Objective:To explore the effect of Guipi Decoction Combined with non steroidal anti-inflammatory drugs on sleep time of elderly patients with traumatic pain and Qi deficiency constitution during hospitalization.Method...Objective:To explore the effect of Guipi Decoction Combined with non steroidal anti-inflammatory drugs on sleep time of elderly patients with traumatic pain and Qi deficiency constitution during hospitalization.Methods:A total of 52 elderly patients hospitalized in the orthopedic(trauma)ward of the Second Affiliated Hospital of Zhejiang Chinese Medical University from November 2020 to may 2021 were randomly divided into control group and treatment group.Patients in the control group were treated with loxoprofen sodium tablets immediately after admission,and placebo was added to loxoprofen sodium tablets from the second day of admission;The patients in the treatment group were treated with loxoprofen sodium tablets after admission.Guipi Decoction was added on the basis of loxoprofen sodium tablets from the second day of admission.Before and after admission,all patients used the TCM constitution classification judgment table to evaluate the score of qi deficiency and VAS;From the first day to the fourth day after admission,the bracelet was worn to monitor the sleep time(total sleep time,deep sleep time,light sleep time and awakening times)every night.The patients were scored by VAS after taking drugs every morning.Results:Finally 25 patients in the control group and 24 patients in the treatment group completed the experiment.There was no significant difference in gender,age,fracture location,chronic medical history VAS score and TCM Qi deficiency constitution score,between two groups at admission(P>0.05).At the time of discharge,the score of qi deficiency constitution in the treatment group was 33.724±12.634;The TCM Qi deficiency constitution score of the control group was 42.25±15.912,and there was significant difference between the two groups(P<0.05);and there was significant difference in VAS score between the two groups at discharge(P<0.05).There were significant differences in total sleep time,light sleep time,deep sleep time and night awakening times between the two groups on the second,third and fourth day of admission(P<0.05).Conclusion:1.Guipi Decoction can significantly improve the sleep time of patients with Qi deficiency acute traumatic pain.2.Guipi Decoction can not only improve the constitution of patients with Qi deficiency bias,but also improve the VAS score at discharge.展开更多
目的:研究中药联合免疫检查点抑制剂(Immune Checkpoint Inhibitors,ICI)治疗中晚期恶性肿瘤能否产生更佳的效果。方法:选取就诊于辽宁中医药大学附属医院肿瘤科住院部、初次使用ICI治疗的中晚期恶性肿瘤患者60名,根据是否使用中药分成...目的:研究中药联合免疫检查点抑制剂(Immune Checkpoint Inhibitors,ICI)治疗中晚期恶性肿瘤能否产生更佳的效果。方法:选取就诊于辽宁中医药大学附属医院肿瘤科住院部、初次使用ICI治疗的中晚期恶性肿瘤患者60名,根据是否使用中药分成两组,中药组和对照组。本研究纳入患者瘤种包括肺癌、肝癌、乳腺癌、食管癌、胰腺癌等共16种,其中以肺癌占比最大。统计两组患者的性别、年龄、瘤种、远处转移情况、ICI的使用情况、治疗线数、治疗方案、中医辨证分型及免疫部分缓解的时间并求出平均值,大于该平均值的记为1,小于的记为0;其余变量“是=1,否=0”。通过统计方法,对试验数据分别进行单因素分析、危险因素分析、正负反馈相关分析,且对其疗效预测价值使用受试者工作特征(Receiver Operating Characteristic,ROC)曲线进行分析。结果:中药组的免疫部分缓解时间更短(P<0.05),且对于免疫部分缓解时间呈负相关。中药组疗效预测价值的ROC曲线下面积(Area Under the Curve,AUC)值为0.699(P<0.05)。结论:中药联合ICI治疗中晚期恶性肿瘤的临床疗效呈正相关关系。展开更多
On the heels of France's year of cultural promotion in China comes Italy, hoping to wow the Middle Kingdom with the best of Italian operas, Renaissance art and industrial designs
An excellent analytical tool for the separation and analysis of TCM(Traditional Chinese Medicine) by using HR ESI TOF MS(High Resolution Electrospray Ionization Time of flight Mass Spectrometry) was developed. A home ...An excellent analytical tool for the separation and analysis of TCM(Traditional Chinese Medicine) by using HR ESI TOF MS(High Resolution Electrospray Ionization Time of flight Mass Spectrometry) was developed. A home built HR ESI TOF MS was applied to detect fat soluble components in Danshen( Salvia miltiorrhiza Bage ) directly. Compared with the method of HPLC ESI MS(High Performance Liquid Chromatograph Electrospray ionization Mass Spectrometry) method, HR ESI TOF MS method is more accurate, quick, simple and reliable, so the method can become an effective tool for the quality control of TCM.展开更多
