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Instrumented oscillographic study on impact toughness of an axle steel DZ2 with different tempering temperatures
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作者 Shuo Liu Peng Zhang +6 位作者 Bin Wang Kaizhong Wang Zikuan Xu Fangzhong Hu Xin Bai Qiqiang Duan Zhefeng Zhang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第7期1590-1598,共9页
Compared with the conventional Charpy impact test method,the oscillographic impact test can help in the behavioral analysis of materials during the fracture process.In this study,the trade-off relationship between the... Compared with the conventional Charpy impact test method,the oscillographic impact test can help in the behavioral analysis of materials during the fracture process.In this study,the trade-off relationship between the strength and toughness of a DZ2 axle steel at various tempering temperatures and the cause of the improvement in impact toughness was evaluated.The tempering process dramatically influenced carbide precipitation behavior,which resulted in different aspect ratios of carbides.Impact toughness improved along with the rise in tempering temperature mainly due to the increase in energy required in impact crack propagation.The characteristics of the impact crack propagation process were studied through a comprehensive analysis of stress distribution,oscilloscopic impact statistics,fracture morphology,and carbide morphology.The poor impact toughness of low-tempering-temperature specimens was attributed to the increased number of stress concentration points caused by carbide morphology in the small plastic zone during the propagation process,which resulted in a mixed distribution of brittle and ductile fractures on the fracture surface. 展开更多
关键词 axle steel DZ2 tempering process impact toughness oscillographic impact test impact crack propagation carbides
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Effect of Seasonal Variations on the Behavior of Flexible Pavements in Burkina Faso: Towards Alternating and Periodic Loading of Multi-Axle Heavy Goods Vehicles for Road Durability
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作者 Kokoro Kobori Doua Allain Gnabahou Bouto Kossi Imbga 《Journal of Materials Science and Chemical Engineering》 2024年第6期24-42,共19页
Bituminous materials are heat-sensitive, and their mechanical properties vary with temperature. This variation in properties is not without consequences on the performance of flexible road structures under the repeate... Bituminous materials are heat-sensitive, and their mechanical properties vary with temperature. This variation in properties is not without consequences on the performance of flexible road structures under the repeated passage of multi-axles. This study determines the influence of seasonal variations on the rate of permanent deformation, the rut depth of flexible pavements and the effect of alternating loading of heavy goods vehicles following the temperature variations on the durability of roads. Thus, an ambient and pavement surface temperature measurement was carried out in 2022. The temperature profile at different layers of the modelled pavement, the evaluation of deformation rates and rutting depth were determined using several models. The results show that the permanent deformation and rutting rates are higher at the level of the bituminous concrete layer than at the level of the asphalt gravel layer because the stresses decrease from the surface to the depth of the pavement. On the other hand, the variations in these rates, permanent deformations and ruts between the hot and so-called cold periods are more pronounced in the bitumen gravel than in bituminous concrete, showing that gravel bitumen is more sensitive to temperature variations than bituminous concrete despite its higher rigidity. Of these results, we suggested a periodic and alternating loading of the different types of heavy goods vehicles. These loads consist of fully applying the WAEMU standards with a tolerance of 15% during periods of high and low temperatures. This regulation has increased 2 to 3 times in the durability of roadways depending on the type of heavy goods vehicle. 展开更多
