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Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older 被引量:4
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作者 Bojin Xu Hui Yang +7 位作者 Zhixiao Wang Tao Yang Hongwei Guo Pei Cheng Wei He Min Sun Huanhuan Chen Yu Duan 《The Journal of Biomedical Research》 CAS CSCD 2016年第6期476-482,共7页
This study investigated whether high-normal thyrotropin(TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old.Clinical and metabolic factors were assessed in 2,356 subjects(40... This study investigated whether high-normal thyrotropin(TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old.Clinical and metabolic factors were assessed in 2,356 subjects(40-77 years old) with TSH levels in the normal range(0.35-5.00 mU/L).Using 2.50 mU/L as the cut-off point of TSH level within the normal range,we divided subjects into the high-TSH(2.50-5.00 mU/L;n= 1,064) and low-TSH(0.35-2.50mU/L;n= 1,292) group.The results showed that the mean levels of body mass index(BMI),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),and fasting plasma glucose(FPG) were higher in the high-TSH group and TSH levels were significantly positively con-elated with BMI,LDL-C,TC,and FPG.The prevalence of central obesity,hypertriglyceridemia,low high density lipoprotein cholesterol(HDL-C),and high FPG(〉5.60 mmol/L) was significantly higher in females and subjects with high-TSH levels.Metabolic syndrome was also more prevalent in the high-TSH group.People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk of metabolic syndrome,compared with those with low-normal TSII levels,after adjusting for age and gender.In conclusion,high normal TSH is a risk factor for metabolic syndrome in people ≥40 years old. 展开更多
关键词 thyroid stimulating hormone euthyroid metabolic syndrome central obesity dyslipidemia
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Association of Serum Ferritin Levels and Thyroid Hormones
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作者 Hari Krishnan Krishnamurthy Swarnkumar Reddy +6 位作者 Vasanth Jayaraman Karthik Krishna Qi Song Karenah E. Rajasekaran Tianhao Wang Kang Bei John J. Rajasekaran 《Open Journal of Clinical Diagnostics》 2023年第3期68-79,共12页
Thyroid metabolism is orchestrated by the action of various minerals and trace elements including iron, iodine, selenium, and zinc. Iron deficiency, specifically deficiency in serum ferritin levels, is one of the comm... Thyroid metabolism is orchestrated by the action of various minerals and trace elements including iron, iodine, selenium, and zinc. Iron deficiency, specifically deficiency in serum ferritin levels, is one of the common causes of thyroid dysfunction. Our objective was to evaluate the relationship between serum ferritin levels and circulating thyroid hormones. For this, a retrospective analysis was performed on 16,512 individuals who tested for serum levels of ferritin and thyroid profile at Vibrant America Clinical Laboratories. Subjects were stratified based on the serum levels of ferritin. Age (p −0.03232, p < 0.0001). Analysis of Linear association by Pearson’s correlation exhibited a considerable correlation between varying serum ferritin levels with all tested thyroid hormones. The study concludes that serum ferritin levels were associated with thyroid hormone synthesis and metabolism in individuals with optimal levels of circulating ferritin. 展开更多
关键词 FERRITIN THYROXINE Free Triiodothyronine Free Thyroxine thyroid stimulating hormone
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Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing
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作者 Kimberly Tafuri Denise Dixon +2 位作者 Katherine Markarian Andrew Lane Thomas A. Wilson 《International Journal of Clinical Medicine》 2015年第12期912-918,共7页
Background: The relationship between growth hormone (GH) and cytokines remains unclear. Several studies have suggested that GH increases tumor necrosis factor (TNF)-α production in both children and adults. However, ... Background: The relationship between growth hormone (GH) and cytokines remains unclear. Several studies have suggested that GH increases tumor necrosis factor (TNF)-α production in both children and adults. However, a number of studies have demonstrated a negative correlation between GH and TNF α. The aim of this study is to explore the relationship between endogenous GH secretion and certain pro and anti-inflammatory cytokines in short children undergoing GH stimulation testing for evaluation for GH deficiency. Methods: Plasma growth hormone, TNF α, CRP, IL-6, IL1-β, IL-4 and IL-10 levels are obtained at baseline and every 30 minutes for 150 minutes following two provocative agents (clonidine, and either arginine or glucagon). Results: Among the 23 children, 7 are found to be GH deficient. No significant differences in baseline TNF α levels are found between GH deficient and GH sufficient children. No correlation is identified between TNF α levels and GH levels during stimulation testing. Furthermore, no relationship is found between GH and pro-inflammatory cytokines or GH and anti-inflammatory cytokines. Conclusion: Our results do not demonstrate an acute relationship between endogenous GH secretion and the cytokines examined. 展开更多
