OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomize...OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomized, single-blind, placebo controlled trial was conducted. Children with intermittent asthma were enrolled and their baseline conditions were measured using a questionnaire. A total of 60 participants, aged 2 to 5, were randomized into either the treatment group(n = 40) or the placebo group(n = 20). The treatment group was treated with granules of TCM herbs for tonifying Qi and kidney, and replenishing spleen, and the placebo group was given placebo granules for 3 months.The number of asthma attacks was counted and TCM syndrome scores were measured at 1, 2, 3, 6, 9,and 12 months. The airway resistance and levels of eosinophil cationic protein for the two groups were observed before and after 3 months. The results were statistically analyzed.RESULTS: Compared with the placebo group, the number of asthma attacks significantly decreased in the treatment group(P < 0.05). For the treatment group, the TCM syndrome scores decreased after 1 and 2 months; there was also a significant difference in scores between the two groups(P < 0.05).The difference remained after the medicine was stopped for 9 months(P < 0.05). After the 3-month treatment, compared with the placebo group, the airway resistance decreased in the treatment group(P < 0.05). No adverse events were reported in the treatment group.CONCLUSION: The TCM herbs for tonifying Qi and kidney, and replenishing spleen reduced the number of intermittent asthma attacks, decreased the TCM syndrome scores, and reduced the airway resistance in the children aged 2 to 5.展开更多
目的:分析脾气虚与现代慢性疾病的相关性,并对常用补气健脾的中药材、食材、药对及经典药膳方进行综述,以期为相关功能性产品开发提供科学依据。方法:以脾气虚、补气健脾、代谢障碍、药膳等为检索词在古籍以及中国知网、万方数据库、维...目的:分析脾气虚与现代慢性疾病的相关性,并对常用补气健脾的中药材、食材、药对及经典药膳方进行综述,以期为相关功能性产品开发提供科学依据。方法:以脾气虚、补气健脾、代谢障碍、药膳等为检索词在古籍以及中国知网、万方数据库、维普数据库、PubMed和Web of Science等数据库查找相关文献进行归纳整理。结果:脾胃气虚证的药理作用研究逐渐深入,补气健脾药物成分研究也达到一定程度,但是对于药食同源食物类的研究较少。结论:应加大对药食同源补气健脾产品的研究。展开更多
目的探究功能性消化不良的中医辨证分型及用药规律,为该病的中医治疗提供参考。方法检索中国知网(CNKI)、万方数据库(Wangfang)、维普数据库(VIP)、PubMed、Web of Science数据库中有关中医药治疗功能性消化不良的临床研究文献,收集中...目的探究功能性消化不良的中医辨证分型及用药规律,为该病的中医治疗提供参考。方法检索中国知网(CNKI)、万方数据库(Wangfang)、维普数据库(VIP)、PubMed、Web of Science数据库中有关中医药治疗功能性消化不良的临床研究文献,收集中药复方,建立数据库,使用Excel 2019、Clementine 12.0和SPSS 21.0对功能性消化不良的中医证型、中药使用频次、功效分类、性味归经进行频次统计,并对高频药物进行关联规则分析、因子分析和聚类分析。结果共纳入文献428篇,提取处方442首,涉及中药225味,高频药物24味,其中党参、茯苓、陈皮、柴胡的使用频次最多,功效分类以补虚药、理气药最为常见,药性以温为主,药味以苦、辛、甘为主,多归脾、肺、胃经;关联规则分析得到20种药物组合,因子分析提取了9个公因子,聚类分析可将药物分为4类。功能性消化不良肝胃不和证最多,对其进行关联规则分析得到12种药物组合,因子分析提取了3个公因子,聚类分析可将药物分为2类。结论中医临床治疗功能性消化不良以益气健脾、疏肝行气药为主,甘温补虚、辛开苦降,辨证配伍化湿、解表、清热等药物。展开更多
