Analytical and NumericalMethods to Study the MFPT and SR of a Stochastic Tumor-Immune Model

The Mean First-Passage Time (MFPT) and Stochastic Resonance (SR) of a stochastic tumor-immune model withnoise perturbation are discussed in this paper. Firstly, considering environmental perturbation, Gaussian whitenoise and Gaussian colored noise are introduced into a tumor growth model under immune surveillance. Asfollows, the long-time evolution of the tumor characterized by the Stationary Probability Density (SPD) and MFPTis obtained in theory on the basis of the Approximated Fokker-Planck Equation (AFPE). Herein the recurrenceof the tumor from the extinction state to the tumor-present state is more concerned in this paper. A moreefficient algorithmof Back-Propagation Neural Network (BPNN) is utilized in order to testify the correction of thetheoretical SPDandMFPT.With the existence of aweak signal, the functional relationship between Signal-to-NoiseRatio (SNR), noise intensities and correlation time is also studied. Numerical results show that both multiplicativeGaussian colored noise and additive Gaussian white noise can promote the extinction of the tumors, and themultiplicative Gaussian colored noise can lead to the resonance-like peak on MFPT curves, while the increasingintensity of the additiveGaussian white noise results in theminimum of MFPT. In addition, the correlation timesare negatively correlated with MFPT. As for the SNR, we find the intensities of both the Gaussian white noise andthe Gaussian colored noise, as well as their correlation intensity can induce SR. Especially, SNR is monotonouslyincreased in the case ofGaussian white noisewith the change of the correlation time.At last, the optimal parametersin BPNN structure are analyzed for MFPT from three aspects: the penalty factors, the number of neural networklayers and the number of nodes in each layer.

Logical stochastic resonance in a cross-bifurcation non-smooth system

This paper investigates logical stochastic resonance(LSR)in a cross-bifurcation non-smooth system driven by Gaussian colored noise.In this system,a bifurcation parameter triggers a transition between monostability,bistability and tristability.By using Novikov's theorem and the unified colored noise approximation method,the approximate Fokker-Planck equation is obtained.Then we derive the generalized potential function and the transition rates to analyze the LSR phenomenon using numerical simulations.We simulate the logic operation of the system in the bistable and tristable regions respectively.We assess the impact of Gaussian colored noise on the LSR and discover that the reliability of the logic response depends on the noise strength and the bifurcation parameter.Furthermore,it is found that the bistable region has a more extensive parameter range to produce reliable logic operation compared with the tristable region,since the tristable region is more sensitive to noise than the bistable one.

Target acquisition performance in the presence of JPEG image compression

This paper presents an investigation on the effect of JPEG compression on the similarity between the target image and the background,where the similarity is further used to determine the degree of clutter in the image.Four new clutter metrics based on image quality assessment are introduced,among which the Haar wavelet-based perceptual similarity index,known as HaarPSI,provides the best target acquisition prediction results.It is shown that the similarity between the target and the background at the boundary between visually lossless and visually lossy compression does not change significantly compared to the case when an uncompressed image is used.In future work,through subjective tests,it is necessary to check whether this presence of compression at the threshold of just noticeable differences will affect the human target acquisition performance.Similarity values are compared with the results of subjective tests of the well-known target Search_2 database,where the degree of agreement between objective and subjective scores,measured through linear correlation,reached a value of 90%.

Alpha-reliable combined mean traffic equilibrium model with stochastic travel times

Based on the reliability budget and percentile travel time(PTT) concept, a new travel time index named combined mean travel time(CMTT) under stochastic traffic network was proposed. CMTT here was defined as the convex combination of the conditional expectations of PTT-below and PTT-excess travel times. The former was designed as a risk-optimistic travel time index, and the latter was a risk-pessimistic one. Hence, CMTT was able to describe various routing risk-attitudes. The central idea of CMTT was comprehensively illustrated and the difference among the existing travel time indices was analyzed. The Wardropian combined mean traffic equilibrium(CMTE) model was formulated as a variational inequality and solved via an alternating direction algorithm nesting extra-gradient projection process. Some mathematical properties of CMTT and CMTE model were rigorously proved. Finally, a numerical example was performed to characterize the CMTE network. It is founded that that risk-pessimism is of more benefit to a modest(or low) congestion and risk network, however, it changes to be risk-optimism for a high congestion and risk network.

