Changes in the water cycle on the Tibetan Plateau(TP)have a significant impact on local agricultural production and livelihoods and its downstream regions.Against the background of widely reported warming and wetting,...Changes in the water cycle on the Tibetan Plateau(TP)have a significant impact on local agricultural production and livelihoods and its downstream regions.Against the background of widely reported warming and wetting,the hydrological cycle has accelerated and the likelihood of extreme weather events and natural disasters occurring(i.e.,snowstorms,floods,landslides,mudslides,and ice avalanches)has also intensified,especially in the highelevation mountainous regions.Thus,an accurate estimation of the intensity and variation of each component of the water cycle is an urgent scientific question for the assessment of plateau environmental changes.Following the transformation and movement of water between the atmosphere,biosphere and hydrosphere,the authors highlight the urgent need to strengthen the three-dimensional comprehensive observation system(including the eddy covariance system;planetary boundary layer tower;profile measurements of temperature,humidity,and wind by microwave radiometers,wind profiler,and radiosonde system;and cloud and precipitation radars)in the TP region and propose a practical implementation plan.The construction of such a three-dimensional observation system is expected to promote the study of environmental changes and natural hazards prevention.展开更多
The divergence three-dimensional millet-seed body model and the continuous distributing layer-imitating model were introduced, which were used to express geologic body, and the procedure of generating these two models...The divergence three-dimensional millet-seed body model and the continuous distributing layer-imitating model were introduced, which were used to express geologic body, and the procedure of generating these two models and their merits and demerits were synthesized. Three methods of geologic body’s three-dimensional expression were separately introduced, and the merits of the continuous distributing layer imitating model were proposed as comparing with the divergence three-dimensional millet-seed body model. The three-dimensional cubes were observed from any direction and any tangle with the application of dealing methods such as peeling, hollowing out, transparent or half-transparent.展开更多
Objective To explore three-dimensional relations of pedicle screw channel (PSC) ,screw entry point and lateral surface of cervical vertebral body by digital techniques. Methods CT scan images of cervical
By using the Somigliana representation and the concepts offinite-part integrals, a set of hypersingular integral equations ofthe interaction between two parallel planar cracks in a three-dimen-sional finite body subje...By using the Somigliana representation and the concepts offinite-part integrals, a set of hypersingular integral equations ofthe interaction between two parallel planar cracks in a three-dimen-sional finite body subjected to arbitrary loads is derived, and thenits numerical method is proposed by the finite-part integral methodcombined with the boundary element method. According to the analytictheory of hypersingular integral equations, the square root models ofdisplacement discontinuities in the elements near the crack front areapplied, and thus the computational precision is raised. Based onthis, the stress intensity factors can be directly calculated.Finally, the stress intensity factors of sever- al typicalinteraction problems are calculated.展开更多
Based on the loose medium flow field theory, the loose top-coal drawing law of longwall top-coal caving(LTCC) mining technology is studied by using self-developed three-dimensional(3D) test device. The loose top-c...Based on the loose medium flow field theory, the loose top-coal drawing law of longwall top-coal caving(LTCC) mining technology is studied by using self-developed three-dimensional(3D) test device. The loose top-coal drawing test with shields and the controlled test without shields are performed in the condition without any boundary effect. Test results show that shields will cause reduction in drawing volume of coal in the LTCC mining. The deflection phenomenon of drawing body is also observed in the controlled test, which is verified that the deflection of drawing body is caused by shield. It is found that the deflection angle decreases with increasing caving height, with the maximum value of atailand the minimum value of 0. In addition, the formula to calculate the drawing volume is proposed subsequently.The deflection of drawing body is numerically simulated using particle flow code PFC3 Dand the proposed formula to calculate drawing volume in LTCC is also verified.展开更多
