Gobi spans a large area of China,surpassing the combined expanse of mobile dunes and semi-fixed dunes.Its presence significantly influences the movement of sand and dust.However,the complex origins and diverse materia...Gobi spans a large area of China,surpassing the combined expanse of mobile dunes and semi-fixed dunes.Its presence significantly influences the movement of sand and dust.However,the complex origins and diverse materials constituting the Gobi result in notable differences in saltation processes across various Gobi surfaces.It is challenging to describe these processes according to a uniform morphology.Therefore,it becomes imperative to articulate surface characteristics through parameters such as the three-dimensional(3D)size and shape of gravel.Collecting morphology information for Gobi gravels is essential for studying its genesis and sand saltation.To enhance the efficiency and information yield of gravel parameter measurements,this study conducted field experiments in the Gobi region across Dunhuang City,Guazhou County,and Yumen City(administrated by Jiuquan City),Gansu Province,China in March 2023.A research framework and methodology for measuring 3D parameters of gravel using point cloud were developed,alongside improved calculation formulas for 3D parameters including gravel grain size,volume,flatness,roundness,sphericity,and equivalent grain size.Leveraging multi-view geometry technology for 3D reconstruction allowed for establishing an optimal data acquisition scheme characterized by high point cloud reconstruction efficiency and clear quality.Additionally,the proposed methodology incorporated point cloud clustering,segmentation,and filtering techniques to isolate individual gravel point clouds.Advanced point cloud algorithms,including the Oriented Bounding Box(OBB),point cloud slicing method,and point cloud triangulation,were then deployed to calculate the 3D parameters of individual gravels.These systematic processes allow precise and detailed characterization of individual gravels.For gravel grain size and volume,the correlation coefficients between point cloud and manual measurements all exceeded 0.9000,confirming the feasibility of the proposed methodology for measuring 3D parameters of individual gravels.The proposed workflow yields accurate calculations of relevant parameters for Gobi gravels,providing essential data support for subsequent studies on Gobi environments.展开更多
The shear behavior of rock joints is important in solving practical problems of rock mechanics. Three group rock joints with different morphologies are made by cement mortar material and a series of CNL(constant norma...The shear behavior of rock joints is important in solving practical problems of rock mechanics. Three group rock joints with different morphologies are made by cement mortar material and a series of CNL(constant normal loading) shear tests are performed. The influences of the applied normal stress and joint morphology to its shear strength are analyzed. According to the experimental results, the peak dilatancy angle of rock joint decreases with increasing normal stress, but increases with increasing roughness. The shear strength increases with the increasing normal stress and the roughness of rock joint. It is observed that the modes of failure of asperities are tensile, pure shear, or a combination of both. It is suggested that the three-dimensional roughness parameters and the tensile strength are the appropriate parameter for describing the shear strength criterion. A new peak shear criterion is proposed which can be used to predict peak shear strength of rock joints. All the used parameters can be easily obtained by performing tests.展开更多
Sometimes endometrial polyps,submucosal myomas,and endometrial cancer show similar findings under ultrasonography.The aim of this study was to assess the antidiastole value of blood flow parameters using three-dimensi...Sometimes endometrial polyps,submucosal myomas,and endometrial cancer show similar findings under ultrasonography.The aim of this study was to assess the antidiastole value of blood flow parameters using three-dimensional(3D)power Doppler ultrasonography angiography(PDA)between endometrial cancer and uterine parenchyma lumps.The data of the blood flow indices in 3D-PDA including the vascularization index(VI),flow index(FI),and vascularization flow index(VFI)in 40 patients with endometrial cancer and 41 patients with uterine parenchyma lumps(endometrial polyps and submucosal myomas)were retrospectively analysed and compared utilizing Virtual Organ Computer-aided AnaLysis(VOCAL)software.The results showed that all the blood flow parameters(VI,FI,VFI)were significantly higher in women with endometrial cancer than in those with uterine parenchyma lumps(P<0.001).The area under the curve of ROC of VI,FI,and VFI was 0.98,0.84,and 0.97,respectively.Thus,the best predictor of endometrial carcinoma was VI with a sensitivity of 97.0% and a specificity of 91.0%.The optimal cutoff value of VI was 4.06%.Our data demonstrated that all of the blood flow signal parameters(including VI,FI,and VFI)in 3D power Doppler ultrasonography had significant antidiastole values between endometrial cancer and uterine parenchyma lumps to assist clinicians in properly diagnosing patients.展开更多
It is important to calibrate micro-parameters for applying partied flow code(PFC)to study mechanical characteristics and failure mechanism of rock materials.Uniform design method is firstly adopted to determine the mi...It is important to calibrate micro-parameters for applying partied flow code(PFC)to study mechanical characteristics and failure mechanism of rock materials.Uniform design method is firstly adopted to determine the microscopic parameters of parallel-bonded particle model for three-dimensional discrete element particle flow code(PFC3D).Variation ranges of microscopic of the microscopic parameters are created by analyzing the effects of microscopic parameters on macroscopic parameters(elastic modulus E,Poisson ratio v,uniaxial compressive strengthσc,and ratio of crack initial stress to uniaxial compressive strengthσci/σc)in order to obtain the actual uniform design talbe.The calculation equations of the microscopic and macroscopic parameters of rock materials can be established by the actual uniform design table and the regression analysis and thus the PFC3D microscopic parameters can be quantitatively determined.The PFC3D simulated results of the intact and pre-cracked rock specimens under uniaxial and triaxial compressions(including the macroscopic mechanical parameters,stress−strain curves and failure process)are in good agreement with experimental results,which can prove the validity of the calculation equations of microscopic and macroscopic parameters.展开更多
