized laser field is investigated based on a semiclassical model. Asymmetry parameter α of the correlated electron momentum distribution is u... The three-dimensional electron-electron correlation in an elliptically polarized laser field is investigated based on a semiclassical model. Asymmetry parameter α of the correlated electron momentum distribution is used to quantitatively describe the electron-electron correlation. The dependence of α on elliptieity e is totally different in three directions. For the z direction (maJor polarization direction), α first increases and reaches a maximum at ε = 0.275, then it decreases quickly. For the y direction in which the laser field is always absent, the ellipticity has a minor effect, and the asymmetry parameter fluctuates around α = -0.15. However, for the x direction (minor polarization direction), α increases monotonously with ellipticity though starts from the same value as in the y direction when ε = 0. The behavior of α in the x direction actually indicates a transformation from the Coulomb interaction dominated correlation to the laser field dominated correlation. Therefore, our work provides an efficient way to control the three-dimensional electron electron correlation via an elliptically polarized intense laser field. 展开更多
关键词 Controlling three-dimensional Electron-Electron Correlation via Elliptically Polarized Intense Laser field RII
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Three-dimensional stochastic seepage field for embankment engineering
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作者 Ya-jun WANG Wo-hua ZHANG +1 位作者 Chang-yu WU Da-chun REN 《Water Science and Engineering》 EI CAS 2009年第1期58-73,共16页
关键词 anisotropic random seepage field three-dimensional seepage finite element method Monte Carlo simulation inhomogeneous permeability coefficient stochastic disturbance of hydraulic head boundary
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Three-dimensional Monte Carlo simulation of bulk fin field effect transistor
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作者 王骏成 杜刚 +2 位作者 魏康亮 张兴 刘晓彦 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第11期421-426,共6页
In this paper, we investigate the performance of the bulk fin field effect transistor (FinFET) through a three- dimensional (3D) full band Monte Carlo simulator with quantum correction. Several scattering mechanis... In this paper, we investigate the performance of the bulk fin field effect transistor (FinFET) through a three- dimensional (3D) full band Monte Carlo simulator with quantum correction. Several scattering mechanisms, such as the acoustic and optical phonon scattering, the ionized impurity scattering, the impact ionization scattering and the surface roughness scattering are considered in our simulator. The effects of the substrate bias and the surface roughness scattering near the Si/SiO2 interface on the performance of bulk FinFET are mainly discussed in our work. Our results show that the on-current of bulk FinFET is sensitive to the surface roughness and that we can reduce the substrate leakage current by modulating the substrate bias voltage. 展开更多
关键词 bulk fin field effect transistor (FinFET) three-dimensional (3D) Monte Carlo simulation surface roughness scattering substrate bias effect
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VISUALIZATION OF THREE-DIMENSIONAL DATA FIELD AND ITS APPLICATION IN MACHINE TESTING
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作者 YIN Aijun QIN Shuren TANG Baoping 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2006年第1期81-84,共4页
In order to realize visualization of three-dimensional data field (TDDF) in instrument, two methods of visualization of TDDF and the usual manner of quick graphic and image processing are analyzed. And how to use Op... In order to realize visualization of three-dimensional data field (TDDF) in instrument, two methods of visualization of TDDF and the usual manner of quick graphic and image processing are analyzed. And how to use OpenGL technique and the characteristic of analyzed data to construct a TDDF, the ways of reality processing and interactive processing are described. Then the medium geometric element and a related realistic model are constructed by means of the first algorithm. Models obtained for attaching the third dimension in three-dimensional data field are presented. An example for TDDF realization of machine measuring is provided. The analysis of resultant graphic indicates that the three-dimensional graphics built by the method developed is featured by good reality, fast processing and strong interaction 展开更多
关键词 Visualization in scientific computing three-dimensional data field (TDDF) Test
