Purpose:.To present a case of frosted branch angiitis with tuberculous meningoencephalitis who was followed up for 18 months after treatment.Methods: Case report.Results:.A 19-year-old female with tuberculous meningoe...Purpose:.To present a case of frosted branch angiitis with tuberculous meningoencephalitis who was followed up for 18 months after treatment.Methods: Case report.Results:.A 19-year-old female with tuberculous meningoencephalitis complained of bilateral blurred vision, and presented with frosted branch angiitis and macula edema in both eyes. Treatment with systemic glucocorticoid and standard anti-tuberculosis medicine totally resolved the retinal periphlebitis and macular edema, with vision improvement achieved at the 18-month follow-up.Conclusion: Frosted branch angiitis could be secondary to tuberculous meningoencephalitis. Based on standard anti-tuberculosis medicine, systemic glucocorticoid may help in the remission of frosted branch angiitis.展开更多
BACKGROUND Although coronavirus disease 2019(COVID-19)vaccines have been effective in controlling the COVID-19 pandemic,a variety of post-vaccination neurological complications have been reported worldwide.Amyloidβ-r...BACKGROUND Although coronavirus disease 2019(COVID-19)vaccines have been effective in controlling the COVID-19 pandemic,a variety of post-vaccination neurological complications have been reported worldwide.Amyloidβ-related angiitis(ABRA)is a rare neurological disease.The underlying cause of ABRA is unknown,but several studies suggest that it is caused by an excessive immune response to amyloid-βdeposited in blood vessels.In addition,limited attention has been paid to potential triggers of ABRA,such as infection or vaccination.CASE SUMMARY We report a case of ABRA that developed 2 wk after COVID-19 vaccination.A 75-year-old woman developed a frontal headache after receiving a second dose of COVID-19 BNT162b2 vaccine(Pfizer-BioNTech).Diffusion-weighted magnetic resonance imaging(DW-MRI)of the head showed abnormal hyperintensity,suggesting cerebral infarctions in the left parietal and occipital lobes.We diagnosed her condition as ABRA based on a brain biopsy.We administered steroid pulse therapy and the patient’s symptoms and DW-MRI abnormalities improved.This case had a good outcome due to prompt diagnosis and treatment.CONCLUSION We report a case of ABRA that may have been triggered by COVID-19 vaccination.展开更多
Frosted branch angiitis(FBA)is a rare retinal vascular disease that usually affects healthy,young adolescents and tends to be bilateral.Cxirrently,there are limited reports on FBA worldwide.In this paper,we will prese...Frosted branch angiitis(FBA)is a rare retinal vascular disease that usually affects healthy,young adolescents and tends to be bilateral.Cxirrently,there are limited reports on FBA worldwide.In this paper,we will present a case of FBA after fever.展开更多
目的总结瘤样脱髓鞘病(tumefactive demyelinating lesions, TDLs)与瘤样原发性中枢神经系统血管炎(tumefactive primary angiitis of the central nervous system, TPACNS)的MRI特点,为临床鉴别提供重要参考依据。方法选择2009年12月至...目的总结瘤样脱髓鞘病(tumefactive demyelinating lesions, TDLs)与瘤样原发性中枢神经系统血管炎(tumefactive primary angiitis of the central nervous system, TPACNS)的MRI特点,为临床鉴别提供重要参考依据。方法选择2009年12月至2018年3月于衡水市第四人民医院和解放军总医院第六医学中心住院治疗的经病理证实的TPACNS患者19例和TDLs患者17例,回顾性分析二者的MRI特点。结果 TPACNS和TDLs的发病平均年龄分别为(32.0±13.7)岁和(39.3±12.8)岁,差异无统计学意义(P=0.113)。TPACNS平均病程(42.2±7.7)周,明显长于TDLs组[(4.0±2.7)周],差异有统计学意义(P=0.033)。TPACNS以慢性起病常见,TDLs则以亚急性起病常见,差异有统计学意义(P<0.05)。TPACNS组病灶累及皮质或皮质下明显多于TDLs组,病灶累及脑干明显少于TDLs组。所有TPACNS的T1WI、T2WI病灶均为不均匀病灶,而所有TDLs均呈均匀病灶。TPACNS组中12例的DWI呈病灶中心低信号、周边高信号,TDLs组则无。TPACNS组中12例呈现不规则、不连续、不均匀强化,可表现为不规则肠腔样强化、不规则不均一弥漫样强化、不规则不连续壁薄厚不均匀强化。TDLs组强化方式多样。结论 TDLs和TPACNS患者的MRI影像学有一定特征,累及部位、T1WI、T2WI及DWI信号特点、病灶均匀度、MRI增强图像,对于鉴别TDLs和TPACNS有重大提示意义。展开更多
原发性中枢神经系统血管炎(primary angiitis of the central nervous system,PACNS)是一种罕见重度的累及脑实质、脊髓、软脑膜中小血管的免疫炎性疾病。该病由Harbitz在1922年首次报道,随后20世纪50~70年代陆续有数10篇相关病例的报道...原发性中枢神经系统血管炎(primary angiitis of the central nervous system,PACNS)是一种罕见重度的累及脑实质、脊髓、软脑膜中小血管的免疫炎性疾病。该病由Harbitz在1922年首次报道,随后20世纪50~70年代陆续有数10篇相关病例的报道,其中绝大多数都是尸检后诊断[1],在1988年由Calabrese和Mallek正式命名为PACNS。展开更多
文摘Purpose:.To present a case of frosted branch angiitis with tuberculous meningoencephalitis who was followed up for 18 months after treatment.Methods: Case report.Results:.A 19-year-old female with tuberculous meningoencephalitis complained of bilateral blurred vision, and presented with frosted branch angiitis and macula edema in both eyes. Treatment with systemic glucocorticoid and standard anti-tuberculosis medicine totally resolved the retinal periphlebitis and macular edema, with vision improvement achieved at the 18-month follow-up.Conclusion: Frosted branch angiitis could be secondary to tuberculous meningoencephalitis. Based on standard anti-tuberculosis medicine, systemic glucocorticoid may help in the remission of frosted branch angiitis.