关键词 GROWTH hormone Tumor Necrosis Factor-α CYTOKINES CRP IL-6 IL1-β IL-4 IL-10 GROWTH hormone stimulATION TESTING CLONIDINE Arginine Glucagon
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Optimal Threshold of Stimulated Serum Thyroglobulin Level for ^(18)F-FDG PET/CT imaging in Patients with Thyroid Cancer
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作者 柴红 张虎 +1 位作者 余永利 高云朝 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2017年第3期429-432,共4页
This study was to explore the optimal threshold of thyroid-stimulating hormone(TSH)-stimulated serum thyroglobulin(s-Tg) for patients who were to receive18F-fluorodeoxyglucose(18F-FDG) PET/CT scan owing to clinical su... This study was to explore the optimal threshold of thyroid-stimulating hormone(TSH)-stimulated serum thyroglobulin(s-Tg) for patients who were to receive18F-fluorodeoxyglucose(18F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer(DTC) recurrence but negative post-therapeutic 131I whole-body scan(131I-WBS). A total of 60 qualified patients underwent PET/CT scanning from October 2010 to July 2014. The receiver operating characteristic(ROC) curve analyses showed that s-Tg levels over 49 μg/L led to the highest diagnostic accuracy of PET/CT to detect recurrence, with a sensitivity of 89.5% and a specificity of 90.9%. Besides, bivariate correlation analysis showed positive correlation between s-Tg levels and the maximum standardized uptake values(SUVmax) of18F-FDG in patients with positive PET/CT scanning, suggesting a significant influence of TSH both on Tg release and uptake of18F-FDG. So, positive PET/CT imaging is expected when patients have negative 131I-WBS but s-Tg levels over 49 μg/L. 展开更多
关键词 18F-fluorodeoxyglucose(18F-FDG) positron emission tomography/computed tomography(PET/CT) differentiated thyroid cancer(DTC) post-therapeutic 131I whole-body scan(131I-WBS) serum thyroglobulin(Tg) thyroid-stimulating hormone(TSH)
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孕早期孕妇促甲状腺激素、甲状腺过氧化物酶抗体及微小RNA-873-5p水平与妊娠期糖尿病相关性研究 被引量:2
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作者 杨静 郭永 郭润民 《陕西医学杂志》 CAS 2024年第4期479-482,495,共5页
目的:分析研究孕早期促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)及微小RNA-873-5p(miR-873-5p)水平与妊娠期糖尿病(GDM)的相关性。方法:选取定期产检的GDM孕妇命名为GDM组(n=109),另选同期在本院产检的糖耐量正常孕妇为对照组(n=... 目的:分析研究孕早期促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)及微小RNA-873-5p(miR-873-5p)水平与妊娠期糖尿病(GDM)的相关性。方法:选取定期产检的GDM孕妇命名为GDM组(n=109),另选同期在本院产检的糖耐量正常孕妇为对照组(n=60)。收集两组孕妇的一般资料及孕早期实验室检测指标(TSH、TPOAb、miR-873-5p),采用单因素、多因素分析TSH、TPOAb、miR-873-5p水平与GDM的关系;并绘制ROC曲线分析血清TSH、TPOAb、miR-873-5p水平对GDM的预测价值。结果:GDM组的血清TSH、TPOAb、miR-873-5p水平均高于对照组,差异具有统计学意义(均P<0.05);多因素Logistic回归分析显示,年龄>30岁(OR=1.982)、孕前BMI≥24 kg/m^(2)(OR=2.020)、TSH升高(OR=2.113)、TPOAb升高(OR=2.307)及miR-873-5p水平升高(OR=2.059)是发生GDM的独立危险因素(均P<0.05);ROC曲线分析显示,血清TSH、TPOAb、miR-873-5p及联合检测的曲线下面积(AUC)分别为0.830、0.829、0.762、0.936,联合检测优于单一检测(P<0.05)。结论:TSH、TPOAb及miR-873-5p在GDM孕妇体内呈高表达,可能成为GDM发生的辅助预测指标。 展开更多
关键词 孕早期 妊娠期糖尿病 促甲状腺激素 甲状腺过氧化物酶抗体 微小RNA-873-5p 相关性
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Efficacy of the long-acting octreotide formulation in patients with thyroid-stimulating hormone-secreting pituitary adenomas after incomplete surgery and octreotide treatment failure 被引量:3
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作者 ZHANG Chun-fang LIANG Dan ZHONG Li-yong 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第15期2758-2763,共6页