This paper conducts a trade-off between efficiency and accuracy of three-dimensional(3 D)shape measurement based on the triangulation principle,and introduces a flying and precise 3 D shape measurement method based on...This paper conducts a trade-off between efficiency and accuracy of three-dimensional(3 D)shape measurement based on the triangulation principle,and introduces a flying and precise 3 D shape measurement method based on multiple parallel line lasers.Firstly,we establish the measurement model of the multiple parallel line lasers system,and introduce the concept that multiple base planes can help to deduce the unified formula of the measurement system and are used in simplifying the process of the calibration.Then,the constraint of the line spatial frequency,which maximizes the measurement efficiency while ensuring accuracy,is determined according to the height distribution of the object.Secondly,the simulation analyzing the variation of the systemic resolution quantitatively under the circumstance of a set of specific parameters is performed,which provides a fundamental thesis for option of the four system parameters.Thirdly,for the application of the precision measurement in the industrial field,additional profiles are acquired to improve the lateral resolution by applying a motor to scan the 3 D surface.Finally,compared with the line laser,the experimental study shows that the present method of obtaining 41220 points per frame improves the measurement efficiency.Furthermore,the accuracy and the process of the calibration are advanced in comparison with the existing multiple-line laser and the structured light makes an accuracy better than 0.22 mm at a distance of 956.02 mm.展开更多
Three-dimensional sand printing(3DSP)is widely applied in sand mold fabrication.In this study,the effects of printing parameters including the resolution of printehead holes,activator content,layer thickness,and recoa...Three-dimensional sand printing(3DSP)is widely applied in sand mold fabrication.In this study,the effects of printing parameters including the resolution of printehead holes,activator content,layer thickness,and recoating speed on the tensile and bending strengths,gas evolution,and loss-on-ignition(LOI)of 3DSP samples were investigated by changing single parameter,and the dimension deviation was also measured.As the resolution increases,the tensile strength,bending strength,gas evolution,LOI,and deviations at X-and Y-axis directions decrease gradually while the deviation at Z-axis direction firstly increases and then deceases.The gas evolution and LOI drops by 13.02%and 8.13%respectively,but the strength only reduces by 2.2% when the resolution increases from 0.08 mm to 0.09 mm.The strengths of samples rise at first and then decline while the gas evolution and LOI rise gradually with the increasing activator content or recoating speed.The activator content is found to have little effect on the gas evolution as the activator increases from 0.14%to 0.34%,the gas evolution is increased by 7.3%which is far less than the LOI increment of 24.1%.As the layer thickness increases,the tensile and bending strengths firstly rise and then drop while gas evolution and LOI descend.Under the optimal printing parameters of 0.09 mm resolution,0.18%activator,-10.28 mm layer thickness and 160 mm·s^(-1) recoating speed,the tensile strengths for X-sample and Y-sample are 1.48 MPa and 1.37 MPa,the bending strengths are 1.84 MPa and 1.75 MPa,the gas evolution and LOI are-19.62 mL·g^(-1) and 1.92%,respectively.展开更多
In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare co...In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers.展开更多
Recently,low-cost desktop three-dimensional(3D)printers,employing the fused deposition modeling(FDM)technique,have gained widespread popularity.However,most users cannot test the strength of printed parts,and little i...Recently,low-cost desktop three-dimensional(3D)printers,employing the fused deposition modeling(FDM)technique,have gained widespread popularity.However,most users cannot test the strength of printed parts,and little information is available about the mechanical properties of printed high-impact polystyrene(HIPS)parts using desktop 3D printers.In this study,the user-adjustable parameters of desktop 3D printers,such as crisscross raster orientation,layer thickness,and infill density,were tested.The experimental plans were designed using the Box-Behnken method,and tensile,3-point bending,and compression tests were carried out to determine the mechanical responses of the printed HIPS.The prediction models of the process parameters were regressed to produce the optimal combination of process parameters.The experimental results showcase that the crisscross raster orientation has significant effects on the flexural and compression strengths,but not on the tensile strength.With an increase in the layer thickness,the tensile,flexural,and compression strengths first decreased and then increased,reaching their minimum values at approximately 0.16 mm layer thickness.In addition,they all increased with an increase of infill density.It was demonstrated that when the raster orientation,layer thickness,and infill density were 13.08°/–76.92°,0.09 mm,and 80%,respectively,the comprehensive mechanical properties of the printed HIPS were optimal.Our results can help end-users of desktop 3D printers understand the effects of process parameters on the mechanical properties,and offer practical suggestions for setting proper printing parameters for fabricating HIPS parts.展开更多
Hydraulic fracturing treatments of oil wells are greatly affected by the perforation parameters selected. The three-dimensional finite element model together with the tensile criterion of rock materials is employed t...Hydraulic fracturing treatments of oil wells are greatly affected by the perforation parameters selected. The three-dimensional finite element model together with the tensile criterion of rock materials is employed to systematically investigate the influence of perforation parameters, such as perforation density, perforation orientation, perforation diameter, and perforation length as well as wellbore ellipticity, in vertical wells on the formation fracturing pressure. Based on a six-month simulation research in the University of Petroleum, China, several conclusions are drawn for the first time. Perforation density and perforation orientation angle are the most important parameters controlling the formation fracturing pressure. As the perforation density increases, the fracturing pressure decreases, not linearly but progressively. The fracturing pressure increases with the perforation orientation angle only when the angle is less than 45 degrees, and the relationship becomes very flat when the angle is 45 degrees. However, with regards to the perforation diameter and perforation length, their influences are much slighter. The wellbore ellipticity has a significant effect on the formation fracturing pressure. It is obvious that fracturing pressure increases linearly with the ellipticity of the wellbore.展开更多
By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D deve...By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology.展开更多
