The IDD Transcription Factors:Their Functions in Plant Development and Environmental Response

INDETERMINATE-DOMAIN proteins(IDDs)are a plant-specific transcription factor family characterized by a conserved ID domain with four zinc finger motifs.Previous studies have demonstrated that IDDs coordinate a diversity of physiological processes and functions in plant growth and development,including floral transition,plant architecture,seed and root development,and hormone signaling.In this review,we especially summarized the latest knowledge on the functions and working models of IDD members in Arabidopsis,rice,and maize,particularly focusing on their role in the regulatory network of biotic and abiotic environmental responses,such as gravity,temperature,water,and pathogens.Understanding these mechanisms underlying the function of IDD proteins in these processes is important for improving crop yields by manipulating their activity.Overall,the review offers valuable insights into the functions and mechanisms of IDD proteins in plants,providing a foundation for further research and potential applications in agriculture.

Human Rights and Development:China's Contributions Based on a Larger Concept of Human Rights

The Western liberal view of global governance can no longer effectively address the challenges facing the world today or respond to the demands of developing countries in the fields of human rights and development.Meanwhile,the United Nations human rights and development agenda also has its limitations.Against such a backdrop,China's path of human rights development has avoided the trap of human rights confrontation and the clash of civilizations.It has set an example of complementarity and positive interaction between human rights and development by unifying collective human rights with individual human rights and integrating the universality and particularity of human rights.Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,delivered a speech at the 37th group study session of the Political Bureau of the CPC Central Committee on China's Path of Human Rights Development.This elevated China's human rights development to a new historical height.Practice has proved that China's concept and path of human rights in the new era have not only effectively promoted the development of its human rights cause,but also contributed Chinese wisdom to the global cause of human rights and development with a larger concept of human rights.Under the framework of the concept of building a community with a shared future for mankind,the Belt and Road Initiative,and the Global Development Initiative,China has contributed to enhancing the discourse power of developing countries in human rights and building a fairer,more just,more reasonable and more inclusive system for global human rights governance.

Pioneering a New Realm of Human Rights Civilization in the Chinese Path to Modernization——An Overview of the Symposium on“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”

On October 14,2023,a symposium themed“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”was held in Changchun,Jilin Province,China.More than fifty experts,scholars,and researchers from national institutions and universities engaged in discussions and exchanges on human rights on the Chinese path to modernization,including the path,practice,knowledge systems,and civilization forms of human rights.This symposium played a significant role in advancing the construction of the disciplinary system,academic system,and discourse system of human rights in China.

The Market Development of Children’s Go Training and the Difficulty and Countermeasure Analysis of Go Training

The children’s Go training market is experiencing vigorous growth but also faces several challenges.As the importance of Go in cultural education increases,the market expands,with growing demand and involvement from training and educational institutions.However,the market encounters difficulties such as a shortage of high-quality Go coaches,uniformity in training content and methods,and high training costs.To address these issues,measures can be taken to strengthen the team of Go coaches,diversify training content and methods,and optimize the training cost structure,thereby promoting the healthy development of the children’s Go training market.

A Historical Review of the Development of Women’s Higher Education in China (1908-2020): Stages, Explanations, and Trends

The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work considers the principal institutional mechanisms that contributed to this development.First,flexibly planned parenthood gradually promoted gender equality and openness in society facilitated by systematic“awards,grants,and loans”initiatives to support women’s higher education economically.Second,compulsory education ensured that left-out and migrant children had access to higher education.Third,effective connectivity across different education types bridged education gaps between those with different levels of education.Fourth,China made great efforts to invite and integrate international experiences that promoted the development of women’s higher education.Looking beyond these achievements,we also discuss the future trends of women’s higher education in China.

Regional Economic Development Trend Prediction Method Based on Digital Twins and Time Series Network

At present,the interpretation of regional economic development(RED)has changed from a simple evaluation of economic growth to a focus on economic growth and the optimization of economic structure,the improvement of economic relations,and the change of institutional innovation.This article uses the RED trend as the research object and constructs the RED index to conduct the theoretical analysis.Then this paper uses the attention mechanism based on digital twins and the time series network model to verify the actual data.Finally,the regional economy is predicted according to the theoretical model.The specific research work mainly includes the following aspects:1)This paper introduced the development status of research on time series networks and economic forecasting at home and abroad.2)This paper introduces the basic principles and structures of long and short-term memory(LSTM)and convolutional neural network(CNN),constructs an improved CNN-LSTM model combined with the attention mechanism,and then constructs a regional economic prediction index system.3)The best parameters of the model are selected through experiments,and the trained model is used for simulation experiment prediction.The results show that the CNN-LSTM model based on the attentionmechanism proposed in this paper has high accuracy in predicting regional economies.