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Three-Dimensional Phase Field Simulations of Hysteresis and Butterfly Loops by the Finite Volume Method
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作者 席丽莹 陈焕铭 +3 位作者 郑富 高华 童洋 马治 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第9期128-131,共4页
Three-dimensional simulations of ferroelectric hysteresis and butterfly loops are carried out based on solving the time dependent Ginzburg-Landau equations using a finite volume method. The influence of externally mec... Three-dimensional simulations of ferroelectric hysteresis and butterfly loops are carried out based on solving the time dependent Ginzburg-Landau equations using a finite volume method. The influence of externally mechanical loadings with a tensile strain and a compressive strain on the hysteresis and butterfly loops is studied numerically. Different from the traditional finite element and finite difference methods, the finite volume method is applicable to simulate the ferroelectric phase transitions and properties of ferroelectric materials even for more realistic and physical problems. 展开更多
关键词 three-dimensional Phase field Simulations of Hysteresis and Butterfly Loops by the Finite Volume Method
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Model calibration concerning risk coefficients of driving safety field model 被引量:5
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作者 李洋 王建强 吴剑 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第6期1494-1502,共9页
Driving safety field(DSF) model has been proposed to represent comprehensive driving risk formed by interactions of driver-vehicle-road in mixed traffic environment. In this work, we establish an optimization model ba... Driving safety field(DSF) model has been proposed to represent comprehensive driving risk formed by interactions of driver-vehicle-road in mixed traffic environment. In this work, we establish an optimization model based on grey relation degree analysis to calibrate risk coefficients of DSF model. To solve the optimum solution, a genetic algorithm is employed. Finally, the DSF model is verified through a real-world driving experiment. Results show that the DSF model is consistent with driver's hazard perception and more sensitive than TTC. Moreover, the proposed DSF model offers a novel way for criticality assessment and decision-making of advanced driver assistance systems and intelligent connected vehicles. 展开更多
关键词 intelligent CONNECTED vehicles advanced DRIVER ASSISTANCE systems (ADAS) driving risk assessment driving safety field (DSF) model parameter calibration GREY RELATION degree
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The stress field variation caused by faulting and the prediction for seismic risk 被引量:1
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作者 赵根模 姚兰予 马淑芹 《Acta Seismologica Sinica(English Edition)》 CSCD 1994年第4期559-566,共8页
The stress field caused by faulting has an effect on the stability of the neighboring faults, and the study on the fault interaction has a close relation with the prediction of seismic risk. Stress field caused by the... The stress field caused by faulting has an effect on the stability of the neighboring faults, and the study on the fault interaction has a close relation with the prediction of seismic risk. Stress field caused by the rectangle fault in the semi-infinite elastic medium is calculated on the basis of the elastic dislocation theory. The result shows that most of the successive large earthquakes, in the southwestern part of China and North China, occurred in the increasing area of shear stress S(xy) and the decreasing area of normal stress S(yy) The increasing of earthquake occurrence probability has a function relation with the increasing of stress. Earthquake triggering is resulted from the increasing of shear stress and the decreasing of normal stress. An activation coefficient A, of the earthquake is defined to express the change of seismic activity. The concrete risk region can be obtained through space scanning of At value. Finally, the fault interaction in a large scope is discussed in this paper. 展开更多
关键词 fault interaction variation of stress field earthquake triggering seismic risk
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High-precision three-dimensional Rydberg atom localization in a four-level atomic system 被引量:1
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作者 张恒飞 元晋鹏 +2 位作者 汪丽蓉 肖连团 贾锁堂 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第5期348-352,共5页
