Vehicle routing optimization algorithm based on time windows and dynamic demand

To provide the supplier with the minimizum vehicle travel distance in the distribution process of goods in three situations of new customer demand,customer cancellation service,and change of customer delivery address,based on the ideas of pre-optimization and real-time optimization,a two-stage planning model of dynamic demand based vehicle routing problem with time windows was established.At the pre-optimization stage,an improved genetic algorithm was used to obtain the pre-optimized distribution route,a large-scale neighborhood search method was integrated into the mutation operation to improve the local optimization performance of the genetic algorithm,and a variety of operators were introduced to expand the search space of neighborhood solutions;At the real-time optimization stage,a periodic optimization strategy was adopted to transform a complex dynamic problem into several static problems,and four neighborhood search operators were used to quickly adjust the route.Two different scale examples were designed for experiments.It is proved that the algorithm can plan the better route,and adjust the distribution route in time under the real-time constraints.Therefore,the proposed algorithm can provide theoretical guidance for suppliers to solve the dynamic demand based vehicle routing problem.

Whole-brain CT Perfusion at Admission and During Delayed Time-window Detects the Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage

Objective To evaluate the utility of computed tomography perfusion(CTP)both at admission and during delayed cerebral ischemia time-window(DCITW)in the detection of delayed cerebral ischemia(DCI)and the change in CTP parameters from admission to DCITW following aneurysmal subarachnoid hemorrhage.Methods Eighty patients underwent CTP at admission and during DCITW.The mean and extreme values of all CTP parameters at admission and during DCITW were compared between the DCI group and non-DCI group,and comparisons were also made between admission and DCITW within each group.The qualitative color-coded perfusion maps were recorded.Finally,the relationship between CTP parameters and DCI was assessed by receiver operating characteristic(ROC)analyses.Results With the exception of cerebral blood volume(P=0.295,admission;P=0.682,DCITW),there were significant differences in the mean quantitative CTP parameters between DCI and non-DCI patients both at admission and during DCITW.In the DCI group,the extreme parameters were significantly different between admission and DCITW.The DCI group also showed a deteriorative trend in the qualitative color-coded perfusion maps.For the detection of DCI,mean transit time to the center of the impulse response function(Tmax)at admission and mean time to start(TTS)during DCITW had the largest area under curve(AUC),0.698 and 0.789,respectively.Conclusion Whole-brain CTP can predict the occurrence of DCI at admission and diagnose DCI during DCITW.The extreme quantitative parameters and qualitative color-coded perfusion maps can better reflect the perfusion changes of patients with DCI from admission to DCITW.

Improved ant colony optimization for multi-depot heterogeneous vehicle routing problem with soft time windows

Considering that the vehicle routing problem （VRP） with many extended features is widely used in actual life, such as multi-depot, heterogeneous types of vehicles, customer service priority and time windows etc., a mathematical model for multi-depot heterogeneous vehicle routing problem with soft time windows （MDHVRPSTW） is established. An improved ant colony optimization （IACO） is proposed for solving this model. First, MDHVRPSTW is transferred into different groups according to the nearest principle, and then the initial route is constructed by the scanning algorithm （SA）. Secondly, genetic operators are introduced, and crossover probability and mutation probability are adaptively adjusted in order to improve the global search ability of the algorithm. Moreover, the smooth mechanism is used to improve the performance of the ant colony optimization （ACO）. Finally, the 3-opt strategy is used to improve the local search ability. The proposed IACO was tested on three new instances that were generated randomly. The experimental results show that IACO is superior to the other three existing algorithms in terms of convergence speed and solution quality. Thus, the proposed method is effective and feasible, and the proposed model is meaningful.

Multi-type ant system algorithm for the time dependent vehicle routing problem with time windows

The time dependent vehicle routing problem with time windows（TDVRPTW） is considered. A multi-type ant system（MTAS） algorithm hybridized with the ant colony system（ACS）and the max-min ant system（MMAS） algorithms is proposed. This combination absorbs the merits of the two algorithms in solutions construction and optimization separately. In order to improve the efficiency of the insertion procedure, a nearest neighbor selection（NNS） mechanism, an insertion local search procedure and a local optimization procedure are specified in detail. And in order to find a balance between good scouting performance and fast convergence rate, an adaptive pheromone updating strategy is proposed in the MTAS. Computational results confirm the MTAS algorithm＇s good performance with all these strategies on classic vehicle routing problem with time windows（VRPTW） benchmark instances and the TDVRPTW instances, and some better results especially for the number of vehicles and travel times of the best solutions are obtained in comparison with the previous research.