Effects of Different Application Times of Tillering Fertilizer on Grain Yield and Population Development of Double-cropping Rice Transplanted by Machine

The application of tillering fertilizer plays an important role in promoting rice tillering and improving rice yield. However, under the condition of mechanical transplanting, the optimal application time of tillering fertilizer is still unclear. In this study, the early rice cultivar Zhongjiazao 17 and late rice cultivar H You 518 were used as materials, and the effects of different application times of tillering fertilizer on yield and population development of double-cropping rice transplanted by machine were investigated. The tillering fertilizer was applied 7（D07）, 10（D10） and 13（D13） d after the transplanting, respectively. The results showed that compared with those in the D07 treatment groups, the yield of early rice in the D10 and D13 treatment groups were reduced by 9.4% and 3.8%, respectively, and the yield of late rice in the D10 and D13 treatment groups were reduced by 4.5% and 12.6%,respectively. However, there were no significant differences in rice yield among the treatment groups. The application time of tillering fertilizer showed significant effects on grain number per panicle and seed setting rate of early rice. The grain number per panicle in the D10 treatment group was significantly lower than that in the D07 treatment group, and the seed setting rate of the D13 treatment group was significantly lower than that in the D07 treatment group（P〈0.05）. For the late rice, the effect of application time of tillering fertilizer on effective tiller number was most obvious, and the effective tiller number in the D13 treatment group was significantly lower than that in the D07 treatment group（P〈0.05）. Compared with those in the D07 treatment group, the effective tiller numbers, leaf area indexes and biomasses in the D10 and D13 treatment groups were all trended to be decreased. Therefore,to improve the quality of population and fulfill the high-yielding potential of double-cropping rice transplanted by machine, the tillering fertilizer should be applied as early as possible after rice seedlings turn green.

Ectopic expression of OsNF-YA8,an endosperm-specific nuclear factor Y transcription-factor gene,causes vegetative and reproductive development defects in rice

Nuclear factor Y(NF-Y),a group of conserved transcription-factor complexes that consist of NF-YA,B,and C subunits,is essential for developmental regulation and for responses to environmental changes in eukaryotes.We previously found that some NF-Y genes,such as OsNF-YA8,were expressed specifically in the endosperm of rice.In the present study,overexpression of OsNF-YA8 in rice resulted in reduced plant height due to suppressed cell elongation in internodes.Gibberellin(GA)biosynthetic genes,including OsCPS1,OsGA20ox1,and OsGA20ox2,were down-regulated.OsNF-YA8 bound to the promoters of these genes to repress their expression.Endogenous GA content was decreased in OsNF-YA8 overexpressors,whose dwarf phenotype could be partially rescued by exogenous GA treatment.The findings suggested that ectopic expression of OsNF-YA8 causes defective GA biosynthesis in vegetative stage.Heading date in OsNF-YA8 overexpressors was delayed,especially under short-day conditions.OsNFYA8 bound to the promoter of Heading Date 3a(Hd3a),the florigen gene in rice,to negatively regulate flowering.Either ectopic activation or knockout of OsNF-YA8 impaired seed development,as indicated by reduced seed size and increased grain chalkiness.These results suggest that ectopic expression of the endosperm-specific OsNF-YA8 in rice disrupts both vegetative and reproductive development.

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.

Research on Coordinated Development and Optimization of Distribution Networks at All Levels in Distributed Power Energy Engineering

The uncertainty of distributed generation energy has dramatically challenged the coordinated development of distribution networks at all levels.This paper focuses on the multi-time-scale regulation model of distributed generation energy under normal conditions.The simulation results of the example verify the self-optimization characteristics and the effectiveness of real-time dispatching of the distribution network control technology at all levels under multiple time scales.

