In this paper results of acute toxicitv (oral and dermal), cumulative toxicitv, subchronic toxicitv. and conjunctiva irritation tests are reported. The mutagenic effects of fenthion. using SCE (in vivo) and UDS(in vit...In this paper results of acute toxicitv (oral and dermal), cumulative toxicitv, subchronic toxicitv. and conjunctiva irritation tests are reported. The mutagenic effects of fenthion. using SCE (in vivo) and UDS(in vitro) as indicators, were also tested. Histochemical changes in enzyme activities (including AChE. ATPase. and AK.P) in tissues were observed. The results showed that the acute toxicitv of fenthion belongs to highly toxic category. The highly cumulative effect of fenthion was also observed. The subchronic toxicitv test. however. did not reveal any abnormal effects except the inhibition of ChE activity in plasma. The dose and ChE activity relationship equation was V=0.82.x+4.71. The SCE and UDS tests revealed no mutagenic potential. In histochemical experiments we found that AChE activity in tissues was markediv inhibited. AKP and ATPase activities at the cortex rcnis were increased in the treated rats.(c) 1990 Academic Press. Inc.展开更多
文摘In this paper results of acute toxicitv (oral and dermal), cumulative toxicitv, subchronic toxicitv. and conjunctiva irritation tests are reported. The mutagenic effects of fenthion. using SCE (in vivo) and UDS(in vitro) as indicators, were also tested. Histochemical changes in enzyme activities (including AChE. ATPase. and AK.P) in tissues were observed. The results showed that the acute toxicitv of fenthion belongs to highly toxic category. The highly cumulative effect of fenthion was also observed. The subchronic toxicitv test. however. did not reveal any abnormal effects except the inhibition of ChE activity in plasma. The dose and ChE activity relationship equation was V=0.82.x+4.71. The SCE and UDS tests revealed no mutagenic potential. In histochemical experiments we found that AChE activity in tissues was markediv inhibited. AKP and ATPase activities at the cortex rcnis were increased in the treated rats.(c) 1990 Academic Press. Inc.