基金general scientific research project of Zhejiang Provincial Department of education in 2020,Project No.:Y202044448。
文摘Objective:To explore the effect of Guipi Decoction Combined with non steroidal anti-inflammatory drugs on sleep time of elderly patients with traumatic pain and Qi deficiency constitution during hospitalization.Methods:A total of 52 elderly patients hospitalized in the orthopedic(trauma)ward of the Second Affiliated Hospital of Zhejiang Chinese Medical University from November 2020 to may 2021 were randomly divided into control group and treatment group.Patients in the control group were treated with loxoprofen sodium tablets immediately after admission,and placebo was added to loxoprofen sodium tablets from the second day of admission;The patients in the treatment group were treated with loxoprofen sodium tablets after admission.Guipi Decoction was added on the basis of loxoprofen sodium tablets from the second day of admission.Before and after admission,all patients used the TCM constitution classification judgment table to evaluate the score of qi deficiency and VAS;From the first day to the fourth day after admission,the bracelet was worn to monitor the sleep time(total sleep time,deep sleep time,light sleep time and awakening times)every night.The patients were scored by VAS after taking drugs every morning.Results:Finally 25 patients in the control group and 24 patients in the treatment group completed the experiment.There was no significant difference in gender,age,fracture location,chronic medical history VAS score and TCM Qi deficiency constitution score,between two groups at admission(P>0.05).At the time of discharge,the score of qi deficiency constitution in the treatment group was 33.724±12.634;The TCM Qi deficiency constitution score of the control group was 42.25±15.912,and there was significant difference between the two groups(P<0.05);and there was significant difference in VAS score between the two groups at discharge(P<0.05).There were significant differences in total sleep time,light sleep time,deep sleep time and night awakening times between the two groups on the second,third and fourth day of admission(P<0.05).Conclusion:1.Guipi Decoction can significantly improve the sleep time of patients with Qi deficiency acute traumatic pain.2.Guipi Decoction can not only improve the constitution of patients with Qi deficiency bias,but also improve the VAS score at discharge.
文摘目的:研究中药联合免疫检查点抑制剂(Immune Checkpoint Inhibitors,ICI)治疗中晚期恶性肿瘤能否产生更佳的效果。方法:选取就诊于辽宁中医药大学附属医院肿瘤科住院部、初次使用ICI治疗的中晚期恶性肿瘤患者60名,根据是否使用中药分成两组,中药组和对照组。本研究纳入患者瘤种包括肺癌、肝癌、乳腺癌、食管癌、胰腺癌等共16种,其中以肺癌占比最大。统计两组患者的性别、年龄、瘤种、远处转移情况、ICI的使用情况、治疗线数、治疗方案、中医辨证分型及免疫部分缓解的时间并求出平均值,大于该平均值的记为1,小于的记为0;其余变量“是=1,否=0”。通过统计方法,对试验数据分别进行单因素分析、危险因素分析、正负反馈相关分析,且对其疗效预测价值使用受试者工作特征(Receiver Operating Characteristic,ROC)曲线进行分析。结果:中药组的免疫部分缓解时间更短(P<0.05),且对于免疫部分缓解时间呈负相关。中药组疗效预测价值的ROC曲线下面积(Area Under the Curve,AUC)值为0.699(P<0.05)。结论:中药联合ICI治疗中晚期恶性肿瘤的临床疗效呈正相关关系。
文摘On the heels of France's year of cultural promotion in China comes Italy, hoping to wow the Middle Kingdom with the best of Italian operas, Renaissance art and industrial designs
文摘An excellent analytical tool for the separation and analysis of TCM(Traditional Chinese Medicine) by using HR ESI TOF MS(High Resolution Electrospray Ionization Time of flight Mass Spectrometry) was developed. A home built HR ESI TOF MS was applied to detect fat soluble components in Danshen( Salvia miltiorrhiza Bage ) directly. Compared with the method of HPLC ESI MS(High Performance Liquid Chromatograph Electrospray ionization Mass Spectrometry) method, HR ESI TOF MS method is more accurate, quick, simple and reliable, so the method can become an effective tool for the quality control of TCM.
