Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer:A bidirectional Mendelian randomization study

BACKGROUND Previous epidemiologic investigations have consistently demonstrated a strong association between the ratio of cholesterol to total lipids in medium very-lowdensity lipoprotein(VLDL)and the occurrence of peptic ulcers(PU).However,the precise causal relationship between these factors remains ambiguous.Consequently,this study aims to elucidate the potential correlation between the ratio of cholesterol to total lipids in medium VLDL and the incidence of peptic ulcer.AIM To investigate the ratio of cholesterol to total lipids in medium very-low-density lipoprotein(VLDL)association with PU via genetic methods,guiding future clinical research.METHODS Genome-wide association study(GWAS)datasets for the ratio of cholesterol to total lipids in intermediate VLDL and peptic ulcer were retrieved from the IEU OpenGWAS project(https://gwas.mrcieu.ac.uk).For the forward Mendelian randomization(MR)analysis,72 single nucleotide polymorphisms(SNPs)were identified as instrumental variables.These SNPs were selected based on their association with the ratio of cholesterol to total lipids in intermediate VLDL,with peptic ulcer as the outcome variable.Conversely,for the inverse MR analysis,no SNPs were identified with peptic ulcer as the exposure variable and the ratio of cholesterol to total lipids in intermediate VLDL as the outcome.All MR analyses utilized inverse variance weighted(IVW)as the primary analytical method.Additionally,weighted median and MR-Egger methods were employed as supplementary analytical approaches to assess causal effects.Egger regression was used as a supplementary method to evaluate potential directional pleiotropy.Heterogeneity and multiplicity tests were conducted using the leave-one-out method to evaluate result stability and mitigate biases associated with multiple testing.RESULTS The genetically predicted ratio of cholesterol to total lipids in medium VLDL was significantly associated with an elevated risk of peptic ulcer(IVW:OR=2.557,95%CI=1.274-5.132,P=0.008).However,no causal association of peptic ulcer with the ratio of cholesterol to total lipids in medium VLDL was observed in the inverse Mendelian randomization analysis.CONCLUSION In conclusion,our study reveals a significant association between the ratio of cholesterol to total lipids in medium VLDL and an elevated risk of peptic ulcers.However,further validation through laboratory investigations and larger-scale studies is warranted to strengthen the evidence and confirm the causal relationship between these factors.

The effects of simvastatin on cardiovascular outcomes in hypertensive patients with a high-normal level of total cholesterol

Objective To investigate the effects of simvastatin compared with standard treatment on cardiovascular outcomes and all-cause mortality in high-risk hypertensive patients with a high–normal level of total cholesterol(TC).Methods In a randomized,open-label,blinded-endpoint trial,hypertensive patients at high risk for cardiovascular events from 180 clinical centers in China were assigned to receive treatment with amlodipine plus amiloride/hydrochlorothiazide(n=6,776)or telmisartan(n=6,766).

The Ability of Baseline Triglycerides and Total Cholesterol Concentrations to Predict Incidence of Type 2 Diabetes Mellitus in Chinese Men and Women:A Longitudinal Study in Qingdao, China

Objectives The purpose of this study was to assess the association between triglycerides(TG),total cholesterol(TC)at baseline,and type 2 diabetes mellitus(T2DM)incidence in a general Chinese population.Further,it aimed to evaluate the ability of TG and TC to predict T2DM incidence.Methods Qingdao Diabetes Prevention Program participants recruited between 2006 and 2009 were followed up in 2012–2015.TG,TC,and T2DM status were measured.Cox proportional hazards models were used to estimate the association between TG,TC,and T2DM incidence.The receiver operating characteristic(ROC)curve was used to evaluate the ability of TG and TC to identify T2DM participants.Results The incidence of T2DM significantly increased with TG in women and TC in both men and women(Ptrend<0.05).Univariate Cox regression indicated that higher TG{borderline high TG[hazards ratio(HR):2.05;95%confidence interval(CI):1.40,3.00]and hypertriglyceridemia[HR:2.64;95%CI:1.68,4.15]}and TC[hypercholesterolemia(HR:2.05;95%CI:1.43,2.95)]were significantly associated with increased risk of T2DM incidence in women but not in men.Multivariate Cox regression showed that hypertriglyceridemia in women(HR:1.78,95%CI:1.07,2.97),borderline high TC in men(HR:1.61,95%CI:1.04,2.48),and hypercholesterolemia in women(HR:1.68,95%CI:1.81,2.61)had a higher significant risk of T2DM incidence.The optimal cutoff values of TG were>1.15 and>1.23 mmol/L in men and women,respectively.For TC,they were>5.17 and>5.77 mmol/L in men and women,respectively.The area under the ROCs of TG and TC were 0.54(0.51–0.57)and 0.55(0.52–0.58),respectively,in men,and 0.60(0.58–0.62)and 0.59(0.56–0.61),respectively,in women.Conclusion Elevated TG and TC were risk factors for T2DM incidence.However,no predictive capacity was found for both factors to identify T2DM incidence in Chinese men and women.Hence,TG and TC levels in both Chinese men and women might be used for decreasing the incidence of T2DM but no clinical predictive capacity for T2DM.

Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography

Background The correlation among the ratios of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol(LDL-C/HDL-C), total cholesterol/high-density lipoprotein cholesterol(TC/HDL-C) and thin-cap fibroatheroma has not yet been established. Methods It was a single center, retrospective observational study. In total, we recruited 421 patients(82.4% men;mean age 65.73 ± 10.44 years) with one culprit vessel which determined by intravascular optical coherence tomography(OCT). The thinnest-capped fibroatheroma(TCFA) group was defined as lipid contents in > 2 quadrants, with the thinnest fibrous cap measuring less than 65 μm. Univariate and multivariate logistic regression were carried out to explore the relationship between lipoprotein ratios, TCFA and other characteristics of plaque. To compare different ratios, the area under curve(AUC) of receiver-operating characteristic(ROC) curve was assessed. Results OCT was performed in 421 patients(TCFA group(n = 109), non-TCFA group(n = 312)). LDL-C/HDL-C in the TCFA group was significantly higher than in the non-TCFA group(2.95 ± 1.20 vs. 2.43 ± 0.92, P < 0.05), as was TC/LDL in TCFA and non-TCFA group(4.57 ± 1.58 vs. 4.04 ± 1.13, P < 0.05). Both LDL-C/HDL-C(OR: 1.002(1.002-1.003), P < 0.05) and TC/HDL-C(OR: 1.001(1.001-1.004), P < 0.05) were considered independent factors for the prediction of TCFA according to the logistic regression. Based on the AUC comparison, LDL-C/HDL-C and TC/HDL-C had no significant difference statistically(LDL-C/HDL-C AUC: 0.63;TC/HDL-C AUC: 0.61;P = 0.10) for the prediction of TCFA. Conclusions LDL-C/HDL-C and TC/HDL-C could be the independent factors for predicting the presence of TCFA, indicating coronary plaque vulnerability in CAD patients. Moreover, TC/HDL-C also showed a comparative performance for the prediction of TCFA as LDL-C/HDL-C.

Pollution Tolerance of Smoke in the Distribution of Neurotransmitter Enzyme (Acetylcholine Esterase) and Total Cholesterol in Tissues of Wistar Rats

This study was designed to assess total animal exposure to non-occupational but environmentally induced smoke through short-term landfill burning toxicity tests at the biochemical levels. Exposure to municipal land-fill burning using rat model focused primarily on inhalation exposure. The environmental monitoring consisted of 60 days exposure to refuse burning by evaluating the level of protein concentrations, neurotransmitter enzyme acetylcholine esterase (AcHE), and total cholesterol in different tissues of Wistar rats. Protein concentrations tended to decrease in the brain, liver and kidney and slightly increased in the plasma while acetylcholine esterase decreased in brain and liver and increased in the kidney. The non-depletion in total cholesterol levels in the tissues tended to be due to active mobilization towards tissue metabolism. The data were sufficient to support risk assessment for human.