目的:探讨补气健脾化痰法对2型糖尿病患者中医证候积分与血管内皮功能的影响。方法:将2019年9月-2021年9月北京中医药大学房山医院月华分院收治的148例2型糖尿病患者随机分成对照组和观察组,对照组74例给予二甲双胍+格列美脲治疗,观察...目的:探讨补气健脾化痰法对2型糖尿病患者中医证候积分与血管内皮功能的影响。方法:将2019年9月-2021年9月北京中医药大学房山医院月华分院收治的148例2型糖尿病患者随机分成对照组和观察组,对照组74例给予二甲双胍+格列美脲治疗,观察组74例给予二甲双胍+格列美脲+补气健脾化痰法治疗,两组均治疗3个月。观察两组的中医证候积分、血糖水平[空腹血糖(Glucose,GLU)、餐后2 h血糖(2 h Postprandial Blood Glucose,2 h PBG)、糖化血红蛋白(Glycosylated Hemoglobin,HbA1c)]、血管内皮功能指标[内皮素-1(Endothelin-1,ET-1)、一氧化氮(Nitric Oxide,NO)、血管性假血友病因子(von Willebrand Factor,vWF)、血栓调节蛋白(Thrombomodulin,TM)]、临床疗效以及不良反应(恶心、呕吐、头晕、嗜睡)。结果:两组治疗后的口渴喜饮、气短寡言、少食易饥、疲乏无力的评分均降低(P<0.05),且观察组治疗后口渴喜饮、气短寡言、少食易饥、疲乏无力的评分低于对照组(P<0.05);两组治疗后的GLU、2 h PBG、HbA1c均降低(P<0.05),且观察组治疗后的GLU、2 h PBG、HbA1c低于对照组(P<0.05);两组治疗后的ET-1、vWF、TM均降低(P<0.05),NO均升高(P<0.05),且观察组治疗后的ET-1、vWF、TM低于对照组(P<0.05),NO高于对照组(P<0.05);观察组总有效率为95.95%(71/74),高于对照组的81.08%(60/74)(P<0.05);观察组不良反应发生率为9.46%(7/74),与对照组的10.81%(8/74)相近(P>0.05)。结论:补气健脾化痰法对2型糖尿病患者的治疗效果较好,可降低中医证候积分,减轻患者症状,且能改善血糖水平与血管内皮功能指标,总有效率高,不良反应少,有效性与安全性兼备,可推广。展开更多
目的探究补气健脾疏肝法联合生物反馈治疗出口梗阻型便秘的临床疗效。方法选择河北省石家庄市中医院肛肠科气虚秘型出口梗阻型便秘患者80例作为研究对象,根据随机数字法分为试验组与对照组,两组各40例。对照组予以生物反馈治疗,30 min/...目的探究补气健脾疏肝法联合生物反馈治疗出口梗阻型便秘的临床疗效。方法选择河北省石家庄市中医院肛肠科气虚秘型出口梗阻型便秘患者80例作为研究对象,根据随机数字法分为试验组与对照组,两组各40例。对照组予以生物反馈治疗,30 min/次,每周3次;试验组在对照组基础上予补气健脾疏肝法治疗,每日1剂,水煎取汁400 mL,分早晚两次温服。两组均连续治疗4周。观察两组治疗前后的中医临床疗效、证候评分、肛门疼痛情况、生活质量及安全性。结果治疗后,试验组的临床总有效率(97.5%)优于对照组(72.5%)(P<0.05)。治疗后,与治疗前比较,两组排便频率、排便困难、粪便性状、排便时间、肛门堵塞感、排便不尽感的中医证候评分、疼痛数字评定量表(numerical rating scale,NRS)、便秘患者生活质量自评量表(patient assessment of constipation quality of life questionnaire,PAC-QOL)评分均下降(P<0.05);与对照组比较,试验组各项证候评分、NRS评分、PAC-QOL评分较低(P<0.05)。与对照组相比,试验组不良反应较低(P<0.05)。结论生物反馈联合补气健脾疏肝法治疗出口梗阻型便秘疗效确切,可有效缓解患者的临床症状,减轻患者的肛门疼痛,并提高患者的生活质量。展开更多
基金Supported by the Research Fund of Capital Medical Development(Traditional Chinese Medicine):Function Evaluation on Influence of TCM Herbs for Tonifying Qi and Kidney,and Replenishing Spleen To Children with Intermittent Asthma(No.SF-2007-Ⅲ-16)
文摘OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomized, single-blind, placebo controlled trial was conducted. Children with intermittent asthma were enrolled and their baseline conditions were measured using a questionnaire. A total of 60 participants, aged 2 to 5, were randomized into either the treatment group(n = 40) or the placebo group(n = 20). The treatment group was treated with granules of TCM herbs for tonifying Qi and kidney, and replenishing spleen, and the placebo group was given placebo granules for 3 months.The number of asthma attacks was counted and TCM syndrome scores were measured at 1, 2, 3, 6, 9,and 12 months. The airway resistance and levels of eosinophil cationic protein for the two groups were observed before and after 3 months. The results were statistically analyzed.RESULTS: Compared with the placebo group, the number of asthma attacks significantly decreased in the treatment group(P < 0.05). For the treatment group, the TCM syndrome scores decreased after 1 and 2 months; there was also a significant difference in scores between the two groups(P < 0.05).The difference remained after the medicine was stopped for 9 months(P < 0.05). After the 3-month treatment, compared with the placebo group, the airway resistance decreased in the treatment group(P < 0.05). No adverse events were reported in the treatment group.CONCLUSION: The TCM herbs for tonifying Qi and kidney, and replenishing spleen reduced the number of intermittent asthma attacks, decreased the TCM syndrome scores, and reduced the airway resistance in the children aged 2 to 5.