Solving Multitrip Pickup and Delivery Problem With Time Windows and Manpower Planning Using Multiobjective Algorithms

The multitrip pickup and delivery problem with time windows and manpower planning(MTPDPTW-MP)determines a set of ambulance routes and finds staff assignment for a hospital. It involves different stakeholders with diverse interests and objectives. This study firstly introduces a multiobjective MTPDPTW-MP(MO-MTPDPTWMP) with three objectives to better describe the real-world scenario. A multiobjective iterated local search algorithm with adaptive neighborhood selection(MOILS-ANS) is proposed to solve the problem. MOILS-ANS can generate a diverse set of alternative solutions for decision makers to meet their requirements. To better explore the search space, problem-specific neighborhood structures and an adaptive neighborhood selection strategy are carefully designed in MOILS-ANS. Experimental results show that the proposed MOILS-ANS significantly outperforms the other two multiobjective algorithms. Besides, the nature of objective functions and the properties of the problem are analyzed. Finally, the proposed MOILS-ANS is compared with the previous single-objective algorithm and the benefits of multiobjective optimization are discussed.

Weapon configuration, allocation and route planning with time windows for multiple unmanned combat air vehicles

Unmanned combat air vehicles(UCAVs) mission planning is a fairly complicated global optimum problem. Military attack missions often employ a fleet of UCAVs equipped with weapons to attack a set of known targets. A UCAV can carry different weapons to accomplish different combat missions. Choice of different weapons will have different effects on the final combat effectiveness. This work presents a mixed integer programming model for simultaneous weapon configuration and route planning of UCAVs, which solves the problem optimally using the IBM ILOG CPLEX optimizer for simple missions. This paper develops a heuristic algorithm to handle the medium-scale and large-scale problems. The experiments demonstrate the performance of the heuristic algorithm in solving the medium scale and large scale problems. Moreover, we give suggestions on how to select the most appropriate algorithm to solve different scale problems.

Therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion injury

The time window in which a drug is effective varies between drugs. The present study investigated the therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion in mice. Animals underwent middle cerebral artery occlusion and were injected with Qingkailing （1.5, 3, 6 mL/kg）. Infarct volume and neurological function were assessed after 24 hours of ischemia. In addition, to establish the therapeutic time window, mice were injected with 3 mL/kg Qingkailing at 0, 1, 3, 4, 6, 9 and 12 hours after occlusion. Results revealed that Qingkailing injection significantly reduced infarct volume and improved neurological function in model mice after cerebral infarction for up to 9 hours, demonstrating that the therapeutic window of Qingkailing injection can extend to 9 hours for cerebral ischemia/reperfusion in mice.

A GA approach to vehicle routing problem with time windows considering loading constraints

As a new variant of vehicle routing problem( VRP),a finished vehicle routing problem with time windows in finished vehicle logistics( FVRPTW) is modeled and solved. An optimization model for FVRPTW is presented with the objective of scheduling multiple transport routes considering loading constraints along with time penalty function to minimize the total cost. Then a genetic algorithm( GA) is developed. The specific encoding and genetic operators for FVRPTW are devised.Especially,in order to accelerate its convergence,an improved termination condition is given. Finally,a case study is used to evaluate the effectiveness of the proposed algorithm and a series of experiments are conducted over a set of finished vehicle routing problems. The results demonstrate that the proposed approach has superior performance and satisfies users in practice. Contributions of the study are the modeling and solving of a complex FVRPTW in logistics industry.