Association between apolipoprotein E promoter-219G/T polymorphism and total cholesterol level in patients with Alzheimer disease

BACKGROUND: Many researches have suggested that apolipoprotein E (APOE) and total cholesterol metabolism are closely related with dementia. In the supposed theory, 219 site of APOE promoter region is near gene coding region, so its polymorphism may result in the abnormality of APOE gene and protein expression, and finally lead to dementia. OBJECTIVE: To observe the association between APOE promoter-219G/T polymorphisms with serum total cholesterol in patients with Alzheimer disease, and compare it with non-dementia people. DESIGN: Case-control, comparative observation. SETTING: Department of Neurology, Fengtian Hospital of Shenyang Medical College. PARTICIPANTS: Fifty-five dementia patients including 27 males and 28 females aged (66±3) years and treated in the Department of Neurology, Fengtian Hospital were selected from January 2002 to December 2005 as the Alzheimer disease group. They all diagnosed according to the DSM-Ⅳdiagnostic criteria of Alzheimer disease instituted by American Psychiatry Association in 1994. Meanwhile, 44 none-dementia patients including 21 males and 23 females aged (66±3) years were selected from other clinical departments of Fengtian Hospital as control group. All the participants were informed the detection and agreed. METHODS: Genomic DNA was extracted from the peripheral blood of all subjects, then 'NEST'PCR, DNA sequence and enzyme digestion were adopted to detect the expression of APOE promoter-219 polymorphism, following by biomedical statistics analysis based on the clinical total cholesterol level. MAIN OUTCOME MEASURES: Polymorphism of APOE promoter-219 G/T and total cholesterol level. RESULTS: All 55 dementia patients and 44 non-dementia ones were involved in the result analysis. ①Allele and genotype frequency: The T allele frequency of the Alzheimer disease group was significantly higher than that in the control group [88.2% (97/110), 54.5% (48/88)], while G allele frequency was remarkably lower than that in the control group [11.8%(13/110), 45.5%(40/88), χ2=8.2, P < 0.01]. The TT allele frequency of the Alzheimer disease group was significantly higher than that in the control group [76% (42/55), 48% (21/44)], while GT+GG allele frequency was remarkably lower than that in the control group [24%(13/55), 52%(23/44), χ2=8.7, P < 0.01]. ②Total cholesterol level: The level of the TT genotype patients in the Alzheimer group was obviously higher than that in GT+GG genotype patients (t =2.46, P < 0.05); the cholesterol level in the two genotypes of the control group was similar (P > 0.05). CONCLUSION: TT genotype and allele T in the APOE promoter-219 polymorphisms are the sensitive gene, and genotype TT has a relationship with the increase of total cholesterol level.

Disposable Electrochemical Biosensor for Amperometric Measurement of β-hydroxybutyrate and Total Cholesterol

A new type of disposable thin-film amperometric biosensor has been developed for measurement ofβ-hydroxybutyrate and total cholesterol in serum.The biosensor consists of two plain gold electrodes mounted on a Polyethylene terephthalate (PET) substrate.The reagent solution contains bienzymes (cholesterol oxidase and cholesterol esterase for total cholesterol,β-hydroxybutyrate dehydrogenase and diaphorase forβ-hydroxybutyrate respectively) with mediator (ferricyanide) were absorption at the surface of electrodes coated by electrodepositing platinum black.The presence of the mediator lowers the applied potential and eliminates the interference from other oxidizable species enhancing the sensitivity and selectivity of the biosensor without modifying the dynamic parameters of the response.The enzymes stably retains in the matrices of platinum black film improving the performance of the mediated sensor.The linearity is observed in the concentration range from 1.0×10^(-4) to 1.0×10^(-2) mM and 1.0×10^(-4) mM to 4.99×10^(-3) mM with sensitivity of 1.958μA/mM and 2.447μA/mM respectively.The optimized biosensor exhibits excellent reproducibility and stability retaining more than 90% of its original activity over a period of one month.The simple operation of the biosensor mass-produced at low cost is expected to find clinical application and homecare.