Moments and Mean First—Passage Time of Parabolic—Bistable Potential System Driven by Colored Noise

A parabolic-bistable potential system driven by colored noise is studied. The exact analytical expressions of the stationary probability distribution (SPD) and the moments of the system are derived. Furthermore, the mean first-passage time is calculated by the use of two approximate methods, respectively. It is found that (i) the double peaks of SPD are rubbed-down into a flat single peak with the increasing of noise intensity; (ii) a minimum occurs on the curve of the second-order moment of the system vs. noise intensity at the point ; (iii) the results obtained by our approximate approach are in good agreement with the numerical calculations for either small or large correlation time , while the conventional steepest descent approximation leads to poor results.

Exact scaling for the mean first-passage time of random walks on a generalized Koch network with a trap

In this paper, we study the scaling for the mean first-passage time （MFPT） of the random walks on a generalized Koch network with a trap. Through the network construction, where the initial state is transformed from a triangle to a polygon, we obtain the exact scaling for the MFPT. We show that the MFPT grows linearly with the number of nodes and the dimensions of the polygon in the large limit of the network order. In addition, we determine the exponents of scaling efficiency characterizing the random walks. Our results are the generalizations of those derived for the Koch network, which shed light on the analysis of random walks over various fractal networks.

Mean waiting time approximation for a real time polling system

This paper considers a novel polling system with two classes of message which can experience an up-per bounded time before being served. The station serves these two classes with mixed service discipline, one class with exhaustive service discipline, and the other with gated service discipline. Using iterative method, we have developed an approximation method to obtain the mean waiting time for each message class. The performance of approximation has been compared with the simulation results. The expression for the upper bound of waiting time is given too.

Mean first-passage time of an asymmetric bistable system driven by colour-correlated noise

In this paper, the effect of every parameter （including p, q, r, λ, τ） on the mean first-passage time （MFPT） is investigated in an asymmetric bistable system driven by colour-correlated noise. The expression of MFPT has been obtained by applying the steepest-descent approximation. Numerical results show that （1） the intensity of multiplicative noise p and the intensity of additive noise q play different roles in the MFPT of the system, （2） suppression appears on the curve of the MFPT with small λ （e.g. λ 〈 0.5） but there is a peak on the curve of the MFPT when λ is big （e.g. λ 〉 0.5）, and （3） with different values of r （e.g. r = 0.1, 0.5, 1.5）, the effort of τ on the MFPT is diverse.

Transient Properties of a Bistable System with Delay Time Driven by Non-Gaussian and Gaussian Noises:Mean First-Passage Time

The mean first-passage time of a bistable system with time-delayed feedback driven by multiplicative non-Gaussian noise and additive Gaussian white noise is investigated. Firstly, the non-Markov process is reduced to the Markov process through a path-integral approach; Secondly, the approximate Fokker-Planck equation is obtained by applying the unified coloured noise approximation, the small time delay approximation and the Novikov Theorem. The functional analysis and simplification are employed to obtain the approximate expressions of MFPT. The effects of non-Gaussian parameter （measures deviation from Gaussian character） r, the delay time τ, the noise correlation time to, the intensities D and a of noise on the MFPT are discussed. It is found that the escape time could be reduced by increasing the delay time τ, the noise correlation time τ0, or by reducing the intensities D and α. As far as we know, this is the first time to consider the effect of delay time on the mean first-passage time in the stochastic dynamical system.

Mean First-Passage Time of an Asymmetric Kinetic Model Driven by Two Different Kinds of Colored Noises

The mean first-passage time （MFPT） of an asymmetric bistable system between multiplicative non-Gaussian noise and additive Gaussian white noise with nonzero cross-correlation time is investigated. Firstly, the non-Markov process is reduced to the Markov process through a path-integral approach; Secondly, the approximate Fokker Planck equation is obtained by applying the unified colored noise approximation and the.Novikov Theorem. The steady-state probability distribution （SPD） is also obtained. The basal functional analysis and simplification are employed to obtain the approximate expressions of MFPT T^±. The effects of the asymmetry parameter β, the non-Gaussian parameter （measures deviation from Gaussian character） r, the noise correlation times τ and τ2, the coupling coefficient A, the intensities D and a of noise on the MFPT are discussed. It is found that the asymmetry parameter β, the non-Gaussian parameter r and the coupling coefficient A can induce phase transition. Moreover, the main findings are that the effect of self-existent parameters （D, α, and τ） of noise and cross-correlation parameters （A, 7-2） between noises on MFPT T^± is different.

Could one single dichotomous noise cause resonant activation for exit time over potential barrier?