文摘目的:分析脾气虚与现代慢性疾病的相关性,并对常用补气健脾的中药材、食材、药对及经典药膳方进行综述,以期为相关功能性产品开发提供科学依据。方法:以脾气虚、补气健脾、代谢障碍、药膳等为检索词在古籍以及中国知网、万方数据库、维普数据库、PubMed和Web of Science等数据库查找相关文献进行归纳整理。结果:脾胃气虚证的药理作用研究逐渐深入,补气健脾药物成分研究也达到一定程度,但是对于药食同源食物类的研究较少。结论:应加大对药食同源补气健脾产品的研究。
文摘目的:探讨补气健脾化痰法对2型糖尿病患者中医证候积分与血管内皮功能的影响。方法:将2019年9月-2021年9月北京中医药大学房山医院月华分院收治的148例2型糖尿病患者随机分成对照组和观察组,对照组74例给予二甲双胍+格列美脲治疗,观察组74例给予二甲双胍+格列美脲+补气健脾化痰法治疗,两组均治疗3个月。观察两组的中医证候积分、血糖水平[空腹血糖(Glucose,GLU)、餐后2 h血糖(2 h Postprandial Blood Glucose,2 h PBG)、糖化血红蛋白(Glycosylated Hemoglobin,HbA1c)]、血管内皮功能指标[内皮素-1(Endothelin-1,ET-1)、一氧化氮(Nitric Oxide,NO)、血管性假血友病因子(von Willebrand Factor,vWF)、血栓调节蛋白(Thrombomodulin,TM)]、临床疗效以及不良反应(恶心、呕吐、头晕、嗜睡)。结果:两组治疗后的口渴喜饮、气短寡言、少食易饥、疲乏无力的评分均降低(P<0.05),且观察组治疗后口渴喜饮、气短寡言、少食易饥、疲乏无力的评分低于对照组(P<0.05);两组治疗后的GLU、2 h PBG、HbA1c均降低(P<0.05),且观察组治疗后的GLU、2 h PBG、HbA1c低于对照组(P<0.05);两组治疗后的ET-1、vWF、TM均降低(P<0.05),NO均升高(P<0.05),且观察组治疗后的ET-1、vWF、TM低于对照组(P<0.05),NO高于对照组(P<0.05);观察组总有效率为95.95%(71/74),高于对照组的81.08%(60/74)(P<0.05);观察组不良反应发生率为9.46%(7/74),与对照组的10.81%(8/74)相近(P>0.05)。结论:补气健脾化痰法对2型糖尿病患者的治疗效果较好,可降低中医证候积分,减轻患者症状,且能改善血糖水平与血管内皮功能指标,总有效率高,不良反应少,有效性与安全性兼备,可推广。
文摘目的探究补气健脾疏肝法联合生物反馈治疗出口梗阻型便秘的临床疗效。方法选择河北省石家庄市中医院肛肠科气虚秘型出口梗阻型便秘患者80例作为研究对象,根据随机数字法分为试验组与对照组,两组各40例。对照组予以生物反馈治疗,30 min/次,每周3次;试验组在对照组基础上予补气健脾疏肝法治疗,每日1剂,水煎取汁400 mL,分早晚两次温服。两组均连续治疗4周。观察两组治疗前后的中医临床疗效、证候评分、肛门疼痛情况、生活质量及安全性。结果治疗后,试验组的临床总有效率(97.5%)优于对照组(72.5%)(P<0.05)。治疗后,与治疗前比较,两组排便频率、排便困难、粪便性状、排便时间、肛门堵塞感、排便不尽感的中医证候评分、疼痛数字评定量表(numerical rating scale,NRS)、便秘患者生活质量自评量表(patient assessment of constipation quality of life questionnaire,PAC-QOL)评分均下降(P<0.05);与对照组比较,试验组各项证候评分、NRS评分、PAC-QOL评分较低(P<0.05)。与对照组相比,试验组不良反应较低(P<0.05)。结论生物反馈联合补气健脾疏肝法治疗出口梗阻型便秘疗效确切,可有效缓解患者的临床症状,减轻患者的肛门疼痛,并提高患者的生活质量。
