To compare the characteristics of the dose response relationship and the time course of action between atracurium and rocuronium in adult patients anesthetized with N 2O O 2 fentanyl thiopene Methods Sixty pat...To compare the characteristics of the dose response relationship and the time course of action between atracurium and rocuronium in adult patients anesthetized with N 2O O 2 fentanyl thiopene Methods Sixty patients, ASA grade Ⅰ, aged 18-50 years, scheduled for elective plastic surgery were studied All patients were randomly divided into either the atracurium or rocuronium group General anesthesia was maintained with 60% nitrous oxide and 40% oxygen, thiopentone, and fentanyl Neuromuscular function was assessed using an accelograph with train of four (TOF) stimulation at the wrist every 12 seconds The percentage depression of the first twitch (T 1) was used as the study parameter The dose response relationship of atracurium and rocuronium was determined by the cumulative dose response technique Results According to the dose response curves established by a least squares linear regression, the potency ratio of atracurium to rocuronium was 1∶1 2 There were significant differences in the ED 50 , ED 90 , and ED 95 between the two drugs After the intravenous administration of equipotent doses of both drugs (1 5×ED 95 ), the duration of peak effect, clinical duration, and total duration were significantly different between the two drugs, but their recovery indexes were similar Conclusions Atracurium and rocuronium are low potency nondepolarizing relaxants with intermediate duration As compared to atracurium, the neuromuscular blocking effect of rocuronium was about 20% less potent and its duration of action was shorter展开更多
基金This study was supported by the Scientific Research Fund of the Chinese Acadeny of Medical Sciences and Peking Union Medical College(Nom 954006)the Excellent Young Scientists Fund of the Ministry of Health,China(No.97004).
文摘To compare the characteristics of the dose response relationship and the time course of action between atracurium and rocuronium in adult patients anesthetized with N 2O O 2 fentanyl thiopene Methods Sixty patients, ASA grade Ⅰ, aged 18-50 years, scheduled for elective plastic surgery were studied All patients were randomly divided into either the atracurium or rocuronium group General anesthesia was maintained with 60% nitrous oxide and 40% oxygen, thiopentone, and fentanyl Neuromuscular function was assessed using an accelograph with train of four (TOF) stimulation at the wrist every 12 seconds The percentage depression of the first twitch (T 1) was used as the study parameter The dose response relationship of atracurium and rocuronium was determined by the cumulative dose response technique Results According to the dose response curves established by a least squares linear regression, the potency ratio of atracurium to rocuronium was 1∶1 2 There were significant differences in the ED 50 , ED 90 , and ED 95 between the two drugs After the intravenous administration of equipotent doses of both drugs (1 5×ED 95 ), the duration of peak effect, clinical duration, and total duration were significantly different between the two drugs, but their recovery indexes were similar Conclusions Atracurium and rocuronium are low potency nondepolarizing relaxants with intermediate duration As compared to atracurium, the neuromuscular blocking effect of rocuronium was about 20% less potent and its duration of action was shorter
