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Hierarchical multihead self-attention for time-series-based fault diagnosis
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作者 Chengtian Wang Hongbo Shi +1 位作者 Bing Song Yang Tao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第6期104-117,共14页
Fault diagnosis is important for maintaining the safety and effectiveness of chemical process.Considering the multivariate,nonlinear,and dynamic characteristic of chemical process,many time-series-based data-driven fa... Fault diagnosis is important for maintaining the safety and effectiveness of chemical process.Considering the multivariate,nonlinear,and dynamic characteristic of chemical process,many time-series-based data-driven fault diagnosis methods have been developed in recent years.However,the existing methods have the problem of long-term dependency and are difficult to train due to the sequential way of training.To overcome these problems,a novel fault diagnosis method based on time-series and the hierarchical multihead self-attention(HMSAN)is proposed for chemical process.First,a sliding window strategy is adopted to construct the normalized time-series dataset.Second,the HMSAN is developed to extract the time-relevant features from the time-series process data.It improves the basic self-attention model in both width and depth.With the multihead structure,the HMSAN can pay attention to different aspects of the complicated chemical process and obtain the global dynamic features.However,the multiple heads in parallel lead to redundant information,which cannot improve the diagnosis performance.With the hierarchical structure,the redundant information is reduced and the deep local time-related features are further extracted.Besides,a novel many-to-one training strategy is introduced for HMSAN to simplify the training procedure and capture the long-term dependency.Finally,the effectiveness of the proposed method is demonstrated by two chemical cases.The experimental results show that the proposed method achieves a great performance on time-series industrial data and outperforms the state-of-the-art approaches. 展开更多
关键词 Self-attention mechanism Deep learning Chemical process time-series Fault diagnosis
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Modeling urban redevelopment:A novel approach using time-series remote sensing data and machine learning
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作者 Li Lin Liping Di +6 位作者 Chen Zhang Liying Guo Haoteng Zhao Didarul Islam Hui Li Ziao Liu Gavin Middleton 《Geography and Sustainability》 CSCD 2024年第2期211-219,共9页
Accurate mapping and timely monitoring of urban redevelopment are pivotal for urban studies and decisionmakers to foster sustainable urban development.Traditional mapping methods heavily depend on field surveys and su... Accurate mapping and timely monitoring of urban redevelopment are pivotal for urban studies and decisionmakers to foster sustainable urban development.Traditional mapping methods heavily depend on field surveys and subjective questionnaires,yielding less objective,reliable,and timely data.Recent advancements in Geographic Information Systems(GIS)and remote-sensing technologies have improved the identification and mapping of urban redevelopment through quantitative analysis using satellite-based observations.Nonetheless,challenges persist,particularly concerning accuracy and significant temporal delays.This study introduces a novel approach to modeling urban redevelopment,leveraging machine learning algorithms and remote-sensing data.This methodology can facilitate the accurate and timely identification of urban redevelopment activities.The study’s machine learning model can analyze time-series remote-sensing data to identify spatio-temporal and spectral patterns related to urban redevelopment.The model is thoroughly evaluated,and the results indicate that it can accurately capture the time-series patterns of urban redevelopment.This research’s findings are useful for evaluating urban demographic and economic changes,informing policymaking and urban planning,and contributing to sustainable urban development.The model can also serve as a foundation for future research on early-stage urban redevelopment detection and evaluation of the causes and impacts of urban redevelopment. 展开更多
关键词 Urban redevelopment Urban sustainability Remote sensing time-series analysis Machine learning
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Missing Value Imputation for Radar-Derived Time-Series Tracks of Aerial Targets Based on Improved Self-Attention-Based Network
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作者 Zihao Song Yan Zhou +2 位作者 Wei Cheng Futai Liang Chenhao Zhang 《Computers, Materials & Continua》 SCIE EI 2024年第3期3349-3376,共28页