关键词 PAVEMENT RUTTING Permanent Deformation Multi-axle Seasonal
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可溶性Axl受体酪氨酸激酶在老年急性失代偿性心力衰竭患者短期预后中的价值
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作者 马同亮 韩若东 +1 位作者 黄羽 朱德才 《中华老年心脑血管病杂志》 CAS 北大核心 2024年第3期262-266,共5页
目的 探讨急性失代偿性心力衰竭(ADHF)患者血清可溶性Axl受体酪氨酸激酶(sAxlTK)水平在评估短期预后中的临床价值。方法 选择2018年1月1日至2021年10月1日亳州市人民医院收治的老年ADHF患者238例,根据随访90 d内复合事件发生情况分为预... 目的 探讨急性失代偿性心力衰竭(ADHF)患者血清可溶性Axl受体酪氨酸激酶(sAxlTK)水平在评估短期预后中的临床价值。方法 选择2018年1月1日至2021年10月1日亳州市人民医院收治的老年ADHF患者238例,根据随访90 d内复合事件发生情况分为预后不良组45例和预后良好组193例。又根据血清sAxlTK最佳截断值分为高水平组80例和低水平组158例。检测血清sAxlTK、肌钙蛋白I(cTnI)和N末端B型钠尿肽前体(NT-proBNP)水平。结果 预后不良组血清sAxlTK水平明显高于预后良好组[43.89(33.95,51.44)μg/L vs 23.89(18.73,33.92)μg/L,P<0.01]。多因素logistic回归分析显示,血清cTnI和sAxlTK是ADHF患者短期预后不良的独立危险因素(OR=1.922,95%CI:1.035~3.568,P=0.039;OR=1.021,95%CI:1.008~1.034,P=0.001)。ROC曲线分析显示,血清sAxlTK、cTnI和NT-proBNP联合预测短期预后不良的曲线下面积为0.836(95%CI:0.778~0.895)。高水平组90 d内复合事件发生率明显高于低水平组(45.0%vs 5.7%,P<0.05)。Kaplan-Meier曲线分析显示,高水平组复合事件累积发生率较低水平组更高(χ^(2)=66.991,P_(log rank)<0.01)。高水平组总生存率较低水平组更低,生存预后更差(χ^(2)=16.899,P_(log rank)<0.01)。结论 老年ADHF患者入院时高血清sAxlTK水平与短期预后不良高风险有关。血清sAxlTK有希望成为短期预后不良早期预测的有用工具,且其与cTnI、NT-proBNP联合使用可进一步提高预后预测准确性。 展开更多
关键词 心力衰竭 axl受体酪氨酸激酶 预后 预测 危险因素
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受体酪氨酸激酶AXL在肿瘤生物学中的作用研究进展
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作者 何凯桐 周阳 +2 位作者 王明珠 郭婷 孙轶华 《现代肿瘤医学》 CAS 2024年第1期167-171,共5页
AXL是一种受体酪氨酸激酶(receptor tyrosine kinase,RTK),属于TAM(TYRO3-AXL-MER)家族。在生理条件下,AXL表达于人体的心脏、骨骼肌、甲状腺中。AXL通过调控多条信号通路介导了肿瘤细胞的血管生成、迁移、侵袭、增殖与转移等过程。此外... AXL是一种受体酪氨酸激酶(receptor tyrosine kinase,RTK),属于TAM(TYRO3-AXL-MER)家族。在生理条件下,AXL表达于人体的心脏、骨骼肌、甲状腺中。AXL通过调控多条信号通路介导了肿瘤细胞的血管生成、迁移、侵袭、增殖与转移等过程。此外,AXL在多种癌症中高表达,对于肿瘤患者的预后评价具有重要意义,并极有可能成为一种新的诊断及预后生物标志物和治疗靶点。本文就近年来AXL在肿瘤生物学中的作用研究进展进行综述。 展开更多
关键词 受体酪氨酸激酶 axl 肿瘤 耐药
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Research on fatigue evaluation method of high-speed train axle based on axle box acceleration
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作者 Wenjing Wang Yiming Zeng +1 位作者 Ruiguo Yan Yiyue Chen 《High-Speed Railway》 2023年第4期233-240,共8页
As a key safety component of the high-speed train, fatigue fracture of the axle would lead to major accidents such as derailment or overturning. The complexity of the axle dynamic stress test seriously enhances the di... As a key safety component of the high-speed train, fatigue fracture of the axle would lead to major accidents such as derailment or overturning. The complexity of the axle dynamic stress test seriously enhances the difficulty of axle fatigue damage analysis. In this paper, the dynamic stress test of the high-speed train axle was carried out,the axle box acceleration was monitored on-track during the test, and the relationship between the axle stress spectrum and acceleration was analyzed on-track. The results show that the relationships between the axle equivalent stresses and the Root Mean Square(RMS) values of the axle box vertical acceleration and lateral acceleration exhibit a strong joint probability density distribution. The concept of the virtual surface density of wheel-rail contact is also proposed to realize the purpose of using axle box acceleration to deduce axle equivalent force. The results quantify the relationship between axle box acceleration and axle equivalent force, provide a new method for predicting the axle damage using the acceleration RMS values, and open up a new approach for structural health monitoring of high-speed train axles. 展开更多
关键词 High-speed train axles axle-box acceleration Dynamic stress of wheelset axle Fatigue damage Wheel-rail contact virtual surface density
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Factors determining changes in the network of marked hiking trails in the Sudetes
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作者 Krzysztof KOŁODZIEJCZYK 《Journal of Mountain Science》 SCIE CSCD 2024年第4期1075-1099,共25页