Rydberg atoms have been widely investigated due to their large size,long radiative lifetime,huge polarizability and strong dipole-dipole interactions.The position information of Rydberg atoms provides more possibiliti... Rydberg atoms have been widely investigated due to their large size,long radiative lifetime,huge polarizability and strong dipole-dipole interactions.The position information of Rydberg atoms provides more possibilities for quantum optics research,which can be obtained under the localization method.We study the behavior of three-dimensional(3D)Rydberg atom localization in a four-level configuration with the measurement of the spatial optical absorption.The atomic localization precision depends strongly on the detuning and Rabi frequency of the involved laser fields.A 100%probability of finding the Rydberg atom at a specific 3D position is achieved with precision of~0.031λ.This work demonstrates the possibility for achieving the 3D atom localization of the Rydberg atom in the experiment. 展开更多
关键词 Rydberg atom three-dimensional localization standing-wave field
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Beat-to-Beat Variability in Field Potential Duration in Human Embryonic Stem Cell-Derived Cardiomyocyte Clusters for Assessment of Arrhythmogenic Risk, and a Case Study of Its Application 被引量:1
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作者 Kazuto Yamazaki Taro Hihara +7 位作者 Hiroshi Kato Tatsuto Fukushima Kazuyuki Fukushima Tomohiko Taniguchi Takashi Yoshinaga Norimasa Miyamoto Masashi Ito Kohei Sawada 《Pharmacology & Pharmacy》 2014年第1期117-128,共12页
We established a QT interval assessment system that uses human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs) in which the field potential duration (FPD) or corrected FPD (FPDc) was measured as an indic... We established a QT interval assessment system that uses human embryonic stem cell-derived cardiomyocyte clusters (hES-CMCs) in which the field potential duration (FPD) or corrected FPD (FPDc) was measured as an indicator of drug-induced QT interval prolongation. To investigate the applicability of the hES-CMC system to drug safety assessment, we investigated short-term variability in FPDc (STVFPDc) (beat rate rhythmicity) as a marker of torsadogenic risk. We investigated the FPDc and STVFPDc of hES-CMCs treated with hERG channel blockers (E-4031 or cisapride) or with our proprietary compounds X, Y, and Z. We also evaluated the electrocardiograms and hemodynamics of dogs treated with compound X, Y, or Z. The torsadogenic hERG channel blockers increased STVFPDc and prolonged FPDc. Compounds X, Y, and Z had hERG inhibitory activity. Compound X prolonged FPDc with increased STVFPDc, whereas compounds Y and Z tended to shorten FPDc in the hES-CMC system. In the in vivo canine study, compound X prolonged corrected QT (QTc), and compounds Y and Z tended to shorten QTc, showing a good correlation with the results in hES-CMCs. These findings suggest that combined assessment of FPDc and STVFPDc in the hES-CMC system increases the predictability of torsadogenic risk. 展开更多
关键词 Human Embryonic Stem Cell-Derived Cardiomyocytes field Potential DURATION Short-Term VARIABILITY QT Interval Torsades de POINTES risk ASSESSMENT
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Modeling the fate of paddy field pesticide in surface water and environmental risk assessment
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作者 LI Shi\|yu 1, Tohru Morioka 2 (1. Institute of Environmental Science, Zhongshan University, Guangzhou 510275, China. E-mail: eeslsy@zsu.edu.cn 2.Department of Environmental Engineering, Osaka University, Yamada oka 2 1, Suita, Osaka 565, Japan. E- 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2000年第3期337-343,共7页
The risk of drinking water is greatly concerned because of the large amount of pesticide applied to paddy field and the contamination of drinking water sources due to the runoff. A mathematical model is developed, ba... The risk of drinking water is greatly concerned because of the large amount of pesticide applied to paddy field and the contamination of drinking water sources due to the runoff. A mathematical model is developed, based on the mass balance, to predict the fate of paddy field pesticides from application, runoff and mixing in a river, taking account of the physical chemical properties and processes of volatilization, degradation, adsorption and desorption. The model is applied to a river basin in Japan to estimate the contaminant level of several popularly used pesticides at the water intakes. The health risk in drinking water induced by each pesticide concerned is estimated and evaluated by comparing with the acceptable daily intake values(ADI) and with that induced by trihalomethanes. An index to evaluate the total risk of all pesticides appearing in water is proposed. The methods for risk management are also discussed. 展开更多
关键词 MODELING PESTICIDE paddy field environmental risk assessment drinking water
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