The frequent missing values in radar-derived time-series tracks of aerial targets(RTT-AT)lead to significant challenges in subsequent data-driven tasks.However,the majority of imputation research focuses on random mis... The frequent missing values in radar-derived time-series tracks of aerial targets(RTT-AT)lead to significant challenges in subsequent data-driven tasks.However,the majority of imputation research focuses on random missing(RM)that differs significantly from common missing patterns of RTT-AT.The method for solving the RM may experience performance degradation or failure when applied to RTT-AT imputation.Conventional autoregressive deep learning methods are prone to error accumulation and long-term dependency loss.In this paper,a non-autoregressive imputation model that addresses the issue of missing value imputation for two common missing patterns in RTT-AT is proposed.Our model consists of two probabilistic sparse diagonal masking self-attention(PSDMSA)units and a weight fusion unit.It learns missing values by combining the representations outputted by the two units,aiming to minimize the difference between the missing values and their actual values.The PSDMSA units effectively capture temporal dependencies and attribute correlations between time steps,improving imputation quality.The weight fusion unit automatically updates the weights of the output representations from the two units to obtain a more accurate final representation.The experimental results indicate that,despite varying missing rates in the two missing patterns,our model consistently outperforms other methods in imputation performance and exhibits a low frequency of deviations in estimates for specific missing entries.Compared to the state-of-the-art autoregressive deep learning imputation model Bidirectional Recurrent Imputation for Time Series(BRITS),our proposed model reduces mean absolute error(MAE)by 31%~50%.Additionally,the model attains a training speed that is 4 to 8 times faster when compared to both BRITS and a standard Transformer model when trained on the same dataset.Finally,the findings from the ablation experiments demonstrate that the PSDMSA,the weight fusion unit,cascade network design,and imputation loss enhance imputation performance and confirm the efficacy of our design. 展开更多
关键词 Missing value imputation time-series tracks probabilistic sparsity diagonal masking self-attention weight fusion
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Meteorological factors, ambient air pollution, and daily hospital admissions for depressive disorder in Harbin: A time-series study 被引量:1
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作者 Ting Hu Zhao-Yuan Xu +2 位作者 Jian Wang Yao Su Bing-Bing Guo 《World Journal of Psychiatry》 SCIE 2023年第12期1061-1078,共18页
BACKGROUND The literature has discussed the relationship between environmental factors and depressive disorders;however,the results are inconsistent in different studies and regions,as are the interaction effects betw... BACKGROUND The literature has discussed the relationship between environmental factors and depressive disorders;however,the results are inconsistent in different studies and regions,as are the interaction effects between environmental factors.We hypo-thesized that meteorological factors and ambient air pollution individually affect and interact to affect depressive disorder morbidity.AIM To investigate the effects of meteorological factors and air pollution on depressive disorders,including their lagged effects and interactions.METHODS The samples were obtained from a class 3 hospital in Harbin,China.Daily hos-pital admission data for depressive disorders from January 1,2015 to December 31,2022 were obtained.Meteorological and air pollution data were also collected during the same period.Generalized additive models with quasi-Poisson regre-ssion were used for time-series modeling to measure the non-linear and delayed effects of environmental factors.We further incorporated each pair of environ-mental factors into a bivariate response surface model to examine the interaction effects on hospital admissions for depressive disorders.RESULTS Data for 2922 d were included in the study,with no missing values.The total number of depressive admissions was 83905.Medium to high correlations existed between environmental factors.Air temperature(AT)and wind speed(WS)significantly affected the number of admissions for depression.An extremely low temperature(-29.0℃)at lag 0 caused a 53%[relative risk(RR)=1.53,95%confidence interval(CI):1.23-1.89]increase in daily hospital admissions relative to the median temperature.Extremely low WSs(0.4 m/s)at lag 7 increased the number of admissions by 58%(RR=1.58,95%CI:1.07-2.31).In contrast,atmospheric pressure and relative humidity had smaller effects.Among the six air pollutants considered in the time-series model,nitrogen dioxide(NO_(2))was the only pollutant that showed significant effects over non-cumulative,cumulative,immediate,and lagged conditions.The cumulative effect of NO_(2) at lag 7 was 0.47%(RR=1.0047,95%CI:1.0024-1.0071).Interaction effects were found between AT and the five air pollutants,atmospheric temperature and the four air pollutants,WS and sulfur dioxide.CONCLUSION Meteorological factors and the air pollutant NO_(2) affect daily hospital admissions for depressive disorders,and interactions exist between meteorological factors and ambient air pollution. 展开更多