Background Little information about the current management of patients with thyroid-stimulating hormone (TSH)-secreting pituitary adenomas or about the usefulness of the somatostatin analogue octreotide was containe... Background Little information about the current management of patients with thyroid-stimulating hormone (TSH)-secreting pituitary adenomas or about the usefulness of the somatostatin analogue octreotide was contained in the literature. This study aimed to report the efficacy and safety of the long-acting octreotide formulation in patients with TSH-secreting pituitary adenomas after incomplete surgery and octreotide treatment failure. Methods Fifteen patients with TSH-secreting pituitary adenomas (8 men and 7 women), who previously underwent incomplete surgical resection and/or adjuvant radiotherapy (n=12) and failure of octreotide treatment (n=15), followed between 2007 and 2010 in Beijing Tiantan Hospital were included in this study. All patients received 1- to 2-months of the long-acting octreotide formulation treatment after the above combination of treatment. Paired samples t-test was used to analysis the variables. Results After two-month duration of the long-acting octreotide formulation treatment, the mean serum free or unbound thyroxine (FT4) ((16.02±1.72) pmol/L) and free triiodothyronine (FT3) ((2.87±0.43) pmol/L) levels of 15 patients significantly decreased compared with those after octreotide-treatment (FT4, (35.36±7.42) pmol/L, P 〈0.001; FT3, (17.85±7.22) pmol/L, P 〈0.001). Mean TSH levels stayed in the normal range after the long-acting octreotide formulation treatment ((0.72±0.21) mUlL) and were significantly lower than the pretreatment value ((5.27±1.04) mUlL, P 〈0.001), post-surgery value ((3.37±0.31) mU/L, P 〈0.001) and post-octreotide-treatment value ((4.52±0.41) mU/L, P 〈0.001). In these patients with TSH-secreting pituitary adenomas there was no evidence of tachyphylaxis. Conclusion The long-acting octreotide formulation may be a useful and safe therapeutic tool to facilitate the medical treatment of TSH-secreting pituitary adenomas in patients who underwent incomplete surgery or need long-term somatostatin analog therapy. 展开更多
关键词 pituitary adenomas thyroid-stimulating hormone long-acting octreotide formulation OCTREOTIDE SURGERY
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Enzyme-loaded liposome with biocatalytic precipitation for potentiometric immunoassay of thyroid-stimulating hormone in thyroid carcinoma 被引量:1
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作者 Yongjin Cao Min Zheng +1 位作者 Weihua Cai Zongcai Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第2期463-467,共5页
A simple and feasible potentiometric immunosensing platform based on enzymatic biocatalytic precipitation technique was designed for the sensitive detection of thyroid-stimulating hormone(TSH;a typical kind of biomark... A simple and feasible potentiometric immunosensing platform based on enzymatic biocatalytic precipitation technique was designed for the sensitive detection of thyroid-stimulating hormone(TSH;a typical kind of biomarkers for thyroid carcinoma),using horseradish peroxidase(HRP)-loaded liposome for the signal amplification.To construct such an assay system,a sandwich-type immunoreaction was readily carried out on monoclonal anti-TSH capture antibody-coated electrode by using polyclonal antiTSH secondary antibody-conjugated HRP-loaded liposome.Accompanying the formation of sandwichtype immunocomplex,the carried liposome was lysed through the added Triton X-100 to release the entrapped HRP molecules,which catalyzed the oxidation of 4-chloro-1-naphthol to produce an insoluble and uncharged organic precipitation on the electrode surface,thereby causing the change of the local electrical potential.Two labeling protocols with and without the liposome were investigated for detection of target TSH,improved analytical features were achieved with HRP-entrapped liposome.Under optimal conditions,the potentiometric immunosensor had good responses for TSH detection within the linear range of 0.01-30 p IU/mL at a detection limit of 0.0067 p IU/mL.Good reproducibility,high specificity and long-time stability were acquired during the assay procedure.Importantly,a wellmatched accuracy between the potentiometric immunosensor and commercial human TSH ELISA kit was gave for the analysis of human serum samples. 展开更多
关键词 POTENTIOMETER Modification electrode POTENTIOMETRIC IMMUNOASSAY thyroid-stimulating hormone Enzyme-encapsulated LIPOSOME ENZYME biocatalytic PRECIPITATION
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Wavelength-dependent three-dimensional single-molecule superlocalization imaging for yoctomole detection of thyroid-stimulating hormone on a quantum dot nanobiosensor
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作者 Junghwa Lee Seungah Lee Seong Ho Kang 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第12期518-521,共4页