A new algorithm for solving the three-dimensional elastic contact problem with friction is presented. The algorithm is a non-interior smoothing algorithm based on an NCP-function. The parametric variational principle ...A new algorithm for solving the three-dimensional elastic contact problem with friction is presented. The algorithm is a non-interior smoothing algorithm based on an NCP-function. The parametric variational principle and parametric quadratic programming method were applied to the analysis of three-dimensional frictional contact problem. The solution of the contact problem was finally reduced to a linear complementarity problem, which was reformulated as a system of nonsmooth equations via an NCP-function. A smoothing approximation to the nonsmooth equations was given by the aggregate function. A Newton method was used to solve the resulting smoothing nonlinear equations. The algorithm presented is easy to understand and implement. The reliability and efficiency of this algorithm are demonstrated both by the numerical experiments of LCP in mathematical way and the examples of contact problems in mechanics.展开更多
Quantitative damage identification of surrounding rock is important to assess the current condition and residual strength of underground tunnels.In this work,an underground tunnel model with marble-like cementitious m...Quantitative damage identification of surrounding rock is important to assess the current condition and residual strength of underground tunnels.In this work,an underground tunnel model with marble-like cementitious materials was first fabricated using the three-dimensional(3D)printing technique and then loaded to simulate its failure mode in the laboratory.Lead zirconate titanate piezoelectric(PZT)transducers were embedded in the surrounding rock around the tunnel in the process of 3D printing.A 3D monitoring network was formed to locate damage areas and evaluate damage extent during loading.Results show that as the load increased,main cracks firstly appeared above the tunnel roof and below the floor,and then they coalesced into the tunnel boundary.Finally,the tunnel model was broken into several parts.The resonant frequency and the peak of the conductance signature firstly shifted rightwards with loading due to the sealing of microcracks,and then shifted backwards after new cracks appeared.An overall increase in the root-mean-square deviation(RMSD)calculated from conductance signatures of all the PZT transducers was observed as the load(damage)increased.Damage-dependent equivalent stiffness parameters(ESPs)were calculated from the real and imaginary signatures of each PZT at different damage states.Satisfactory agreement between equivalent and experimental ESP values was achieved.Also,the relationship between the change of the ESP and the residual strength was obtained.The method paves the way for damage identification and residual strength estimation of other 3D printed structures in civil engineering.展开更多
Objective: The purpose of this study was to compare the dose distribution and dose volume histogram (DVH) of the planning target volume (PTV) and organs at risk (OARs) among conventional radiation therapy (CR), three-...Objective: The purpose of this study was to compare the dose distribution and dose volume histogram (DVH) of the planning target volume (PTV) and organs at risk (OARs) among conventional radiation therapy (CR), three-dimensional conformal radiation therapy (3DCRT), two-step intensity-modulated radiation therapy (TS-IMRT) and direct machine parameter optimization intensity-modulated radiation therapy (DMPO-IMRT) after breast-conserving surgery. Methods: For each of 20 randomly chosen patients, 4 plans were designed using 4 irradiation techniques. The prescribed dose was 50 Gy/2 Gy/25 f, 95% of the planning target volume received this dose. The cumulated DVHs and 3D dose distributions of CR, 3DCRT, TS-IMRT and DMPO-IMRT plans were compared. Results: For the homogeneity indices, no statistically significant difference was observed among CR, 3DCRT, TS-IMRT and DMPO-IMRT while the difference of the conformality indices were statistically significant. With regard to the organs at risk, IMRT and 3DCRT showed a significantly fewer exposure dose to the ipsilateral lung than CR in the high-dose area while in the low-dose area, IMRT demonstrated a significant increase of exposure dose to ipsilateral lung, heart and contralateral breast compared with 3DCRT and CR. In addition, the monitor units (MUs) for DMPO-IMRT were approximately 26% more than those of TS-IMRT and the segments of the former were approximately 24% less than those of the latter. Conclusion: Compared with CR, 3DCRT and IMRT improved the homogeneity and conformity of PTV, reduced the irradiated volume of OARs in high dose area but IMRT increased the irradiated volume of OARs in low dose area. DMPO-IMRT plan has fewer delivery time but more MUs than TS-IMRT.展开更多
The binding of flucytosine to bovine serum albumin (BSA) was studied by means of fluorescence and absorption spectra under the conditions of simulant clay physiology. It showed a powerful ability to quench the fluor...The binding of flucytosine to bovine serum albumin (BSA) was studied by means of fluorescence and absorption spectra under the conditions of simulant clay physiology. It showed a powerful ability to quench the fluorescence launching from BSA. After analyzing the fluorescence quenching data by Stem-Volmer equation and Lineweaver-Burk double-reciprocal equation, it was found that they matched the latter better and so they belonged to static quenching. The binding constant was calculated to be 5.710 × 10^3 L·mol^-1 at 297 K. The binding locality was a distance 2.49 nm away from tryptophan residue-212 based on Foster's non-radiation energy transfer mechanism. The binding power is mainly the hydrogen bond and van der Waals force according to the thermodynamic parameters. The information of BSA conformation was acquired by synchronous fluorescence spectrum and three-dimensional fluorescence spectrum.展开更多
At different temperatures, the interactions between imidacloprid (IMI) and bovine serum albumin (BSA) were investigated with a fluorescence quenching spectrum, a synchronous fluorescence spectrum, a three-dimensio...At different temperatures, the interactions between imidacloprid (IMI) and bovine serum albumin (BSA) were investigated with a fluorescence quenching spectrum, a synchronous fluorescence spectrum, a three-dimensional fluorescence spectrum and an ultraviolet-visible spectrum. The average values of bonding constants (KLB: 3.424 × 10^4 L,mol^-1), thermodynamic parameters (△H: 5.188 kJ,mol^-1, △G^(○—):-26.36 kJ,mol^-1, △S: 103.9 J,K^-1,mol^-1) and the numbers of bonding sites (n: 1.156) could be obtained through Stern-Volmer, Lineweaver-Burk and ther- modynamic equations. It was shown that the fluorescence of BSA could be quenched for its reactions with IMI to form a certain kind of new compound. The quenching belonged to a static fluorescence quenching, with a non-radiation energy transfer happening within a single molecule. The thermodynamic parameters agree with △H〉 0, △S〉0 and△G^(○-)〈0, suggesting that the binding power between IMI and BSA should be mainly a hydrophobic interaction.展开更多