A systems perspective on national prioritisation of sustainable development goals:Insights from Australia

Achieving the Sustainable Development Goals(SDGs)requires effective national initiatives and resource allo-cation.Yet,the simultaneous attainment of all goals is hindered by constraints such as limited budgets and resources,varied national priorities,and the intricate nature of the goals.As we approach 2030 and beyond,an urgent need for an effective,data-driven prioritisation system exists to optimise what can be accomplished.A considerable knowledge gap persists in identifying the priority areas that demand concentrated attention and how their improvement would propel overall sustainability goals.To bridge this gap,our study presents a priori-tisation approach that identifies significant SDG indicators based on urgency and impact,utilising Benchmarking,Bivariate,and Network analysis.Furthermore,we introduce an innovative Impact Index(IMIN)to assess an indi-cator’s extensive effect on the SDG network.This system carries significant international relevance by establishing a robust framework to identify key,potent,and interconnected indicators.It supports decision-makers worldwide in comprehending their nation’s SDG performance and promotes efficient resource allocation.In the specific con-text of Australia,our analysis spotlights several impactful,yet underperforming SDG indicators.These include the protection of Freshwater,Terrestrial,and Mountain Key Biodiversity Areas(KBAs),the share of renewable energy and energy intensity level of primary energy,targeted research and development,gender equality in national parliaments,and carbon-efficient manufacturing,amongst others.

People's Well-rounded Development:The Value Orientation of Common Prosperity in the New Era

Achieving common prosperity for all is an important feature of Chinese modernization and an essential requirement of socialism with Chinese characteristics,with the core value orientation of promoting the people’s well-rounded development.This reflects the close relationship between people’s well-rounded development and common prosperity and implies that common prosperity is not just an economic issue,but also a political matter,a moral subject,and a human rights goal.Being“people-centered”is the core positioning of common prosperity,with its inherent collective and individual attributes.In terms of the object dimension of prosperity,it encompasses a wide range of rights such as material and spiritual well-being,which are advanced in a coordinated manner,and a deepening level of guarantee gradually improving.In the practical concept of“shared development,”it emphasizes the unity of state obligations and individual responsibilities,as well as the phased approach and promotion of common prosperity through the rule of law.Therefore,the essence of common prosperity lies in shifting from a“material-centered”perspective to a“people’s well-rounded development-centered”perspective.It combines the principles of fairness and inclusiveness with the recognition of diverse developmental needs.The focus is on enhancing the subjective initiative of the people,aiming to truly achieve the happiness of the people and promote people’s well-rounded development through the realization of“common prosperity.”

Counteraction to China?Impact of the U.S.International Development Finance Corporation on China’s Development Finance

The United States passed the Better Utilization of Investment Leading to Development(BUILD Act),as a counterweight to China’s overseas development activities.Under the Act,the US established a new federal agency,the U.S.International Development Finance Corporation(DFC),to enhance U.S.development financing capabilities.To better understand the impact of the DFC on China’s development finance,this article analyzes the DFC’s purpose,functions,structure,and funding.Then it focuses on the purpose of establishing the DFC,providing a preliminary analysis of the potential motivation for its establishment.It also compares the China Development Bank(CDB)and the DFC based on their focused sectors.Finally,through an in-depth analysis of financial frictions in China-U.S.relations,this article argues that the DFC competes with China’s overseas development financing activities in the context of broader strategic competition between China and the U.S.

Time-lapse培养与桌面台式培养箱胚胎培养对胚胎发育的影响

目的探讨Time-lapse培养与桌面台式培养箱胚胎培养对胚胎发育的影响。方法选取2021年3月—2023年3月在本院生殖中心行IVF-ET/ICSI-ET治疗的613个周期的胚胎发育数据,随机分配胚胎培养方式。分为对照组与研究组,其中对照组为桌面台式培养箱方式(360个周期),研究组为Time-lapse培养与桌面台式培养箱方式(253个周期),统计两组胚胎发育质量。结果研究组中正常受精数、可移植胚胎数、形成囊胚数、优质胚胎数、高评分囊胚数、受精率、冷冻胚胎率、胚囊形成率、优质胚胎率、高评分囊胚率高于对照组,组间差异有统计学意义(P<0.05)。结论Time-lapse培养与桌面台式培养箱胚胎培养方式优于桌面台式培养箱方式,可为胚胎培养提供适宜的环境、温度、湿度等,有助于胚胎发育,具有较强的实用性和推广性,值得推广应用。

Effects of Nitrogen Application Time on Caryopsis Development and Grain Quality of Rice Variety Yangdao 6

A pot experiment was conducted to study the effects of different nitrogen application time （during the tillering or the booting stages） with the same nitrogen rates on the caryopsis development and grain quality of rice variety Yangdao 6. The increased nitrogen fertilizer （urea）, especially applied during the booting stage, could evidently increase the milled rice rate, head rice rate and protein content in rice grains compared with the control （no nitrogen application）, and decrease chalky grain rate and amylose content. Moreover, the increased nitrogen fertilizer significantly affected the caryopsis development and enhanced the grain weight when nitrogen applied during the tillering and the booting stages, especially during the booting stage. During caryopsis development the increased nitrogen fertilizer applied during the tillering and booting stages could obviously decrease the total starch and amylose contents, but not obviously for the amylopectin content in rice grain. Increased topdressing of nitrogen fertilizer, especially applied during the booting stage, had significant effect on the development and structures of amyloplasts and proteinoplasts. That is, it could change the distribution, number and shape of amyloplasts and proteinoplasts in the endosperm cells especially in grain abdomen, Compared with the control the arrangements of amyloplasts and proteinoplasts were closer, with more numbers, higher density and less interspaces each ohter. Furthermore, most amyloplasts showed polyhedron under the increased nitrogen fertilizer level.