A wavelength-dependent three-dimensional(3D)superlocalization imaging method on gold nanoislands(GNIs)chip was developed as a supersensitive single-molecule thyroid-stimulating hormone(TSH)nanobiosensor.Scattered and ... A wavelength-dependent three-dimensional(3D)superlocalization imaging method on gold nanoislands(GNIs)chip was developed as a supersensitive single-molecule thyroid-stimulating hormone(TSH)nanobiosensor.Scattered and fluorescent signals from gold nanoislands on the substrate and quantum dots(QDs)nanoprobes were simultaneously isolated and acquired within an evanescent field layer generated by total internal reflection(TIR)of incident light using a dual-view device.The 3D TIR fluorescence images of TSH-bound QDs on the GNIs were obtained using z-axis optical sectioning at 10nm intervals before/after immunoreaction to identify the optimal conditions for detection.The localized centroid position of QD nanoprobes and GNI were distinguished at a subdiffraction limit resolution using 3D Gaussian fitting to the point spread function.The QD TSH nanobiosensor using wavelength-dependent 3D TIR fluorescence-based single-molecule localization microscopy(3D TIRF-SLM)imaging technique showed an excellent detection limit of 90 yoctomoles(~54 molecules)and a wide linear dynamic range of 1.14 zmol/L-100 pmol/L for TSH.The detection sensitivity was about 4.4×10^(9)times higher than conventional enzyme-linked immunosorbent assay and could successfully quantify TSH in human serum.The wavelength-dependent 3D TIRF-SLM technique may emerge as a reliable platform for ultrahigh-sensitive nanobiosensors at the single-molecule level and early diagnosis with quantification of disease-related ultra-tracebiomolecules. 展开更多
关键词 Single-molecule nanobiosensor thyroid stimulating hormone Yoctomole detection 3D superlocalization IMAGING
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超声联合血清TSH、FGF-19检测在甲状腺癌术前N分期中的应用价值
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作者 富威东 程起 《全科医学临床与教育》 2024年第6期497-500,505,共5页
目的探讨超声联合血清促甲状腺激素(TSH)、成纤维细胞生长因子19(FGF-19)检测在甲状腺癌术前N分期中的应用价值。方法回顾分析2021年10月至2022年10月在深圳市宝安区人民医院实施甲状腺切除手术的100例患者临床资料,根据术后淋巴结节活... 目的探讨超声联合血清促甲状腺激素(TSH)、成纤维细胞生长因子19(FGF-19)检测在甲状腺癌术前N分期中的应用价值。方法回顾分析2021年10月至2022年10月在深圳市宝安区人民医院实施甲状腺切除手术的100例患者临床资料,根据术后淋巴结节活检病理结果将其分为pN0期、pN1a期和pN1b期,采用Kappa检验分析超声评估N分期和病理评估的一致性;采用单因素及多因素分析甲状腺癌术前N分期的影响因素,并绘制受试者工作特征(ROC)曲线分析超声联合血清TSH、FGF-19检测对甲状腺癌术前N分期诊断的价值。结果术前超声评估N分期与病理N分期呈中等一致性(Kappa=0.52,P<0.05)。单因素分析提示超声结节数量、纵横比、形态、边缘情况及血清TSH、FGF-19水平与术前N分期相关(χ^(2)分别=15.76、4.83、29.19、28.93,t分别=8.17、12.21,P均<0.05),多因素分析显示超声征象(结节数量、纵横比、形态、边缘情况)及血清TSH、FGF-19水平均为甲状腺癌术前N分期的独立影响因素(OR分别=1.04、1.30、1.05、1.29、1.18、1.62,P均<0.05)。ROC分析显示超声联合血清TSH、FGF-19检测诊断术前N分期的曲线下面积(AUC)为0.87,灵敏度为81.08%,特异度为93.65%,其中AUC、特异度均明显高于单一诊断(Z分别=5.64、8.24、4.52,χ^(2)分别=7.50、13.18、10.79,P均<0.05)。结论术前超声联合血清TSH、FGF-19对甲状腺癌术前N分期的诊断具有一定价值,三者联合可提高诊断特异度,为淋巴结转移的早期诊断提供可靠信息。 展开更多
关键词 超声 促甲状腺激素 成纤维细胞生长因子-19 甲状腺癌 N分期 淋巴结转移
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Thyroid Hormone Biomonitoring:A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals
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作者 Shijie Chen Mengjie Yu +7 位作者 Yiming Yao Yongcheng Li Ana He Zijun Zhou Liyang Pan Nan Xiao Haining Luo Hongwen Sun 《Environment & Health》 2024年第6期350-372,共23页
The thyroid is an essential endocrine organ in human body,and thyroid hormones(THs)are pivotal signaling molecules and mediators in various physiological processes.THs,particularly in their free form,play a critical r... The thyroid is an essential endocrine organ in human body,and thyroid hormones(THs)are pivotal signaling molecules and mediators in various physiological processes.THs,particularly in their free form,play a critical role in regulating body temperature and in the metabolism of lipid and glucose,making the maintenance of TH levels crucial for human health.THs undergo a series of metabolic processes,producing TH metabolites(THMs).THMs are significant in endocrine regulation,such as 3,5-diiothyronine(3,5-T2)and 3-iodothyronamine(3-T1AM),which exhibit activities akin to THs.The production and distribution of THMs are intricately linked to the function of specific organs and tissues,highlighting the need for advanced research into the determination and mechanisms of THMs in body.Exposure to endocrine disrupting chemicals(EDCs)can significantly affect the levels of thyroid stimulating hormone(TSH)and THs.This review utilizes machine learning to analyze epidemiological data,identifying potential EDCs that pose risks of hyperthyroidism and hypothyroidism.Additionally,it delves into the toxicological mechanisms of these EDCs,examining their effects on TH production,binding processes,related proteins,and metabolic enzymes.This approach effectively bridges the gap between epidemiological studies and toxicological researches,laying the groundwork for future research trends.By integrating epidemiological studies with machine learning,this review offers insightful perspectives on the potential risks associated with chemical exposure and underscores the necessity for further research in understanding the impact of EDCs on TH metabolism and TH-related health effects. 展开更多
