The Ability of Baseline Triglycerides and Total Cholesterol Concentrations to Predict Incidence of Type 2 Diabetes Mellitus in Chinese Men and Women:A Longitudinal Study in Qingdao, China

Objectives The purpose of this study was to assess the association between triglycerides(TG),total cholesterol(TC)at baseline,and type 2 diabetes mellitus(T2DM)incidence in a general Chinese population.Further,it aimed to evaluate the ability of TG and TC to predict T2DM incidence.Methods Qingdao Diabetes Prevention Program participants recruited between 2006 and 2009 were followed up in 2012–2015.TG,TC,and T2DM status were measured.Cox proportional hazards models were used to estimate the association between TG,TC,and T2DM incidence.The receiver operating characteristic(ROC)curve was used to evaluate the ability of TG and TC to identify T2DM participants.Results The incidence of T2DM significantly increased with TG in women and TC in both men and women(Ptrend<0.05).Univariate Cox regression indicated that higher TG{borderline high TG[hazards ratio(HR):2.05;95%confidence interval(CI):1.40,3.00]and hypertriglyceridemia[HR:2.64;95%CI:1.68,4.15]}and TC[hypercholesterolemia(HR:2.05;95%CI:1.43,2.95)]were significantly associated with increased risk of T2DM incidence in women but not in men.Multivariate Cox regression showed that hypertriglyceridemia in women(HR:1.78,95%CI:1.07,2.97),borderline high TC in men(HR:1.61,95%CI:1.04,2.48),and hypercholesterolemia in women(HR:1.68,95%CI:1.81,2.61)had a higher significant risk of T2DM incidence.The optimal cutoff values of TG were>1.15 and>1.23 mmol/L in men and women,respectively.For TC,they were>5.17 and>5.77 mmol/L in men and women,respectively.The area under the ROCs of TG and TC were 0.54(0.51–0.57)and 0.55(0.52–0.58),respectively,in men,and 0.60(0.58–0.62)and 0.59(0.56–0.61),respectively,in women.Conclusion Elevated TG and TC were risk factors for T2DM incidence.However,no predictive capacity was found for both factors to identify T2DM incidence in Chinese men and women.Hence,TG and TC levels in both Chinese men and women might be used for decreasing the incidence of T2DM but no clinical predictive capacity for T2DM.

Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography

Background The correlation among the ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol(LDL-C/HDL-C), total cholesterol/high-density lipoprotein cholesterol(TC/HDL-C) and thin-cap fibroatheroma has not yet been established. Methods It was a single center, retrospective observational study. In total, we recruited 421 patients(82.4% men;mean age 65.73 ± 10.44 years) with one culprit vessel which determined by intravascular optical coherence tomography(OCT). The thinnest-capped fibroatheroma(TCFA) group was defined as lipid contents in > 2 quadrants, with the thinnest fibrous cap measuring less than 65 μm. Univariate and multivariate logistic regression were carried out to explore the relationship between lipoprotein ratios, TCFA and other characteristics of plaque. To compare different ratios, the area under curve(AUC) of receiver-operating characteristic(ROC) curve was assessed. Results OCT was performed in 421 patients(TCFA group(n = 109), non-TCFA group(n = 312)). LDL-C/HDL-C in the TCFA group was significantly higher than in the non-TCFA group(2.95 ± 1.20 vs. 2.43 ± 0.92, P < 0.05), as was TC/LDL in TCFA and non-TCFA group(4.57 ± 1.58 vs. 4.04 ± 1.13, P < 0.05). Both LDL-C/HDL-C(OR: 1.002(1.002-1.003), P < 0.05) and TC/HDL-C(OR: 1.001(1.001-1.004), P < 0.05) were considered independent factors for the prediction of TCFA according to the logistic regression. Based on the AUC comparison, LDL-C/HDL-C and TC/HDL-C had no significant difference statistically(LDL-C/HDL-C AUC: 0.63;TC/HDL-C AUC: 0.61;P = 0.10) for the prediction of TCFA. Conclusions LDL-C/HDL-C and TC/HDL-C could be the independent factors for predicting the presence of TCFA, indicating coronary plaque vulnerability in CAD patients. Moreover, TC/HDL-C also showed a comparative performance for the prediction of TCFA as LDL-C/HDL-C.