In order to reveal the appearance of the clothing prototype on the human body,the characteristics of the human body’s structure above the waist section were studied.Based on the experimental data of the fit prototype...In order to reveal the appearance of the clothing prototype on the human body,the characteristics of the human body’s structure above the waist section were studied.Based on the experimental data of the fit prototype,three-dimensional prototypes features were comparatively analyzed.And then objectively evaluating the relationship was conducted between the planar structure lines of different prototypes and the human body.The results showed that the prototypes analyzed basically conformed to the size of the human body.However,when they were worn on the human body,there were problems in the structure and forming.The main reason was that the side seam was skewed to different degrees.The results of this study provide reference for many practitioners to choose prototypes.展开更多
Human induced pluripotent stem cells(hiPSCs)are invaluable resources for producing high-quality differentiated cells in unlimited quantities for both basic research and clinical use.They are particularly useful for st...Human induced pluripotent stem cells(hiPSCs)are invaluable resources for producing high-quality differentiated cells in unlimited quantities for both basic research and clinical use.They are particularly useful for studying human disease mechanisms in vitro by making it possible to circumvent the ethical issues of human embryonic stem cell research.However,significant limitations exist when using conventional flat culturing methods especially concerning cell expansion,differentiation efficiency,stability maintenance and multicellular 3D structure establishment,differentiation prediction.Embryoid bodies(EBs),the multicellular aggregates spontaneously generated from iPSCs in the suspension system,might help to address these issues.Due to the unique microenvironment and cell communication in EB structure that a 2D culture system cannot achieve,EBs have been widely applied in hiPSC-derived differentiation and show significant advantages especially in scaling up culturing,differentiation efficiency enhancement,ex vivo simulation,and organoid establishment.EBs can potentially also be used in early prediction of iPSC differentiation capability.To improve the stability and feasibility of EB-mediated differentiation and generate high quality EBs,critical factors including iPSC pluripotency maintenance,generation of uniform morphology using micro-pattern 3D culture systems,proper cellular density inoculation,and EB size control are discussed on the basis of both published data and our own laboratory experiences.Collectively,the production of a large quantity of homogeneous EBs with high quality is important for the stability and feasibility of many PSCs related studies.展开更多
BACKGROUND Knee joint pain and stiffness are the two main symptoms of knee osteoarthritis(OA)and thus restrict a patient’s activities,such as walking and walking up and downstairs.The lower body positive pressure(LBP...BACKGROUND Knee joint pain and stiffness are the two main symptoms of knee osteoarthritis(OA)and thus restrict a patient’s activities,such as walking and walking up and downstairs.The lower body positive pressure(LBPP)treadmill as one of the emerging body weight support system devices brings new hope for exerciserelated rehabilitation for knee OA patients.AIM To investigate the biomechanical effects and the subjective clinical assessment of LBPP treadmill walking exercise when compared with conventional therapy in mild to moderate knee OA patients.METHODS Eighteen patients with mild-to-moderate knee OA were recruited in this randomized controlled trial(RCT)study.The eligible knee OA patients were randomly assigned to two groups:LBPP and control groups.The patients in the LBPP group performed an LBPP walking training program for 30 min/session per day,6 d per week for 2 wk whereas the patients in the control group performed walking on the ground for the same amount.All patients underwent clinical assessments and three-dimensional gait analysis at pre-and 2-wk post-treatment.RESULTS The Western Ontario and McMaster Universities Arthritis Index and visual analog scale scores in both the LBPP group and control group were found to decrease significantly at the post-treatment point than the pre-treatment point(LBPP:70.25±13.93 vs 40.50±11.86;3.88±0.99 vs 1.63±0.52;control:69.20±8.88 vs 48.10±8.67;3.80±0.79 vs 2.60±0.70,P<0.001).Moreover,compared with the control group,the LBPP group showed more improvements in walking speed(P=0.007),stride length(P=0.037),and knee range of motion(P=0.048)during walking,which represented more improvement in walking ability.CONCLUSION The results of our RCT study showed that the LBPP group has a greater effect on improving gait parameters than the conventional group,although there was no significant advantage in clinical assessment.This finding indicates that LBPP treadmill walking training might be an effective approach for alleviating pain symptoms and improving lower extremity locomotion in mild to moderate knee OA patients.展开更多