关键词 thyroid stimulating hormone Emerging contaminants Data mining THYROXINE 3 3′ 5-Triiodothyronine HOMEOSTASIS
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TSGF、Tpo-Ab、TSH在分化型甲状腺癌患者中的表达及意义
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作者 贾新琴 李文东 许开利 《国际检验医学杂志》 CAS 2024年第9期1136-1140,共5页
目的 探讨肿瘤特异性生长因子(TSGF)、抗甲状腺过氧化物酶抗体(Tpo-Ab)和促甲状腺激素(TSH)在分化型甲状腺癌(DTC)患者中的表达及意义。方法 选取上海曲阳医院2017年8月至2020年8月收治的96例DTC患者,以术中所取得的癌组织作为DTC组,另... 目的 探讨肿瘤特异性生长因子(TSGF)、抗甲状腺过氧化物酶抗体(Tpo-Ab)和促甲状腺激素(TSH)在分化型甲状腺癌(DTC)患者中的表达及意义。方法 选取上海曲阳医院2017年8月至2020年8月收治的96例DTC患者,以术中所取得的癌组织作为DTC组,另取其癌旁正常甲状腺组织作为对照组。采用酶联免疫吸附试验(ELISA)检测TSGF、TSH水平,采用荧光磁微粒免疫法检测Tpo-Ab水平,Kaplan-Meier法分析TSGF、Tpo-Ab、TSH水平与DTC患者预后的关系,Cox回归分析影响DTC患者预后的危险因素。结果 与对照组相比,DTC组的TSGF、Tpo-Ab、TSH水平显著升高,差异有统计学意义(P<0.05);肿瘤分期Ⅲ期、发生腺外浸润的DTC患者TSGF、Tpo-Ab、TSH水平显著高于肿瘤分期Ⅰ~Ⅱ期、未发生腺外浸润的DTC患者,差异有统计学意义(P<0.05)。TSGF、Tpo-Ab、TSH高水平组患者2年生存率分别显著低于低水平组,差异有统计学意义(χ^(2)=6.095、6.095、9.524,P=0.014、0.014、0.002)。与生存组相比,死亡组TSGF、Tpo-Ab、TSH水平显著升高,差异有统计学意义(P<0.05)。多因素Cox回归分析显示,肿瘤分期、腺外浸润、TSGF、Tpo-Ab、TSH水平是影响DTC患者预后的危险因素(P<0.05)。结论 DTC组织中TSGF、Tpo-Ab、TSH水平增加,三者水平与DTC患者临床病理特征和预后密切相关。 展开更多
关键词 肿瘤特异性生长因子 抗过氧化物酶抗体 促甲状腺激素 分化型甲状腺癌 预后
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MSCT特征及血清Gal-3、TSH、E-cad与PTMC颈部淋巴结转移的相关分析
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作者 周逢春 陈传新 童朝阳 《临床和实验医学杂志》 2024年第11期1207-1211,共5页
目的 分析多层螺旋CT(MSCT)特征及血清半乳糖凝集素-3(Gal-3)、促甲状腺激素(TSH)、上皮钙黏素(E-cad)与甲状腺微小乳头状癌(PTMC)颈部淋巴结转移(LNM)的相关性。方法 回顾性选择2018年1月至2019年12月于马鞍山十七冶医院就诊的PTMC患... 目的 分析多层螺旋CT(MSCT)特征及血清半乳糖凝集素-3(Gal-3)、促甲状腺激素(TSH)、上皮钙黏素(E-cad)与甲状腺微小乳头状癌(PTMC)颈部淋巴结转移(LNM)的相关性。方法 回顾性选择2018年1月至2019年12月于马鞍山十七冶医院就诊的PTMC患者84例纳入实验组,选择同期于本院治疗的甲状腺良性结节患者84例纳入对照组。观察两组病灶及淋巴结的MSCT特征(病灶多发、最大直径、形态不规则、微钙化、结节突破甲状腺包膜、淋巴结肿大、淋巴结不均匀强化),并检查与比较两组血清Gal-3、TSH、E-cad水平。统计实验组颈部LNM、无颈部LNM患者例数,并观察实验组颈部LNM、无颈部LNM患者病灶及淋巴结的MSCT特征,血清Gal-3、TSH、E-cad水平。分析PTMC患者病灶的MSCT特征及血清Gal-3、TSH、E-cad水平与颈部LNM的相关性。结果 实验组病灶多发比例、最大直径≥5 mm比例、形态不规则比例、结节突破甲状腺包膜比例、淋巴结肿大比例及淋巴结不均匀强化比例分别为63.10%、67.86%、72.62%、54.76%、73.81%、51.19%,均大于对照组(32.14%、38.10%、4.76%、0、17.86%、0),差异均有统计学意义(P<0.05);两组微钙化比例比较,差异无统计学意义(P>0.05)。实验组Gal-3、TSH、E-cad水平分别为(4.73±0.49)μg/L、(2.40±0.26) mIU/L、(109.64±13.47) ng/mL,均高于对照组[(1.69±0.18)μg/L、(1.28±0.13) mIU/L、(57.63±5.89) ng/mL],差异均有统计学意义(P<0.05)。颈部LNM、无颈部LNM患者例数分别为19例、65例。颈部LNM患者病灶多发、最大直径≥5 mm、形态不规则、结节突破甲状腺包膜、淋巴结肿大及淋巴结不均匀强化等比例均大于无颈部LNM患者,差异均有统计学意义(P<0.05);颈部LNM、无颈部LNM患者微钙化比例比较,差异无统计学意义(P>0.05)。颈部LNM患者血清Gal-3、TSH、E-cad水平均高于无颈部LNM患者,差异均有统计学意义(P<0.05)。经Pearson相关分析,病灶多发、最大直径≥5 mm、形态不规则、结节突破甲状腺包膜及淋巴结不均匀强化及血清Gal-3、TSH、E-cad水平与PTMC颈部LNM呈正相关(P<0.05)。淋巴结肿大、病灶微钙化与PTMC颈部LNM不相关(P>0.05)。结论 PTMC颈部LNM具有典型的MSCT特征及血清Gal-3、TSH、E-cad水平异常升高,且部分MSCT特征及血清Gal-3、TSH、E-cad与PTMC颈部LNM具有明显的相关性。 展开更多
关键词 多层螺旋CT 半乳糖凝集素-3 促甲状腺激素 上皮钙黏素 甲状腺微小乳头状癌 颈部淋巴结转移
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Sensitive detection of thyroid stimulating hormone by inkjet printed microchip with a double signal amplification strategy
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作者 Beibei Yang Dongmei Liu +5 位作者 Lina Zhu Yun Liu Xiaoning Wang Liang Qiao Weijia Zhang Baohong Liu 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第12期1879-1882,共4页
An electrochemical immunosensor for sensitive detection of thyroid stimulating hormone(TSH) has been developed by using an inkjet printed microchip and based on a double signal amplification strategy using magnetic be... An electrochemical immunosensor for sensitive detection of thyroid stimulating hormone(TSH) has been developed by using an inkjet printed microchip and based on a double signal amplification strategy using magnetic beads(MBs), alkaline phosphatase(ALP) and p-aminophenyl phosphate(pAPP) reaction.Differential pulse voltammetry(DPV), cyclic voltammogram(CV) and amperometric i-t curve(i-t) were employed to characterize the immunosensor. High sensitivity and good selectivity were observed. The detection linear range was from 0.01 μIU/mL to 10 μIU/mL, in which the peak currents increased along with the concentration. The detection limit was 0.005 μIU/mL at S/N = 3. The immunosensor was also applied for TSH detection in human serum with recoveries from 98.0% to 101.8% and relative standard deviations from 1.3% to 3.1%, demonstrating potential value in clinical diagnosis. 展开更多
关键词 Electrochemical immunosensor Inkjet printed microchip Signal amplification thyroid stimulating hormone Alkaline phosphatase
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Is there A Link between Serum Thyroid Stimulating Hormone Level and the Results of in vitro Fertilization and Embryo Transfer?