Association between apolipoprotein E promoter-219G/T polymorphism and total cholesterol level in patients with Alzheimer disease

BACKGROUND: Many researches have suggested that apolipoprotein E (APOE) and total cholesterol metabolism are closely related with dementia. In the supposed theory, 219 site of APOE promoter region is near gene coding region, so its polymorphism may result in the abnormality of APOE gene and protein expression, and finally lead to dementia. OBJECTIVE: To observe the association between APOE promoter-219G/T polymorphisms with serum total cholesterol in patients with Alzheimer disease, and compare it with non-dementia people. DESIGN: Case-control, comparative observation. SETTING: Department of Neurology, Fengtian Hospital of Shenyang Medical College. PARTICIPANTS: Fifty-five dementia patients including 27 males and 28 females aged (66±3) years and treated in the Department of Neurology, Fengtian Hospital were selected from January 2002 to December 2005 as the Alzheimer disease group. They all diagnosed according to the DSM-Ⅳdiagnostic criteria of Alzheimer disease instituted by American Psychiatry Association in 1994. Meanwhile, 44 none-dementia patients including 21 males and 23 females aged (66±3) years were selected from other clinical departments of Fengtian Hospital as control group. All the participants were informed the detection and agreed. METHODS: Genomic DNA was extracted from the peripheral blood of all subjects, then 'NEST'PCR, DNA sequence and enzyme digestion were adopted to detect the expression of APOE promoter-219 polymorphism, following by biomedical statistics analysis based on the clinical total cholesterol level. MAIN OUTCOME MEASURES: Polymorphism of APOE promoter-219 G/T and total cholesterol level. RESULTS: All 55 dementia patients and 44 non-dementia ones were involved in the result analysis. ①Allele and genotype frequency: The T allele frequency of the Alzheimer disease group was significantly higher than that in the control group [88.2% (97/110), 54.5% (48/88)], while G allele frequency was remarkably lower than that in the control group [11.8%(13/110), 45.5%(40/88), χ2=8.2, P < 0.01]. The TT allele frequency of the Alzheimer disease group was significantly higher than that in the control group [76% (42/55), 48% (21/44)], while GT+GG allele frequency was remarkably lower than that in the control group [24%(13/55), 52%(23/44), χ2=8.7, P < 0.01]. ②Total cholesterol level: The level of the TT genotype patients in the Alzheimer group was obviously higher than that in GT+GG genotype patients (t =2.46, P < 0.05); the cholesterol level in the two genotypes of the control group was similar (P > 0.05). CONCLUSION: TT genotype and allele T in the APOE promoter-219 polymorphisms are the sensitive gene, and genotype TT has a relationship with the increase of total cholesterol level.

Disposable Electrochemical Biosensor for Amperometric Measurement of β-hydroxybutyrate and Total Cholesterol

A new type of disposable thin-film amperometric biosensor has been developed for measurement ofβ-hydroxybutyrate and total cholesterol in serum.The biosensor consists of two plain gold electrodes mounted on a Polyethylene terephthalate (PET) substrate.The reagent solution contains bienzymes (cholesterol oxidase and cholesterol esterase for total cholesterol,β-hydroxybutyrate dehydrogenase and diaphorase forβ-hydroxybutyrate respectively) with mediator (ferricyanide) were absorption at the surface of electrodes coated by electrodepositing platinum black.The presence of the mediator lowers the applied potential and eliminates the interference from other oxidizable species enhancing the sensitivity and selectivity of the biosensor without modifying the dynamic parameters of the response.The enzymes stably retains in the matrices of platinum black film improving the performance of the mediated sensor.The linearity is observed in the concentration range from 1.0×10^(-4) to 1.0×10^(-2) mM and 1.0×10^(-4) mM to 4.99×10^(-3) mM with sensitivity of 1.958μA/mM and 2.447μA/mM respectively.The optimized biosensor exhibits excellent reproducibility and stability retaining more than 90% of its original activity over a period of one month.The simple operation of the biosensor mass-produced at low cost is expected to find clinical application and homecare.