The interaction between BSA and epicatechin was studied using fluorescence quenching titrations combined with trilinear decomposition method and excitation-emission matrix(EEM)fluorescence.The resolved spectra were hi...The interaction between BSA and epicatechin was studied using fluorescence quenching titrations combined with trilinear decomposition method and excitation-emission matrix(EEM)fluorescence.The resolved spectra were highly similar with the actual ones which indicated that the resolved results were reliable.The relevant parameters of the binding process were obtained by quantifying each substance in the complicated mixtures in situ.The quenching was static quenching,epicatechin had a weak interaction with BSA and the binding site was one.The total concentration and the free concentration of quenchers had different effect on the system.The results demonstrated that the method exploited in this article is a useful tool to investigate complicated interactions,avoiding complicated pretreatment and simplify experimental procedure.展开更多
Corner stall predictions are important and difficult in axial compressors.However,all of the prediction models have proved to be ineffective for advanced compressor blades,which tend to use the combined sweep and dihe...Corner stall predictions are important and difficult in axial compressors.However,all of the prediction models have proved to be ineffective for advanced compressor blades,which tend to use the combined sweep and dihedral.As for the prediction parameter DL,although it effectively modeled the effects of the adverse pressure gradient and secondary flow,it failed to predict the corner stall of curved blades because the model failed to consider the intersection of the boundary layer at the corner region.In this paper,the shape factor gradientψof the boundary layer at the corner region was investigated by numerically studying specially shaped expansion pipes under different adverse pressure gradients.The improved prediction parameter DJ was presented based on the model of ψ and the circumferential pressure gradient ζ.A comparison of the critical range of the prediction parameters DL and DJ was investigated using the NACA65 cascade database,which was established by a numerical method.Then,the stall criterion was validated according to the experimental results of various test facilities with different blade geometries and experimental conditions.The results show that the improved prediction parameter is able to predict the corner separation/stall flows and is in good agreement with the experimental results for axial compressors with three-dimensional designed blades.展开更多
The local climate zone(LCZ)scheme has been widely utilized in regional climate modeling,urban planning,and thermal comfort investigations.However,existing LCz classification methods face challenges in characterizing c...The local climate zone(LCZ)scheme has been widely utilized in regional climate modeling,urban planning,and thermal comfort investigations.However,existing LCz classification methods face challenges in characterizing complex urban structures and human activities involving local climatic environments.In this study,we proposed a novel LCZ mapping method that fully uses space-borne multi-view and diurnal observations,i.e.daytime Ziyuan-3 stereo imageries(2.1 m)and Luojia-1 nighttime light(NTL)data(130 m).Firstly,we performed land cover classification using multiple machine learning methods(i.e.random forest(RF)and XGBoost algorithms)and various features(i.e.spectral,textural,multi-view features,3D urban structure parameters(USPs),and NTL).In addition,we developed a set of new cumulative elevation indexes to improve building roughness assessments.The indexes can estimate building roughness directly from fused point clouds generated by both along-and across-track modes.Finally,based on the land cover and building roughness results,we extracted 2D and 3D USPs for different land covers and used multi-classifiers to perform LCZ mapping.The results for Beijing,China,show that our method yielded satisfactory accuracy for LCZ mapping,with an overall accuracy(OA)of 90.46%.The overall accuracy of land cover classification using 3D USPs generated from both along-and across-track modes increased by 4.66%,compared to that of using the single along-track mode.Additionally,the OA value of LCZ mapping using 2D and 3D USPs(88.18%)achieved a better result than using only 2D USPs(83.83%).The use of NTL data increased the classification accuracy of LCZs E(bare rock or paved)and F(bare soil or sand)by 6.54%and 3.94%,respectively.The refined LCZ classification achieved through this study will not only contribute to more accurate regional climate modeling but also provide valuable guidance for urban planning initiatives aimed at enhancing thermal comfort and overall livabillity in urban areas.Ultimately,this study paves the way for more comprehensive and effective strategies in addressing the challenges posed by urban microclimates.展开更多
Three-dimensional(3D)-printed porous Ti6Al4V implants have good mechanical properties and excellent biocompatibility.As such,these implants are widely used in orthopedics.Particles adhere between the sintered and nons...Three-dimensional(3D)-printed porous Ti6Al4V implants have good mechanical properties and excellent biocompatibility.As such,these implants are widely used in orthopedics.Particles adhere between the sintered and nonsintered interfaces of the porous samples during 3D printing.These excess particles can be cleaned by blowing the particles and via ultrasound,but the excess internal particles of complex structural parts are difficult to remove.During long-term cyclic loading,stress and strain can cause residual Ti6Al4V particles in the pores of the implant to shed.These detached Ti6Al4V particles are in extensive contact with osteoblasts and scattered around the implant.In this study,we examined the effects of different concentrations of Ti6Al4V particles on osteoblasts and bones.MC3T3-E1 cells were used to evaluate the effects of different concentrations of Ti6Al4V particles on cells after 72 h on the basis of the expression levels of genes,involving osteopontin,alkaline phosphatase,bone morphogenetic protein-2 and runt-related transcription factor-2.Microtubule-associated protein 1 light chain 3 was used to detect the autophagy of MC3T3-E1 with different concentrations of Ti6Al4V particles.The distal femoral defects of rats were examined to examine bone growth with different concentrations of Ti6Al4V particles.All rats were accepted by micro-CT and biochemical analyses after 12 weeks.The results indicated that 10 and 100μg/ml of Ti6Al4V particles may improve osteogenic differentiation.Micro-CT revealed that low concentrations of Ti6Al4V particles may improve the osteogenesis of the rats.However,the(cortical and trabecular)BMD of middle and high dose groups was no significant change compared with control group.In conclusion,low-dose residual particles do not inhibit osteoblast differentiation and do not decrease the bone mineral density of rats.展开更多
基金funded by the National Natural Science Foundation of China(42071014).
