New type of substituted 1H-pyrazole-4-carboxamides were obtained byregioselective synthesis under the catalysis of different bases. The structures of the titlecompounds were confirmed by elemental analysis, ~1H NMR, I...New type of substituted 1H-pyrazole-4-carboxamides were obtained byregioselective synthesis under the catalysis of different bases. The structures of the titlecompounds were confirmed by elemental analysis, ~1H NMR, IR, MS and X-ray crystallography. Compounds1 were transacylated into their corresponding amides 3 in the presence of sodium hydride.Preliminary bioassays indicated that some compounds showed fungicidal activities against Rhizoctoniasolani and Sclerotinia sclerotiorum.展开更多
The syntheses of 5-substituted-3-[( 2’ R, 4’ R)-4 ’ -hydroxy-2 ’ -hydroxymethyltetra-hydrofuran-4’ -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazol...The syntheses of 5-substituted-3-[( 2’ R, 4’ R)-4 ’ -hydroxy-2 ’ -hydroxymethyltetra-hydrofuran-4’ -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization.展开更多
文摘New type of substituted 1H-pyrazole-4-carboxamides were obtained byregioselective synthesis under the catalysis of different bases. The structures of the titlecompounds were confirmed by elemental analysis, ~1H NMR, IR, MS and X-ray crystallography. Compounds1 were transacylated into their corresponding amides 3 in the presence of sodium hydride.Preliminary bioassays indicated that some compounds showed fungicidal activities against Rhizoctoniasolani and Sclerotinia sclerotiorum.
文摘The syntheses of 5-substituted-3-[( 2’ R, 4’ R)-4 ’ -hydroxy-2 ’ -hydroxymethyltetra-hydrofuran-4’ -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization.
