Study on the Biological Basis of Qi, Blood, and Vessel in Immune Thrombocytopenia Patients With Syndrome of Qi Failing to Govern Blood Based on the Theory of Qi and Blood

Objective: To investigate the biological basis of qi, blood and vessel in immune thrombocytopenia(ITP) patients with syndrome of qi failing to govern blood(SQFGB) based on traditional Chinese medicine.Methods: A total of 52 ITP patients with SQFCB were enrolled and divided into bleeding group(38 cases) and non-bleeding group(14 cases).Bleeding group was further divided into mild qi deficiency group(25 cases) and moderate/severe qi deficiency group(13 cases) based on Chinese Medicine syndrome score.20 healthy volunteer were recruited as control group.The count of platelet(PLT) was taken as the blood related indicator.The expressions of cytokines including IL-1β, IL-17 A, TNF-α, CD40 L, and TGF-β, detected by Aim Plex Multiple Immunoassays for Flow, were taken as the qi related indicators.The expressions of VEGF-A, detected by Aim Plex Multiple Immunoassays for Flow and NO, NOS, and ET-1 detected by ELISA, were taken as the vessel related indicators.Results: As compared to the control group, the count of PLT, taken as the blood related indicator, was significantly lower in ITP group patients with SQFCB(P<0.05).The expression levels of IL-17 A and TNF-α, taken as the qi related indicators, were significantly higher, while those of CD40 L, IL-1β, and TGF-β, also taken as the qi related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The expression levels of NO and ET-1, taken as the vessel related indicators, were significantly higher, while the expression levels of NOS and VEGF-A also taken as the vessel related indicators, were significantly lower in ITP patients with SQFCB, respectively(P<0.05).The count of PLT, taken as the blood related indicator, was significantly lower in moderate/severe group than those in mild group(P<0.05).The expression levels of CD40 L and TGF-β, taken as the qi related indicators, were also significantly lower in moderate/severe group than those in mild group, respectively(P<0.05).Conclusion: The count of PLT might be the biological basis of blood.The expressions of NO, NOS, ET-1 and VEGF-A might be the biological basis of vessel.The expressions of IL-1β, IL-17 A, TNF-α, TGF-β, and CD40 L may be the biological basis of qi.The expressions of CD40 L and TGF-β could reflect the degree of qi deficiency in ITP patients based on the theory of qi and blood.

区块链技术赋能乡村治理数字化的机理与路径——基于TOED框架的理论分析

乡村治理数字化是创新乡村治理方式、提升乡村治理效能的重要举措,是实现乡村全面振兴的关键过程。近年来兴起的区块链技术由于具备去中心化、匿名性、公开透明等一系列特性,改变了传统乡村治理的场域情境,能够较好解决乡村治理过程中遇到的空间难题从而有效赋能乡村治理数字化。基于TOE理论框架,结合当前乡村数字治理的新情境,构建包含技术、组织、环境、数据四要素在内的TOED理论分析框架,着力探讨区块链技术驱动乡村治理数字化的内在机理,进而提出区块链技术赋能乡村治理数字化的优化路径。即:技术层面推动乡村治理协同效能最大化、组织层面助力乡村治理结构体系最优化、环境层面增进乡村治理共治情境最佳化、数据层面促使乡村治理数据流动最畅化。

档案工作数字化转型的驱动因素和推进路径探析——基于TOED理论框架

在国家数字化转型战略和现代化国家治理体系建设的背景下,档案工作数字化转型将是推进档案治理体系和治理能力现代化的必由之路。基于TOE理论框架构建包含技术、组织、环境、数据等四要素的TOED理论分析框架,深入探究各要素对档案工作数字化转型的驱动作用:技术是转型的推进动力、组织是转型的重要基础、社会和政策环境是转型的条件保障、数据是转型的支撑关键,进而提出档案工作数字化转型的推进路径:不断提高档案部门的技术应用能力、主体协同能力、统筹规划能力、开放共享能力,以促进档案事业高质量发展。