文摘Gobi spans a large area of China,surpassing the combined expanse of mobile dunes and semi-fixed dunes.Its presence significantly influences the movement of sand and dust.However,the complex origins and diverse materials constituting the Gobi result in notable differences in saltation processes across various Gobi surfaces.It is challenging to describe these processes according to a uniform morphology.Therefore,it becomes imperative to articulate surface characteristics through parameters such as the three-dimensional(3D)size and shape of gravel.Collecting morphology information for Gobi gravels is essential for studying its genesis and sand saltation.To enhance the efficiency and information yield of gravel parameter measurements,this study conducted field experiments in the Gobi region across Dunhuang City,Guazhou County,and Yumen City(administrated by Jiuquan City),Gansu Province,China in March 2023.A research framework and methodology for measuring 3D parameters of gravel using point cloud were developed,alongside improved calculation formulas for 3D parameters including gravel grain size,volume,flatness,roundness,sphericity,and equivalent grain size.Leveraging multi-view geometry technology for 3D reconstruction allowed for establishing an optimal data acquisition scheme characterized by high point cloud reconstruction efficiency and clear quality.Additionally,the proposed methodology incorporated point cloud clustering,segmentation,and filtering techniques to isolate individual gravel point clouds.Advanced point cloud algorithms,including the Oriented Bounding Box(OBB),point cloud slicing method,and point cloud triangulation,were then deployed to calculate the 3D parameters of individual gravels.These systematic processes allow precise and detailed characterization of individual gravels.For gravel grain size and volume,the correlation coefficients between point cloud and manual measurements all exceeded 0.9000,confirming the feasibility of the proposed methodology for measuring 3D parameters of individual gravels.The proposed workflow yields accurate calculations of relevant parameters for Gobi gravels,providing essential data support for subsequent studies on Gobi environments.
基金Project(41130742)supported by the Key Program of National Natural Science Foundation of ChinaProject(2014CB046904)supportedby the National Basic Research Program of China+1 种基金Project(2011CDA119)supported by Natural Science Foundation of Hubei Province,ChinaProject(40972178)supported by the General Program of National Natural Science Foundation of China
文摘The shear behavior of rock joints is important in solving practical problems of rock mechanics. Three group rock joints with different morphologies are made by cement mortar material and a series of CNL(constant normal loading) shear tests are performed. The influences of the applied normal stress and joint morphology to its shear strength are analyzed. According to the experimental results, the peak dilatancy angle of rock joint decreases with increasing normal stress, but increases with increasing roughness. The shear strength increases with the increasing normal stress and the roughness of rock joint. It is observed that the modes of failure of asperities are tensile, pure shear, or a combination of both. It is suggested that the three-dimensional roughness parameters and the tensile strength are the appropriate parameter for describing the shear strength criterion. A new peak shear criterion is proposed which can be used to predict peak shear strength of rock joints. All the used parameters can be easily obtained by performing tests.
基金This research was supported by grants from the National Natural Science Foundation of China(No.81501530)Hubei Province Health and Family Planning Scientific Research Project(No.WJ2019M130).
文摘Sometimes endometrial polyps,submucosal myomas,and endometrial cancer show similar findings under ultrasonography.The aim of this study was to assess the antidiastole value of blood flow parameters using three-dimensional(3D)power Doppler ultrasonography angiography(PDA)between endometrial cancer and uterine parenchyma lumps.The data of the blood flow indices in 3D-PDA including the vascularization index(VI),flow index(FI),and vascularization flow index(VFI)in 40 patients with endometrial cancer and 41 patients with uterine parenchyma lumps(endometrial polyps and submucosal myomas)were retrospectively analysed and compared utilizing Virtual Organ Computer-aided AnaLysis(VOCAL)software.The results showed that all the blood flow parameters(VI,FI,VFI)were significantly higher in women with endometrial cancer than in those with uterine parenchyma lumps(P<0.001).The area under the curve of ROC of VI,FI,and VFI was 0.98,0.84,and 0.97,respectively.Thus,the best predictor of endometrial carcinoma was VI with a sensitivity of 97.0% and a specificity of 91.0%.The optimal cutoff value of VI was 4.06%.Our data demonstrated that all of the blood flow signal parameters(including VI,FI,and VFI)in 3D power Doppler ultrasonography had significant antidiastole values between endometrial cancer and uterine parenchyma lumps to assist clinicians in properly diagnosing patients.
基金Projects(51474251,51874351)supported by the National Natural Science Foundation,China。
文摘It is important to calibrate micro-parameters for applying partied flow code(PFC)to study mechanical characteristics and failure mechanism of rock materials.Uniform design method is firstly adopted to determine the microscopic parameters of parallel-bonded particle model for three-dimensional discrete element particle flow code(PFC3D).Variation ranges of microscopic of the microscopic parameters are created by analyzing the effects of microscopic parameters on macroscopic parameters(elastic modulus E,Poisson ratio v,uniaxial compressive strengthσc,and ratio of crack initial stress to uniaxial compressive strengthσci/σc)in order to obtain the actual uniform design talbe.The calculation equations of the microscopic and macroscopic parameters of rock materials can be established by the actual uniform design table and the regression analysis and thus the PFC3D microscopic parameters can be quantitatively determined.The PFC3D simulated results of the intact and pre-cracked rock specimens under uniaxial and triaxial compressions(including the macroscopic mechanical parameters,stress−strain curves and failure process)are in good agreement with experimental results,which can prove the validity of the calculation equations of microscopic and macroscopic parameters.