Therapeutic imaging window of cerebral infarction revealed by multisequence magnetic resonance imaging An animal and clinical study

In this study, we established a Wistar rat model of right middle cerebral artery occlusion and observed pathological imaging changes （T2-weighted imaging [T2WI], T2FLAIR, and diffusion-weighted imaging [DWI]） following cerebral infarction. The pathological changes were divided into three phases： early cerebral infarction, middle cerebral infarction, and late cerebral infarction. In the early cerebral infarction phase （less than 2 hours post-infarction）, there was evidence of intracellular edema, which improved after reperfusion. This improvement was defined as the ischemic penumbra. In this phase, a high DWI signal and a low apparent diffusion coefficient were observed in the right basal ganglia region. By contrast, there were no abnormal T2WI and T2FLAIR signals. For the middle cerebral infarction phase （2-4 hours post-infarction）, a mixed edema was observed. After reperfusion, there was a mild improvement in cell edema, while the angioedema became more serious. A high DWI signal and a low apparent diffusion coefficient signal were observed, and some rats showed high T2WI and T2FLAIR signals. For the late cerebral infarction phase （4-6 hours post-infarction）, significant angioedema was visible in the infarction site. After reperfusion, there was a significant increase in angioedema, while there was evidence of hemorrhage and necrosis. A mixed signal was observed on DWI, while a high apparent diffusion coefficient signal, a high T2WI signal, and a high T2FLAIR signal were also observed. All 86 cerebral infarction patients were subjected to T2WI, T2FLAIR, and DWI. MRI results of clinic data similar to the early infarction phase of animal experiments were found in 51 patients, for which 10 patients （10/51） had an onset time greater than 6 hours. A total of 35 patients had MRI results similar to the middle and late infarction phase of animal experiments, of which eight patients （8/35） had an onset time less than 6 hours. These data suggest that defining the ＂therapeutic time window＂ as the time 6 hours after infarction may not be suitable for all patients. Integrated application of MRI sequences including T2WI, T2FLAIR, DW-MRI, and apparent diffusion coefficient mapping should be used to examine the ischemic penumbra, which may provide valuable information for identifying the ＂therapeutic time window＂.

Optimal therapeutic dose and time window of picroside II in cerebral ischemic injury

A preliminary study from our research group showed that picroside II inhibited neuronal apop- tosis in ischemic penumbra, reduced ischemic volume, and improved neurobehavioral function in rats with cerebral ischemia. The aim of the present study was to validate the neuroprotective effects of picroside II and optimize its therapeutic time window and dose in a rat model of cerebral ischemia. We found that picroside Ⅱ inhibited cell apoptosis and reduced the expression of neuron-specific enolase, a marker of neuronal damage, in rats after cerebral ischemic injury. The optimal treatment time after ischemic injury and dose were determined, respectively, as follows： （1） 2.0 hours and 10 mg/kg according to the results of toluidine blue staining; （2） 1.5 hours and 10 mg/kg according to early apoptotic ratio by flow cytometry; （3） 2.0 hours and 10 mg/kg according to immunohistochemical and western blot analysis; and （4） 1.5 hours and 10 mg/kg according to reverse transcription polymerase chain reaction. The present findings suggest that an intraperitoneal injection of 10 mg/kg picroside II 1.5-2.0 hours after cerebral ischemic injury in rats is the optimal dose and time for therapeutic benefit.

Research on Vehicle Routing Problem with Soft Time Windows Based on Hybrid Tabu Search and Scatter Search Algorithm

With the expansion of the application scope of social computing problems,many path problems in real life have evolved from pure path optimization problems to social computing problems that take into account various social attributes,cultures,and the emotional needs of customers.The actual soft time window vehicle routing problem,speeding up the response of customer needs,improving distribution efficiency,and reducing operating costs is the focus of current social computing problems.Therefore,designing fast and effective algorithms to solve this problem has certain theoretical and practical significance.In this paper,considering the time delay problem of customer demand,the compensation problem is given,and the mathematical model of vehicle path problem with soft time window is given.This paper proposes a hybrid tabu search(TS)&scatter search(SS)algorithm for vehicle routing problem with soft time windows(VRPSTW),which mainly embeds the TS dynamic tabu mechanism into the SS algorithm framework.TS uses the scattering of SS to avoid the dependence on the quality of the initial solution,and SS uses the climbing ability of TS improves the ability of optimizing,so that the quality of search for the optimal solution can be significantly improved.The hybrid algorithm is still based on the basic framework of SS.In particular,TS is mainly used for solution improvement and combination to generate new solutions.In the solution process,both the quality and the dispersion of the solution are considered.A simulation experiments verify the influence of the number of vehicles and maximum value of tabu length on solution,parameters’control over the degree of convergence,and the influence of the number of diverse solutions on algorithm performance.Based on the determined parameters,simulation experiment is carried out in this paper to further prove the algorithm feasibility and effectiveness.The results of this paper provide further ideas for solving vehicle routing problems with time windows and improving the efficiency of vehicle routing problems and have strong applicability.