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作者 Chen DING Shu-juan HUANG Shu-qin ZHAO 《Journal of Reproduction and Contraception》 CAS 2012年第1期51-56,共6页
Objective To analyze the clinical features and outcomes in infertile patients with different levels of thyroid stimulating hormone (TSH) undergoing IVF/ICSL and to investigate whether inappropriate level of TSH has ... Objective To analyze the clinical features and outcomes in infertile patients with different levels of thyroid stimulating hormone (TSH) undergoing IVF/ICSL and to investigate whether inappropriate level of TSH has the adverse effect on the results of the IVF-ET.Methods A total of 389 patients undergoing IVF/ICSI from January 2009 to December 2011 were divided into 3 groups according to the basal TSH level: group A (TSH〈 2.0 mlU/L), group B (TSH 2.0-4.5 mlU/L) and group C (TSH〉4.5 mlU/L). Oocyte retrieved, fertilization rate, cleavage rate, available embryo rate, pregnancy rate and miscarriage rate were analyzed to explore whether serum TSH level was correlated with the results of lVF/ICSI.Results There were no differences in number of oocyte retrieved, fertilization rate, cleavage rate and available embryo rate among 3 groups (P〉0.05). Clinical pregnancy rate in group B (43.0%) was significantly higher than that in group A (30.2%) and group B (23.5%), respectively (P〈0.05). There were no significant differences in miscarriage rate among 3 groups.Conclusion TSH level has no effect on fertility rate or miscarriage rate in patients undergoing IVF/ICSL Inadequacy TSH level would decrease the IVF/ICSI pregnancy rate. 展开更多
关键词 in vitro fertilization and embryo transfer (IVF-ET) thyroid stimulating hormone(TSH) FERTILIZATION PREGNANCY
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血清VEGF-C、VEGF-D及VEGFR-3联合TSH检测在甲状腺乳头状癌诊断中的价值 被引量:14
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作者 黄静 李燕萍 +4 位作者 薛刚 张文静 李少英 张静 吴靖芳 《南方医科大学学报》 CAS CSCD 北大核心 2014年第12期1814-1817,1821,共5页
目的探讨甲状腺乳头状癌患者血清VEGF-C、VEGF-D和VEGFR-3的表达水平,分析3个指标与临床病理和甲状腺功能的关系。方法收集就诊于河北北方学院附属第一医院的甲状腺疾病患者的血清及甲功资料。其中甲状腺乳头状癌(PTC)55例,甲状腺良性肿... 目的探讨甲状腺乳头状癌患者血清VEGF-C、VEGF-D和VEGFR-3的表达水平,分析3个指标与临床病理和甲状腺功能的关系。方法收集就诊于河北北方学院附属第一医院的甲状腺疾病患者的血清及甲功资料。其中甲状腺乳头状癌(PTC)55例,甲状腺良性肿瘤(BT)24例。采用酶联免疫吸附法检测血清VEGF-C/D和VEGFR-3浓度,并分析每位患者上述3个指标与甲状腺功能的关系。结果 PTC组血清VEGF-C和VEGFR-3浓度明显高于BT组(P<0.05);VEGF-D浓度在两组间差异无统计学意义(P>0.05)。PTC患者血清VEGF-C和VEGFR-3浓度在临床Ⅲ/Ⅳ期高于Ⅰ/Ⅱ期、TSH升高组明显高于TSH正常组、年龄>45岁者明显高于≤45岁者、肿瘤直径>2 cm的患者明显高于≤2 cm的患者(P<0.05或P<0.01),VEGF-C和VEGFR-3在有无淋巴结转移组变化不一致,淋巴结转移组VEGF-C浓度明显高于无转移组,而VEGFR-3则低于无转移组;二者均与性别无关;血清VEGF-D浓度在PTC伴淋巴结转移组明显高于无转移组、TSH升高组明显高于正常组(P<0.05或P<0.01),与临床分期、肿瘤直径以及年龄、性别均无关。血清VEGF-C、VEGFR-3和TSH浓度的ROC曲线及线下面积分别为0.803,0.734和0.707(P<0.01);VEGF-D浓度线下面积0.556(P>0.05)。联合VEGF-C、VEGFR-3和TSH三个指标线下面积0.862(P<0.01)。结论联合检测血清VEGF-C和VEGFR-3的表达水平并结合患者的TSH结果,可以提高甲状腺乳头状癌的早期诊断率。 展开更多
关键词 甲状腺乳头状癌 淋巴结转移 VEGFR-3 酶联免疫吸附试验
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肝硬化病人下丘脑-垂体-甲状腺轴的功能变化及临床意义 被引量:9
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作者 俞建家 张东军 +1 位作者 赵宏 孙志坚 《安徽医药》 CAS 2017年第4期664-668,共5页