关键词 Mental health Depressive disorder Hospital admissions Meteorological factors Air pollution time-series
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Graph Construction Method for GNN-Based Multivariate Time-Series Forecasting
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作者 Wonyong Chung Jaeuk Moon +1 位作者 Dongjun Kim Eenjun Hwang 《Computers, Materials & Continua》 SCIE EI 2023年第6期5817-5836,共20页
Multivariate time-series forecasting(MTSF)plays an important role in diverse real-world applications.To achieve better accuracy in MTSF,time-series patterns in each variable and interrelationship patterns between vari... Multivariate time-series forecasting(MTSF)plays an important role in diverse real-world applications.To achieve better accuracy in MTSF,time-series patterns in each variable and interrelationship patterns between variables should be considered together.Recently,graph neural networks(GNNs)has gained much attention as they can learn both patterns using a graph.For accurate forecasting through GNN,a well-defined graph is required.However,existing GNNs have limitations in reflecting the spectral similarity and time delay between nodes,and consider all nodes with the same weight when constructing graph.In this paper,we propose a novel graph construction method that solves aforementioned limitations.We first calculate the Fourier transform-based spectral similarity and then update this similarity to reflect the time delay.Then,we weight each node according to the number of edge connections to get the final graph and utilize it to train the GNN model.Through experiments on various datasets,we demonstrated that the proposed method enhanced the performance of GNN-based MTSF models,and the proposed forecasting model achieve of up to 18.1%predictive performance improvement over the state-of-the-art model. 展开更多
关键词 Deep learning graph neural network multivariate time-series forecasting
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Timosaponin AⅢ induces drug-metabolizing enzymes by activating constitutive androstane receptor (CAR) via dephosphorylation of the EGFR signaling pathway 被引量:1
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作者 Muhammad Zubair Hafiz Jie Pan +4 位作者 Zhiwei Gao Ying Huo Haobin Wang Wei Liu Jian Yang 《Journal of Biomedical Research》 CAS CSCD 2024年第4期382-396,共15页
The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer therapy.The in vivo experiments were conducted on nude and ICR mice.Following a 24-day administratio... The current study aimed to assess the effect of timosaponin AⅢ(T-AⅢ)on drug-metabolizing enzymes during anticancer therapy.The in vivo experiments were conducted on nude and ICR mice.Following a 24-day administration of T-AⅢ,the nude mice exhibited an induction of CYP2B10,MDR1,and CYP3A11 expression in the liver tissues.In the ICR mice,the expression levels of CYP2B10 and MDR1 increased after a three-day T-AⅢ administration.The in vitro assessments with HepG2 cells revealed that T-AⅢ induced the expression of CYP2B6,MDR1,and CYP3A4,along with constitutive androstane receptor(CAR)activation.Treatment with CAR siRNA reversed the T-AⅢ-induced increases in CYP2B6 and CYP3A4 expression.Furthermore,other CAR target genes also showed a significant increase in the expression.The up-regulation of murine CAR was observed in the liver tissues of both nude and ICR mice.Subsequent findings demonstrated that T-AⅢ activated CAR by inhibiting ERK1/2 phosphorylation,with this effect being partially reversed by the ERK activator t-BHQ.Inhibition of the ERK1/2 signaling pathway was also observed in vivo.Additionally,T-AⅢ inhibited the phosphorylation of EGFR at Tyr1173 and Tyr845,and suppressed EGF-induced phosphorylation of EGFR,ERK,and CAR.In the nude mice,T-AⅢ also inhibited EGFR phosphorylation.These results collectively indicate that T-AⅢ is a novel CAR activator through inhibition of the EGFR pathway. 展开更多
关键词 timosaponin AⅢ CAR metabolism enzyme ERK1/2 signaling pathway EGFR signaling pathway
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Sentinel-1 In SAR observations and time-series analysis of co-and postseismic deformation mechanisms of the 2021 Mw 5.8 Bandar Ganaveh Earthquake,Southern Iran
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作者 Reza SABER Veysel ISIK +1 位作者 Ayse CAGLAYAN Marjan TOURANI 《Journal of Mountain Science》 SCIE CSCD 2023年第4期911-927,共17页