This paper studies the mean first passage time （or exit time, or escape time） over the non-fluctuating potential harrier for a system driven only by a dichotomous noise. It finds that the dichotomous noise can make the particles escape over the potential barrier, in some circumstances; but in other circumstances, it can not. In the case that the particles escape over the potential harrier, a resonant activation phenomenon for the mean first passage time over the potential barrier is obtained.

Mean First Passage Time for System with Fluctuating Potential Barrier and Coupled Noise

In this paper we study the mean first passage time （MFPT） over a fluctuation potential barrier driven by a coupled noise. It is shown that the MFPT over the fluctuation potential barrier displays resonant activations as the function of the flipping rate of the fluctuation potential barrier, and as the function of the dichotomous noise transition rate.

The mean first passage time of a three-level atomic optical bistable system subjected to noise

The transient properties of a three-level atomic optical bistable system in the presence of multiplicative and additive noises are investigated. The explicit expressions of the mean first-passage time （MFPT） of the transition from the high intracavity intensity state to the low one are obtained by numerical computations. The impacts of the intensities of the multiplicative noise DM and the additive noise DA, the intensity of correlation between two noises λ, and the intensity of the incident light y on the MFPT are discussed, respectively. Our results show： （i） for the case of no correlation between two noises （2, = 0.0）, the increase in DM and DA can lead to an increase in the probability of the transition to the low intracavity intensity state, while the increase in y can lead to a retardation of the transition; and （ii） for the case of correlation between two noises （λ≠ 0.0）, the increase in λ can cause an increase in the probability of the transition, and the increase in DA can cause a retardation of the transition firstly and then an increase in the probability of the transition, i.e., the noise-enhanced stability is observed for the case of correlation between two noises.

Bayesian Reliability Modeling and Assessment Solution for NC Machine Tools under Small-sample Data

Although Markov chain Monte Carlo（MCMC） algorithms are accurate, many factors may cause instability when they are utilized in reliability analysis; such instability makes these algorithms unsuitable for widespread engineering applications. Thus, a reliability modeling and assessment solution aimed at small-sample data of numerical control（NC） machine tools is proposed on the basis of Bayes theories. An expert-judgment process of fusing multi-source prior information is developed to obtain the Weibull parameters＇ prior distributions and reduce the subjective bias of usual expert-judgment methods. The grid approximation method is applied to two-parameter Weibull distribution to derive the formulas for the parameters＇ posterior distributions and solve the calculation difficulty of high-dimensional integration. The method is then applied to the real data of a type of NC machine tool to implement a reliability assessment and obtain the mean time between failures（MTBF）. The relative error of the proposed method is 5.8020×10-4 compared with the MTBF obtained by the MCMC algorithm. This result indicates that the proposed method is as accurate as MCMC. The newly developed solution for reliability modeling and assessment of NC machine tools under small-sample data is easy, practical, and highly suitable for widespread application in the engineering field; in addition, the solution does not reduce accuracy.

Predicting dynamics of soil organic carbon mineralization with a double exponential model in different forest belts of China

The dynamics of soil organic carbon （SOC） was analyzed by using laboratory incubation and double exponential model that mineralizable SOC was separated into active carbon pools and slow carbon pools in forest soils derived from Changbai and Qilian Mountain areas. By analyzing and fitting the CO2 evolved rates with SOC mineralization, the results showed that active carbon pools accounted tor 1.0% to 8.5% of SOC with an average of mean resistant times （MRTs） for 24 days, and slow carbon pools accounted for 91% to 99% of SOC with an average of MRTs for 179 years. The sizes and MRTs of slow carbon pools showed that SOC in Qilian Mountain sites was more difficult to decompose than that in Changbai Mountain sites. By analyzing the effects of temperature, soil clay content and elevation on SOC mineralization, results indicated that mineralization of SOC was directly related to temperature and that content of accumulated SOC and size of slow carbon pools from Changbai Mountain and Qilian Mountain sites increased linearly with increasing clay content, respectively, which showed temperature and clay content could make greater effect on mineralization of SOC.