Solving open vehicle problem with time window by hybrid column generation algorithm

This paper addresses the open vehicle routing problem with time window(OVRPTW), where each vehicle does not need to return to the depot after completing the delivery task.The optimization objective is to minimize the total distance. This problem exists widely in real-life logistics distribution process.We propose a hybrid column generation algorithm(HCGA) for the OVRPTW, embedding both exact algorithm and metaheuristic. In HCGA, a label setting algorithm and an intelligent algorithm are designed to select columns from small and large subproblems, respectively. Moreover, a branch strategy is devised to generate the final feasible solution for the OVRPTW. The computational results show that the proposed algorithm has faster speed and can obtain the approximate optimal solution of the problem with 100 customers in a reasonable time.

Generalized multiple time windows model based parallel machine scheduling for TDRSS

The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.

An Alternative Algorithm for Vehicle Routing Problem with Time Windows for Daily Deliveries

This study attempts to solve vehicle routing problem with time window (VRPTW). The study first identifies the real problems and suggests some recommendations on the issues. The technique used in this study is Genetic Algorithm (GA) and initialization applied is random population method. The objective of the study is to assign a number of vehicles to routes that connect customers and depot such that the overall distance travelled is minimized and the delivery operations are completed within the time windows requested by the customers. The analysis reveals that the problems experienced in vehicle routing with time window can be solved by GA and retrieved for optimal solutions. After a thorough study on VRPTW, it is highly recommended that a company should implement the optimal routes derived from the study to increase the efficiency and accuracy of delivery with time insertion.

The Coherence Cube Computing Method with Self-adaptive Time Window Based on Wavelet Transform

The coherence cube technology has become an important technology for the seismic attribute interpretation, which extracts the discontinuities of the events through analyzing the similarities of adjacent seismic channels to identify the fault form. The coherence cube technology which uses constant time window lengths can not balance the shallow layers and the deep layers, because the frequency band of seismic data varies with time. When analyzing the shallow layers, the time window will crossover a lot of events, which will lead to weak focusing ability and failure to delineate the details. While the time window will not be long enough for analyzing deep layers, which will lead to low accuracy because the coherences near the zero points of the events are heavily influenced by noise. For solving the problem, we should make a research on the coherence cube technology with self-adaptive time window. This paper determines the sample points＆#39; time window lengths in real time by computing the instantaneous frequency bands with Wavelet Transformation, which gives a coherence computing method with the self-adaptive time window lengths. The result shows that the coherence cube technology with self-adaptive time window based on Wavelet Transformation improves the accuracy of fault identification, and supresses the noise effectively. The method combines the advantages of long time window method and short time window method.

A High Spectral Efficiency System Enabled by Free Window with Full Duplex

This paper studies the capacity issues of a wireless communication system that implements single channel full duplex(SCFD) communication at the base station(BS), thereby the mobile stations share the channel via time division duplex(TDD). The system makes use of the same setup as has been used in previous studies of SCFD, but unlike these previous systems, the new system uses water-filling to maximize the spectral efficiency of the uplink channel. The concept of a free window is introduced to the duplex model for measuring, intuitively, the effective bandwidth of the bi-directional communication. The capacity gain is calculated and numerical results show the advantage of the proposed system over that of conventional TDD.

A novel genetic algorithm for vehicle routing problem with time windows

A novel genetic algorithm with multiple species in dynamic region is proposed,each of which occupies a dynamic region determined by the weight vector of a fuzzy adaptive Hamming neural network. Through learning and classification of genetic individuals in the evolutionary procedure,the neural network distributes multiple species into different regions of the search space. Furthermore,the neural network dynamically expands each search region or establishes new region for good offspring individuals to continuously keep the diversification of the genetic population. As a result,the premature problem inherent in genetic algorithm is alleviated and better tradeoff between the ability of exploration and exploitation can be obtained. The experimental results on the vehicle routing problem with time windows also show the good performance of the proposed genetic algorithm.