This paper focuses on numerical simulations of bluff body aerodynamics with three-dimensional CFD(computational fluid dynamics) modeling,where a computational scheme for fluid-structure interactions is implemented.The...This paper focuses on numerical simulations of bluff body aerodynamics with three-dimensional CFD(computational fluid dynamics) modeling,where a computational scheme for fluid-structure interactions is implemented.The choice of an appropriate turbulence model for the computational modeling of bluff body aerodynamics using both two-dimensional and three-dimensional CFD numerical simulations is also considered.An efficient mesh control method which employs the mesh deformation technique is proposed to achieve better simulation results.Several long-span deck sections are chosen as examples which were stationary and pitching at a high Reynolds number.With the proposed CFD method and turbulence models,the force coefficients and flutter derivatives thus obtained are compared with the experimental measurement results and computed values completely from commercial software.Finally,a discussion on the effects of oscillation amplitude on the flutter instability of a bluff body is carried out with extended numerical simulations.These numerical analysis results demonstrate that the proposed three-dimensional CFD method,with proper turbulence modeling,has good accuracy and significant benefits for aerodynamic analysis and computational FSI studies of bluff bodies.展开更多
In the case of three-dimensional flows, the separation can be defined in more than one way. Discussions about three-dimensional boundary layer separation in the literature have found a rational extension of the zero s...In the case of three-dimensional flows, the separation can be defined in more than one way. Discussions about three-dimensional boundary layer separation in the literature have found a rational extension of the zero skin friction. Attempts have been made to establish the identity of “separation lines”. Among definitions, these may be found: (1) envelopes of limiting streamlines, (2) lines dividing flow which has come from different regions, (3) lines of singularities (problems of topology), (4) lines on which some component of the skin friction vanishes. Each of these is valid under certain conditions, but none is universally valid. In the present work, we use the definition (4), i.e. at low incidence of a blunt body the separation line is identified as the zero of the meridian skin friction component (Wang 1975). So the separation line on a flattened spheroid (6:3:1) at 6° of incidence is calculated, as well as experimentally determined by using the electrochemical method, which allows to follow the evolution of the parietal velocity gradient.展开更多
基金This research was jointly funded by the Second Tibetan Plateau Scientific Expedition and Research Program(Grant Nos.2019QZKK0103 and 2019QZKK0105)the National Natural Science Foundation of China(Grant Nos.91837208 and 42075085).
文摘Changes in the water cycle on the Tibetan Plateau(TP)have a significant impact on local agricultural production and livelihoods and its downstream regions.Against the background of widely reported warming and wetting,the hydrological cycle has accelerated and the likelihood of extreme weather events and natural disasters occurring(i.e.,snowstorms,floods,landslides,mudslides,and ice avalanches)has also intensified,especially in the highelevation mountainous regions.Thus,an accurate estimation of the intensity and variation of each component of the water cycle is an urgent scientific question for the assessment of plateau environmental changes.Following the transformation and movement of water between the atmosphere,biosphere and hydrosphere,the authors highlight the urgent need to strengthen the three-dimensional comprehensive observation system(including the eddy covariance system;planetary boundary layer tower;profile measurements of temperature,humidity,and wind by microwave radiometers,wind profiler,and radiosonde system;and cloud and precipitation radars)in the TP region and propose a practical implementation plan.The construction of such a three-dimensional observation system is expected to promote the study of environmental changes and natural hazards prevention.
基金Project supported by the Opening Foundation of the Key Lab of Resource , Environment and GISin Beijing
文摘The divergence three-dimensional millet-seed body model and the continuous distributing layer-imitating model were introduced, which were used to express geologic body, and the procedure of generating these two models and their merits and demerits were synthesized. Three methods of geologic body’s three-dimensional expression were separately introduced, and the merits of the continuous distributing layer imitating model were proposed as comparing with the divergence three-dimensional millet-seed body model. The three-dimensional cubes were observed from any direction and any tangle with the application of dealing methods such as peeling, hollowing out, transparent or half-transparent.
