Analysis on Serum Trace Element Levels of Echinococciasis Patients in Garze Tibetan Autonomous Prefecture in Sichuan,China,2011

In Garze Tibetan autonomous prefecture inSichuan province, China, 41 echinococciasis patientswho had received surgical treatment were recruitedin the study, and 82 health persons who had livedin Garze for at least 10 years were selected ascontrols. The serum levels of Zn, Se and Cu of thecases and controls were detected. The resultsshowed that most echinococciasis cases weredistributed in Shiqu county （17.1%, 7/41）, and only1 case was distributed in Yajiang county （2.4%）. Themale to female ratio of the cases was 1：1.56. Theechinococciasis patients were mainly aged 30-39years （36.59%, 15/41）. And, the cases aged 20-49years accounted for 68.29% （28/41）. Comparedwith health controls, the serum levels of Zn and Seof the cases significantly declined. However, theserum level of Cu of the cases had no significantlychange. It was confirmed that the serum levels ofZn and Se were interrelated with the prevalence ofechinococciasis.

Effects of Ferrous Fumarate on Growth Performance,Blood Biochemical Parameters and Trace Elements of Oncorhynchus mykiss

[ Objective] The study aimed to discuss the effects of ferrous fumarate on growth performance, blood biochemical parameters and content of trace element of Oncorhynchus mykiss. [ Method ] Juvenile rainbow trout with an initial weight of （89.2 ±0.2） g were fed with the basal fodder supplemented with different levels of ferrous fumarate （0, 20, 40, 80,160 and 480 mg/kg iron） for 60 d, and the six groups were named DO, D20, D40, D80, D160 and D480, wherein DO was as the control group, actually containing 62.60, 79.50, 99.60, 139.30, 215.20 and 538.40 mg/kg iron respectively. [ Result] The growth performance of juvenile rainbow trout was not affected by different dietary iron levels obviously （ P 〉 0.05）. With the increase of dietary iron level, hemoglobin （Hb） content and number of red blood cells（RBC） rose firstly and then leveled off. No significance was found in hematocrit （Hct） among the six groups （P 〉0.05）. Iron content in the whole body, vertebrae and muscle increased significantly with the improvement of dietary iron level（ P 〈0.05）, and iron concentration in the liver increased firstly and then leveled off in groups from D40 to D480. No significant difference in zinc content of the whole body was found among the six groups （ P〉0.05）, while zinc content in the vertebrae and muscle in control group was significantly higher than that of other groups （ P〈0.05）, and zinc concentration in the liver in groups DO and 1320 was significantly higher than that of other groups （ P 〈0.05）. Copper content in the whole body increased significantly with the increase of dietary iron level （P 〈 0.05 ）, while no significant difference was observed in the vertebrae （ P 〉0.05）, and copper concentration in the muscle in control group was significantly lower than that of other groups （ P 〈0.05）. Serum lysozyme （LZM） activity of group DO was significantly lower than that of other groups （ P 〈 0.05） except for group D480 （ P 〉 0.05）. Catalase （CAT） activity of serum enhanced significantly （ P 〈 0.05） from DO to EH0 and then decreased obviously （P 〈0.05）. [ Conclusion] Based on hemoglobin and iron content in the liver, the broken-line model analysis showed that the dietary iron level provided by ferrous fumarate for juvenile rainbow trout was estimated to be 99.8 and 100.4 mg/kg respectively in the experiment.

Level of Contamination of Fishponds Water in Pesticide Residues and Metallic Trace Elements (Pb, Cd, As, Hg): Case of Fishponds of ZEPREGUHE (Daloa, Côte d’Ivoire)