Relationship between apolipoprotein E gene polymorphism and total cholesterol level in patients with kidney diseases

AIM： To evaluate the association between apolipoprotein E （apoE） gene polymorphism and total cholesterol （TC） level in patients with kidney diseases. METHODS： A predefined literature search was performed to collect data from the electronic databases of PubMed, Embase and the Cochrane Library and eligible relevant studies reporting the association of apoE gene polymorphism with TC level in patients with kidney diseases were recruited for meta-analysis.RESULTS： Twenty-one studies were identifed for the analysis of association between apoE gene polymorphism and TC level in patients with kidney disease. Subjects with E3E4 had a higher TC than those with E3E3 [weighted mean differences （WMD）=2.14, P=0.01] and subjects with E2E3 had a lower TC than those with E3E3 （WMD=-1.93, P=0.01）. Subjects with ε2 had a lower TC than those with ε3 （ε2 vs ε3： WMD=-1.23, P=0.002; ε2 vs ε4： WMD=-2.77, P﹤0.0001） and subjects with 3 had a lower TC than those with 4 （WMD=-0.79, P=0.03）. CONCLUSION： Subjects with apoE E3E4 and ε4 had a higher TC level and subjects with apoE E2E3 and ε2 had a higher TC level in patients with kidney disease. However, more well-designed studies should be per-formed in the future to confrm these fndings.

A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients

Background: Diabetes mellitus is a common disease and it is a major cause of morbidity;several studies indicate that diabetes is a likely under reported cause of death. Chromium’s is important trace element to control diabetes mellitus and metabolism of carbohydrate, lipid and protein. Objective: The purpose of this study was to understand the relationship between serum chromium, with HbA1c, Total cholesterol and Triglycerides among type 2 diabetes patients among diabetic patients. Methodology: This is cross-sectional study done in Jabber Abu Ezz Centre for treatment and care of diabetics in Khartoum—Sudan. Four hundred subjects were enrolled in this study;one hundred subjects were normal healthy as control group, and three hundred subjects diabetic patient type 2 as test group;demographic and biochemical data were collected;serum chromium, Glycosylated Haemoglobin (HbA1c), Total cholesterol Triglycerides, were determined by using NYCOCARD READER II, spectrophotometer (Biosystem 310) and spectrophotometer 210-VGP. Result: In this study there is significant parameters level means of FBS HbA1c, Total Cholesterol, Triglycerides and Chromium of the test groups when compared with healthy control groups subjects (P = 0.001, 0.018, 0.01, 0.011, 0.004), respectively. Significant negative correlation is between FBS, HbA1c, Total Cholesterol, Triglycerides and Chromium (r = ?0.555, P value = 0.003), (r = ?0.668, P value = 0.002), (r = ?0.335, P value = 0.004) and (r = ?0.774, P value = 0.002) respectively. Conclusion: There was significant correlation between serum Chromium level with fasting blood sugaer, Glycosylated Haemoglobin (HbA1c), Total cholesterol and Triglycerides among type 2 diabetes patients.

Is low postoperative cholesterol level really an independent risk factor of adverse outcomes after living donor liver transplantation?

To the Editor:We read with great interest the article by Yang et al.[1]evaluating the effects of postoperative serum total cholesterol(s TC)changes on early allograft dysfunction and survival after living donor liver transplantation(LDLT).By the multivariate regression analysis,they showed that patients with s TC<1.42 mmol/L on postoperative day 3 had 4.08-fold and 2.72-fold greater risks of

血清TC、MHR和Hcy联合检测对急性脑梗死的诊断价值

目的 探讨总胆固醇(TC)、单核细胞与高密度脂蛋白胆固醇(HDL-C)比值(MHR)和同型半胱氨酸(Hcy)在急性脑梗死(ACI)患者血清中的表达水平及TC、MHR、Hcy单独及3项指标联合检测对ACI的诊断价值。方法 选取2023年5-8月在该院神经内科诊断为ACI的患者144例作为病例组,另随机选取同期该院收治的非脑血管疾病患者83例作为对照组。收集并比较所有研究对象的入院资料各项数据[白细胞计数(WBC)、中性粒细胞计数(NEUT)、淋巴细胞计数(LY)、单核细胞计数(MONO)];记录生化全套检测数据[TC、甘油三酯(TG)、HDL-C、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)、空腹血糖(FPG)和Hcy],计算MHR,比较两组临床数据及化验结果。采用多因素Logistic回归进行ACI的危险因素分析,绘制受试者工作特征(ROC)曲线评估判断各项指标对ACI的诊断价值。结果 两组吸烟史、饮酒史、WBC、TG和FPG水平比较,差异均无统计学意义(P>0.05)。病例组男性比例、年龄、高血压比例、2型糖尿病比例均大于对照组,差异均有统计学意义(P<0.05)。病例组NEUT、MONO、TC、LDL-C、UA、Hcy水平和MHR均明显高于对照组,LY和HDL-C水平均低于对照组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,高血压、年龄≥69岁、Hcy≥15.3μmol/L、TC≥4.76μmol/L和MHR≥0.43是ACI发生的独立危险因素(P<0.05)。ROC曲线分析结果显示,Hcy、TC、MHR诊断ACI的曲线下面积分别为0.859、0.752、0.799,低于3项联合诊断的0.957。结论 TC、MHR和Hcy是ACI发生的独立危险因素,3项指标联合检测对ACI具有较高的诊断价值和临床意义。