Relationship between apolipoprotein E gene polymorphism and total cholesterol level in patients with kidney diseases

AIM: To evaluate the association between apolipoprotein E(apoE) gene polymorphism and total cholesterol(TC) level in patients with kidney diseases. METHODS: A predefined literature search was performed to collect data from the electronic databases of PubM ed, Embase and the Cochrane Library and eligible relevant studies reporting the association of apoE gene polymorphism with TC level in patients with kidney diseases were recruited for meta-analysis.RESULTS: Twenty-one studies were identified for the analysis of association between apo E gene polymorphism and TC level in patients with kidney disease. Subjects with E3E4 had a higher TC than those with E3E3 [weighted mean differences(WMD) = 2.14, P = 0.01] and subjects with E2E3 had a lower TC than those with E3E3(WMD =-1.93, P = 0.01). Subjects with ε2 had a lower TC than those with ε3(ε2 vs ε3: WMD =-1.23, P = 0.002; ε2 vs ε4: WMD =-2.77, P ﹤0.0001) and subjects with 3 had a lower TC than those with 4(WMD =-0.79, P = 0.03). CONCLUSION: Subjects with apo E E3E4 and ε4 had a higher TC level and subjects with apoE E2E3 and ε2 had a higher TC level in patients with kidney disease. However, more well-designed studies should be performed in the future to confirm these findings.

Pollution Tolerance of Smoke in the Distribution of Neurotransmitter Enzyme (Acetylcholine Esterase) and Total Cholesterol in Tissues of Wistar Rats

This study was designed to assess total animal exposure to non-occupational but environmentally induced smoke through short-term landfill burning toxicity tests at the biochemical levels. Exposure to municipal land-fill burning using rat model focused primarily on inhalation exposure. The environmental monitoring consisted of 60 days exposure to refuse burning by evaluating the level of protein concentrations, neurotransmitter enzyme acetylcholine esterase (AcHE), and total cholesterol in different tissues of Wistar rats. Protein concentrations tended to decrease in the brain, liver and kidney and slightly increased in the plasma while acetylcholine esterase decreased in brain and liver and increased in the kidney. The non-depletion in total cholesterol levels in the tissues tended to be due to active mobilization towards tissue metabolism. The data were sufficient to support risk assessment for human.

A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients

Background: Diabetes mellitus is a common disease and it is a major cause of morbidity;several studies indicate that diabetes is a likely under reported cause of death. Chromium’s is important trace element to control diabetes mellitus and metabolism of carbohydrate, lipid and protein. Objective: The purpose of this study was to understand the relationship between serum chromium, with HbA1c, Total cholesterol and Triglycerides among type 2 diabetes patients among diabetic patients. Methodology: This is cross-sectional study done in Jabber Abu Ezz Centre for treatment and care of diabetics in Khartoum—Sudan. Four hundred subjects were enrolled in this study;one hundred subjects were normal healthy as control group, and three hundred subjects diabetic patient type 2 as test group;demographic and biochemical data were collected;serum chromium, Glycosylated Haemoglobin (HbA1c), Total cholesterol Triglycerides, were determined by using NYCOCARD READER II, spectrophotometer (Biosystem 310) and spectrophotometer 210-VGP. Result: In this study there is significant parameters level means of FBS HbA1c, Total Cholesterol, Triglycerides and Chromium of the test groups when compared with healthy control groups subjects (P = 0.001, 0.018, 0.01, 0.011, 0.004), respectively. Significant negative correlation is between FBS, HbA1c, Total Cholesterol, Triglycerides and Chromium (r = ?0.555, P value = 0.003), (r = ?0.668, P value = 0.002), (r = ?0.335, P value = 0.004) and (r = ?0.774, P value = 0.002) respectively. Conclusion: There was significant correlation between serum Chromium level with fasting blood sugaer, Glycosylated Haemoglobin (HbA1c), Total cholesterol and Triglycerides among type 2 diabetes patients.