Fishponds waters intended to satisfy the nutritional needs of the populations in terms of supply of fish resources are strongly and unfortunately exposed to the mobility and dispersion of metallic trace elements (TMEs) or to the persistence in the environment and in the form of pesticide residues from human activities. The objective of this work is to evaluate, on the one hand, the levels of identified pesticide residues and, on the other hand, those of researched TMEs (lead, cadmium, mercury and arsenic) in the waters of ponds used for fish farming in Zépréguhé, a locality located 9 km from the town of Daloa in the centre-west of Côte d’Ivoire. The dosage of the samples carried out by means of a gas chromatograph coupled to a mass spectrometer (GC/MS) made it possible to detect nine (9) pesticide molecules, including eight (8) organochlorines and a single molecule from the pyrethroid family, obtained from the detection limit of 0.006 μg/L and the quantification limit of 0.018 μg/L. The maximum average concentration was obtained with α-endosulfan for a content reaching 0.8038 μg/L and well above the maximum admissible concentration of 0.1 μg/L. The TMEs were quantified using an atomic absorption spectrophotometer (AAS). Arsenic is the most abundant metal with an average concentration of 9.497 μg/L. With the exception of lead, these measured levels are above the acceptable limit values for freshwater. This study showed that human activities such as the use of fertilisers and plant protection products in plantations, sand extraction and road traffic have a negative impact on the quality of the water in ponds used for fish breeding.

Distribution, bioaccumulation, trophic transfer and risk assessment of trace elements in fish from a typical shallow outflow lake basin, China

Fish are important food sources for humans,and the availability of appropriate amount of trace elements(TEs)plays a crucial role in fish growth.Currently,due to large volumes of sewage discharge,high levels of certain elements are present in aquatic environments,and these elements accumulate in fish and potentially affect human health.In this study,the distribution and bioaccumulation capacity of trace elements in six dominant fish species from Chaohu Lake(China)were analyzed.The results showed that the bioaccumulation capacity of fish for Zn was greater than other TEs.And the source of the TEs in the fish were explored along with the concentration of the TEs in the aquatic environment,which indicated that TEs in fish were mainly obtained through ingestion and indirectly affected by the industrial activities in the basin.Additionally,stable carbon and nitrogen isotopes were used to classify the trophic levels and explore the biological magnification of TEs of the fish.It was found that Sb and Sr showed biomagnification with the increase of trophic level of fish.Based on the above analyses,the environmental biogeochemical cycle model of TEs in the lake was distinguished and established,which can offer valuable insights for sustainable fishery management in the downstream Yangtze River Delta ecosystem.

母体微量元素状态与妊娠期糖尿病的关系

目的探讨6种微量元素(Zn、Ca、Fe、Cu、Mg和Se)的血浆水平对妊娠期糖尿病(GDM)的发生风险和血糖水平的影响。方法选取2019年10月至2021年10月在湖南省妇幼保健院接受第一次产前检查的122例孕妇作为研究对象,包括61名GDM孕妇(GDM组)和61名健康孕妇(对照组)。2组均于第一次产前检查中采集血样,测定血浆内Zn、Ca、Fe、Cu、Mg和Se的浓度。通过条件Logistic回归模型分析血浆微量元素浓度与GDM风险之间的关联,以及血糖水平与微量元素浓度之间的相关性。结果GDM组的Fe和Cu血浆浓度显著高于对照组(P<0.01),而Zn、Ca和Se的血浆浓度显著低于对照组(P<0.01)。血浆中Fe(OR=4.56,95%CI:2.68,7.79)和Cu高水平(OR=2.48,95%CI:1.48,4.16)与高GDM风险相关;血浆中Zn(OR=0.29,95%CI:0.17,0.49)和Ca(OR=0.50,95%CI:0.30,0.83)高水平与低GDM风险相关。调整主要混杂因素后多因素分析显示,血浆Zn水平与1 h-负荷血糖(PBG)(β=-0.16;95%CI:-0.11,-0.04)和2 h-PBG(β=-0.16;95%CI:-0.10,-0.04)血糖水平呈负相关;血浆Ca水平和空腹血糖水平呈负相关(调整后β=-0.11,95%CI:-0.23,-0.04),但相关性较弱。血浆Fe水平与1 h-PBG(调整后β=0.13,95%CI:0.04,0.17)和2 h-PBG水平(调整后β=0.09,95%CI:0.01,0.12)均呈正相关。结论孕妇血浆中Zn、Ca、Fe和Cu水平与妊娠早期GDM的风险显著相关,且Fe和Cu水平升高与血糖水平升高有关。