In the past two decades,because of the significant increase in the availability of differential interferometry from synthetic aperture radar and GPS data,spaceborne geodesy has been widely employed to determine the co... In the past two decades,because of the significant increase in the availability of differential interferometry from synthetic aperture radar and GPS data,spaceborne geodesy has been widely employed to determine the co-seismic displacement field of earthquakes.On April 18,2021,a moderate earthquake(Mw 5.8)occurred east of Bandar Ganaveh,southern Iran,followed by intensive seismic activity and aftershocks of various magnitudes.We use two-pass D-InSAR and Small Baseline Inversion techniques via the LiCSBAS suite to study the coseismic displacement and monitor the four-month post-seismic deformation of the Bandar Ganaveh earthquake,as well as constrain the fault geometry of the co-seismic faulting mechanism during the seismic sequence.Analyses show that the co-and postseismic deformation are distributed in relatively shallow depths along with an NW-SE striking and NE dipping complex reverse/thrust fault branches of the Zagros Mountain Front Fault,complying with the main trend of the Zagros structures.The average cumulative displacements were obtained from-137.5 to+113.3 mm/yr in the SW and NE blocks of the Mountain Front Fault,respectively.The received maximum uplift amount is approximately consistent with the overall orogen-normal shortening component of the Arabian-Eurasian convergence in the Zagros region.No surface ruptures were associated with the seismic source;therefore,we propose a shallow blind thrust/reverse fault(depth~10 km)connected to the deeper basal decollement fault within a complex tectonic zone,emphasizing the thin-skinned tectonics. 展开更多
关键词 Sentinel‑1 InSAR time-series Neotectonic reactivation Seismogenic fault Bandar Ganaveh earthquakes Zagros Fold-Thrust Belt Arabian-Eurasian collision
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Generating Time-Series Data Using Generative Adversarial Networks for Mobility Demand Prediction
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作者 Subhajit Chatterjee Yung-Cheol Byun 《Computers, Materials & Continua》 SCIE EI 2023年第3期5507-5525,共19页
The increasing penetration rate of electric kickboard vehicles has been popularized and promoted primarily because of its clean and efficient features.Electric kickboards are gradually growing in popularity in tourist... The increasing penetration rate of electric kickboard vehicles has been popularized and promoted primarily because of its clean and efficient features.Electric kickboards are gradually growing in popularity in tourist and education-centric localities.In the upcoming arrival of electric kickboard vehicles,deploying a customer rental service is essential.Due to its freefloating nature,the shared electric kickboard is a common and practical means of transportation.Relocation plans for shared electric kickboards are required to increase the quality of service,and forecasting demand for their use in a specific region is crucial.Predicting demand accurately with small data is troublesome.Extensive data is necessary for training machine learning algorithms for effective prediction.Data generation is a method for expanding the amount of data that will be further accessible for training.In this work,we proposed a model that takes time-series customers’electric kickboard demand data as input,pre-processes it,and generates synthetic data according to the original data distribution using generative adversarial networks(GAN).The electric kickboard mobility demand prediction error was reduced when we combined synthetic data with the original data.We proposed Tabular-GAN-Modified-WGAN-GP for generating synthetic data for better prediction results.We modified The Wasserstein GAN-gradient penalty(GP)with the RMSprop optimizer and then employed Spectral Normalization(SN)to improve training stability and faster convergence.Finally,we applied a regression-based blending ensemble technique that can help us to improve performance of demand prediction.We used various evaluation criteria and visual representations to compare our proposed model’s performance.Synthetic data generated by our suggested GAN model is also evaluated.The TGAN-Modified-WGAN-GP model mitigates the overfitting and mode collapse problem,and it also converges faster than previous GAN models for synthetic data creation.The presented model’s performance is compared to existing ensemble and baseline models.The experimental findings imply that combining synthetic and actual data can significantly reduce prediction error rates in the mean absolute percentage error(MAPE)of 4.476 and increase prediction accuracy. 展开更多
关键词 Machine learning generative adversarial networks electric vehicle time-series TGAN WGAN-GP blend model demand prediction regression
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Na^(+)/K^(+)-ATPase:ion pump,signal transducer,or cytoprotective protein,and novel biological functions 被引量:2
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作者 Songqiang Huang Wanting Dong +1 位作者 Xiaoqian Lin Jinsong Bian 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2684-2697,共14页
Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^... Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^(+)/K^(+)-ATPase participates in Ca^(2+)-signaling transduction and neurotransmitter release by coordinating the ion concentration gradient across the cell membrane.Na^(+)/K^(+)-ATPase works synergistically with multiple ion channels in the cell membrane to form a dynamic network of ion homeostatic regulation and affects cellular communication by regulating chemical signals and the ion balance among different types of cells.Therefo re,it is not surprising that Na^(+)/K^(+)-ATPase dysfunction has emerged as a risk factor for a variety of neurological diseases.However,published studies have so far only elucidated the important roles of Na^(+)/K^(+)-ATPase dysfunction in disease development,and we are lacking detailed mechanisms to clarify how Na^(+)/K^(+)-ATPase affects cell function.Our recent studies revealed that membrane loss of Na^(+)/K^(+)-ATPase is a key mechanism in many neurological disorders,particularly stroke and Parkinson's disease.Stabilization of plasma membrane Na^(+)/K^(+)-ATPase with an antibody is a novel strategy to treat these diseases.For this reason,Na^(+)/K^(+)-ATPase acts not only as a simple ion pump but also as a sensor/regulator or cytoprotective protein,participating in signal transduction such as neuronal autophagy and apoptosis,and glial cell migration.Thus,the present review attempts to summarize the novel biological functions of Na^(+)/K^(+)-ATPase and Na^(+)/K^(+)-ATPase-related pathogenesis.The potential for novel strategies to treat Na^(+)/K^(+)-ATPase-related brain diseases will also be discussed. 展开更多
关键词 ANTIBODY biological functions cellular communication electrochemical gradient ion balance ion channels Na^(+)/K^(+)-ATPase neurological diseases neurotransmitter release signal transduction
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Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder 被引量:2
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作者 Luyi Wang Man Xu +8 位作者 Yan Wang Feifei Wang Jing Deng Xiaoya Wang Yu Zhao Ailing Liao Feng Yang Shali Wang Yingbo Li 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1618-1624,共7页
Autism spectrum disorders are a group of neurodevelopmental disorders involving more than 1100 genes,including Ctnnd2 as a candidate gene.Ctnnd2knockout mice,serving as an animal model of autis m,have been demonstrate... Autism spectrum disorders are a group of neurodevelopmental disorders involving more than 1100 genes,including Ctnnd2 as a candidate gene.Ctnnd2knockout mice,serving as an animal model of autis m,have been demonstrated to exhibit decreased density of dendritic spines.The role of melatonin,as a neuro hormone capable of effectively alleviating social interaction deficits and regulating the development of dendritic spines,in Ctnnd2 deletion-induced nerve injury remains unclea r.In the present study,we discove red that the deletion of exon 2 of the Ctnnd2 gene was linked to social interaction deficits,spine loss,impaired inhibitory neurons,and suppressed phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt) signal pathway in the prefrontal cortex.Our findings demonstrated that the long-term oral administration of melatonin for 28 days effectively alleviated the aforementioned abnormalities in Ctnnd2 gene-knockout mice.Furthermore,the administration of melatonin in the prefro ntal cortex was found to improve synaptic function and activate the PI3K/Akt signal pathway in this region.The pharmacological blockade of the PI3K/Akt signal pathway with a PI3K/Akt inhibitor,wo rtmannin,and melatonin receptor antagonists,luzindole and 4-phenyl-2-propionamidotetralin,prevented the melatonin-induced enhancement of GABAergic synaptic function.These findings suggest that melatonin treatment can ameliorate GABAe rgic synaptic function by activating the PI3K/Akt signal pathway,which may contribute to the improvement of dendritic spine abnormalities in autism spectrum disorders. 展开更多
关键词 AUTISM Ctnnd2 deletion GABAergic neurons MELATONIN PI3K/Akt signal pathway prefrontal cortex social behavior spine density synaptic-associated proteins
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Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye 被引量:1
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作者 Qihong Jiang Lin Chen +5 位作者 Rui Wang Yin Chen Shanggui Deng Guoxin Shen Shulai Liu Xingwei Xiang 《Food Science and Human Wellness》 SCIE CSCD 2024年第2期842-855,共14页
Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2... Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin.TGP(5.1×10^(3) Da)was composed of mannose,glucosamine,rhamnose,glucuronic acid,galactosamine,glucose,galactose,xylose,and fucose.It could significantly alleviate weight loss,reduce fasting blood glucose levels,reverse dyslipidemia,reduce liver damage from oxidative stress,and improve insulin sensitivity.RT-PCR and Western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance.TGP increased the abundance of Allobaculum,Akkermansia,and Bifidobacterium,restored the microbiota abundance in the intestinal tracts of mice with T2DM,and promoted short-chain fatty acid production.This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical. 展开更多
关键词 Tegillarca granosa polysaccharide Type 2 diabetes mellitus Glycolipid metabolism PI3K/Akt signaling pathway
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Gut microbiota dysbiosis contributes toα-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson’s disease 被引量:1