Hiking trails are a basic type of tourist infrastructure,which,on the one hand,make areas available for tourist traffic,and on the other hand,can contribute to the protection of the natural environment(if they are wel... Hiking trails are a basic type of tourist infrastructure,which,on the one hand,make areas available for tourist traffic,and on the other hand,can contribute to the protection of the natural environment(if they are well designed and maintained).Owing to the variety of performed functions,their designation is determined by several factors:natural,technical,economic,social.Networks of trails change constantly.The aim of this article is to determine exactly what factors influence transformations within the hiking trail networks and what is their significance.To this end,three study areas in the Sudetes were analysed:one on the Polish side of the Sudetes-the Table(Stołowe)Mountains,and two on the Czech side-the rock town near the village of Sloup vČechách and the central part of Zlatohorskávrchovina.An analysis of changes in the shape of the networks over time was carried out,as well as surveys of institutions that were responsible for or influenced these transformations.These areas are characterised by a significant level of changes in the trail network.Among the factors influencing these changes,the tourist attractiveness of the area,the resilience of the environment,the intensity of tourism traffic,the environmental transformations associated with it,the history of tourism development and land ownership changes should be considered the most important.At each stage of forming networks,the key factor should be tourists’needs,including the desire to escape the urbanised environment.For this reason,trails should avoid roads with artificial(hard)surfaces and heavy automobile traffic. 展开更多
关键词 Hiking trails trail networks Graphs Tourist traffic SUDETES
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血清TRAIL水平与晚期非小细胞肺癌患者免疫治疗反应的关联性研究
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作者 张雅君 张振安 +2 位作者 王继华 周媛 梁凤霞 《中国临床新医学》 2024年第6期645-650,共6页
目的探讨血清肿瘤坏死因子相关凋亡诱导配体(TRAIL)水平与晚期非小细胞肺癌(NSCLC)患者免疫治疗反应的关联性。方法回顾性分析2019年1月至2020年5月唐山市人民医院收治的70例晚期NSCLC患者的临床资料。在免疫治疗前24 h内采用酶联免疫... 目的探讨血清肿瘤坏死因子相关凋亡诱导配体(TRAIL)水平与晚期非小细胞肺癌(NSCLC)患者免疫治疗反应的关联性。方法回顾性分析2019年1月至2020年5月唐山市人民医院收治的70例晚期NSCLC患者的临床资料。在免疫治疗前24 h内采用酶联免疫吸附试验法(ELISA)测定患者血清TRAIL水平。免疫治疗反应通过客观缓解率(ORR)和临床获益率(CBR)进行评估。分析患者血清TRAIL水平与免疫治疗反应、肺功能及肺气肿、临床预后的关联性。结果经免疫治疗后,NSCLC患者获得客观缓解23例,临床获益46例。获得客观缓解患者的血清TRAIL水平显著高于未获得客观缓解者[27.77(23.13,39.13)pg/mL vs 12.36(8.76,18.15)pg/mL;Z=4.508,P<0.001]。临床获益患者的血清TRAIL水平显著高于临床未获益者[23.13(16.99,30.63)pg/mL vs 11.75(8.76,15.56)pg/mL;Z=4.887,P<0.001]。Spearman秩相关性分析结果显示,血清TRAIL水平与1秒用力呼气容积/用力肺活量(FEV1/FVC)呈正相关(rs=0.288,P=0.016),与肺气肿总比值(rs=-0.257,P=0.032)、肺叶肺气肿比率(LER)(rs=-0.324,P=0.006)呈负相关。多因素logistic回归分析结果显示,以血清TRAIL>27.46 pg/mL为参考,血清TRAIL<18.15 pg/mL患者经免疫治疗不能获得客观缓解和临床获益的风险显著增加(P<0.05)。ROC曲线分析结果显示,血清TRAIL水平可有效预测NSCLC患者对免疫治疗的反应(P<0.05)。TRAIL高水平组(血清TRAIL≥18.15 pg/mL)的总体生存(OS)、无进展生存(PFS)预后显著优于TRAIL低水平组(血清TRAIL<18.15 pg/mL)(P<0.05)。结论血清TRAIL低水平与晚期NSCLC患者免疫治疗无反应以及临床预后不良有关,该指标监测有助于筛选能从免疫治疗中获益的NSCLC患者。 展开更多
关键词 肿瘤坏死因子相关凋亡诱导配体 晚期非小细胞肺癌 免疫治疗反应 肺气肿 预后
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血清Occludin、Axl水平与急性缺血性脑卒中溶栓后出血转化的关系
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作者 张立娜 王海虹 王适达 《国际检验医学杂志》 CAS 2024年第2期246-249,共4页
目的探讨血清闭合蛋白(Occludin)、Axl水平与急性缺血性脑卒中(AIS)溶栓治疗后出血转化(HT)的关系。方法选取2019年1月至2022年1月该院AIS患者126例为研究对象,根据是否发生HT分为HT组(43例)和非HT组(83例)。比较两组一般资料及血清Occl... 目的探讨血清闭合蛋白(Occludin)、Axl水平与急性缺血性脑卒中(AIS)溶栓治疗后出血转化(HT)的关系。方法选取2019年1月至2022年1月该院AIS患者126例为研究对象,根据是否发生HT分为HT组(43例)和非HT组(83例)。比较两组一般资料及血清Occludin、Axl水平,采用多因素Logistic回归分析AIS患者发生HT的影响因素,采用受试者工作特征(ROC)曲线分析血清Occludin、Axl对AIS患者发生HT的预测价值,并分析血清Occludin、Axl预测HT发生的交互作用。结果两组心房颤动、入院时美国国立卫生研究院卒中量表(NIHSS)评分及血清Occludin、Axl水平比较,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,心房颤动、入院时NIHSS评分高、血清Occludin高水平、Axl低水平均为AIS患者发生HT的独立危险因素(P<0.05);ROC曲线结果显示,血清Occludin、Axl预测AIS患者溶栓治疗后HT风险均有较高价值,二者联合预测的曲线下面积(AUC)、灵敏度、特异度分别为0.742、70.73%、66.93%。Occludin和Axl对HT发生存在负向交互作用。结论AIS患者血清Occludin、Axl均异常表达,可作为HT的预测指标,且二者对HT发生存在负向交互作用。 展开更多
关键词 闭合蛋白 axl 急性缺血性脑卒中 出血转化 交互作用