降脂消胰汤内服与灌肠联合西药治疗高脂血症性胰腺炎疗效及对患者血脂、凝血功能的影响

目的:研究降脂消胰汤内服与灌肠联合西药治疗对高脂血症性胰腺炎(HLP)患者血脂水平、凝血功能及预后的影响。方法:选取128例HLP患者,按随机数字表法分为两组,中医组64例,对照组61例(随访过程脱落3例)。对照组采用常规西药治疗,中医组在此基础上采用降脂消胰汤内服和灌肠治疗,比较两组患者临床疗效、血脂水平、凝血功能和预后情况。结果:中医组HLP患者治疗总有效率为95.31%,高于对照组的83.61%(P<0.05)。治疗后,中医组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)低于对照组,高密度脂蛋白(HDL)高于对照组(P<0.05)。治疗后,中医组血管性血友病因子(vWF)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-dimer)均低于对照组(P<0.05)。中医组禁食禁水时间、住院总时间均短于对照组,SAP转化率低于对照组(P<0.05)。结论:降脂消胰汤内服与灌肠联合西医治疗HLP可提高患者临床疗效,有效改善血脂水平和凝血功能。

总胆固醇与高密度脂蛋白胆固醇比值同肩袖撕裂的相关性

目的 探讨总胆固醇与高密度脂蛋白胆固醇比值同肩袖撕裂发生的相关性。方法 选取2018年1月至2023年6月期间在昆山市中医医院骨科住院行肩关节镜手术治疗的患者797例,其中男259例,女538例;年龄40~79岁,平均(58.86±8.73)岁。按照是否存在肩袖撕裂分为肩袖撕裂组559例及非肩袖撕裂组238例。收集患者基本信息及实验室检查结果,使用多因素Logistics回归分析探讨总胆固醇与高密度脂蛋白胆固醇比值同肩袖撕裂发生的相关性。结果 肩袖撕裂组的年龄、空腹血糖、中性粒细胞、总胆固醇与高密度脂蛋白比值高于非肩袖撕裂组。肩袖撕裂组的血红蛋白、高密度脂蛋白、血清镁及血清磷水平低于非肩袖撕裂组。多因素Logistic回归分析结果表明,总胆固醇与高密度脂蛋白比值同肩袖撕裂的发生有关。肩袖撕裂的患病率在总胆固醇与高密度脂蛋白比值四个四分位呈升高的趋势(21.65%、24.15%、25.76%及28.44%)。结论 血脂异常与肩袖撕裂具有相关性,总胆固醇与高密度脂蛋白比值越高,肩袖撕裂发生的风险越大。

Predictive value of preoperative routine examination for the prognosis of patients with pT2N0M0 or pT3N0M0 colorectal cancer

BACKGROUND In recent years,the incidence of colorectal cancer(CRC)has been increasing.With the popularization of endoscopic technology,a number of early CRC has been diagnosed.However,despite current treatment methods,some patients with early CRC still experience postoperative recurrence and metastasis.AIM To search for indicators associated with early CRC recurrence and metastasis to identify high-risk populations.METHODS A total of 513 patients with pT2N0M0 or pT3N0M0 CRC were retrospectively enrolled in this study.Results of blood routine test,liver and kidney function tests and tumor markers were collected before surgery.Patients were followed up through disease-specific database and telephone interviews.Tumor recurrence,metastasis or death were used as the end point of study to find the risk factors and predictive value related to early CRC recurrence and metastasis.RESULTS We comprehensively compared the predictive value of preoperative blood routine,blood biochemistry and tumor markers for disease-free survival(DFS)and overall survival(OS)of CRC.Cox multivariate analysis demonstrated that low platelet count was significantly associated with poor DFS[hazard ratio(HR)=0.995,95% confidence interval(CI):0.991-0.999,P=0.015],while serum carcinoembryonic antigen(CEA)level(HR=1.008,95%CI:1.001-1.016,P=0.027)and serum total cholesterol level(HR=1.538,95%CI:1.026-2.305,P=0.037)were independent risk factors for OS.The cutoff value of serum CEA level for predicting OS was 2.74 ng/mL.Although the OS of CRC patients with serum CEA higher than the cutoff value was worse than those with lower CEA level,the difference between the two groups was not statistically significant(P=0.075).CONCLUSION For patients with T2N0M0 or T3N0M0 CRC,preoperative platelet count was a protective factor for DFS,while serum CEA level was an independent risk factor for OS.Given that these measures are easier to detect and more acceptable to patients,they may have broader applications.