白癜风患者与健康体检者全血微量元素比较

目的分析比较健康体检者与白癜风患者全血微量元素的差异,从而探究微量元素对于白癜风发病的影响。方法选取2022年8月至2023年6月河南科技大学第二附属医院皮肤科收治的29例白癜风患者作为白癜风组;选取同期的健康人群53例作为健康组。利用Agilent 7850电感耦合等离子体质谱仪检测全血中十种微量元素(钙、镁、铁、铜、锌、铅、硒、钼、锰、铬)的含量,统计两组微量元素差异情况。结果健康组铜元素浓度高于白癜风组,差异有统计学意义(P<0.05)。两组的其余微量元素(钙、镁、铁、锌、铅、硒、钼、锰、铬)比较,差异无统计学意义(P>0.05)。结论白癜风患者相比健康体检者全血中铜元素含量降低,证明铜元素与白癜风的发病机制具有重要关系;而钙、镁、铁、锌、铅、硒、钼、锰、铬9种微量元素与白癜风的发病没有相关联系,本研究为国内微量元素与白癜风发病机制联系的研究提供了重要的数据支撑,扩展了相关检验数据统计分析量,为白癜风的临床治疗提供了重要依据。

Comparison of serum Zn, Cu and Se contents between healthy people and patients in high, middle and low incidence areas of gastric cancer of Fujian Province

ＴｏｆｉｎｄｏｕｔｔｈｅｄｉｆｅｒｅｎｃｅｏｆＺｎ，ＣｕａｎｄＳｅｃｏｎｔｅｎｔｓｉｎｔｈｅｓｅｒａｂｅｔｗｅｅｎｈｅａｌｔｈｙｇｒｏｕｐｉｎｈｉｇｈｇａｓｔｒｉｃｃａｎｃｅｒｉｎｃｉｄｅｎｃｅａｒｅａａｎｄｉｎｌｏｗｉｎｃｉｄｅｎｃｅａｒｅａ，...

The Study of Relationships between the Damage of Visual Function and Hemorrheology, Ocular Rheography, as well as Other Related Factors in Patients with Primary Open Angle Glaucoma (POAG)

Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platele...

Heavy metals in sediments and their bioaccumulation in Phragmites australis in the Anzali wetland of Iran

Accumulation of metals in both sediments and Phragmites australis organs was studied. Samples were collected from seven stations located in Anzali wetland, Iran. The samples were analyzed by inductively coupled plasma mass spectrometry(ICP-MS). The results showed that concentration of the studied metals(except As and Cd) were higher in sediments than in P.australis organs. Metal accumulation was found to be signifi cantly(P <0.05) higher in roots than in above-ground organs of P.australis. The bioaccumulation factor(BAF) and the transfer factor(TF) also verifi ed the highest rate of metal accumulation in roots and their reduced mobility from roots to the above-ground organs. Pearson correlation coeffi cient showed signifi cant relationships between metal concentrations in sediments and those in plant organs. It should be pointed out that sediment and plant samples exhibited higher metal concentrations in eastern and central parts than in western and southern parts of the wetland. The mean concentrations of all studied elements(except for Fe, V and Al) were higher in these sediment samples than in the Earth's crust and shale. High accumulation of metals in P. australis organs(roots and shoots) is indicative of their high bioavailability in sediments of the wetland. The correlation between metal concentrations in sediments and in P. australis indicates that plant organs are good bioindicators of metal pollution in sediments of Anzali wetland.

严重少弱精子症患者血液和精液中微量元素含量分析及相关性研究

目的 对比分析严重少弱精子症患者血液和精液锌、钙、铜、铁4种微量元素含量,探讨该类患者微量元素失衡的相关性,拟定调理方案及时预防和治疗因微量元素失衡所致男性不育症。方法 回顾性分析2021年6月至2022年12月该院辅助生殖科收治的确诊为严重少弱精子症患者100例作为观察组,诊断标准根据世界卫生组织第5版精液常规分析标准操作规程文件标准,且排除遗传性疾病家族史。另选取100例精子质量正常的健康体检者作为对照组。2组研究对象纳入标准:(1)年龄25~40岁;(2)既往体健,无生殖系统疾病史;(3)睾丸、附睾及输精管无创伤疾病史;(5)最近6个月无服用含有上述微量元素药物史。结果 观察组患者血液和精液锌、钙含量均明显低于对照组(P<0.05),铁、铜含量均明显高于对照组,差异均有统计学意义(P<0.05)。观察组患者血液与精液锌含量存在直线关系(r=0.746,P=0.003)。结论 严重少弱精子症患者血液和精液微量元素含量对男性生殖能力意义重大,针对性的微量元素治疗有望改善该类患者的精子质量,从而借助现代辅助生殖技术达到良好的助孕结局。