文摘Objective To explore three-dimensional relations of pedicle screw channel (PSC) ,screw entry point and lateral surface of cervical vertebral body by digital techniques. Methods CT scan images of cervical
文摘By using the Somigliana representation and the concepts offinite-part integrals, a set of hypersingular integral equations ofthe interaction between two parallel planar cracks in a three-dimen-sional finite body subjected to arbitrary loads is derived, and thenits numerical method is proposed by the finite-part integral methodcombined with the boundary element method. According to the analytictheory of hypersingular integral equations, the square root models ofdisplacement discontinuities in the elements near the crack front areapplied, and thus the computational precision is raised. Based onthis, the stress intensity factors can be directly calculated.Finally, the stress intensity factors of sever- al typicalinteraction problems are calculated.
基金financially supported by the Coal Joint Funds of the National Natural Science Foundation of China(No.U1361209)the National Basic Research Program of China(973 Program)(No.2013CB227903)
文摘Based on the loose medium flow field theory, the loose top-coal drawing law of longwall top-coal caving(LTCC) mining technology is studied by using self-developed three-dimensional(3D) test device. The loose top-coal drawing test with shields and the controlled test without shields are performed in the condition without any boundary effect. Test results show that shields will cause reduction in drawing volume of coal in the LTCC mining. The deflection phenomenon of drawing body is also observed in the controlled test, which is verified that the deflection of drawing body is caused by shield. It is found that the deflection angle decreases with increasing caving height, with the maximum value of atailand the minimum value of 0. In addition, the formula to calculate the drawing volume is proposed subsequently.The deflection of drawing body is numerically simulated using particle flow code PFC3 Dand the proposed formula to calculate drawing volume in LTCC is also verified.
文摘In order to reveal the appearance of the clothing prototype on the human body,the characteristics of the human body’s structure above the waist section were studied.Based on the experimental data of the fit prototype,three-dimensional prototypes features were comparatively analyzed.And then objectively evaluating the relationship was conducted between the planar structure lines of different prototypes and the human body.The results showed that the prototypes analyzed basically conformed to the size of the human body.However,when they were worn on the human body,there were problems in the structure and forming.The main reason was that the side seam was skewed to different degrees.The results of this study provide reference for many practitioners to choose prototypes.
基金Supported by National Natural Science Foundation of China,No.81770621,No.81573053Ministry of Education,Culture,Sports,Science,and Technology of Japan,KAKENHI,No.16K15604,No.18H02866Natural Science Foundation of Jiangsu Province,No.BK20180281
文摘Human induced pluripotent stem cells(hiPSCs)are invaluable resources for producing high-quality differentiated cells in unlimited quantities for both basic research and clinical use.They are particularly useful for studying human disease mechanisms in vitro by making it possible to circumvent the ethical issues of human embryonic stem cell research.However,significant limitations exist when using conventional flat culturing methods especially concerning cell expansion,differentiation efficiency,stability maintenance and multicellular 3D structure establishment,differentiation prediction.Embryoid bodies(EBs),the multicellular aggregates spontaneously generated from iPSCs in the suspension system,might help to address these issues.Due to the unique microenvironment and cell communication in EB structure that a 2D culture system cannot achieve,EBs have been widely applied in hiPSC-derived differentiation and show significant advantages especially in scaling up culturing,differentiation efficiency enhancement,ex vivo simulation,and organoid establishment.EBs can potentially also be used in early prediction of iPSC differentiation capability.To improve the stability and feasibility of EB-mediated differentiation and generate high quality EBs,critical factors including iPSC pluripotency maintenance,generation of uniform morphology using micro-pattern 3D culture systems,proper cellular density inoculation,and EB size control are discussed on the basis of both published data and our own laboratory experiences.Collectively,the production of a large quantity of homogeneous EBs with high quality is important for the stability and feasibility of many PSCs related studies.