血清小而密低密度脂蛋白胆固醇和总抗氧化能力水平与脑梗死患者认知功能障碍的相关性分析

目的:探究脑梗死患者血清小而密低密度脂蛋白胆固醇(small dense low-density lipoprotein cholesterol, sdLDL-C)和总抗氧化能力(total antioxidant capacity, T-AOC)水平变化及其与认知功能障碍发生的关系。方法:选择148例脑梗死患者,依据发病后7 d是否出现认知功能障碍,分为非障碍组(n=77)和障碍组(n=71);分别采用过氧化氢酶法和比色法测定两组血清sdLDL-C和T-AOC水平,并进行比较;Pearson相关系数法分析脑梗死患者血清sdLDL-C、T-AOC水平与蒙特利尔认知评估(MoCA)评分相关性;二元Logistic回归分析影响脑梗死患者认知功能障碍发生的危险因素。结果:与非障碍组相比,障碍组血清sdLDL-C水平明显升高(P<0.05),T-AOC水平明显降低(P<0.05)。相关性分析显示,血清sdLDL-C水平与MoCA评分呈负相关(r=-0.516,P<0.05),T-AOC水平与MoCA评分呈正相关(r=0.446,P<0.05)。Logistic回归分析显示,高血压、糖尿病、病情严重程度、血清sdLDL-C和T-AOC是脑梗死患者认知功能障碍发生的独立影响因素(P<0.05)。结论:脑梗死患者血清sdLDL-C水平升高,T-AOC水平降低,二者是影响脑梗死患者并发认知功能障碍的独立影响因素。

术后脂代谢对胃癌根治术后早期吻合口瘘发生的预测价值

目的 探讨术后血脂指标对胃癌根治术患者术后早期吻合口瘘发生的预测价值。方法 回顾性收集41例胃癌根治术后10 d内发生吻合口瘘的患者临床资料,纳入发生组;另收集同期医院胃癌根治术后10 d内未发生吻合口瘘的患者临床资料,纳入未发生组。所有患者术后1 d均完成血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]检查。统计2组一般基线资料,比较2组术后早期血脂指标,并绘制受试者工作特征(ROC)曲线,分析术后血脂指标对胃癌根治术后吻合口瘘的预测价值。结果 发生组合并2型糖尿病、合并低蛋白血症例数占比高于未发生组,差异有统计学意义(P<0.05)。发生组术后1 d时血清TC、LDL-C均高于未发生组,差异有统计学意义(P<0.05)。初步表明合并2型糖尿病、合并低蛋白血症、术后早期血清TC、LDL-C高与胃癌根治术患者术后发生吻合口瘘有关。绘制ROC曲线结果显示,术后1 d时血清TC、LDL-C预测胃癌根治术患者术后发生吻合口瘘的曲线下面积(AUC)均≥0.7,均有一定的预测价值。结论 胃癌根治术患者术后早期血清TC、LDL-C水平高与其吻合口瘘发生存在一定关系,术后早期联合检测二者水平可用于预测胃癌根治术后吻合口瘘发生风险。

青年首发抑郁症患者继发精神病性症状的危险因素

目的 探讨青年首发重度抑郁症(major depression disorder, MDD)患者继发精神病性症状的相关危险因素。方法 收集232例首发抑郁症患者首诊时的一般人口学资料、汉密尔顿抑郁量表(Hamilton depression scale, HAMD-17)、汉密尔顿焦虑量表(Hamilton anxiety scale, HAMA)得分,于次日采集肘静脉血并检测患者血糖、血脂、甲状腺功能、泌乳素和25-羟基维生素D[25(OH)D]水平,经过1年随访,根据患者是否继发精神病性症状,分为伴有精神病性症状的重度抑郁症组(PMD组,n=46)和不伴有精神病性症状的重度抑郁症组(MDD组,n=186),比较组间差异并分析各指标与精神病性症状的相关性,并探讨与青年首发PMD发生相关的危险因素。结果 PMD组未婚人数占比高于MDD组(P<0.05);PMD组HAMD-17量表得分高于MDD组(P<0.05);PMD组血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及促甲状腺激素(TSH)水平高于MDD组,高密度脂蛋白胆固醇(HDL-C)及25(OH)D水平低于MDD组(P<0.05)。相关性分析显示HAMD-17评分(r=0.345)、TC(r=0.148)、LDL-C(r=0.162)及TSH水平(r=0.134)与精神病性症状呈正相关(P<0.05),已婚(r=-0.208)、HDL-C(r=-0.258)及25(OH)D水平(r=-0.276)与精神病性症状呈负相关(P<0.05)。多因素Logistic回归分析显示,未婚、HAMD-17量表得分、高TC、低HDL-C及低25(OH)D水平为MDD患者精神病性症状的独立危险因素(P<0.05)。ROC曲线提示由婚姻状况、HAMD-17得分、血清TC、HDL-C及25(OH)D水平组成的联合指标能够较好地预测MDD患者精神病性症状的发生(AUC=0.887)。结论 血清脂代谢及25(OH)D水平可能是预测青年MDD患者继发精神病性症状的的生物标志物。