目的探讨不同级别肝硬化(LC)病人下丘脑-垂体-甲状腺轴的变化及临床意义。方法 91例LC病人按Child-Turcotte-Pugh(CTP)计分评级分为三组:LC-A组25例,LC-B组35例,LC-C组31例;另选27名健康人作为对照组。血清总三碘甲状腺原氨酸(TT3)、游... 目的探讨不同级别肝硬化(LC)病人下丘脑-垂体-甲状腺轴的变化及临床意义。方法 91例LC病人按Child-Turcotte-Pugh(CTP)计分评级分为三组:LC-A组25例,LC-B组35例,LC-C组31例;另选27名健康人作为对照组。血清总三碘甲状腺原氨酸(TT3)、游离T3(FT3)、反T3(rT3)、总甲状腺素(TT4)、游离甲状腺素(FT4)及促甲状腺激素(TSH)均采用化学发光法检测,肝功能生化指标用RXL生化分析仪检测,凝血酶原时间(PT)用全自动血凝仪(血凝固法)检测。结果从LC-A组到LC-C组随着肝硬化级别的增加,血清TT3和FT3水平逐渐降低,rT3渐次增高,TT4/rT3比值顺次下降,血清TT3分别与白蛋白、前白蛋白、载脂蛋白-A1和胆碱酯酶呈显著正相关(df=89,r值分别为0.568,0.260,0.317和0.599,P<0.05),与CTP分值及PT呈显著负相关(df=89,r值分别为-0.447和-0.297,P<0.01),TSH在各组间差异无统计学意义。共26例LC病人出现低T3综合征,LC-A组为0,LC-B组8例(22.9%),LC-C组18例(58.1%)。经保肝、支持治疗1~2周后,随着肝功能好转低T3综合征也随之消失。心得安试验仅见FT4有所下降(16.84±3.16)vs(14.00±2.45)pmol·L^(-1),地塞米松试验未见甲状腺激素及TSH有明显变化。结论肝硬化失代偿期随着肝功能的下降,发生低T3综合征的比例增多,与甲状腺激素转运蛋白合成功能减退、T4向T3转化减少有关,但随着病情好转低T3综合征便逐渐消失,无须补充甲状腺素。心得安或地塞米松试验对甲状腺功能未产生明显的影响,提示短期适量应用此类药物是安全的。 展开更多
关键词 肝硬化 肝功能 甲状腺激素 促甲状腺激素 低T3综合征
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促甲状腺激素对大鼠脂肪组织中瘦素、脂联素、TNF-α及IL-6表达水平的影响 被引量:9
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作者 赖亚新 王浩宇 +4 位作者 范晨玲 张红梅 王红 滕卫平 单忠艳 《山东医药》 CAS 北大核心 2015年第13期1-3,共3页
目的观察促甲状腺激素(TSH)对大鼠脂肪组织中瘦素、脂联素、TNF-α及IL-6表达水平的影响。方法将24只Wistar大鼠随机分为3组、每组8只。完全甲减组手术完全切除甲状腺,皮下注射生理盐水。正常对照组行甲状腺切除假手术,皮下注射生理盐... 目的观察促甲状腺激素(TSH)对大鼠脂肪组织中瘦素、脂联素、TNF-α及IL-6表达水平的影响。方法将24只Wistar大鼠随机分为3组、每组8只。完全甲减组手术完全切除甲状腺,皮下注射生理盐水。正常对照组行甲状腺切除假手术,皮下注射生理盐水。亚临床甲减组手术完全切除甲状腺,于颈背部每日皮下注射左甲状腺素钠溶液建立亚临床甲减模型。建模成功后,留取各组附睾周围的内脏脂肪组织,分别采用Western blotting、Real-time PCR法检测其瘦素、脂联素、TNF-α、IL-6蛋白及mRNA表达水平。结果亚临床甲减组及完全甲减组脂肪组织瘦素、TNF-α及IL-6蛋白及mRNA表达水平高于正常对照组(P均<0.05),而脂联素蛋白及mRNA表达水平低于正常对照组(P均<0.05)。完全甲减组脂肪组织瘦素、TNF-α及IL-6蛋白及mRNA表达水平高于亚临床甲减组(P均<0.05),而脂联素蛋白及mRNA表达水平低于亚临床甲减组(P均<0.05)。结论 TSH能促进大鼠脂肪组织瘦素、TNF-α、IL-6表达,抑制脂联素表达。 展开更多
关键词 脂肪组织 促甲状腺激素 瘦素 脂联素 肿瘤坏死因子Α 白细胞介素6 大鼠
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脾虚证大鼠下丘脑-垂体-甲状腺轴功能及下丘脑、胸腺细胞核T_3受体水平的变化 被引量:13
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作者 李刚 夏天 姬统理 《中国中医基础医学杂志》 CAS CSCD 2002年第10期58-62,共5页
目的 :研究脾虚状态时下丘脑 垂体 甲状腺轴调控功能及下丘脑、胸腺细胞核T3 受体水平变化 ,为脾虚证本质的研究提供新的实验资料。方法 :成年SD大鼠 32只随机分为 4组 (每组 8只 ) ,即正常组、脾虚组、治疗组、自复组。采用免疫放射... 目的 :研究脾虚状态时下丘脑 垂体 甲状腺轴调控功能及下丘脑、胸腺细胞核T3 受体水平变化 ,为脾虚证本质的研究提供新的实验资料。方法 :成年SD大鼠 32只随机分为 4组 (每组 8只 ) ,即正常组、脾虚组、治疗组、自复组。采用免疫放射分析法和放射免疫分析法 ,测定各组大鼠下丘脑、血清TRH、垂体、血清TSH及血清T3 、T4、FT3 、FT4、γT3 及下丘脑、胸腺细胞核T3 受体的含量。结果 :①脾虚组、自复组大鼠血清T3 、T4、FT3 、FT4以及下丘脑TRH、垂体TSH含量 ,下丘脑、胸腺细胞核T3 受体的含量均较正常组、治疗组为低 ,有极显著差异 (P <0 0 1) ;血清TRH、TSH含量均较正常组、治疗组为高 ,有极显著差异 (P <0 0 1)。②治疗组大鼠的上述指标与正常组无显著性差异 (P>0 0 5 )。结论 :脾虚状态时下丘脑、垂体、甲状腺合成、分泌及调控功能低下 ,各级反馈不能使各层次激素水平恢复正常 ;血清甲状腺激素及下丘脑、胸腺细胞核T3 受体水平的降低 ,致甲状腺激素生物效应低下 ,经由神经内分泌调节环路 ,削弱免疫功能 ,这部分反映了脾虚证的本质 ;健脾益气的四君子汤能修复下丘脑 垂体 甲状腺轴功能的损伤。 展开更多
关键词 脾虚证 受体 甲状腺激素 促甲状腺激素 动物模型 促甲状腺释放激素
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Relationship between fibroblast growth factor 21 and thyroid stimulating hormone in healthy subjects without components of metabolic syndrome
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作者 Tianxu Fu Shanshan Yuan +6 位作者 Ying Gao Chenxue Qu Lan Chen Yan Hui Guizhi Lu Yanming Gao Xiaohui Guo 《Family Medicine and Community Health》 2014年第3期1-6,共6页