评估5种真空采血管对常见微量元素检测的影响

目的评估不同真空采血管对ICP-MS法检测微量元素的影响。方法分别采用5种真空采血管采集超纯水和11名健康志愿者静脉血,采用ICP-MS方法检测血清/血浆微量元素钴、铬、铜、锰、钼、镍、硒、锶、锌、锂,比较5种真空采血管测定不同微量元素的差异,分析采血管对检测结果的影响。结果血清管中锂、铬、锰、锶、钼、镍本底含量较高。锂在红帽血清管中含量显著高于微量元素管,铬、锰、钴、硒、镍在不同采血管之间差异有统计学意义,微量元素管检测结果比血清管测定结果降低,差异有统计学意义(P<0.05)。结论真空采血管的选择对微量元素的检测影响很大,各实验室应根据检测元素评估选择最适宜的微量元素专用真空采血管。

湖南湘西农村幼儿营养状况调查

目的:了解湖南湘西农村幼儿生长发育水平及营养状况,为少数民族地区幼儿保健及营养干预提供依据。方法:采用整群随机抽样的方法对小班399名幼儿进行体格测量,包括身高和体重测量、血液微量元素的检测,对样本儿童生长发育及营养状况进行评价。结果:样本儿童生长迟缓占比11.0%,低体重占比3.8%、消瘦占比1.5%、超重占比8.3%、肥胖占比3.8%。不同组别在生长迟缓、低体重、消瘦、超重上差异无统计学意义(P>0.05);在肥胖上差异显著(P<0.05)。不同性别在生长迟缓、低体重、超重和肥胖上差异不具有统计学意义(P>0.05);消瘦上差异显著(P<0.05)。不同家庭结构在生长迟缓、低体重、消瘦、肥胖上差异无统计学意义(P>0.05);在超重上差异显著(P<0.05)。不同县城、不同民族、是否是留守、是否是独生子样本儿童在生长迟缓、低体重、消瘦、超重和肥胖上差异无统计学意义(P>0.05)。样本儿童的血微量元素检测中,发现样本儿童缺锌(Zn)、缺铁(Fe)、缺镁(Mg)较为严重。不同县城样本儿童铜、锌、铁、镁和钙5种元素浓度差异具有统计学意义(P<0.05)。不同组别在铜、镁两种元素浓度差异显著(P<0.05);锌、铁、钙3种元素浓度差异无统计学意义(P>0.05)。不同民族在铜、铁两种元素浓度差异无统计学意义(P>0.05);锌、镁、钙3种元素浓度差异具有统计学意义(P<0.05),且差异显著。不同性别、不同家庭结构、留守与非留守、是否独生子女在铜、锌、铁、镁和钙5种元素浓度差异无统计学意义(P>0.05)。结论:样本儿童的总体营养不足,发病率仍较高,其营养状况仍有提升空间。

温控湿法消解ICP-MS测定全血中铅镉硒砷汞5种微量元素

采用温控HNO3-H2O2湿法消解,ICP-MS测定全血中Pb,Cd,Se,As,Hg 5种微量元素的含量。在选定的测试条件下,仪器系统稳定性良好,Pb等5种元素的检出限范围2～40 ng.L-1,全过程中样品均重复测定3次,RSD均在3%内。采用国家全血溶液标准物质GBW(E)09034-09036和人发标准物质GBW09101b中的相应元素进行质量控制,检测结果和推荐值相吻合。同时,应用本方法实测了湘西汞矿区34名村民全血中的5种元素的含量,结果表明:矿区村民Se和As处于正常水平,血Pb、血Cd、血Hg含量均偏高,有较高的健康风险,应当引起有关部门的重视。本方法快速、灵敏,精密度及准确度均符合要求,适于人体全血样中Pb,Cd,Se,As,Hg等微量元素的测定。