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作者 Xiaoli Fang Sha Liu +9 位作者 Bilal Muhammad Mingxuan Zheng Xing Ge Yan Xu Shu Kan Yang Zhang Yinghua Yu Kuiyang Zheng Deqin Geng Chun-Feng Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期2081-2088,共8页
Parkinson’s disease is a neurodegenerative disease characterized by motor and gastrointestinal dysfunction.Gastrointestinal dysfunction can precede the onset of motor symptoms by several years.Gut microbiota dysbiosi... Parkinson’s disease is a neurodegenerative disease characterized by motor and gastrointestinal dysfunction.Gastrointestinal dysfunction can precede the onset of motor symptoms by several years.Gut microbiota dysbiosis is involved in the pathogenesis of Parkinson’s disease,whether it plays a causal role in motor dysfunction,and the mechanism underlying this potential effect,remain unknown.CCAAT/enhancer binding proteinβ/asparagine endopeptidase(C/EBPβ/AEP)signaling,activated by bacterial endotoxin,can promoteα-synuclein transcription,thereby contributing to Parkinson’s disease pathology.In this study,we aimed to investigate the role of the gut microbiota in C/EBPβ/AEP signaling,α-synuclein-related pathology,and motor symptoms using a rotenone-induced mouse model of Parkinson’s disease combined with antibiotic-induced microbiome depletion and fecal microbiota transplantation.We found that rotenone administration resulted in gut microbiota dysbiosis and perturbation of the intestinal barrier,as well as activation of the C/EBP/AEP pathway,α-synuclein aggregation,and tyrosine hydroxylase-positive neuron loss in the substantia nigra in mice with motor deficits.However,treatment with rotenone did not have any of these adverse effects in mice whose gut microbiota was depleted by pretreatment with antibiotics.Importantly,we found that transplanting gut microbiota derived from mice treated with rotenone induced motor deficits,intestinal inflammation,and endotoxemia.Transplantation of fecal microbiota from healthy control mice alleviated rotenone-induced motor deficits,intestinal inflammation,endotoxemia,and intestinal barrier impairment.These results highlight the vital role that gut microbiota dysbiosis plays in inducing motor deficits,C/EBPβ/AEP signaling activation,andα-synuclein-related pathology in a rotenone-induced mouse model of Parkinson’s disease.Additionally,our findings suggest that supplementing with healthy microbiota may be a safe and effective treatment that could help ameliorate the progression of motor deficits in patients with Parkinson’s disease. 展开更多
关键词 C/EBP/AEP signaling pathway ENDOTOXEMIA fecal microbiota transplantation intestinal barrier intestinal inflammation microbiota-gut-brain axis Parkinson’s disease
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2D DOA Estimation of Coherent Signals with a Separated Linear Acoustic Vector-Sensor Array
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作者 Sheng Liu Jing Zhao +2 位作者 Decheng Wu Yiwang Huang Kaiwu Luo 《China Communications》 SCIE CSCD 2024年第2期155-165,共11页
In this paper, a two-dimensional(2D) DOA estimation algorithm of coherent signals with a separated linear acoustic vector-sensor(AVS) array consisting of two sparse AVS arrays is proposed. Firstly,the partitioned spat... In this paper, a two-dimensional(2D) DOA estimation algorithm of coherent signals with a separated linear acoustic vector-sensor(AVS) array consisting of two sparse AVS arrays is proposed. Firstly,the partitioned spatial smoothing(PSS) technique is used to construct a block covariance matrix, so as to decorrelate the coherency of signals. Then a signal subspace can be obtained by singular value decomposition(SVD) of the covariance matrix. Using the signal subspace, two extended signal subspaces are constructed to compensate aperture loss caused by PSS.The elevation angles can be estimated by estimation of signal parameter via rotational invariance techniques(ESPRIT) algorithm. At last, the estimated elevation angles can be used to estimate automatically paired azimuth angles. Compared with some other ESPRIT algorithms, the proposed algorithm shows higher estimation accuracy, which can be proved through the simulation results. 展开更多
关键词 acoustic vector-sensor coherent signals extended signal subspace sparse array
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A feedback control method for phase signal demodulation in fber-optic hydrophones
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作者 Zhiqiang LIU Lei XIA +3 位作者 Qiangfeng LYU Bin WU Ronghua HUAN Zhilong HUANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第3期515-528,共14页