双向孟德尔随机化分析总胆固醇升高风险与胆石症发生风险的关系

目的 运用双向孟德尔随机化评估总胆固醇升高风险与胆石症发生风险之间的关联。方法 总胆固醇与胆石症相关的单核苷酸多态性数据来自open gwas公共数据库,对基于全基因组相关联研究(GWAS)的所有汇总数据进行二次数据分析,分别选择与总胆固醇或者胆石症密切关联的遗传位点作为暴露或者结局变量,用Egger回归法、加权中位数法、IVW随机效应模型、IVW固定效应模型等方法进行双向孟德尔随机化分析,以OR值评价总胆固醇和胆石症之间的因果关系。结果 以总胆固醇为暴露、胆石症为结局,去除异质性前总胆固醇-胆石症的总体OR=0.91,95%CI:0.85~0.97;去除异质性后总胆固醇-胆石症的总体OR=0.93,95%CI:0.89~0.97。以胆石症为暴露、总胆固醇为结局,去除异质性前胆石症-总胆固醇的总体OR=0.20,95%CI:0.06~0.65;去除异质性后胆石症-总胆固醇的总体OR=0.28,95%CI:0.10~0.83。基因预测的总胆固醇和胆石症之间存在双向因果关系。结论 本研究证实了总胆固醇与胆石症之间的双向因果关系,随着遗传上有关能使总胆固醇水平升高的等位基因的增加,发生胆石症的风险降低。反之,随着遗传上有关能使胆石症发病增高的等位基因的增加,总胆固醇水平升高的风险降低。

血脂康联合阿利西尤单抗对他汀类药物不耐受动脉粥样硬化性心血管疾病患者LDL-C达标率和其他血脂指标影响

目的探讨对他汀类药物不耐受动脉粥样硬化性心血管疾病患者应用血脂康联合阿利西尤单抗的价值。方法选取2022年6月—2023年9月收治的对他汀类药物不耐受的动脉粥样硬化性心血管疾病80例,根据治疗方法不同将其分为研究组和对照组2组各40例。研究组给予血脂康联合阿利西尤单抗治疗,对照组给予阿利西尤单抗治疗。比较2组治疗前和治疗4、8、12周后低密度脂蛋白胆固醇(LDL-C)、其他血脂指标[总胆固醇、高密度脂蛋白胆固醇(HDL-C)和三酰甘油],治疗4周后LDL-C达标率和降低>50%达标率,以及治疗期间不良反应发生情况。结果与治疗前比较,治疗4、8和12周后2组LDL-C均降低,且治疗4、8和12周后研究组LDL-C低于对照组(P<0.05)。与治疗前比较,治疗4、8和12周后2组总胆固醇和三酰甘油均降低,HDL-C升高(P<0.05)。治疗4、8和12周后,研究组总胆固醇较对照组降低(P<0.05)。治疗4周后,研究组LDL-C达标率和降低>50%达标率高于对照组(P<0.05)。治疗期间,2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论血脂康联合阿利西尤单抗应用于他汀类药物不耐受动脉粥样硬化性心血管疾病患者利于改善血脂水平,提高LDL-C达标率,且安全性较高。