孕妇全血、脐血中微量元素和重金属元素检测及相关性探讨

目的检测孕妇全血(简称母血)及脐血中微量元素和重金属元素水平,并分析两者之间的相关性。方法采集上海市和辽宁省大连市249例健康孕妇母血及259例胎儿脐血(其中母血和脐血配对241对);采用电感耦合等离子质谱系统检测全血中的铜(Cu)、铁(Fe)、硒(Se)、锰(Mn)、锌(Zn)、铅(Pb)、镉(Cd)的质量浓度;采用自动测汞仪测定全血中汞(Hg)的质量浓度。采用Spearm an相关分析对母血与脐血中各元素水平的相关性进行分析。结果母血中Cu、Se、Zn、Pb和Cd的质量浓度分别为1 493.0、126.2、6 260.0、57.2和1.1μg/L,明显高于脐血中的614.6、107.6、2 150.0、35.0和0.6μg/L(P<0.01);脐血中的Fe、Mn和Hg的质量浓度分别为512.2、77.1和2.4μg/L,明显高于母血中的432.6、52.9和1.5μg/L(P<0.01)。其中,1.2%(3/249)的母血Hg和3.4%(9/259)的脐血Hg超过美国环境保护局推荐的参考标准(5.8μg/L);12.0%(30/249)的母血Pb和5.8%(15/259)的脐血Pb超过联邦职业环境卫生委员会推荐的参考标准(100μg/L);5.6%(14/249)的母血Cd和3.5%(9/259)的脐血Cd超过美国职业安全与卫生管理局推荐的参考标准(5μg/L)。除Fe元素外,其他元素在母血和脐血中的质量浓度均呈正相关(P<0.01)。结论一定比例的母血和脐血中Pb、Cd、Hg水平超过有关机构推荐的参考标准;微量元素及重金属元素在母血中的水平与在胎儿脐血中的水平有一定相关性,孕期应合理补充微量元素并监测重金属元素水平。

不同年龄儿童全血锌铅钙铁值的调查结果分析

目的：了解近几年北京市海淀区儿童全血锌、铅、钙、铁等微量元素的含量，以提高儿童保健水平。方法：随机选取海淀区健康儿童544名，按不同年龄段分为4个年龄组。采集静脉血1ml，用火焰原子吸收法测定血锌、钙、铁含量，用石墨炉原子吸收法测定血铅含量。结果：①血铅水平≥0．1μg／ml者占43．2％，男女性别之间无显著性差异，血铅水平随年龄增长有上升趋势。0～1岁组血铅最低，3～6岁组血铅最高；②血锌、钙、铁水平随年龄增长而上升，血锌6～12岁组明显高于1～3岁组，血钙、铁6～12岁组明显高于0～1岁组，男女性别之间无显著性差异；③血铅增高率与血钙缺乏率各组之间差异有显著意义，血锌与血铁缺乏率各组之间比较则无显著性差异。结论：①由于环境、生活习惯、空气污染等各方面的影响，学龄前儿童的血铅水平较高；②婴幼儿期是锌、钙、铁营养不良的防治重点；③随年龄增长，饮食多样化，锌、钙、铁营养状况明显改善。

献血员血清中20种元素的ICP-MS测定

用电感耦合等离子体质谱（ＩＣＰ－ ＭＳ） 测定献血员血清中２０ 种元素， 采用多元素内标法校正基体效应引起的系统误差， 加入内标元素Ｓｃ 、Ｉｎ 和Ｔｌ 分别校正质量数＜ １００ 、１００ ～１８０ 和＞ １８０ 的元素测定， 用牛血清标样ＧＢＷ ０９１３１ 为质控标准物质， 检验方法的可靠性。 测定了献血组和健康对照组血清中微量元素含量， 进行数理统计， 检验其差异性。

2～6岁儿童全血微量元素和铅含量调查

目的：调查石家庄市2—6岁儿童全血微量元素（Cu、Fe、Ca、Mg、Zn）和铅状况，以便制定合理的膳食结构，纠正儿童不良的饮食习惯和行为，保障儿童的生长、发育。方法：采用随机整群抽样的方式从8所幼儿园中抽取儿童1581名，其中男835名；女746名。按年龄分成4组。2岁一组360名；3岁一组408名；4岁一组420名；5岁～组393名。采用原子吸收分光光度仪和阳极溶出电解仪分别对儿童全血微量元素和铅进行测定。利用SPSS11．0统计软件包进行数据处理，对不同年龄、不同性别间进行F、t检验作统计分析。结果；以平均值±1倍标准差的形式来表示所有儿童全血微量和铅的测定结果如下（-↑x±5）：Fe，（5．14±1．17）斗μmol／L；Ca，（1．15±0．27）mmoL／L；Zn，（107±20．9）μmol／L；Cu，（20．43±7．48）μmol/L；Mg，（1．70±0．45）mmol／L；Pb，0．357±0．13μmol／L。除Mg、Cu缺乏较少外，Ca、Zn、Fe的缺乏和铅中毒都占相当的比例，各元素间除血铅性别间差异有显著性外。其它元素性别、年龄间差别均无显著性。结论：石家庄市2—6岁儿童全血Fe、Ca、Zn缺乏和铅中毒有相当高的比率．Mg和Cu缺乏的比率较低．