文摘This paper conducts a trade-off between efficiency and accuracy of three-dimensional(3 D)shape measurement based on the triangulation principle,and introduces a flying and precise 3 D shape measurement method based on multiple parallel line lasers.Firstly,we establish the measurement model of the multiple parallel line lasers system,and introduce the concept that multiple base planes can help to deduce the unified formula of the measurement system and are used in simplifying the process of the calibration.Then,the constraint of the line spatial frequency,which maximizes the measurement efficiency while ensuring accuracy,is determined according to the height distribution of the object.Secondly,the simulation analyzing the variation of the systemic resolution quantitatively under the circumstance of a set of specific parameters is performed,which provides a fundamental thesis for option of the four system parameters.Thirdly,for the application of the precision measurement in the industrial field,additional profiles are acquired to improve the lateral resolution by applying a motor to scan the 3 D surface.Finally,compared with the line laser,the experimental study shows that the present method of obtaining 41220 points per frame improves the measurement efficiency.Furthermore,the accuracy and the process of the calibration are advanced in comparison with the existing multiple-line laser and the structured light makes an accuracy better than 0.22 mm at a distance of 956.02 mm.
基金The study was supported by the National Natural Science Foundation of China(No.51975165).
文摘Three-dimensional sand printing(3DSP)is widely applied in sand mold fabrication.In this study,the effects of printing parameters including the resolution of printehead holes,activator content,layer thickness,and recoating speed on the tensile and bending strengths,gas evolution,and loss-on-ignition(LOI)of 3DSP samples were investigated by changing single parameter,and the dimension deviation was also measured.As the resolution increases,the tensile strength,bending strength,gas evolution,LOI,and deviations at X-and Y-axis directions decrease gradually while the deviation at Z-axis direction firstly increases and then deceases.The gas evolution and LOI drops by 13.02%and 8.13%respectively,but the strength only reduces by 2.2% when the resolution increases from 0.08 mm to 0.09 mm.The strengths of samples rise at first and then decline while the gas evolution and LOI rise gradually with the increasing activator content or recoating speed.The activator content is found to have little effect on the gas evolution as the activator increases from 0.14%to 0.34%,the gas evolution is increased by 7.3%which is far less than the LOI increment of 24.1%.As the layer thickness increases,the tensile and bending strengths firstly rise and then drop while gas evolution and LOI descend.Under the optimal printing parameters of 0.09 mm resolution,0.18%activator,-10.28 mm layer thickness and 160 mm·s^(-1) recoating speed,the tensile strengths for X-sample and Y-sample are 1.48 MPa and 1.37 MPa,the bending strengths are 1.84 MPa and 1.75 MPa,the gas evolution and LOI are-19.62 mL·g^(-1) and 1.92%,respectively.
基金supported by the National Natural Science Foundation of China under Grant[52077027]Liaoning Province Science and Technology Major Project[No.2020JH1/10100020].
文摘In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers.
基金supported by the National Natural Science Foundation of China(Grant No.51975097)the National Key Research and Development Project(Grant No.2020YFA0713702).
文摘Recently,low-cost desktop three-dimensional(3D)printers,employing the fused deposition modeling(FDM)technique,have gained widespread popularity.However,most users cannot test the strength of printed parts,and little information is available about the mechanical properties of printed high-impact polystyrene(HIPS)parts using desktop 3D printers.In this study,the user-adjustable parameters of desktop 3D printers,such as crisscross raster orientation,layer thickness,and infill density,were tested.The experimental plans were designed using the Box-Behnken method,and tensile,3-point bending,and compression tests were carried out to determine the mechanical responses of the printed HIPS.The prediction models of the process parameters were regressed to produce the optimal combination of process parameters.The experimental results showcase that the crisscross raster orientation has significant effects on the flexural and compression strengths,but not on the tensile strength.With an increase in the layer thickness,the tensile,flexural,and compression strengths first decreased and then increased,reaching their minimum values at approximately 0.16 mm layer thickness.In addition,they all increased with an increase of infill density.It was demonstrated that when the raster orientation,layer thickness,and infill density were 13.08°/–76.92°,0.09 mm,and 80%,respectively,the comprehensive mechanical properties of the printed HIPS were optimal.Our results can help end-users of desktop 3D printers understand the effects of process parameters on the mechanical properties,and offer practical suggestions for setting proper printing parameters for fabricating HIPS parts.
文摘Hydraulic fracturing treatments of oil wells are greatly affected by the perforation parameters selected. The three-dimensional finite element model together with the tensile criterion of rock materials is employed to systematically investigate the influence of perforation parameters, such as perforation density, perforation orientation, perforation diameter, and perforation length as well as wellbore ellipticity, in vertical wells on the formation fracturing pressure. Based on a six-month simulation research in the University of Petroleum, China, several conclusions are drawn for the first time. Perforation density and perforation orientation angle are the most important parameters controlling the formation fracturing pressure. As the perforation density increases, the fracturing pressure decreases, not linearly but progressively. The fracturing pressure increases with the perforation orientation angle only when the angle is less than 45 degrees, and the relationship becomes very flat when the angle is 45 degrees. However, with regards to the perforation diameter and perforation length, their influences are much slighter. The wellbore ellipticity has a significant effect on the formation fracturing pressure. It is obvious that fracturing pressure increases linearly with the ellipticity of the wellbore.
基金Supported by the National Science and Technology Major Project(2016ZX05023)。
文摘By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology.