文摘BACKGROUND Although coronavirus disease 2019(COVID-19)vaccines have been effective in controlling the COVID-19 pandemic,a variety of post-vaccination neurological complications have been reported worldwide.Amyloidβ-related angiitis(ABRA)is a rare neurological disease.The underlying cause of ABRA is unknown,but several studies suggest that it is caused by an excessive immune response to amyloid-βdeposited in blood vessels.In addition,limited attention has been paid to potential triggers of ABRA,such as infection or vaccination.CASE SUMMARY We report a case of ABRA that developed 2 wk after COVID-19 vaccination.A 75-year-old woman developed a frontal headache after receiving a second dose of COVID-19 BNT162b2 vaccine(Pfizer-BioNTech).Diffusion-weighted magnetic resonance imaging(DW-MRI)of the head showed abnormal hyperintensity,suggesting cerebral infarctions in the left parietal and occipital lobes.We diagnosed her condition as ABRA based on a brain biopsy.We administered steroid pulse therapy and the patient’s symptoms and DW-MRI abnormalities improved.This case had a good outcome due to prompt diagnosis and treatment.CONCLUSION We report a case of ABRA that may have been triggered by COVID-19 vaccination.
文摘Frosted branch angiitis(FBA)is a rare retinal vascular disease that usually affects healthy,young adolescents and tends to be bilateral.Cxirrently,there are limited reports on FBA worldwide.In this paper,we will present a case of FBA after fever.
文摘目的总结瘤样脱髓鞘病(tumefactive demyelinating lesions, TDLs)与瘤样原发性中枢神经系统血管炎(tumefactive primary angiitis of the central nervous system, TPACNS)的MRI特点,为临床鉴别提供重要参考依据。方法选择2009年12月至2018年3月于衡水市第四人民医院和解放军总医院第六医学中心住院治疗的经病理证实的TPACNS患者19例和TDLs患者17例,回顾性分析二者的MRI特点。结果 TPACNS和TDLs的发病平均年龄分别为(32.0±13.7)岁和(39.3±12.8)岁,差异无统计学意义(P=0.113)。TPACNS平均病程(42.2±7.7)周,明显长于TDLs组[(4.0±2.7)周],差异有统计学意义(P=0.033)。TPACNS以慢性起病常见,TDLs则以亚急性起病常见,差异有统计学意义(P<0.05)。TPACNS组病灶累及皮质或皮质下明显多于TDLs组,病灶累及脑干明显少于TDLs组。所有TPACNS的T1WI、T2WI病灶均为不均匀病灶,而所有TDLs均呈均匀病灶。TPACNS组中12例的DWI呈病灶中心低信号、周边高信号,TDLs组则无。TPACNS组中12例呈现不规则、不连续、不均匀强化,可表现为不规则肠腔样强化、不规则不均一弥漫样强化、不规则不连续壁薄厚不均匀强化。TDLs组强化方式多样。结论 TDLs和TPACNS患者的MRI影像学有一定特征,累及部位、T1WI、T2WI及DWI信号特点、病灶均匀度、MRI增强图像,对于鉴别TDLs和TPACNS有重大提示意义。
文摘原发性中枢神经系统血管炎(primary angiitis of the central nervous system,PACNS)是一种罕见重度的累及脑实质、脊髓、软脑膜中小血管的免疫炎性疾病。该病由Harbitz在1922年首次报道,随后20世纪50~70年代陆续有数10篇相关病例的报道,其中绝大多数都是尸检后诊断[1],在1988年由Calabrese和Mallek正式命名为PACNS。