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Performance of the walking trail making test in older adults with white matter hyperintensities
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作者 Hong-Yi Zhao Zhi-Qiang Zhang +2 位作者 Yong-Hua Huang Hong Li Fang-Yuan Wei 《World Journal of Psychiatry》 SCIE 2024年第1期102-110,共9页
BACKGROUND Several studies have reported that the walking trail making test(WTMT)completion time is significantly higher in patients with developmental coordination disorders and mild cognitive impairments.We hypothes... BACKGROUND Several studies have reported that the walking trail making test(WTMT)completion time is significantly higher in patients with developmental coordination disorders and mild cognitive impairments.We hypothesized that WTMT performance would be altered in older adults with white matter hyperintensities(WMH).AIM To explore the performance in the WTMT in older people with WMH.METHODS In this single-center,observational study,25 elderly WMH patients admitted to our hospital from June 2019 to June 2020 served as the WMH group and 20 participants matched for age,gender,and educational level who were undergoing physical examination in our hospital during the same period served as the control group.The participants completed the WTMT-A and WTMT-B to obtain their gait parameters,including WTMT-A completion time,WTMT-B completion time,speed,step length,cadence,and stance phase percent.White matter lesions were scored according to the Fazekas scale.Multiple neuropsychological assessments were carried out to assess cognitive function.The relationships between WTMT performance and cognition and motion in elderly patients with WMH were analyzed by partial Pearson correlation analysis.RESULTS Patients with WMH performed significantly worse on the choice reaction test(CRT)(0.51±0.09 s vs 0.44±0.06 s,P=0.007),verbal fluency test(VFT,14.2±2.75 vs 16.65±3.54,P=0.012),and digit symbol substitution test(16.00±2.75 vs 18.40±3.27,P=0.010)than participants in the control group.The WMH group also required significantly more time to complete the WTMT-A(93.00±10.76 s vs 70.55±11.28 s,P<0.001)and WTMT-B(109.72±12.26 s vs 82.85±7.90 s,P<0.001).WTMT-A completion time was positively correlated with CRT time(r=0.460,P=0.001),while WTMT-B completion time was negatively correlated with VFT(r=-0.391,P=0.008).On the WTMT-A,only speed was found to statistically differ between the WMH and control groups(0.803±0.096 vs 0.975±0.050 m/s,P<0.001),whereas on the WTMT-B,the WMH group exhibited a significantly lower speed(0.778±0.111 vs 0.970±0.053 m/s,P<0.001)and cadence(82.600±4.140 vs 85.500±5.020 steps/m,P=0.039),as well as a higher stance phase percentage(65.061±1.813%vs 63.513±2.465%,P=0.019)relative to controls.CONCLUSION Older adults with WMH showed obviously poorer WTMT performance.WTMT could be a potential indicator for cognitive and motor deficits in patients with WMH. 展开更多
关键词 White matter hyperintensities Cognitive dysfunction Motor deficits Gait analysis trail making test Small vessel disease
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Impact of Multi-Axle Vehicles and Road Overloads on the Durability of Asphalt Pavements
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作者 Kokoro Kobori Doua Allain Gnabahou +1 位作者 Kossi Imbga Alphonse Sibri Sandwidi 《Open Journal of Civil Engineering》 2023年第2期237-251,共15页
The multiplication of heavy vehicle axles and road overloads are phenomena that are becoming increasingly important on the road network of the WAEMU community. These phenomena, although framed by standards, have an im... The multiplication of heavy vehicle axles and road overloads are phenomena that are becoming increasingly important on the road network of the WAEMU community. These phenomena, although framed by standards, have an impact on the durability of pavements. In this manuscript it is a question of evaluating the life of the road under the effect of traffic of these multi-axle vehicles and the different tolerances of overloads observed on the road network. To achieve this, a modeling