OBJECTIVE:To study the development mechanism of kidney-Yang deficiency through the establishment of support vector machine models of relevant hormones of the pituitary-target gland axes in rats with kidney-Yang defici...OBJECTIVE:To study the development mechanism of kidney-Yang deficiency through the establishment of support vector machine models of relevant hormones of the pituitary-target gland axes in rats with kidney-Yang deficiency syndrome.METHODS:The kidney-Yang deficiency rat model was created by intramuscular injection of hydrocortisone,and contents of the hormones of the pituita- ry-thyroid axis:thyroid stimulating hormone(TSH),3,3',5-triiodothyronine(T_3) and thyroxine(T_4);hormones of the pituitary-adrenal gland axis:adrenocorticotropic hormone(ACTH) and Cortisol(CORT);and hormones of the pituitary-gonadal axis:luteinizing hormone(LH),follicle-stimulating hormone(FSH),and testosterone(T),were determined in the early,middle,and advanced stages.Ten support vector regression(SVR) models of the hormones were established to analyze the mutual relationships among the hormones of the three axes.RESULTS:The feedback control action of the pituitary-adrenal axis began to lose efficacy from the middle stage of kidney-Kong deficiency.The contents all hormones of the three pituitary-target gland axes decreased in the advanced stage.Relative errors of the jackknife test of the SVR models all were less than 10%.CONCLUSION:Imbalances in mutual regulation among the hormones of the pituitary-target gland axes,especially loss of effectiveness of the pituitary-adrenal axis,is one pathogenesis of kidney-Yang deficiency.The SVR model can accurately reflect the complicated non-linear relationships among pituitary-target gland axes in rats with of kidney-Yang deficiency.展开更多
目的探究心痛宁口服液对冠状动脉介入手术患者再狭窄和心血管事件的影响。方法 118例接受过冠状动脉介入治疗患者作为研究对象。对照组:给予肠溶阿司匹林、硝酸异山梨酯片、美托洛尔片、辛伐他汀片、氯比格雷片;治疗组:给予肠溶阿司匹...目的探究心痛宁口服液对冠状动脉介入手术患者再狭窄和心血管事件的影响。方法 118例接受过冠状动脉介入治疗患者作为研究对象。对照组:给予肠溶阿司匹林、硝酸异山梨酯片、美托洛尔片、辛伐他汀片、氯比格雷片;治疗组:给予肠溶阿司匹林、硝酸异山梨酯片、美托洛尔片、辛伐他汀片、氯比格雷片,同时服用心痛宁口服液,10 m L/次,3次/d,连续服用6个月。比较2组患者接受治疗前和治疗4、12周后血脂水平、hs-CRP和血红细胞压积水平,比较2组患者术后第6个月的再狭窄和心血管事件的发生率。结果对照组和治疗组治疗4周、12周后的TC水平比治疗前降低,治疗12周后的TG水平比治疗前降低;治疗组治疗12周后的LDLC、hs-CRP和红细胞压积水平与组内治疗前和对照组比较,水平降低(P<0.05);2组患者术后冠状动脉造影支架直径、残余狭窄、扩张后最大(小)内径以及即刻内径获得比较均无统计学意义(P>0.05);术后第6个月随访,治疗组冠状动脉造影结果中,管腔内径净获得和管腔面积净获得均比对照组大(P<0.05),2组患者最小内径、晚期内径丢失和再狭窄率比较无统计学意义(P>0.05);治疗组术后第6个月心血管事件的合计发病率(12.5%)低于对照组(25%)(P<0.05),2组患者心源性死亡、复发心绞痛、严重心衰和再介入治疗发病率比较无统计学意义(P>0.05)。结论心痛宁口服液能够降低冠状动脉介入手术患者术后再狭窄和心血管事件的发生率。展开更多
基金Supported by National Natural Science Foundation for Young Scholars of China(Study on the Mechanism of Kidney-Yang Deficiency Regulation with Yougui Pill Base on Support Vector Regression Machine,No.81403153)National Natural Science Foundation of China(General Program,Study on the Mechanisms of the Premature Ovarian Failure Regulation by Herbs Couples of Cuscuta Chinessis-Radix Bupleuri in Dingjing Decoction based on RBF Artificial Neural Networks,No.81073073) and National Natural Science Foundation of China(General Program,Study on the law of compatibility of Categorized Formula for Tonifying Kidney Yang based on Rough Set,No.30973977)
文摘OBJECTIVE:To study the development mechanism of kidney-Yang deficiency through the establishment of support vector machine models of relevant hormones of the pituitary-target gland axes in rats with kidney-Yang deficiency syndrome.METHODS:The kidney-Yang deficiency rat model was created by intramuscular injection of hydrocortisone,and contents of the hormones of the pituita- ry-thyroid axis:thyroid stimulating hormone(TSH),3,3',5-triiodothyronine(T_3) and thyroxine(T_4);hormones of the pituitary-adrenal gland axis:adrenocorticotropic hormone(ACTH) and Cortisol(CORT);and hormones of the pituitary-gonadal axis:luteinizing hormone(LH),follicle-stimulating hormone(FSH),and testosterone(T),were determined in the early,middle,and advanced stages.Ten support vector regression(SVR) models of the hormones were established to analyze the mutual relationships among the hormones of the three axes.RESULTS:The feedback control action of the pituitary-adrenal axis began to lose efficacy from the middle stage of kidney-Kong deficiency.The contents all hormones of the three pituitary-target gland axes decreased in the advanced stage.Relative errors of the jackknife test of the SVR models all were less than 10%.CONCLUSION:Imbalances in mutual regulation among the hormones of the pituitary-target gland axes,especially loss of effectiveness of the pituitary-adrenal axis,is one pathogenesis of kidney-Yang deficiency.The SVR model can accurately reflect the complicated non-linear relationships among pituitary-target gland axes in rats with of kidney-Yang deficiency.
文摘目的探究心痛宁口服液对冠状动脉介入手术患者再狭窄和心血管事件的影响。方法 118例接受过冠状动脉介入治疗患者作为研究对象。对照组:给予肠溶阿司匹林、硝酸异山梨酯片、美托洛尔片、辛伐他汀片、氯比格雷片;治疗组:给予肠溶阿司匹林、硝酸异山梨酯片、美托洛尔片、辛伐他汀片、氯比格雷片,同时服用心痛宁口服液,10 m L/次,3次/d,连续服用6个月。比较2组患者接受治疗前和治疗4、12周后血脂水平、hs-CRP和血红细胞压积水平,比较2组患者术后第6个月的再狭窄和心血管事件的发生率。结果对照组和治疗组治疗4周、12周后的TC水平比治疗前降低,治疗12周后的TG水平比治疗前降低;治疗组治疗12周后的LDLC、hs-CRP和红细胞压积水平与组内治疗前和对照组比较,水平降低(P<0.05);2组患者术后冠状动脉造影支架直径、残余狭窄、扩张后最大(小)内径以及即刻内径获得比较均无统计学意义(P>0.05);术后第6个月随访,治疗组冠状动脉造影结果中,管腔内径净获得和管腔面积净获得均比对照组大(P<0.05),2组患者最小内径、晚期内径丢失和再狭窄率比较无统计学意义(P>0.05);治疗组术后第6个月心血管事件的合计发病率(12.5%)低于对照组(25%)(P<0.05),2组患者心源性死亡、复发心绞痛、严重心衰和再介入治疗发病率比较无统计学意义(P>0.05)。结论心痛宁口服液能够降低冠状动脉介入手术患者术后再狭窄和心血管事件的发生率。
