小信号增益及环时间非对称性对TOAD开关特性的影响

充分考虑了太赫兹光非对称解复用器 (TOAD)中半导体光放大器 (SOA)的增益饱和与恢复的影响 ,深入分析研究了小信号增益及环时间非对称性对TOAD开关特性的影响 .结果表明 :小信号增益对开关窗口的形状影响显著 ,但对宽度影响很小 ;在环中点附近的某一定范围内 ,TOAD解复用输出随环时间非对称性的变化而急剧变化 。

利用Toad解决Oralce数据库表空间错误问题

数据库是整个信息系统的核心,传统方式的数据库管理一般采用Sqlplus等命令行工具书写SQL命令。相比之下,使用数据库管理工具Toad连接数据库,通过图形化界面解决数据库问题,减少操作失误和繁琐程度,有效降低数据库管理成本。

TOAD中半导体光放大器的动态增益响应及光脉冲传输特性研究

讨论了太赫兹光非对称解复用器中半导体光放大器 (SOA)对具有不同能量和脉宽的控制脉冲的动态增益响应 ,研究了不同的逆时针信号脉冲和控制脉冲时延的情况下通过 SOA后的逆时针信号脉冲的功率和相位变化。

非线性元件的偏移量对TOAD开关窗口的影响

通过数值模拟研究了非线性元件的偏移量对ＴＨｚ光学非对称解复用器开关窗口的影响，结果表明，ＴＨｚ光学非对称解复用器的开关窗口宽度随其时间非对称量作周期性变化，周期为控制脉冲周期的一半。理论计算结果与实验结果完全吻合。

基于QDSOA-TOAD结构的NRZ-RZ格式转换器

针对光网络中非归零(NRZ)与归零(RZ)格式转换的问题,利用量子点半导体光放大器(QD-SOA)的快速非线性效应和全光非对称解复用器(TOAD)干涉结构,提出了一种基于QDSOA-TOAD结构的光数据格式转换器,可以实现高速格式转换,且在很大程度上减少了频率啁啾对转换信号的影响。通过系统建模,验证了160Gbit/s NRZ-RZ光信号格式转换的可行性和有效性;并给出了关键参数的选择范围。通过合理设置系统参数,可以获得较高的输出品质因子Q。

Anti-trypanosomal Activity of Bufonidae(Toad)Venom Crude Extract on Trypanosoma brucei brucei in Swiss Mice

Trypanosomiasis afflicts about 6~7 million people globally and to a large extent impedes livestock production in Africa.Naturally,trypanosomal parasites undergo genetic mutation and have developed resistance over a wide range of therapies.The utilization of animals and plants products has presented therapeutic potential for identifying novel anti-trypanosomal drugs.This study evaluated toad venom for anti-trypanosomal potency in-vivo in Swiss mice.Toads were collected from July to August 2019.The acute oral toxicity and biochemical characterization of the toad venom were determined.The experimental mice were administered various doses(130 mg/kg,173 mg/kg and 217 mg/kg)of the toad venom crude extract and 0.75 mg/mL of Diamizan Plus standard drug for the treatment of trypanosomiasis,once daily for 3 days.The in-vivo anti-trypanosomal activity was evaluated by a curative test,after infecting the mice with Trypanosoma brucei brucei.The pre-patent period was 72 hours before treatment commenced.The overall results showed that trypanosomal load was highest in the control group while the group treated with Diamizan drug had the least trypanosomal load.As such,the mean trypanosomal load in relation to treatments showed a very high significant difference(P<0.05).Also,the mean trypanosomal load in Swiss mice in relation to the highest dosage of toad venom versus Diamizan drug showed a very high significant difference(P<0.05).The mean change in relation to the haematological parameters across treatments groups varied significantly(P<0.05)with the exception of Hb which showed no significant difference(P>0.05)across treatment groups.The over 50%reduction in the trypanosomal load in the 130 mg/kg group in comparison with the control group brings to bare the anti-trypanosomal potency of the toad venom.The anti-trypanosomal activity demonstrated by the toad venom has provided basis for development of new therapeutic agents from different toad species.The study recommends further studies(both in-vivo and in-vitro)followed by the characterization of the active compounds present in the toad venom responsible for the anti-tyrpanosomal activity observed alongside the management and conservation of these species.