of a bituminous pavement was made with the software ALIZE Lcpc Version 231 based on the principle of the French method of sizing. An inventory of multi-axle heavy goods vehicles was also made on a road with a weighing station. This traffic counting made it possible to classify heavy goods vehicles into three categories, namely: 1) trucks, 2) dual-wheeled semi-trailers and 3) single-wheeled semi-trailers. The results obtained show that in terms of aggressiveness, single-wheeled semi-trailers are the most aggressive, followed by heavy goods vehicles in the category of trucks with more than five axles and semi-trailers with dual wheels with more than seven axles. The durability of the road depends on the aggressiveness of heavy goods vehicles, it was found that the tolerance threshold for overloads of 15% of the total permissible rolling weight (TARW) or the total permissible laden weight (TALW) currently granted in the Community area needs to be reviewed. For durable road surfaces, this tolerance may only be allowed for heavy goods vehicles of type P11, P12 and P13. The 5% tolerance can be applied to all vehicles except heavy goods vehicles with single wheels. 展开更多
关键词 AGGRESSIVENESS Multi-axle TARW TALW Allowable Deformation Modeling
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rNDV-IL-2和rNDV-TRAIL治疗肿瘤的协同作用
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作者 李思明 盛美琳 +1 位作者 吴毓斌 白福良 《哈尔滨商业大学学报(自然科学版)》 CAS 2024年第3期273-280,共8页
通过比较rNDV表达的白细胞介素-2(IL-2)和肿瘤坏死因子相关凋亡诱导配体(TRAIL)治疗肿瘤的效果,并进一步探讨联合应用rNDV-IL-2和rNDV-TRAIL是否在肿瘤治疗中产生协同效应.体外培养H22肝癌细胞株和B16-F10黑色素瘤细胞株,并建立小鼠H22... 通过比较rNDV表达的白细胞介素-2(IL-2)和肿瘤坏死因子相关凋亡诱导配体(TRAIL)治疗肿瘤的效果,并进一步探讨联合应用rNDV-IL-2和rNDV-TRAIL是否在肿瘤治疗中产生协同效应.体外培养H22肝癌细胞株和B16-F10黑色素瘤细胞株,并建立小鼠H22肝癌和B16-F10黑色素瘤动物模型,注射rNDV-IL-2和rNDV-TRAIL病毒进行治疗.同时注射人IL-2和TRAIL的重组新城疫病毒(rNDV-IL-2+rNDV-TRAIL)显著提高了rNDV通过诱导细胞凋亡来杀伤肿瘤细胞的能力.小鼠肝癌和恶性黑色素模型鼠的治疗实验表明,与对照相比,rNDV-IL-2或rNDV-TRAIL显著抑制了肿瘤的生长并延长荷瘤小鼠的存活.与rNDV-IL-2和rNDV-TRAIL治疗组相比较,rNDV-IL-2+rNDV-TRAIL联合治疗进一步增强了rNDV的抗肿瘤功效,并进一步延长了动物的存活时间.动物实验结果还表明,荷瘤鼠rNDV-IL-2和rNDV-IL-2+rNDV-TRAIL治疗后均可诱导系小鼠体内的CD4^(+)细胞和CD8^(+)细胞的增殖,并且rNDV-IL-2+rNDV-TRAIL联合治疗表现出明显的协同作用.rNDV-IL-2+rNDV-TRAIL联合治疗在体内外均能够明显抑制肿瘤增殖,较单一应用rNDV-IL-2或rNDV-TRAIL有更好的效果,值得进一步深入研究. 展开更多
关键词 重组新城疫病毒 癌症治疗 白细胞介素-2 肿瘤坏死因子相关凋亡诱导配体 协同治疗
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组织蛋白酶B联合TRAIL诱导胃癌BGC-823细胞凋亡中的作用研究
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作者 查道德 涂龙霞 吴文涌 《包头医学院学报》 CAS 2023年第1期4-7,共4页
目的:观察组织蛋白酶B(CTSB)联合TRAIL诱导胃癌BGC-823细胞凋亡的作用。方法:BGC-823细胞传代培养。采用MTT法检测细胞增殖情况,流式细胞仪检测细胞凋亡率以及免疫印迹法(Western blot)检测Cathepsin B蛋白表达。结果:TRAIL对BGC-823细... 目的:观察组织蛋白酶B(CTSB)联合TRAIL诱导胃癌BGC-823细胞凋亡的作用。方法:BGC-823细胞传代培养。采用MTT法检测细胞增殖情况,流式细胞仪检测细胞凋亡率以及免疫印迹法(Western blot)检测Cathepsin B蛋白表达。结果:TRAIL对BGC-823细胞增殖有抑制作用,对细胞凋亡有促进作用(P<0.05);Cathepsin B抑制剂浓度越高,细胞凋亡率越低(P<0.05);Western blot结果表明,Cathepsin B抑制剂浓度越高,Cathepsin B表达越少(P<0.05)。结论:Cathepsin B和TRAIL联合使用有协同诱导胃腺癌BGC-823细胞凋亡作用。 展开更多
关键词 组织蛋白酶B 肿瘤坏死因子 凋亡配体 BGC-823细胞 细胞凋亡
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Finite element analysis of welding distortion control by trailing intense cooling 被引量:5
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作者 郭绍庆 徐文立 +3 位作者 刘雪松 李晓红 万鑫 田锡唐 《China Welding》 EI CAS 2000年第2期47-54,共8页
A new moving or dynamic thermal tensioning technique-welding with trailing intense cooling was numerically simulated by finite element method(FEM)and experimentally investigated.The simulation results indicate that tr... A new moving or dynamic thermal tensioning technique-welding with trailing intense cooling was numerically simulated by finite element method(FEM)and experimentally investigated.The simulation results indicate that trailing intense cooling can increase significantly the longitudinal tensile plastic strain within the weld and its adjacent zone during cooling stage,which can partially or completely counterbalance the longitudinal compressive plastic strain formed in the heating stage and the solidification shrinkage formed in the cooling stage.Therefore the longitudinal shrinkage remaining in the weld and the adjacent zone is greatly reduced,which means that the residual stresses in the weldments are kept in a lower value and the residual distortion can be mitigated effectively.Meanwhile a series of parametric studies were conducted to demonstrate the influences of several key parameters such as cooling distance, cooling power and cooling width on the effectiveness of distortion control.Experimental results also verify the effectiveness of this distortion control technique and the reliability of the numerical simulation. 展开更多