Objective:To determine the relationship between human fibroblast growth factor 21(FGF21)and thyroid stimulating hormone(TSH)by testing the level of FGF21,lipid metabolism,and car-bohydrate metabolism-related indices,a... Objective:To determine the relationship between human fibroblast growth factor 21(FGF21)and thyroid stimulating hormone(TSH)by testing the level of FGF21,lipid metabolism,and car-bohydrate metabolism-related indices,as well as the level of TSH,among metabolic syndrome-free patients with normal physical examination results.Methods:An enzyme-linked immunosorbent assay(ELISA)was used to test the levels of serum FGF21 and free fatty acids(FFA)in metabolic syndrome-free patients with normal physi-cal examination results,and electrochemiluminescence(ECLIA)was used to measure TSH,thy-roglobulin antibodies(TGAbs),and thyroid peroxidase antibody(TPOAb)levels.Results:Three hundred fifty-six metabolic syndrome-free patients(116 males and 240 females;average age,43±13 years)with normal physical examination results were enrolled.Among the pa-tients with normal physical examination results,FGF21 had a weak relationship with obesity indices,such as the waist circumference(r=0.110,P=0.038),the waist-to-hip ratio(r=0.119,P=0.025),and the triglycerides level(TG;r=0.302,P=0.000),and a weak relationship with blood lipid levels,such as total cholesterol(TCHO;r=0.113,P=0.012)and low-density lipoprotein-cholesterol(LDL-C;r=0.175,P=0.001),but no relationship with TSH(r=-0.023,P=0.666).In addition,the FGF21 levels in thyroid autoantibody-positive and-negative groups were not significantly different.Conclusion:Among the metabolic syndrome-free patients with normal physical examina-tion results,FGF21 has no apparent relationship with TSH or thyroid autoimmunity. 展开更多
关键词 Human fibroblast growth factor 21(FGF21) thyroid stimulating hormone(TSH) AUTOIMMUNITY Free fatty acids(FFA)
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慢乙肝患者的乙肝五项、HBV-DNA和甲状腺参数的结果分析 被引量:13
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作者 黄秀香 叶迎宾 +6 位作者 董志平 马丽 张萍 刘金艳 王君义 靳圆圆 赵斗贵 《标记免疫分析与临床》 CAS 2017年第5期559-563,共5页
目的探讨慢乙肝患者的乙肝五项(HbsAg、HbsAb、HbeAg、HbeAb、HbcAb)、乙肝DNA(HBV-DNA)和甲状腺参数(TSH、FT_3、TT_3、FT_4、TT_4)的临床意义。方法收集在本院2014年6月至2014年12月住院的慢乙肝患者106例,其中慢乙肝轻度患者29例(慢... 目的探讨慢乙肝患者的乙肝五项(HbsAg、HbsAb、HbeAg、HbeAb、HbcAb)、乙肝DNA(HBV-DNA)和甲状腺参数(TSH、FT_3、TT_3、FT_4、TT_4)的临床意义。方法收集在本院2014年6月至2014年12月住院的慢乙肝患者106例,其中慢乙肝轻度患者29例(慢乙肝轻度组)、慢乙肝中度患者57例(慢乙肝中度组)、慢乙肝重度患者20例(慢乙肝重度组)和正常体检者为30例(对照组)。检测其血清的HbsAg、HbsAb、HbeAg、HbeAb、HbcAb、HBV-DNA、TSH、FT_3、TT_3、FT_4、TT_4,并进行统计分析。结果(1)慢乙肝组的TT_3、FT_4、TT_4与对照组相比,差异明显有统计学意义(P<0.001);TSH、FT_3无明显变化(P>0.05)。(2)FT_4、TT_4在慢乙肝轻度组、慢乙肝中度组、慢乙肝重度组和对照组中比较,差异具有统计学意义(P<0.001);慢乙肝重度组的TT_3与轻度组和中度组比较差异有统计学意义(P<0.05)。FT_4在慢乙肝随病情的轻重呈现降低的趋势,慢乙肝重度组和中度组的FT_4水平均低于对照组(P<0.05)。TT_4在慢乙肝加重呈现升高的趋势,但是升高不明显;慢乙肝三组和对照组相比,差异有统计学意义(P<0.05)。(3)慢乙肝组中,TT_3在大三阳组和小三阳组差异有统计学意义(P<0.05)。在DNA≤20IU/mL,大、小三阳两组中的所有检测项目差异不具有统计学意义(P>0.05);在DNA>20 IU/mL中,大、小三阳两组中的TT_3差异具有统计学意义(P<0.05),其余的项目差异不具有统计学意义(P>0.05)。进一步分析TT_3在慢乙肝中度组中的表达,提示在DNA阳性(>20 IU/mL)且大三阳的慢乙肝中度患者的TT_3水平明显高于小三阳(P<0.05)。结论慢乙肝患者血清TT_3和FT_4水平随病情的加重呈现明显降低,与大小三阳无直接关系。DNA阳性(>20 IU/mL)的大三阳慢乙肝中度患者的血清TT_3水平高于DNA阳性的小三阳组。通过检测和监测慢乙肝中度患者的甲状腺激素水平,有助于评估患者的病情和预后判断。 展开更多
关键词 促甲状腺激素 三碘甲状腺原氨酸 四碘甲状腺原氨酸 血清游离三碘甲状腺原氨酸 血清游离四碘甲状腺原氨酸 乙型病毒性肝炎病毒脱氧核糖核酸
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