Erythropoietin reduces apoptosis of brain tissue cells in rats after cerebral ischemia/reperfusion injury:a characteristic analysis using magnetic resonance imaging

Some in vitro experiments have shown that erythropoietin （EPO） increases resistance to apoptosis and facilitates neuronal survival follow- ing cerebral ischemia. However, results from in vivo studies are rarely reported. Perfusion-weighted imaging （PWI） and diffusion-weighted imaging （DWI） have been applied successfully to distinguish acute cerebral ischemic necrosis and penumbra in living animals; therefore, we hypothesized that PWI and DWI could be used to provide imaging evidence in vivo for the conclusion that EPO could reduce apoptosis in brain areas injured by cerebral ischemia/reperfusion. To validate this hypothesis, we established a rat model of focal cerebral ischemia/ reperfusion injury, and treated with intra-cerebroventricular injection of EPO （5,000 U/kg） 20 minutes before injury. Brain tissue in the ischemic injury zone was sampled using MRI-guided localization. The relative area of abnormal tissue, changes in PWI and DWI in the ischemic injury zone, and the number of apoptotic cells based on TdT-mediated dUTP-biotin nick end-labeling （TUNEL） were assessed. Our findings demonstrate that EPO reduces the relative area of abnormally high signal in PWI and DWI, increases cerebral blood volume, and decreases the number of apoptotic cells positive for TUNEL in the area injured by cerebral ischemia/reperfusion. The experiment pro- vides imaging evidence in vivo for EPO treating cerebral ischemia/reperfusion injury.

Effect of Stem Density on Leaf Nutrient Dynamics and Nutrient Use Efficiency of Dwarf Bamboo

The monthly dynamics of nitrogen （N） and phosphorus （P） concentrations and stocks in leaves, resorption efficiency, and resorption proficiency as well as leaf-level use efficiency, nutrient productivity, and mean residence time were studied to understand the effect of stem density of dwarf bamboo （Fargesia denudata Yi） on leaf-level N and P use efficiency in three dwarf bamboo stands with different stem densities under bamboo-fir （Picea puvpurea Mast.） forest over one growing period in the Wanglang National Nature Reserve, Sichuan, China. Dwarf bamboo density had little effect on the dynamics pattern of both N and P concentrations, stocks, resorption efficiency, and resorption proficiency, but strongly affected their absolute values and leaf-level use efficiency. Higher density stands stored more nutrients but had lower concentrations. There was a clear difference in the resorption of limiting nutrient （N） and non-limiting nutrient （P） among the stands. Phosphorus resorption efficiency, N resorption proficiency, and P resorption proficiency increased with increase of stem density, but no significant variation of N resorption efficiency was found among the stands. Moreover, the higher density stands used both N and P more efficiently with higher N productivity and higher P mean residence time, respectively. Higher P productivity was found in the lower density stands, but there was no clear variation in the N mean residence time among stands. These suggested that the higher density stands may have more efficient strategies for utilizing nutrients, especially those which are limiting .

Reliability evaluation method and algorithm for electromechanical product

The reliability of electromechanical product is usually determined by the fault number and working time traditionally. The shortcoming of this method is that the product must be in service. To design and enhance the reliability of the electromechanical product, the reliability evaluation method must be feasible and correct. Reliability evaluation method and algorithm were proposed. The reliability of product can be calculated by the reliability of subsystems which can be gained by experiment or historical data. The reliability of the machining center was evaluated by the method and algorithm as one example. The calculation result shows that the solution accuracy of mean time between failures is 97.4% calculated by the method proposed in this article compared by the traditional method. The method and algorithm can be used to evaluate the reliability of electromechanical product before it is in service.

Investigation of Influence of Winding Structure on Reliability of Permanent Magnet Machines

Winding is an important part of the electrical machine and plays a key role in reliability.In this paper,the reliability of multiphase winding structure in permanent magnet machines is evaluated based on the Markov model.The mean time to failure is used to compare the reliability of different windings structure.The mean time to failure of multiphase winding is derived in terms of the underlying parameters.The mean time to failure of winding is affected by the number of phases,the winding failure rate,the fault-tolerant mechanism success probability,and the state transition success probability.The influence of the phase number,winding distribution types,multi three-phase structure,and fault-tolerant mechanism success probability on the winding reliability is investigated.The results of reliability analysis lay the foundation for the reliability design of permanent magnet machines.

Energy diffusion controlled reaction rate in dissipative Hamiltonian systems

In this paper the energy diffusion controlled reaction rate in dissipative Hamiltonian systems is investigated by using the stochastic averaging method for quasi Hamiltonian systems. The boundary value problem of mean first- passage time （MFPT） of averaged system is formulated and the energy diffusion controlled reaction rate is obtained as the inverse of MFPT. The energy diffusion controlled reaction rate in the classical Kramers bistable potential and in a two-dimensional bistable potential with a heat bath are obtained by using the proposed approach respectively. The obtained results are then compared with those from Monte Carlo simulation of original systems and from the classical Kraraers theory. It is shown that the reaction rate obtained by using the proposed approach agrees well with that from Monte Carlo simulation and is more accurate than the classical Kramers rate.