利用TOAD实现全光逻辑操作的实验研究

未来的全光分组交换网中,全光逻辑操作将起到至关重要的作用。在对太赫兹光非对称解复用器(TOAD)进行详尽理论分析的基础上,提出了基于TOAD实现的全光与门、全光或门方案,并对这些方案进行了20Gbit/s的实验验证,讨论了实验结果。

Microelectronic neural bridging of toad nerves to restore leg function

The present study used a microelectronic neural bridge comprised of electrode arrays for neural signal detection, functional electrical stimulation, and a microelectronic circuit including signal amplifying, processing, and functional electrical stimulation to bridge two separate nerves, and to restore the lost function of one nerve. The left leg of one spinal toad was subjected to external mechanical stimulation and functional electrical stimulation driving. The function of the left leg of one spinal toad was regenerated to the corresponding leg of another spinal toad using a microelectronic neural bridge. Oscilloscope tracings showed that the electromyographic signals from controlled spinal toads were generated by neural signals that controlled the spinal toad, and there was a delay between signals. This study demonstrates that microelectronic neural bridging can be used to restore neural function between different injured nerves.

单向和双向控制脉冲TOAD的开关窗口研究

详细研究了单控制脉冲TOAD(terahertz optical asymmetric demultiplexer)结构开关窗口的非对称缺陷及其产生机理。通过理论分析和optisystem仿真证实了双控制脉冲TOAD结构能够很好地解决单控制脉冲TOAD结构的开关窗口缺陷。仿真结果显示,双控制脉冲TOAD获得了波形对称、对比度更高的开关窗,详细解释了仿真中出现的双峰现象。

Genetic Variation among various populations of spadefoot toads (<i>Pelobates syriacus</i>, Boettger, 1869) at breeding sites in northern Israel

A genetic study was carried out on spadefoot toads (Pelobates syriacus) from habitats of various locations and altitudes in northern Israel. Cytochrome b and 12S were amplified by PCR for the analysis of genetic variation based on five DNA polymorphisms and for RAPD PCR. The nucleotide sequences of the mitochondrial DNA fragments were determined from a 460 bp clone of cytochrome b and a 380 bp clone of 12S (GenBank accession numbers, FJ595199-FJ59-5203). No genetic variation was found among the populations with regard to 12S. According to the analysis of five sequences using Arlequin software, there was a high gene identity among the populations (98.7%-99.6%). Both populations, Elrom Pond breeding site, at the highest altitude and Fara Pond, at the lowest, had the lowest identities as compared to other populations. The DNA variation among P. syri-acus populations from various breeding sites, according to band sharing (BS), when using the OP-4 primer, was 0.92-1.00. Similarity was low between the population of Elrom Pond and the populations of Kash Pond, Raihania Pond and Sasa Pond (0.92 BS), as well as between the population of Fara Pond at the lowest altitude, and the populations of Kash Pond, Raihania Pond and Sasa Pond (0.92 BS). Similar results were obtained when comparing the results obtained using primer OPA-3. The lowest similarity was found between populations of the highest altitude (Elrom Pond) and lowest altitude (Fara Pond), relative to the other ponds (Kash Pond, Raihania Pond and Sasa Pond) with a BS of 0.93.

Habitat Suitability and Distribution Pattern Response to Global Climate Change in a Widespread Species,the Asiatic Toad(Bufo gargarizans)

The distribution and diversity of the species are closely related to the global climate.As the most widely distributed species of Bufonidae in China,the study of the distribution pattern and habitat suitability of the Asiatic toad under climate change can help us understand the reply pattern of Bufonidae habitat to climate change.Here,combined with the Maxent model and GIS technology,the effects of climate change on the distribution pattern and habitat suitability of the Asiatic toad were comprehensively analyzed.The results show that the rainfall during the wettest season(Bio16)and the mean temperature of the driest season(Bio9)have a considerable impact on the distribution of the Asiatic toad.In the next 30 to 50 years,across the overall spacial scale of the Chinese mainland,the habitat of the Asiatic toad will be primarily in the eastern part of China and less in south part,while its distribution area will expand to the midwest and northwest parts of China.Overall,the area in which it can be distributed will be reduced and suitable habitat will shift to some regions of higher latitude and elevation.In a word,we systematically analyzed the changes of the distribution pattern and habitat suitability of the Asiatic toad with climate change,and we aim to provide data on how climatic variation may impact amphibians.