关键词 welding distortion trailing intense cooling finite element analysisd
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Simulation Research on Stress Intensity Factors of Different Crack Aspect Ratios on Hollow Axles 被引量:2
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作者 ZHOU Suxia XIE Jilong 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2009年第5期766-771,共6页
Because of the wicked service environment of the high speed train, it is possible that the hollow axle of the train may encounter the foreign object damage and form a sharp notch. Under the fatigue loading a crack can... Because of the wicked service environment of the high speed train, it is possible that the hollow axle of the train may encounter the foreign object damage and form a sharp notch. Under the fatigue loading a crack can initiate from the notch and propagate to failure. It is noted that the stress intensity factor is the control parameter of the crack propagating, for the purpose of getting the more exact propagation characteristics, the stress intensity factor is studied mainly. The service loads of hollow axles are defined, and the stress distribution of hollow axles is obtained according to the load spectrum. The semi-ellipse crack configuration is defined with three parameters: the aspect ratio, the relative depth and the relative location along the crack front. Quarter point 20-node isoparametric degenerate singular elements are used for the region near the crack tip. The finite element model of crack extension of hollow axle is created, and the crack front is dispersed which can realize orthogonal extension. Based on this the stress intensity factors of crack front were calculated, and the distribution rules of the stress intensity factors of different initial crack shapes are obtained. The conclusions are compared with that of the analytic method and they agree with each other very well, and the calculating results show that there is a close relationship between the stress intensity factor and the initial crack shape. For a round crack the stress intensity factor at the surface point increases faster than the one at the center point with the crock propagation. However, for a narrow crack, the results are in contrast with that of a round one. So, all the cracks with different shapes propagate toward to a similar shape, and they grow at this shape to end. The study may contribute to the crack propagate characteristics research. 展开更多
关键词 hollow axle surface crack propagation stress intensity factor finite element
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Analysis of Quenching Stresses in 35CrMo Axle 被引量:2
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作者 龚海 WU Yunxin +1 位作者 FENG Xiaolei LI Yihua 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2016年第3期630-635,共6页
By using the finite element method (FEM), we comprehensively analyzed the fields of temperature, organization, and stress in 35CrMo train axles during the quenching process is conducted, and experimentally studied t... By using the finite element method (FEM), we comprehensively analyzed the fields of temperature, organization, and stress in 35CrMo train axles during the quenching process is conducted, and experimentally studied the formation and evolution of inner stresses in axles during the quenching process. The results show that in the quenching process, stresses on the axle surface change from tensile to compressive gradually, while stresses in the axle core change from compressive to tensile gradually. Heat stresses and the amount of martensitic transformation are all increased with the increase of cooling rate. As a result, the maximmn instantaneous stresses in the axle are increased greatly when the cooling rate is increased with brine quenching. Large instantaneous tensile stress in the axle core with brine quenching is very likely to cause quench cracking and should be avoided. 展开更多