残余脂蛋白胆固醇与慢性完全闭塞性病变患者侧支循坏的相关性分析

目的:本研究主要探索残余脂蛋白胆固醇(remnant-like particle cholesterol, RLP-c)与慢性完全闭塞性病变(chronic total occlusion, CTO)患者侧支循环的相关性。方法:本研究主要回顾性纳入549例CTO患者,依据rentrop分级系统将纳入人群分为两组,即侧支循环充分组(rentrop 2-3级)412例与侧支循环不充分组(rentrop 0-1级)137例。通过多因素回归分析探索RLP-c与侧支循环的相关性。结果:本研究共纳入549例CTO患者,其中侧支循环不充分组137例。与侧支循环充分组相比,侧支循环不充分组RLP-c浓度较高[0.7(0.4, 1.0)vs. 0.5(0.4, 0.7),P<0.001]。不仅在单因素回归分析中,RLP-c与侧支循环形成不良紧密相关(OR=4.658,95%CI:2.731~7.945,P<0.001),通过多因素回归分析校正其他混杂因素影响后,RLP-c仍是侧支循环形成不良的独立危险因素(OR=4.944,95%CI:2.828~8.645,P <0.001)。进一步依据3分位数将RLP-c调整成分类变量后,上述关系仍成立。最后受试者工作特征曲线进一步证实RLP-c可有效预测侧支循环形不充分的发生(曲线下面积0.664,95%CI:0.613~0.716,P <0.001)。结论:独立于传统血脂参数,RLP-c与CTO患者侧支循环形不充分独立相关。

Aerobic Training Impacts on Blood Cholesterol of Women with Gestational Diabetes

Gestational diabetes mellitus has been identified as a major complication of pregnancies and has remained a major cause of perinatal morbidity and mortality, as well as maternal morbidity. Lipid abnormalities significantly contribute to the increased risk of cardiovascular disease and other morbidities in diabetics. One of the benefits of regular exercise is a reduction in cardiovascular risk factors through the improvement of the lipid profile and reduction of hypertension. This study investigated the effect of aerobic training on the cholesterol level of women with gestational diabetes. Thirty-four (34) women who met the inclusion criteria for this study were randomized into Exercise and Control groups. Exercise group participated in structured exercise programme, 3 sessions a week for 8 weeks with each session lasting a maximum of 60 minutes while the Control group did not participate in any form of structured exercise programme for the period of the study. Data were collected at baseline, at 4th week and at 8th week into the exercise programme. Thirty (30) of the participants completed the study and so only their data were analysed using Repeated Measure ANOVA and Independent t-test. The result showed significant changes in the total cholesterol (F[2, 28]) = 268.316, P = 0.001), of the Exercise group compared to the control. Independent t-test used to compare the lipid profile of the Experimental and Control groups showed significant difference between the means of the 2 groups at week 4 (total cholesterol (t(28) 2.164, P = 0.039, triglyceride [t(28) 3.146 P = 0.004] and week 8 (total cholesterol t(28) 4.596, P = 0.001, triglyceride t(28) 5.534, P = 0.001) but not at baseline (total cholesterol t(28) -901, P = 0.375, triglyceride t(28) 1.612, P = 0.118). It was concluded that structured aerobic exercises may have positive effect on the components of lipid profile in women with gestational diabetes.