基金the Medical Ethics Association of the Fifth Affiliated Hospital of Guangzhou Medical University(No.KY01-2018-10-18).
文摘BACKGROUND Knee joint pain and stiffness are the two main symptoms of knee osteoarthritis(OA)and thus restrict a patient’s activities,such as walking and walking up and downstairs.The lower body positive pressure(LBPP)treadmill as one of the emerging body weight support system devices brings new hope for exerciserelated rehabilitation for knee OA patients.AIM To investigate the biomechanical effects and the subjective clinical assessment of LBPP treadmill walking exercise when compared with conventional therapy in mild to moderate knee OA patients.METHODS Eighteen patients with mild-to-moderate knee OA were recruited in this randomized controlled trial(RCT)study.The eligible knee OA patients were randomly assigned to two groups:LBPP and control groups.The patients in the LBPP group performed an LBPP walking training program for 30 min/session per day,6 d per week for 2 wk whereas the patients in the control group performed walking on the ground for the same amount.All patients underwent clinical assessments and three-dimensional gait analysis at pre-and 2-wk post-treatment.RESULTS The Western Ontario and McMaster Universities Arthritis Index and visual analog scale scores in both the LBPP group and control group were found to decrease significantly at the post-treatment point than the pre-treatment point(LBPP:70.25±13.93 vs 40.50±11.86;3.88±0.99 vs 1.63±0.52;control:69.20±8.88 vs 48.10±8.67;3.80±0.79 vs 2.60±0.70,P<0.001).Moreover,compared with the control group,the LBPP group showed more improvements in walking speed(P=0.007),stride length(P=0.037),and knee range of motion(P=0.048)during walking,which represented more improvement in walking ability.CONCLUSION The results of our RCT study showed that the LBPP group has a greater effect on improving gait parameters than the conventional group,although there was no significant advantage in clinical assessment.This finding indicates that LBPP treadmill walking training might be an effective approach for alleviating pain symptoms and improving lower extremity locomotion in mild to moderate knee OA patients.
基金supported by the National Natural Science Foundation of China(Grant No.11172055)the Foundation for the Author of National Excellent Doctoral(Grant No.2002030)
文摘This paper focuses on numerical simulations of bluff body aerodynamics with three-dimensional CFD(computational fluid dynamics) modeling,where a computational scheme for fluid-structure interactions is implemented.The choice of an appropriate turbulence model for the computational modeling of bluff body aerodynamics using both two-dimensional and three-dimensional CFD numerical simulations is also considered.An efficient mesh control method which employs the mesh deformation technique is proposed to achieve better simulation results.Several long-span deck sections are chosen as examples which were stationary and pitching at a high Reynolds number.With the proposed CFD method and turbulence models,the force coefficients and flutter derivatives thus obtained are compared with the experimental measurement results and computed values completely from commercial software.Finally,a discussion on the effects of oscillation amplitude on the flutter instability of a bluff body is carried out with extended numerical simulations.These numerical analysis results demonstrate that the proposed three-dimensional CFD method,with proper turbulence modeling,has good accuracy and significant benefits for aerodynamic analysis and computational FSI studies of bluff bodies.
文摘In the case of three-dimensional flows, the separation can be defined in more than one way. Discussions about three-dimensional boundary layer separation in the literature have found a rational extension of the zero skin friction. Attempts have been made to establish the identity of “separation lines”. Among definitions, these may be found: (1) envelopes of limiting streamlines, (2) lines dividing flow which has come from different regions, (3) lines of singularities (problems of topology), (4) lines on which some component of the skin friction vanishes. Each of these is valid under certain conditions, but none is universally valid. In the present work, we use the definition (4), i.e. at low incidence of a blunt body the separation line is identified as the zero of the meridian skin friction component (Wang 1975). So the separation line on a flattened spheroid (6:3:1) at 6° of incidence is calculated, as well as experimentally determined by using the electrochemical method, which allows to follow the evolution of the parietal velocity gradient.