关键词 35CrMo axle QUENCHING residual stress FEM X-ray diffraction
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Analysis and Optimization on Factors Affecting Forming Quality of Half Axle Gears Warm Precision Forging 被引量:2
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作者 WANG Menghan CHEN Xihou ZHOU Jie 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2010年第1期110-114,共5页
Half axle gears is produced by precision forging popularly because of the advantages in minimum machining allowances, lower material consumption and good service properties. But the forming quality of precision forgin... Half axle gears is produced by precision forging popularly because of the advantages in minimum machining allowances, lower material consumption and good service properties. But the forming quality of precision forging is difficult to control. Many simulations and analysis of precision forging process were taken by previous researchers. But no concrete method is proposed to evaluate and optimize the forming quality of half axel gears. The primary purpose of this work is improving the forming quality of half axel gears by analyzing and optimizing the affected factors of forming quality. The enclosed-die warm forging process of half axle gears was developed, and a new type of die-set used on double action hydraulic press was brought forward. The main influential factors of precision forming quality were analyzed after the forming process had been simulated by using finite element method(FEM). These factors include die structure, web thickness and web position. A method used to evaluate the forming quality was established, which investigated the maximal forming load, the metal filling rate and the material damage factor. The FEM simulations of half axle gears precision forging were evaluated by this method. The results show that the best forming quality can be achieved when the punches were added with bosses, the web located at the middle plant of the gear, and the web thickness was 30 percent of the inner hole diameter. Verification experiments taking the above optimized parameters were performed on a 7.8 MN double action hydraulic press. The trial products were formed well. And their geometric precision meets the demand. The verification result shows that the optimization of the influential factors, according to the simulations and the evaluation method, can improve the forming quality. The new structure of precision forging die-set and the new evaluation method guarantee a high forming quality ofhalfaxel gears. 展开更多
关键词 warm precision forging half axle gears forming quality die structure WEB
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凝血因子Ⅷ、血小板反应蛋白1及可溶性Axl受体酪氨酸激酶在慢性肾小球肾炎患者中的表达情况及诊断价值 被引量:5
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作者 陈聪永 程莉 《广西医学》 CAS 2023年第1期25-29,共5页
目的分析慢性肾小球肾炎(CGN)患者血浆凝血因子Ⅷ(FⅧ)、血小板反应蛋白1(TSP-1)及可溶性Axl受体酪氨酸激酶(sAxl)水平,并探讨三者对CGN的诊断价值。方法选取63例CGN患者作为研究组,55例健康体检者作为对照组。比较两组研究对象的一般... 目的分析慢性肾小球肾炎(CGN)患者血浆凝血因子Ⅷ(FⅧ)、血小板反应蛋白1(TSP-1)及可溶性Axl受体酪氨酸激酶(sAxl)水平,并探讨三者对CGN的诊断价值。方法选取63例CGN患者作为研究组,55例健康体检者作为对照组。比较两组研究对象的一般临床资料,以及血浆FⅧ活性、TSP-1水平、sAxl水平。分析CGN患者血浆FⅧ活性、TSP-1水平和sAxl水平与肾功能的相关性。采用受试者工作特征曲线分析FⅧ、TSP-1及sAxl对CGN的诊断价值。结果与对照组相比,研究组患者的24 h尿蛋白水平、血尿素氮水平、血肌酐水平、血尿酸水平、血浆FⅧ活性、血浆TSP-1水平、sAxl水平均升高,肾小球滤过率(GFR)降低(均P<0.05)。CGN患者血浆FⅧ活性及TSP-1、sAxl水平与血尿素氮水平、血肌酐水平、血尿酸水平均呈正相关,与GFR均呈负相关(均P<0.05)。血浆FⅧ活性、TSP-1水平、sAxl水平单独检测及联合检测诊断CGN的灵敏度分别为87.30%、77.78%、85.71%、84.13%,特异度分别为56.36%、50.91%、58.18%、61.82%,曲线下面积分别为0.724、0.719、0.702、0.793。结论CGN患者血浆FⅧ活性及TSP-1、sAxl水平明显升高,且与肾功能具有一定相关性,三者联合检测对CGN具有较高的诊断价值。 展开更多
关键词 慢性肾小球肾炎 凝血因子Ⅷ 血小板反应蛋白1 可溶性axl受体酪氨酸激酶 诊断价值
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A new method of welding with trailing peening for controlling welding stress and distortion 被引量:2