文摘A new algorithm for solving the three-dimensional elastic contact problem with friction is presented. The algorithm is a non-interior smoothing algorithm based on an NCP-function. The parametric variational principle and parametric quadratic programming method were applied to the analysis of three-dimensional frictional contact problem. The solution of the contact problem was finally reduced to a linear complementarity problem, which was reformulated as a system of nonsmooth equations via an NCP-function. A smoothing approximation to the nonsmooth equations was given by the aggregate function. A Newton method was used to solve the resulting smoothing nonlinear equations. The algorithm presented is easy to understand and implement. The reliability and efficiency of this algorithm are demonstrated both by the numerical experiments of LCP in mathematical way and the examples of contact problems in mechanics.
基金The study is financially supported by the National Major Research Instrument Development Project of the National Natural Science Foundation of China(Grant No.51627812)the National Natural Science Foundation of China(Grant No.52078181)the Natural Science Foundation of Hebei Province,China(Grant No.E2019202484)。
文摘Quantitative damage identification of surrounding rock is important to assess the current condition and residual strength of underground tunnels.In this work,an underground tunnel model with marble-like cementitious materials was first fabricated using the three-dimensional(3D)printing technique and then loaded to simulate its failure mode in the laboratory.Lead zirconate titanate piezoelectric(PZT)transducers were embedded in the surrounding rock around the tunnel in the process of 3D printing.A 3D monitoring network was formed to locate damage areas and evaluate damage extent during loading.Results show that as the load increased,main cracks firstly appeared above the tunnel roof and below the floor,and then they coalesced into the tunnel boundary.Finally,the tunnel model was broken into several parts.The resonant frequency and the peak of the conductance signature firstly shifted rightwards with loading due to the sealing of microcracks,and then shifted backwards after new cracks appeared.An overall increase in the root-mean-square deviation(RMSD)calculated from conductance signatures of all the PZT transducers was observed as the load(damage)increased.Damage-dependent equivalent stiffness parameters(ESPs)were calculated from the real and imaginary signatures of each PZT at different damage states.Satisfactory agreement between equivalent and experimental ESP values was achieved.Also,the relationship between the change of the ESP and the residual strength was obtained.The method paves the way for damage identification and residual strength estimation of other 3D printed structures in civil engineering.
文摘Objective: The purpose of this study was to compare the dose distribution and dose volume histogram (DVH) of the planning target volume (PTV) and organs at risk (OARs) among conventional radiation therapy (CR), three-dimensional conformal radiation therapy (3DCRT), two-step intensity-modulated radiation therapy (TS-IMRT) and direct machine parameter optimization intensity-modulated radiation therapy (DMPO-IMRT) after breast-conserving surgery. Methods: For each of 20 randomly chosen patients, 4 plans were designed using 4 irradiation techniques. The prescribed dose was 50 Gy/2 Gy/25 f, 95% of the planning target volume received this dose. The cumulated DVHs and 3D dose distributions of CR, 3DCRT, TS-IMRT and DMPO-IMRT plans were compared. Results: For the homogeneity indices, no statistically significant difference was observed among CR, 3DCRT, TS-IMRT and DMPO-IMRT while the difference of the conformality indices were statistically significant. With regard to the organs at risk, IMRT and 3DCRT showed a significantly fewer exposure dose to the ipsilateral lung than CR in the high-dose area while in the low-dose area, IMRT demonstrated a significant increase of exposure dose to ipsilateral lung, heart and contralateral breast compared with 3DCRT and CR. In addition, the monitor units (MUs) for DMPO-IMRT were approximately 26% more than those of TS-IMRT and the segments of the former were approximately 24% less than those of the latter. Conclusion: Compared with CR, 3DCRT and IMRT improved the homogeneity and conformity of PTV, reduced the irradiated volume of OARs in high dose area but IMRT increased the irradiated volume of OARs in low dose area. DMPO-IMRT plan has fewer delivery time but more MUs than TS-IMRT.
基金Project supported by the National Natural Science Foundation of China (No. 20373051) and the National Natural Science Foundation of Hubei Province in China (No. 2005ABA067).
文摘The binding of flucytosine to bovine serum albumin (BSA) was studied by means of fluorescence and absorption spectra under the conditions of simulant clay physiology. It showed a powerful ability to quench the fluorescence launching from BSA. After analyzing the fluorescence quenching data by Stem-Volmer equation and Lineweaver-Burk double-reciprocal equation, it was found that they matched the latter better and so they belonged to static quenching. The binding constant was calculated to be 5.710 × 10^3 L·mol^-1 at 297 K. The binding locality was a distance 2.49 nm away from tryptophan residue-212 based on Foster's non-radiation energy transfer mechanism. The binding power is mainly the hydrogen bond and van der Waals force according to the thermodynamic parameters. The information of BSA conformation was acquired by synchronous fluorescence spectrum and three-dimensional fluorescence spectrum.
基金Project supported by the National Natural Science Foundation of China (Nos. 30570015, 20373051) and Natural Science Foundation of Hubei Province of China (Nos. 2005ABA067, 2005ABC002).
文摘At different temperatures, the interactions between imidacloprid (IMI) and bovine serum albumin (BSA) were investigated with a fluorescence quenching spectrum, a synchronous fluorescence spectrum, a three-dimensional fluorescence spectrum and an ultraviolet-visible spectrum. The average values of bonding constants (KLB: 3.424 × 10^4 L,mol^-1), thermodynamic parameters (△H: 5.188 kJ,mol^-1, △G^(○—):-26.36 kJ,mol^-1, △S: 103.9 J,K^-1,mol^-1) and the numbers of bonding sites (n: 1.156) could be obtained through Stern-Volmer, Lineweaver-Burk and ther- modynamic equations. It was shown that the fluorescence of BSA could be quenched for its reactions with IMI to form a certain kind of new compound. The quenching belonged to a static fluorescence quenching, with a non-radiation energy transfer happening within a single molecule. The thermodynamic parameters agree with △H〉 0, △S〉0 and△G^(○-)〈0, suggesting that the binding power between IMI and BSA should be mainly a hydrophobic interaction.