血清TC、TG及ApoB在输血后脂质代谢监测中的应用价值

目的探讨血清总胆固醇(TC)、甘油三酯(TG)及载脂蛋白B(ApoB)在输血后脂质代谢监测中的应用价值。方法回顾性纳入2022年7月至2023年10月南京医科大学附属淮安第一医院收治的外伤失血性休克患者152例,依据脂质代谢诊断标准将152例患者分为脂质代谢正常组86例、脂质代谢异常组66例。比较两组一般资料、TC、TG及ApoB水平变化;分析影响输血后脂质代谢异常的危险因素,绘制ROC曲线评估TC、TG及ApoB单独及联合检测对输血后脂质代谢异常的预测价值。结果两组年龄、性别、吸烟史、饮酒史、糖尿病史、高血压史占比、输血量比较,差异无统计学意义(P>0.05);脂质代谢异常组年高密度脂蛋白胆固醇水平低于脂质代谢正常组,低密度脂蛋白胆固醇水平高于脂质代谢正常组,差异有统计学意义(P<0.05)。脂质代谢异常组TC、TG及ApoB水平均明显高于脂质代谢正常组,差异有统计学意义(P<0.05)。经logistic多因素分析显示:高密度脂蛋白胆固醇(男性<0.91 mmol/L,女性<1.1 mmol/L)、低密度脂蛋白胆固醇(>4.14 mmol/L)、TC(<2.4 mmol/L,>5.7 mmol/L)、TG(<0.4 mmol/L,>1.8 mmol/L)及ApoB(男性<0.43 g/L,>1.28 g/L,女性<0.42 g/L,>1.12 g/L)是影响输血后脂质代谢异常的危险因素(P<0.05)。依据ROC曲线可知,TC、TG及ApoB联合预测输血后脂质代谢异常的敏感度和特异度分别为89.84%、88.24%,AUC为0.898,高于三指标单独检测(P<0.05)。结论TC、TG及ApoB在输血后脂质代谢异常患者中呈高表达,三指标联合检测可全面、客观地反映输血后脂质代谢异常情况,为临床诊断、治疗提供更为准确、可靠的依据。

螺内酯结合三联降压方案对难治性高血压的效果及对血清hsCRP及TC的影响

目的探讨螺内酯结合三联降压方案对难治性高血压的效果及对血清高敏C反应蛋白(hsCRP)及总胆固醇(TC)的影响。方法选取的研究对象为符合诊断标准的难治性高血压患者80例,将80例难治性高血压患者分为对照组(n=40)和试验组(n=40)。对照组使用三联降压方法进行治疗,试验组在以三联降压治疗的基础上结合服用螺内酯对难治性高血压进行治疗,两组均持续治疗8周后观察两组患者治疗后的临床疗效,以及对血清hsCRP和TC的影响。结果治疗后试验组总有效率(95.00%)显著高于对照组(75.00%)(P<0.05)。治疗后,试验组收缩压、舒张压低于对照组(P<0.05);治疗后血清hsCRP的水平降低,TC水平均无明显变化(P>0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论螺内酯结合三联疗法治疗难治性高血压疗效显著,能进一步增强降压效果,提高治疗疗效,值得临床推广。