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作者 赵建国 李建昌 +3 位作者 郝建军 马跃进 蒋辉 王会强 《China Welding》 EI CAS 2009年第2期65-69,共5页
In order to control welding stress and distortion, a new welding with trailing peening method based on the electromagnetic hammer was developed. This method uses the idea of constant frequency pulse width modulation f... In order to control welding stress and distortion, a new welding with trailing peening method based on the electromagnetic hammer was developed. This method uses the idea of constant frequency pulse width modulation for designing the control circuit of peening force and peening freqneney. The peening force can be adjusted between 0 and 1 000 N and the peening frequency ranges from 0 to 25 Hz. Peening force is applied to the weld metal and the weld toe during the welding by peening head. The experiments show that the method is portable and flexible, and it can adjust the distribution state of welding residual stress, making grain refinement. When the peening force is changed to 700 N and the peening frequency to 3 Hz, both the transverse and longitudinal residual stresses will drop obviously. 展开更多
关键词 welding with trailing peening welding stress peening force peening frequency
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Controlling delayed cracks in welded joints of MCQTT steel by welding with trailing impacting and rolling 被引量:2
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作者 刘殿宝 杨建国 +2 位作者 潘海博 方洪渊 吴林 《China Welding》 EI CAS 2012年第2期33-37,共5页
30CrMnSi, one kind of the medium-carbon quenching and tempering steel( MCQTT) , has been widely utilized in some industrial fields. However, just like some other MCQTT, this kind of steel also faces such problem as ... 30CrMnSi, one kind of the medium-carbon quenching and tempering steel( MCQTT) , has been widely utilized in some industrial fields. However, just like some other MCQTT, this kind of steel also faces such problem as delayed cracking in its welded joints. In this paper, the delayed cracking and microstructure of the joints of 30CrMnSi steel were researched by SEM. Moreover, a method called welding with trailing impacting and rolling (WTIR) was utilized to solve the delayed cracking problem by decreasing the residual welding stress in the joint of 30CrMnSi. The crack-free joints of 30CrMnSi steel were obtained by using optimized parameters. 展开更多
关键词 welding with trailing impacting and rolling delayed cracking welding residual stress MCQTY
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A general model for trailing edge serrations simulation on wind turbine airfoils 被引量:3
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作者 Huijing Cao Mingming Zhang +1 位作者 Yinan Zhang Teng Zhou 《Theoretical & Applied Mechanics Letters》 CSCD 2021年第4期236-244,共9页
Trailing edge serrations(TESs)are capable of noticeably suppressing the turbulent trailing edge noise induced by rotating wind turbine blades and become an integral part of a blade.However,the challenges involved in t... Trailing edge serrations(TESs)are capable of noticeably suppressing the turbulent trailing edge noise induced by rotating wind turbine blades and become an integral part of a blade.However,the challenges involved in the dimensional design of serration height 2 h,wavelengthλand flap angleϕare yet to be dealt with in a satisfactory manner.To address the problem,a general model for simulating the effects of serrations on the hydrodynamic and aeroacoustic performance is proposed due to its ease of use and relatively low requirements for user input.The solid serrations are replicated by momentum sources calculated by its aerodynamic forces.Then,a case relevant to wind turbine airfoil is examined,a hybrid improved delay detached eddy simulation(IDDES)method coupled with FW-H integration is deployed to obtain the flow features and far-field sound pressure level.It is found that the modeling method could reproduce the flow field and noise as serrated airfoil. 展开更多
关键词 Wind turbine airfoil trailing edge serrations trailing edge noise Modeling method
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