Allergy is an adverse immunologic response of increasing prevalence and severity in which immunoglobulin E plays a pivotal role. Total IgE (tIgE) levels show wide variations depending on various factors, such as age, ...Allergy is an adverse immunologic response of increasing prevalence and severity in which immunoglobulin E plays a pivotal role. Total IgE (tIgE) levels show wide variations depending on various factors, such as age, sex, ethnicity, and geographic area. This study set out to quantitatively determine the serum tIgE levels in Bangladeshi population who were clinically suspected cases of allergic diseases and to find out the association of tIgE level with their age and gender. This cross-sectional descriptive exploratory study was conducted at Biomed Diagnostics Laboratory, Panthapath, Dhaka, from March 2021-September 2021. A total of 402 blood samples were collected from clinically suspected cases of allergic diseases. Quantitative detection of tIgE in serum was done by Immunoblot assay manufactured by Proteome Tech Inc. (PROTIATM Allergy-Q64S panel). Among 402 subjects, a wide variation of tIgE levels ranging from 5 to 2000 IU/ml was found but majority of the study population (30.35%) showed tIgE levels within the range of 201 - 350 IU/ml. The study population aging 1 - 10 years showed highest frequency (23.63%) in tIgE concentrations and the mean tIgE level exhibited a declining tendency with an increase in age. Depending on gender there was no difference in tIgE levels. Determination of tIgE level is imperative for screening allergic diseases. The present study enlightened the distribution of tIgE levels and suggested that among Bangladeshi subjects irrespective of gender there is an inverse relationship between tIgE level and age.展开更多
Objective:To investigate the levels of serum vitamin D and IgE in infants with different allergic risks and to analyze their correlations.Methods:In the present study,the participants were selected and recruited from ...Objective:To investigate the levels of serum vitamin D and IgE in infants with different allergic risks and to analyze their correlations.Methods:In the present study,the participants were selected and recruited from the infant ward of our hospital from February 2012 to December 2012.A total of 120 patients were selected and recruited.Among these patients,64 patients with symptoms of allergic diseases were assigned to the experimental group.The remaining 56 patients who had respiratory infections,but without other symptoms of allergic diseases,were assigned to the control group.The serum 25-hydroxyvitamin D3 levels were measured using liquid chromatography tandem mass spectrometry and the IgE levels were measured using radioimmunoassay in both experimental and control groups.Subsequently,the serum 25-hydroxyvitamin D3 levels and IgE levels were compared between the experimental group and control group.Results:The following findings were obtained through data comparison.The serum 25-hydroxyvitamin D3 level in the experimental group was 18.19±7.84 ng/mL,and the IgE level was 551.51±705.88 IU/mL.The serum 25-hydroxyvitamin D3 level in the control group was 21.95±7.834 ng/mL,IgE level was 49.39±32.46 IU/mL.The data comparison indicates that the serum 25-hydroxyvitamin D3 level in the control group was higher than the experimental group,and the IgE level in the control group was lower than the experimental group(P<0.05).Conclusion:The level of vitamin D3 in patients with allergic symptoms is relatively low.This may be one of the causes leading to allergies.At the same time,IgE is also one of the causes contributing to allergies.An elevation of the IgE level is very likely to cause the allergic,and there is a correlation between serum vitamin D and IgE levels.At the same time,research has found that proper supplementation of vitamin D3 can help prevent allergic diseases,and can be considered in a new and highquality program for the prevention of allergic diseases.展开更多
文摘Allergy is an adverse immunologic response of increasing prevalence and severity in which immunoglobulin E plays a pivotal role. Total IgE (tIgE) levels show wide variations depending on various factors, such as age, sex, ethnicity, and geographic area. This study set out to quantitatively determine the serum tIgE levels in Bangladeshi population who were clinically suspected cases of allergic diseases and to find out the association of tIgE level with their age and gender. This cross-sectional descriptive exploratory study was conducted at Biomed Diagnostics Laboratory, Panthapath, Dhaka, from March 2021-September 2021. A total of 402 blood samples were collected from clinically suspected cases of allergic diseases. Quantitative detection of tIgE in serum was done by Immunoblot assay manufactured by Proteome Tech Inc. (PROTIATM Allergy-Q64S panel). Among 402 subjects, a wide variation of tIgE levels ranging from 5 to 2000 IU/ml was found but majority of the study population (30.35%) showed tIgE levels within the range of 201 - 350 IU/ml. The study population aging 1 - 10 years showed highest frequency (23.63%) in tIgE concentrations and the mean tIgE level exhibited a declining tendency with an increase in age. Depending on gender there was no difference in tIgE levels. Determination of tIgE level is imperative for screening allergic diseases. The present study enlightened the distribution of tIgE levels and suggested that among Bangladeshi subjects irrespective of gender there is an inverse relationship between tIgE level and age.
文摘Objective:To investigate the levels of serum vitamin D and IgE in infants with different allergic risks and to analyze their correlations.Methods:In the present study,the participants were selected and recruited from the infant ward of our hospital from February 2012 to December 2012.A total of 120 patients were selected and recruited.Among these patients,64 patients with symptoms of allergic diseases were assigned to the experimental group.The remaining 56 patients who had respiratory infections,but without other symptoms of allergic diseases,were assigned to the control group.The serum 25-hydroxyvitamin D3 levels were measured using liquid chromatography tandem mass spectrometry and the IgE levels were measured using radioimmunoassay in both experimental and control groups.Subsequently,the serum 25-hydroxyvitamin D3 levels and IgE levels were compared between the experimental group and control group.Results:The following findings were obtained through data comparison.The serum 25-hydroxyvitamin D3 level in the experimental group was 18.19±7.84 ng/mL,and the IgE level was 551.51±705.88 IU/mL.The serum 25-hydroxyvitamin D3 level in the control group was 21.95±7.834 ng/mL,IgE level was 49.39±32.46 IU/mL.The data comparison indicates that the serum 25-hydroxyvitamin D3 level in the control group was higher than the experimental group,and the IgE level in the control group was lower than the experimental group(P<0.05).Conclusion:The level of vitamin D3 in patients with allergic symptoms is relatively low.This may be one of the causes leading to allergies.At the same time,IgE is also one of the causes contributing to allergies.An elevation of the IgE level is very likely to cause the allergic,and there is a correlation between serum vitamin D and IgE levels.At the same time,research has found that proper supplementation of vitamin D3 can help prevent allergic diseases,and can be considered in a new and highquality program for the prevention of allergic diseases.