In the realm of acoustic signal detection,the identification of weak signals,particularly in the presence of negative signal-to-noise ratios,poses a significant challenge.This challenge is further heightened when sign... In the realm of acoustic signal detection,the identification of weak signals,particularly in the presence of negative signal-to-noise ratios,poses a significant challenge.This challenge is further heightened when signals are acquired through fiber-optic hydrophones,as these signals often lack physical significance and resist clear systematic modeling.Conventional processing methods,e.g.,low-pass filter(LPF),require a thorough understanding of the effective signal bandwidth for noise reduction,and may introduce undesirable time lags.This paper introduces an innovative feedback control method with dual Kalman filters for the demodulation of phase signals with noises in fiber-optic hydrophones.A mathematical model of the closed-loop system is established to guide the design of the feedback control,aiming to achieve a balance with the input phase signal.The dual Kalman filters are instrumental in mitigating the effects of signal noise,observation noise,and control execution noise,thereby enabling precise estimation for the input phase signals.The effectiveness of this feedback control method is demonstrated through examples,showcasing the restoration of low-noise signals,negative signal-to-noise ratio signals,and multi-frequency signals.This research contributes to the technical advancement of high-performance devices,including fiber-optic hydrophones and phase-locked amplifiers. 展开更多
关键词 feedback control method fiber-optic hydrophone acoustic signal detection phase signal
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Emotion Measurement Using Biometric Signal
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作者 Yukina Miyagi Saori Gocho +4 位作者 Yuka Miyachi Chika Nakayama Shoshiro Okada Kenta Maruyama Taeyuki Oshima 《Health》 2024年第5期395-404,共10页
In recent years, research on the estimation of human emotions has been active, and its application is expected in various fields. Biological reactions, such as electroencephalography (EEG) and root mean square success... In recent years, research on the estimation of human emotions has been active, and its application is expected in various fields. Biological reactions, such as electroencephalography (EEG) and root mean square successive difference (RMSSD), are indicators that are less influenced by individual arbitrariness. The present study used EEG and RMSSD signals to assess the emotions aroused by emotion-stimulating images in order to investigate whether various emotions are associated with characteristic biometric signal fluctuations. The participants underwent EEG and RMSSD while viewing emotionally stimulating images and answering the questionnaires. The emotions aroused by emotionally stimulating images were assessed by measuring the EEG signals and RMSSD values to determine whether different emotions are associated with characteristic biometric signal variations. Real-time emotion analysis software was used to identify the evoked emotions by describing them in the Circumplex Model of Affect based on the EEG signals and RMSSD values. Emotions other than happiness did not follow the Circumplex Model of Affect in this study. However, ventral attentional activity may have increased the RMSSD value for disgust as the β/θ value increased in right-sided brain waves. Therefore, the right-sided brain wave results are necessary when measuring disgust. Happiness can be assessed easily using the Circumplex Model of Affect for positive scene analysis. Improving the current analysis methods may facilitate the investigation of face-to-face communication in the future using biometric signals. 展开更多
关键词 Biometric signals ELECTROENCEPHALOGRAM ELECTROCARDIOGRAM EMOTION Communication
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Special Section on High-Dimensional Signal Processing
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《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期F0002-F0002,共1页
Massive amounts of data are acquired in modern and future information technology industries such as communication,radar,and remote sensing.The presence of large dimensionality and size in these data offers new opportu... Massive amounts of data are acquired in modern and future information technology industries such as communication,radar,and remote sensing.The presence of large dimensionality and size in these data offers new opportunities to enhance the performance of signal processing in such applications and even motivate new ones.However,the curse of dimensionality is always a challenge when processing such high-dimensional signals.In practical tasks,high-dimensional signals need to be acquired,processed,and analyzed with high accuracy,robustness,and computational efficiency.This special section aims to address these challenges,where articles attempt to develop new theories and methods that are best suited to the high dimensional nature of the signals involved,and explore modern and emerging applications in this area. 展开更多
关键词 signal MASSIVE dimensionality
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Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents
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作者 Ammad Ahmad Farooqi Iqra Mobeen +3 位作者 Rukset Attar Khalida I.Noel Baojun Xu William C.Cho 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2353-2362,共10页