降尿酸防痛风饮治疗痰浊阻滞型慢性迁延期痛风性关节炎合并高脂血症患者30例的疗效及安全性观察

目的 观察降尿酸防痛风饮治疗痰浊阻滞型慢性迁延期痛风性关节炎合并高脂血症患者30例的疗效及安全性。方法 选取2021年12月—2022年12月期间就诊于广州中医药大学惠州医院的慢性迁延期痛风性关节炎合并高脂血症患者60例作为研究对象,按随机数字表法分为西药组和综合组,每组各30例。西药组予美洛昔康片治疗,综合组在西药组基础上联合降尿酸防痛风饮治疗。治疗28 d后,观察比较两组患者临床疗效、不良反应情况,治疗前后中医证候积分、关节疼痛视觉模拟量表(Visual analogue scale, VAS)评分、血尿酸(Blood uric acid, BUA)、C反应蛋白(C-reaction protein, CRP)、红细胞沉降率(Erythrocyte sedimentation rate, ESR)、总胆固醇(Triglycerides, TC)、甘油三酯(Triglycerides, TG)水平。结果 治疗后综合组临床总有效率93.33%(28/30)明显高于西药组70.00%(21/30),差异有统计学意义(P<0.05)。治疗14、28 d后,两组患者中医证候积分、关节疼痛VAS评分较治疗前降低,差异有统计学意义(P<0.05);且综合组中医证候积分、关节疼痛VAS评分均明显低于西药组,差异有统计学意义(P<0.05);两组患者治疗28 d后中医证候积分、关节疼痛VAS评分均明显低于治疗14 d后,差异有统计学意义(P<0.05)。治疗14、28 d后,两组患者BUA水平均较治疗前降低,差异有统计学意义(P<0.05);且综合组BUA水平明显低于西药组,差异有统计学意义(P<0.05)。两组患者治疗28 d后BUA水平均低于治疗14 d后,差异有统计学意义(P<0.05)。治疗28 d后,两组患者CRP、ESR、TC、TG水平均较治疗前降低,差异有统计学意义(P<0.05);且综合组CRP、ESR、TC、TG水平明显低于西药组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(χ^(2)=1.071,P=0.301)。结论 降尿酸防痛风饮可改善慢性迁延期痛风性关节炎(痰浊阻滞)合并高脂血症患者临床症状、治疗效果及实验室指标,减轻关节疼痛,且安全可靠。

总胆固醇/甘油三酯预测子宫内膜异位症患者术后复发的价值

目的重点探讨总胆固醇/甘油三酯(TC/TG)对子宫内膜异位症患者术后复发的预测价值。方法回顾分析,采集2020年1月至2022年6月于郑州大学第一附属医院妇科完成腹腔镜手术治疗后,且术后1 a随访期间复发的50例患者资料,纳入复发组;采集同期完成腹腔镜手术治疗后但术后随访1 a未复发的50例患者资料,纳入未复发组。全部患者资料完整(包括人口学资料、病历资料、相关实验室检查结果资料等)。记录患者人口学资料与临床资料,记录并比较两组术前血脂指标[TC、TG、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、TC/TG]检测结果。绘制受试者工作特征(ROC)曲线,重点分析各主要指标预测子宫内膜异位症患者术后复发风险的效能。结果复发组与未复发组患者人口学特征及临床资料差异无统计学意义(P>0.05);复发组术前TC、TG水平低于未复发组,TC/TG比值高于未复发组,差异有统计学意义(P<0.05);绘制ROC曲线,子宫内膜异位症患者的术前TC、TG、TC/TG比值预测术后复发风险均有一定效能,AUC均>0.70,其中TC/TG预测的AUC为0.905,预测价值最高,当cut-off取4.780,敏感度、特异度更高。结论子宫内膜异位症患者术前TC、TG、TC/TG比值均可用于预测术后复发风险,但TC/TG比值对复发风险的预测价值最高,具有更好的应用价值。

ASC自身抗体及总胆固醇与阿尔茨海默病的相关性研究

目的探讨凋亡相关斑点样蛋白自身抗体(NAbs-ASC)及总胆固醇(TC)与阿尔茨海默病(AD)的相关性。方法选取2022年10月—12月陆军军医大学大坪医院神经内科门诊38例AD患者及健康管理科38例为对照组。比较两组血浆NAbs-ASC及总胆固醇水平,分析NAbs-ASC及TC与AD的相关性。结果AD组血浆的NAbs-ASC水平低于对照组(P<0.05),总胆固醇水平高于对照组(P<0.05)。Spearman相关性分析显示,NAbs-ASC水平与总胆固醇水平呈负相关(r_(s)=-0.290,P<0.05),认知功能水平与总胆固醇水平呈负相关(r_(s)=-0.380,P<0.05),而与血浆NAbs-ASC水平呈正相关(r_(s)=0.550,P<0.05)。多因素Logistic回归分析结果显示,总胆固醇升高为AD的危险因素[OR=3.004(95%CI:1.075,8.396)],NAbs-ASC升高为AD的保护因素[OR=0.998(95%CI:0.997,0.999)]。结论NAbs-ASC降低、总胆固醇升高与AD有相关性,并与认知功能水平下降有关。