No Male Preference for Large Females in the Asian Common Toad(Duttaphrynus melanostictus):Effect of the Sex Ratio and Breeding System

Mating preferences are common in natural populations of animals.Numerous studies have shown that male mate choice can occur in a wide range of taxa.However,male mating preferences are still poorly understood in anurans.Sexual selection theory predicts that male mate choice is not expected to arise if 1) adult population exhibited a highly male-biased sex ratio which will diminish male mating success;2) males provide less parental care;3) mating success of males is associated with chorus tenure in which males would maximize their fitness by mating with multiple mates.We tested these predictions in the Asian common toad Duttaphrynus melanostictus from southeastern Tibet,China.Our field experimental results indicated that,the breeding population exhibited a highly male-biased sex ratio,called males did not defend sites which contain significant resources required by females and offspring,both sexes provided no parental care after egg-laying,and the toad species was characterized with prolonged breeding season chorus attendance.In male mate choice experiment,males did not show preferences for a larger gravid female over a smaller gravid female.We suggest that male mating success in the Asian common toad is likely determined by the number but not the quality of mates.Future research should focus on how sexual selection on male acoustic signaling and how female preference exert different types of selection pressure on male call traits in this Tibet toad.

SOA的增益响应特性及其对TOAD解复用器开关窗口的影响

通过数值求解半导体光放大器（SOA）的增益动力学方程，研究了SOA的增益响应特性及其对THz光学非对称解复用器（TOAD）开关窗口的影响。

Studies on the physiological function of spermine in the process of progesterone induced toad oocyte maturation

Spermidine or spermine but not putrescine inhibited progesterone induced Bufo bufo gargarizans oocyte maturation. The ID50 for spermine inhibition via intra - oocyte mi-croinjection on maturation induced by progesterone was 6. 8 mM(100 nl). Spermine could inhibit MPF induced toad oocyte maturation with a much higher ID50.A 55 kD protein was dephosphorylated during the process of progesterone induced oocyte maturation. Spermine selectively promoted the level of phosphorylation of ?this protein in both progesterone - stimulated and hormone - untreated oocytes. The extent of its dephosphorylation was fairly correlated with the percentage of GVBD in the hormone stimulated oocytes.The level of endogenous spermine was reduced by 28% between the period of 0. 40 GVBD50 and 0. 60 GVBD50, at which 55 kD protein was dephosphorylated.Spermine inhibited progesterone - stimulated protein synthesis in almost the same dose dependent manner as its inhibitory effect on the hormone - induced maturation. The endogenous spermine regulated 55 kD protein dephosphorylation which may trigger the increase of protein synthesis and in turn promote the activation of MPF. It is possible that 55 kD protein may be one of the components of messenger ribonucleoprotein (mRNP) particles.

Study of Blood Parasites in Mabuya sp Lizards and Buforegularis Toads in Jebel Awlia and Tuti Island of Khartoum, Sudan

Toads and lizards have been a part of our ecosystems for millions of years and they are good indicators of environmental health. Toads and lizards can be infected by different types of parasites; blood parasites are one of the most important parasites. The present study was conducted to survey and identify different blood parasites in Mabuya sp. lizard and Buforegularis toad in two locations in Khartoum state. Fifteen samples of Mabuya sp and fifteen samples of Buforegularis were collected. All Toads and lizards were dissected and tissue from spleen and liver were examined. The microscopic diagnosis detected Sauroleishmania and Haemogregarina spp parasites in both Mabuya and B. regularis while Microfilariae spp was detected in Mabuya sp. Trypanosoma spp was detected in only one specimen of B. regularis. The results also indicated Sauroleishmania parasites and Haemogregarina spp parasites in the sampled toads and lizards in the two locations. The study of blood parasites and their effects in diversity and health of toads and lizards is necessary to determine the impacts of infections in these animals and the use of the results as indicator of hemoparasites in the environmental as well as the food chain.