基金financially supported by the National Natural Science Foundation of China(21175041)the National Basic Research Program of China(2012CB910602)
文摘The interaction between BSA and epicatechin was studied using fluorescence quenching titrations combined with trilinear decomposition method and excitation-emission matrix(EEM)fluorescence.The resolved spectra were highly similar with the actual ones which indicated that the resolved results were reliable.The relevant parameters of the binding process were obtained by quantifying each substance in the complicated mixtures in situ.The quenching was static quenching,epicatechin had a weak interaction with BSA and the binding site was one.The total concentration and the free concentration of quenchers had different effect on the system.The results demonstrated that the method exploited in this article is a useful tool to investigate complicated interactions,avoiding complicated pretreatment and simplify experimental procedure.
基金supported by the National Natural Science Foundation of China (No. 51676015)
文摘Corner stall predictions are important and difficult in axial compressors.However,all of the prediction models have proved to be ineffective for advanced compressor blades,which tend to use the combined sweep and dihedral.As for the prediction parameter DL,although it effectively modeled the effects of the adverse pressure gradient and secondary flow,it failed to predict the corner stall of curved blades because the model failed to consider the intersection of the boundary layer at the corner region.In this paper,the shape factor gradientψof the boundary layer at the corner region was investigated by numerically studying specially shaped expansion pipes under different adverse pressure gradients.The improved prediction parameter DJ was presented based on the model of ψ and the circumferential pressure gradient ζ.A comparison of the critical range of the prediction parameters DL and DJ was investigated using the NACA65 cascade database,which was established by a numerical method.Then,the stall criterion was validated according to the experimental results of various test facilities with different blade geometries and experimental conditions.The results show that the improved prediction parameter is able to predict the corner separation/stall flows and is in good agreement with the experimental results for axial compressors with three-dimensional designed blades.
基金supported by the National Natural Science Foundation of China[grant number:41930650]the Scientific Research Project of Beijing Municipal Education Commission[grant number:KM202110016004]the Beijing Key Laboratory of Urban Spatial Information Engineering[grant number 20220111].
文摘The local climate zone(LCZ)scheme has been widely utilized in regional climate modeling,urban planning,and thermal comfort investigations.However,existing LCz classification methods face challenges in characterizing complex urban structures and human activities involving local climatic environments.In this study,we proposed a novel LCZ mapping method that fully uses space-borne multi-view and diurnal observations,i.e.daytime Ziyuan-3 stereo imageries(2.1 m)and Luojia-1 nighttime light(NTL)data(130 m).Firstly,we performed land cover classification using multiple machine learning methods(i.e.random forest(RF)and XGBoost algorithms)and various features(i.e.spectral,textural,multi-view features,3D urban structure parameters(USPs),and NTL).In addition,we developed a set of new cumulative elevation indexes to improve building roughness assessments.The indexes can estimate building roughness directly from fused point clouds generated by both along-and across-track modes.Finally,based on the land cover and building roughness results,we extracted 2D and 3D USPs for different land covers and used multi-classifiers to perform LCZ mapping.The results for Beijing,China,show that our method yielded satisfactory accuracy for LCZ mapping,with an overall accuracy(OA)of 90.46%.The overall accuracy of land cover classification using 3D USPs generated from both along-and across-track modes increased by 4.66%,compared to that of using the single along-track mode.Additionally,the OA value of LCZ mapping using 2D and 3D USPs(88.18%)achieved a better result than using only 2D USPs(83.83%).The use of NTL data increased the classification accuracy of LCZs E(bare rock or paved)and F(bare soil or sand)by 6.54%and 3.94%,respectively.The refined LCZ classification achieved through this study will not only contribute to more accurate regional climate modeling but also provide valuable guidance for urban planning initiatives aimed at enhancing thermal comfort and overall livabillity in urban areas.Ultimately,this study paves the way for more comprehensive and effective strategies in addressing the challenges posed by urban microclimates.
基金funded by National Key R&D Program of China(No.2016YFB1101100)National Key R&D Program of China(No.2018YFB1107000)+2 种基金the National Natural Science Foundation of China(No.11902089)Fundamental Research Funds for Central Public Welfare Research Institutes(NO.118009001000160001)Supported by Sichuan Science and Technology Program(No.2018SZ0036).
文摘Three-dimensional(3D)-printed porous Ti6Al4V implants have good mechanical properties and excellent biocompatibility.As such,these implants are widely used in orthopedics.Particles adhere between the sintered and nonsintered interfaces of the porous samples during 3D printing.These excess particles can be cleaned by blowing the particles and via ultrasound,but the excess internal particles of complex structural parts are difficult to remove.During long-term cyclic loading,stress and strain can cause residual Ti6Al4V particles in the pores of the implant to shed.These detached Ti6Al4V particles are in extensive contact with osteoblasts and scattered around the implant.In this study,we examined the effects of different concentrations of Ti6Al4V particles on osteoblasts and bones.MC3T3-E1 cells were used to evaluate the effects of different concentrations of Ti6Al4V particles on cells after 72 h on the basis of the expression levels of genes,involving osteopontin,alkaline phosphatase,bone morphogenetic protein-2 and runt-related transcription factor-2.Microtubule-associated protein 1 light chain 3 was used to detect the autophagy of MC3T3-E1 with different concentrations of Ti6Al4V particles.The distal femoral defects of rats were examined to examine bone growth with different concentrations of Ti6Al4V particles.All rats were accepted by micro-CT and biochemical analyses after 12 weeks.The results indicated that 10 and 100μg/ml of Ti6Al4V particles may improve osteogenic differentiation.Micro-CT revealed that low concentrations of Ti6Al4V particles may improve the osteogenesis of the rats.However,the(cortical and trabecular)BMD of middle and high dose groups was no significant change compared with control group.In conclusion,low-dose residual particles do not inhibit osteoblast differentiation and do not decrease the bone mineral density of rats.