Evaluation of reference genes for quantitative real-time PCR analysis of gene expression during early development processes of the tongue sole(Cynoglossus semilaevis)

Differential expression of genes is crucial to growth and development of fish. To select the appropriate genes for gene normalization during Cynoglossus semilaevis early developmental process, eight candidate reference genes （ACTB, B2M, EF1A, GADPH, RPL7, TUBA, UBCE and 18S） were tested for their adequacy by using quantitative real-time PCR. The results showed that the expression of all the examined genes exhibited tissue dependent variations in the mature C. semilaevis. EFIA was listed as the most stable reference among the 14 tissues by RefFinder. Furthermore, the recommended comprehensive ranking of the stability determined by RefFinder showed that 18S was the most stable gene during the early developmental stages （from oosphere to 90 days old） in this study. However, when divided the Ct value data of the above mentioned early developmental stages into two separate periods （embryo and post-hatching periods）, TUBA and 18S represented the most stable references of these two developmental periods, respectively. Consequently, the reference gene should be carefully and accurately chosen even for studies of the same species at various developmental processes. The relevant data may help in selecting appropriate reference genes for mRNA expression analysis, and is of great value in the studies of fish growth and development.

Egg Development Time (EDT) in <i>Mesocyclops ogunnus</i>

A study was carried out on the impacts of temperature and light/dark regime on the Egg Development Time (EDT) of the cyclopoida copepod, Mesocyclops ogunnus in Lake Kinneret. It was found that EDT was 148, 33 and 20 hours under 15°C, 22°C, and 27°C respectively. EDT was different between the two regimes of 12/12 hrs light/dark and 24 hrs light. Egg hatching and survival were higher under 24 hrs light regime. The results of temperature and light regime impacts on EDT indicate ecological implication on cyclopoida copepod population dynamics in lakes. The implication of the results to the global warming trend is also suggested.

Development of Real-Time Fluorescent PCR for Rapid Detection of Haempohlius parasuis

[ Objective] To develop a real-time fluorescent PCR assay for rapid detection of Haempohlius parasuis （HPS）. [ Method] According to the conservative sequences of 16 S rRNA genes of HPS published in GenBank, a pair of specific primers was designed. The real-time fluorescent PCR was developed by optimizing primer concentration and annealing temperature. And its specificity and reproducibility were evaluated. Ten HPS- suspected samples were detected by the developed method. [ Result] The lowest detection limit of the developed real-time fluorescent PCR was 50 copies/μl. This method had good reproducibility, and its coefficient of variation was lower than 2%. Only HPS rather than Streptococcus suis type 2, Staphylococcus aureus, E. coli DH5 alpha, and swine Salmonella typhi could be detected by the developed real-time fluorescent PCR. The HPS-pesitive samples detected by this method were also positive when they were detected by isolation of bacteria or conventional PCR. [ Conclusion] The developed real-time fluorescent PCR is rapid, sensitive, specific and highly reproducible; thus, it can be used for rapid detection of HPS.

Is it time to rethink the Alzheimer's disease drug development strategy by targeting its silent phase?

Alzheimer＇s disease （AD） is the most frequent cause of dementia in the western world. In clinical terms, AD is characterized by progres- sive cognitive decline that usually begins with memory impairment. As the disease progresses, AD inevitably affects all intellectual functions including executive functions, leading to complete dependence for basic activities of daily life and premature death.

Knowledge Management of Software Productivity and Development Time

In this paper, we identify a set of factors that may be used to forecast software productivity and software development time. Software productivity was measured in function points per person hours, and software development time was measured in number of elapsed days. Using field data on over 130 field software projects from various industries, we empirically test the impact of team size, integrated computer aided software engineering (ICASE) tools, software development type, software development platform, and programming language type on the software development productivity and development time. Our results indicate that team size, software development type, software development platform, and programming language type significantly impact software development productivity. However, only team size significantly impacts software development time. Our results indicate that effective management of software development teams, and using different management strategies for different software development type environments may improve software development productivity.