The Dynamic Relationship of Brain Networks Across Time Windows During Product-Based Creative Thinking

Consensus of creativity research suggests that the measurement of both originality and valuableness is necessary when designing creativity tasks.However,few studies have emphasized valuableness when exploring underlying neural substrates of creative thinking.The present study employs product-based creativity tasks that measure both originality and valuableness in an exploration of the dynamic relationship between the default mode(DMN),executive control(ECN),and salience(SN)networks through time windows.This methodology highlights relevance,or valuableness,in creativity evaluation as opposed to divergent thinking tasks solely measuring originality.The researchers identified seven brain regions belonging to the ECN,DMN,and SN as regions of interest(ROIs),as well as four representative seeds to analyze functional connectivity in 25 college student participants.Results showed that all of the identified ROIs were involved during the creative task.The insula,precuneus,and ventrolateral prefrontal cortex(vlPFC)remained active across all stages of product-based creative thinking.Moreover,the connectivity analyses revealed varied interaction patterns of DMN,ECN,and SN at different thinking stages.The integrated findings of the whole brain,ROI,and connectivity analyses suggest a trend that the DMN and SN(which relate to bottom-up thinking)attenuate as time proceeds,whereas the vlPFC(which relates to top-down thinking)gets stronger at later stages;these findings reflect the nature of our creativity tasks and decision-making of valuableness in later stages.Based on brain region activation throughout execution of the task,we propose that product-based creative process may include three stages:exploration and association,incubation and insight,and finally,evaluation and decision making.This model provides a thinking frame for further research and classroom instruction.

MIP Formulations and Metaheuristics for Multi-Item Capacitated Lot-Sizing Problem with Non-Customer Specific Production Time Windows and Setup Times

Our research focuses on the development of two cooperative approaches for resolution of the multi-item capacitated lot-sizing problems with time windows and setup times (MICLSP-TW-ST). In this paper we combine variable neighborhood search and accurate mixed integer programming (VNS-MIP) to solve MICLSP-TW-ST. It concerns so a particularly important and difficult problem in production planning. This problem is NP-hard in the strong sense. Moreover, it is very difficult to solve with an exact method;it is for that reason we have made use of the approximate methods. We improved the variable neighborhood search (VNS) algorithm, which is efficient for solving hard combinatorial optimization problems. This problem can be viewed as an optimization problem with mixed variables (binary variables and real variables). The new VNS algorithm was tested against 540 benchmark problems. The performance of most of our approaches was satisfactory and performed better than the algorithms already proposed in the literature.

Susceptible time window and endurable duration of cotton fiber development to high temperature stress

The development of the cotton fiber is very sensitive to temperature variation, and high temperature stress often causes reduced fiber yield and fiber quality. Short-term high temperature stress often occurs during cotton production, but little is known about the specific timing and duration of stress that affects fiber development. To make this clear, pot experiments were carried in 2014 and 2015 in a climate chamber using cotton cultivars HY370WR（less sensitive variety） and Sumian 15（heat sensitive variety）, which present different temperature sensitivities. Changes of the most important fiber quality indices（i.e., fiber length, fiber strength and marcironaire） and three very important fiber development components（i.e., cellulose, sucrose and callose） were analyzed to define the time window and critical duration to the high temperature stress at 34°C（max38°C/min30°C）. When developing bolls were subjected to 5 days of high temperature stress at different days post-anthesis（DPA）, the changes（Δ%） of fiber length, strength and micronire, as a function of imposed time followed square polynomial eq. as y=a＋bx＋cx^2, and the time around 15 DPA was the most sensitive period for fiber quality development in response to heat stress. When 15 DPA bolls were heat-stressed for different durations（2, 3, 4, 5, 6, 7 days）, the changes（Δ%） of fiber length, strength and micronire, as a function of stress duration followed logistic equations y=A_1-A_2/1＋（x/x_0）~p＋A_2. Referred to that 5, 10 and 15% are usually used as criteria to decide whether techniques are effective or changes are significant in crop culture practice and reguard to the fiber quality indices change range, we suggested that 5% changes of the major fiber quality indices（fiber length, fiber strength and micronaire） and 10% changes of fiber development components（cellulose, sucrose and callose） could be taken as criteria to judge whether fiber development and fiber quality have been significantly affected by high temperature stress. The key time window for cotton fiber development in response to the high temperature stress was 13–19 DPA, and the critical duration was about 5 days.