儿童多动症与血微量元素水平关系的探讨

目的:探讨儿童多动症(ADHD)和血微量元素铅(Pb)、镉(Cd)、锌(Zn)、铜(Cu)、铁(Fe)、钙(Ca)、镁(Mg)水平的关系。方法:用原子吸收分光光度法对60例ADHD患儿及50例对照组进行血Pb、Cd、Zn、Cu、Fe、Ca、Mg水平测定。结果:ADHD患儿血铅水平93±18.01μg/L明显高于对照组50±20.49μg/L(P<0.001),血锌水平62.42±12.80μmol/L明显低于对照组73.23±13.36μmol/L(P<0.001)。结论:ADHD患儿多伴铅过量、锌缺乏,血铅越高,注意缺陷越明显,在诊治时应常规检测并及早纠正。

男性血液和精液中微量元素含量与精子活力的相关性研究

目的:探讨男性血液和精液中微量元素的分布及其与男性精液参数的相关性。方法:采用BH-5100五通道原子吸收仪、YY-1001血铅仪和伟力彩色精子自动分析仪,对113例男性血液和精液进行钙、镁、铜、锌、铁、铅的测定及精液常规分析,以了解微量元素和精液参数的相互关系。结果:①血液与精液中铅、铜、锌、铁含量显著相关,其中以铜的相关系数最大;钙、镁没有相关性。②血液和精液中铅、铜、锌、钙、镁、铁6种微量元素分布存在显著性差异。③精液中钙与精子活率、直线运动精子活率、曲线速度、平均移动角度、活跃精子密度、直线速度、平均路径速度、侧摆幅度等指标显著正相关;铅与精子活率、直线运动精子活率、活跃精子密度、活动精子密度、直线运动精子密度等指标呈显著负相关;镁元素与精子活率、直线运动精子活率、直线运动精子密度呈显著负相关;精液酸碱度与钙、镁、铁3种元素呈显著负相关。④血液中的锌与精子活率和直线运动精子活率呈显著负相关,镁与精子活率、直线运动精子活率、平均路径速度呈显著负相关,铅与侧摆幅度呈显著正相关。结论:不同体液中的微量元素分布和精子的运动功能存在不同的相关性。

血铅和血镉等多因素与高血压的相关性研究

目的探讨血铅和血镉及多种危险因素与原发性高血压之间的关系。方法随机抽取杭州城区与农村社区各1个,对40岁以上长住户籍共471人进行问卷调查与健康体检,检测血铅、血镉及其他多种危险因素指标,进行多因素相关分析。结果 (1)共453人获得完整资料,高血压组212人,正常血压组241人,高血压组的年龄、收缩压、舒张压水平均明显高于血压正常组,差异有统计学意义(t值分别为4.03、16.56、10.61,P<0.01)。(2)有高血压家族史、吸烟、饮酒、高盐饮食、高脂饮食和缺乏运动的人数以及体质指数、腰围、总胆固醇和血铅、血镉检测值高血压组明显高于血压正常组,差异有统计学意义(P<0.01),高血压组空腹血糖明显高于血压正常组,差异有统计学意义(P<0.05)。(3)多因素Logistic回归分析显示年龄、高血压家族史、饮酒、高盐饮食、体质指数、腰围、血铅、血镉和总胆固醇与高血压发病有密切关系(OR=1.01～12.77,P<0.01)。结论血铅、血镉和年龄、高血压家族史、饮酒、高盐饮食、肥胖以及总胆固醇增高均与原发性高血压发病有密切关系,在高血压的发生发展中起着一定作用。