血清TC、HDL-C表达水平与ST段抬高型心肌梗死患者冠脉病变程度的相关性分析

目的:探讨ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者血清总胆固醇(Total cholesterol,TC)、高密度脂蛋白胆固醇(High-Density lipoprotein cholesterol,HDL-C)表达及与冠脉病变程度的关系。方法:选取2019年1月至2023年5月于本院体检的75例健康者资料,纳入对照组;选取同期于本院就诊的75例SREMI患者资料,纳入观察组。回顾分析TC、HDL-C水平。分析STEMI患者冠脉病变程度,并根据冠脉病变程度将患者分为轻度组(24例)与重度组(51例)。分析比较两组基线资料。探讨血清TC、HDL-C与STEMI患者冠脉病变程度的关系。结果:相较于对照组,观察组的TC显著提高、HDL-C显著降低(P<0.05)。轻度组与重度组在性别、年龄段、体质量指数、基础疾病等方面均无显著差异(P>0.05)。相较于轻度组,重度组的Hcy、TC均显著提高,HDL-C显著降低(P<0.05)。Logistic回归分析结果显示:STEMI患者冠脉病变程度可能与Hcy高表达、TC高表达、HDL-C低表达有关(P<0.05)。TC高表达、HDL-C低表达时STEMI患者冠脉重度病变风险是TC低表达、HDL-C高表达时的43.646倍,协同效应为二者单独存在产生效应之和的3.553倍(交互作用指数(The synergy index,SI)=3.553)。结论:TC高表达、HDL-C低表达可能是STEMI患者的冠脉重度病变的危险因素。

TG、HDL-C、TC与糖尿病周围神经病变的相关性研究

目的探讨甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)与糖尿病周围神经病变的相关性,为糖尿病周围神经病变诊断提供临床依据。方法回顾性分析2017年1月～2018年1月在我院内分泌科确诊为糖尿病周围神经病变患者48例作为DPN组,将同期我院收治的24例2型糖尿病患者作为T2DM组,分析两组甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)等指标差异。通过Logistic回归方程分析上述指标与糖尿病周围神经病变的相关性。结果 DPN组TG、TC、LDL-C、ApoB水平均显著高于T2DM组,HDL-C显著低于T2DM组,差异均具有统计学意义(P<0.05);Logistic回归方程分析得出,TG、TC、HDL-C、LDL-C、ApoB均为DPN发病的危险因素(P<0.05)。结论糖尿病周围神经病变患者血脂水平高于单纯糖尿病患者,TG、TC、HDL-C、LDL-C、ApoB水平与DPN发病关系密切,是导致神经微血管病变的重要因素。

慢性精神分裂症患者血清hs-CRP、TC/HDL-C比值与精神症状的关系

目的探讨慢性精神分裂症患者血清超敏C反应蛋白(hs-CRP)、总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)比值与精神症状的关系。方法检测65例精神分裂症患者(患者组)和62例同期健康体检者(健康对照组)血清hs-CRP、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平,并计算TC/HDL-C比值;阳性和阴性症状量表(PANSS)评定患者入组时的精神症状。结果患者组血清hs-CRP水平[(2.87±0.75)mg/L]显著高于健康对照组[(0.96±0.25)mg/L],患者组血清TC水平[(1.93±0.51)mmol/L]显著低于健康对照组[(3.97±1.15)mg/L],患者组血清HDL-C水平[(1.08±0.33)mmol/L]显著低于健康对照组[(1.74±0.42)mg/L],差异均有统计学意义(P<0.05);患者组血清TC/HDL-C比值(1.78±0.59)显著低于健康对照组的(2.28±0.61)(P=0.028)。相关性分析显示,患者组血清TC/HDL-C比值与阳性症状呈负相关(r=-0.34,P=0.004),患者组血清hs-CRP水平与阳性症状呈正相关(r=0.31,P=0.010)。结论血脂和炎性反应与精神分裂症有密切关系,联合hs-CRP、TC/HDL-C比值的检测有利于预测精神分裂症的发生,可以作为精神分裂症的危险因素。