Experimental Investigation of All-Optical NRZ-DPSK to RZ-DPSK Format Conversion Based on TOAD

We propose and experimentally demonstrate a novel all-optical non-return-to-zero differential-phase-shift-keying （NRZ-DPSK） to return-to-zero differentiM-phase-shift-keying （RZ-DPSK） format conversion scheme. This scheme is based on the terahertz optical asymmetric demultiplexer （TOAD）. A 10 Gb/s converted RZ-DPSK signal is obtained with a wide duty cycle tuning range from 16% to 66%. For all converted RZ-DPSK signals, the receiver sensitivities at BER of 10-9 are 0.4 to 1.7dB higher compared with the original NRZ-DPSK signal. The clear and open eye diagrams are presented to demonstrate the high quality format conversion performance. Moreover, the optical spectra show that this conversion is in a wavelength-preserving operation.

一种基于TOAD的OTDM光网络自同步方案

自同步在OTDM(光时分复用)分组网络中占有十分重要的地位,为此提出了一种简单的基于太赫兹光学非对称解复用器(TOAD)的自同步方案,给出了理论模型并进行了数值仿真,最后分析了SOA(半导体光放大器)饱和能量对该方案性能的影响。

Guardians of the Corn: The Snake, The Bat and the Toad in Pre-Columbian Mayan Art of the Classic Period (ca. 250-900 CE)

The conflict and congruity of dualistic approaches to the world inundate the illustration of agricultural production in the Pre-Columbian Art of the Maya.Crop production is co-dependent on human factors,environmental factors and animal factors.The symbiosis of these elements generated success or failure in harmony with the natural world.This paper explores the relationship of three animals to successful crop production with particular attention placed on the cane toad,as this creature has often been confused with frogs or underplayed in earlier academic research.The cane toad is a powerful force in organic farming,functioning as a deterrent to destructive pests.In addition,the cane toad produces powerful hallucinogenic substances for humans,while at the same time,repelling predators with its bitter taste,acrid smell and poison.This bufo-toxin is a powerful substance that links the toad with the Underworld origins of the maize.

Sex Ratio and Sexual Size Dimorphism in a Toad-headed Lizard, Phrynocephalus guinanensis

Phrynocephalus guinanensis has sexual dimorphism in abdominal coloration, but its ontogenetic development of sexual size dimorphism （SSD） is unknown. Using mark-recapture data during four days each year from August from 2014 to 2016, we investigated the development of sex ratios, SSD, sex-specific survivorship and growth rates in a population of P guinanensis. Our results indicated that the sex ratio of males to females was 1：2.8. Males had a lower survival rate （6%） than females （14%） across the age range from hatchling to adult, which supported the discovered female-biased sex ratio potentially associated with the low survival rate of males between hatchlings and juveniles. Male-biased SSD in tail length and head width existed in adults rather than in hatchling or juvenile lizards. The growth rates in body dimensions were undistinguishable between the sexes during the age from hatchling to juvenile, but the growth rate in head length from juvenile to adult was significantly larger in males than females. Average growth rate of all morphological measurements from hatchling to juvenile were larger compared with corresponding measurements from juvenile to adult, but only being significant in tail length, head width, abdomen length in females and snout-vent length in males. We provided a case study to strengthen our understanding of the important life history traits on how a viviparous lizard population can survive and develop their morphology in cold climates.

Determination of the Content of Five Active Components in Toad Skin

[Objectives] To establish a method for the determination of active components in toad skin. [Methods] HPLC method was used to determine the content of five active components (bufotalin, cinobufotalin, bufalin, cinobufagin and resibufogenin) in toad skin. [Results] Chromatographic conditions are as follows: Agilent ZORBAX SB-C 18 chromatographic column was used;acetonitrile (A)-0.3% glacial acetic acid (B) gradient elution (0-15 min, 28%A-54%A;15-35 min, 54%A-54%A) was conducted;the flow rate was 0.6 mL/min;the detection wavelength was 296 nm;the column temperature was 30 ℃;the sample size was 10 μL. Under the above conditions, the determination method of the five components can be established at one time. [Conclusions] The method was stable and reliable, and can provide experimental basis for the development and utilization of active ingredients in toad skin.