High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and t... High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and resolution.Extra-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of maturity.Interdisciplinary researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).Importantly,garlic and its biologically active chemicals targeted oncogenic signaling cascades.In this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice. 展开更多
关键词 Cancer NUTRIGENOMICS signalING Apoptosis Allium sativum
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Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression
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作者 Damián Sánchez-Ramírez Mónica G Mendoza-Rodríguez +7 位作者 Omar R Alemán Fernando A Candanedo-González Miriam Rodríguez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第5期1705-1724,共20页
Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer worldwide.CRC displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associ... Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer worldwide.CRC displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better prognosis.This reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor microenvironment.CAFs are directly involved in tumorigenesis through different mechanisms.However,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains unclear.Among the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling pathways.Thus,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT inhibitors.Here,we analyze the impact of different STATs on CAF activity and their immunoregulatory role. 展开更多
关键词 Cancer-associated fibroblasts signal transducer and activator of transcription signaling Colorectal cancer IMMUNITY IMMUNOSUPPRESSION
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Machine Learning for Signal Demodulation in Underwater Wireless Optical Communications
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作者 Ma Shuai Yang Lei +6 位作者 Ding Wanying Li Hang Zhang Zhongdan Xu Jing Li Zongyan Xu Gang Li Shiyin 《China Communications》 SCIE CSCD 2024年第5期297-313,共17页
The underwater wireless optical communication(UWOC)system has gradually become essential to underwater wireless communication technology.Unlike other existing works on UWOC systems,this paper evaluates the proposed ma... The underwater wireless optical communication(UWOC)system has gradually become essential to underwater wireless communication technology.Unlike other existing works on UWOC systems,this paper evaluates the proposed machine learningbased signal demodulation methods through the selfbuilt experimental platform.Based on such a platform,we first construct a real signal dataset with ten modulation methods.Then,we propose a deep belief network(DBN)-based demodulator for feature extraction and multi-class feature classification.We also design an adaptive boosting(Ada Boost)demodulator as an alternative scheme without feature filtering for multiple modulated signals.Finally,it is demonstrated by extensive experimental results that the Ada Boost demodulator significantly outperforms the other algorithms.It also reveals that the demodulator accuracy decreases as the modulation order increases for a fixed received optical power.A higher-order modulation may achieve a higher effective transmission rate when the signal-to-noise ratio(SNR)is higher. 展开更多
关键词 ADABOOST DBN machine learning signal demodulation
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Adaptive Bistable Stochastic Resonance Based Weak Signal Reception in Additive Laplacian Noise
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作者 Jin Liu Zan Li +1 位作者 Qiguang Miao Li Yang 《China Communications》 SCIE CSCD 2024年第1期228-241,共14页
Weak signal reception is a very important and challenging problem for communication systems especially in the presence of non-Gaussian noise,and in which case the performance of optimal linear correlated receiver degr... Weak signal reception is a very important and challenging problem for communication systems especially in the presence of non-Gaussian noise,and in which case the performance of optimal linear correlated receiver degrades dramatically.Aiming at this,a novel uncorrelated reception scheme based on adaptive bistable stochastic resonance(ABSR)for a weak signal in additive Laplacian noise is investigated.By analyzing the key issue that the quantitative cooperative resonance matching relationship between the characteristics of the noisy signal and the nonlinear bistable system,an analytical expression of the bistable system parameters is derived.On this basis,by means of bistable system parameters self-adaptive adjustment,the counterintuitive stochastic resonance(SR)phenomenon can be easily generated at which the random noise is changed into a benefit to assist signal transmission.Finally,it is demonstrated that approximately 8dB bit error ratio(BER)performance improvement for the ABSR-based uncorrelated receiver when compared with the traditional uncorrelated receiver at low signal to noise ratio(SNR)conditions varying from-30dB to-5dB. 展开更多
关键词 adaptive bistable stochastic resonance additive Laplacian noise low signal to noise ratio uncorrelated reception scheme weak signal reception
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