泌尿系统结石成分谱及与血清TG、TC及PGE2水平的相关性

目的分析泌尿系统结石成分谱及与血清三酰甘油(TG)、总胆固醇(TC)及前列腺素E2(PGE2)水平的相关性。方法选取2015年5月至2018年12月于该院就诊的肾结石患者1875例为患者组,选取同期于该院体检合格的健康者83例为对照组。在征得受试者同意的前提下,分别于进入研究队列时刻(T0)及治疗后即入选后第90天(T1)对受试者进行血液标本采集(对照组仅采集T0时的血液标本),采用酶联免疫吸附测定(ELISA)检测血清TG、TC及PGE2水平。结果1875例患者中1677例患者的主要结石成分为草酸钙;主要结石成分为磷酸磷灰石的患者为117例;主要结石成分为尿酸的患者55例;主要结石成分为磷酸镁铵的患者23例;主要结石成分为胱氨酸的患者3例。不同结石成分患者24h尿量及尿pH值比较,差异均无统计学意义(P>0.05)。患者组和健康组血清TG、TC及PGE2水平比较,差异均有统计学意义(P<0.05)。患者组T0和T1的血清TG、TC及PGE2水平比较,差异均有统计学意义(P<0.05)。以治疗后水平为基线,血清TG、TC及PGE2水平均存在两两间的正相关(P<0.05)。草酸钙结石患者肾组织标本切片的HE染色显示,肾小管有扩张表现,且多数肾小管中存在草酸钙结晶或结晶团块。结论荆门地区泌尿系统结石成分以草酸钙为主,血清TG、TC及PGE2水平有助于泌尿系统结石的诊断;相比于其他结石成分,草酸钙结石对肾组织损伤更为明显。

宽胸丹胶囊对动脉粥样硬化兔血清TC、TG、HDL、LDL影响的研究

目的 :探讨宽胸丹胶囊 (药物 :瓜蒌、陈皮、枳实、川芎、水蛭、苍术等 )对动脉粥样硬化兔血清总胆固醇 (TC)、甘油三脂(TG)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)的影响。方法 :取健康新西兰纯种大耳白兔 4 0只 ,随机分为 5组 ,即空白组、模型组、宽胸丹大剂量组、宽胸丹小剂量组、多烯康组 ,每日喂养相应的正常、造模或含药饲料 ,4 0d后 ,测定血清TC、TG、HDL、LDL的含量。结果 :模型组与正常组有显著差异 (P <0 .0 5 ) ,宽胸丹大、小剂量组均能明显降低TC、TG、LDL ,较模型组有显著差异 (P <0 .0 5 ) ,大剂量组能明显升高HDL(P <0 .0 5 ) ,且在改善TC、TG、LDL方面 ,优于多烯康组 (P <0 .0 5 )。提示宽胸丹胶囊具有减轻动脉粥样硬化程度、防治冠心病的作用 ,此作用可能与其升高HDL、降低TC、TG、LDL有关。

hs-CRP与TC/HDL-C联合检测在冠心病诊断中的应用

目的探讨超敏C-反应蛋白(hs-CRP)和总胆固醇/高密度脂蛋白胆固醇比值(TC/HDL-C)联合检测对冠状动脉粥样硬化性心脏病(CHD)的预测价值。方法对240例CHD患者和40例健康对照者进行血清hs-CRP和TC、HDL-C测定、分析。结果CHD患者血清hs-CRP浓度和TC/HDL-C比值均显著高于对照组(P<0.01)。联合应用hs-CRP和TC/HDL-C比值2种指标判别,对CHD患者的诊断阳性率(95.0%)高于分别应用hs-CRP(85.0%)、TC/HDL-C(76.7%)单一指标。结论应用hs-CRP和TC/HDL-C比值联合检测,更有助于冠心病的早期诊断。

血清TC、ALB、PA和TBA测定在肝硬化中的临床意义

目的探讨血清总胆固醇(TC)、白蛋白(ALB)、前白蛋白(PA)和总胆汁酸(TBA)测定对肝硬化患者的早期诊断及疾病预后的临床应用价值。方法对临床确诊的肝硬化患者207例和健康对照组100例进行TC、ALB、PA、TBA检测。结果肝硬化组胆汁酸明显升高(P<0.01),而清蛋白、前清蛋白、胆固醇明显降低(P<0.01);随着肝功能减退,胆汁酸逐渐升高,而清蛋白、前清蛋白、胆固醇逐渐降低。且前清蛋白下降比清蛋白下降更早,阳性率更高。结论联合检测血清胆固醇、清蛋白、前清蛋白、胆汁酸对肝硬化患者肝功能评价及预后判断有重要意义。