基于0-1膨胀二项分布的客观贝叶斯分析

在医疗卫生、金融证券等应用领域,经常会同时出现零观测值、一观测值较多的情况。为更好地拟合这类数据,提出一种0-1膨胀二项分布模型并进行客观贝叶斯分析。采用数据扩充策略,基于完全似然函数,得到Jeffreys先验和reference先验。采用WinBUGS软件和R软件进行数值模拟,设定不同的样本量和参数真值,对不同的无信息先验进行评估。对2020年1月28日与2月22日COVID-19死亡人数进行分析,结果表明,在小样本情形下基于客观贝叶斯先验π_(R3)下的拟合效果比π_(R1)和π_(R2)要好。

Evaluation of the Dietary Reference Intakes for Japanese (2010 Edition): Recommended Protein, Pantothenic acid, Vitamin D, and Iron Intakes for Breast-Fed Infants Aged 6 - 11 Months

Objective: With regard to the 2010 edition of Dietary Reference Intakes for Japanese (DRIs-2010), we investigated whether the DRIs for two age groups, breast-fed infants aged 6-8 and 9-11 months, can be fulfilled for every nutrient in actual dietary practice. Design: We evaluated (1) whether the DRIs for all nutrients can be fulfilled in a formula with energy and protein exceeding their DRIs, (2) whether the DRIs for all nutrients can be fulfilled in a formula prepared in accordance with Japanese government-recommended weaning guidelines, and (3) what kinds of formulas can be prepared if the DRIs for all nutrients are fulfilled without referring to the weaning guidelines. Setting: Simulation of diet menu on the basis of published data in our university and survey of diet menu in a university hospital attached to a national medical school. Subjects: The three types of formulas were planned for ten days. Results: It was impossible to simultaneously fulfil the DRIs for 6 - 8-month-old infants concerning pantothenic acid, vitamin D, and iron and those for 9 - 11-month-old infants concerning these nutrients plus protein. Conclusion: According to the DRIs-2010, the DRI for all nutrients could not be fulfilled in an ingestible formula.

Performance of Twelve Mass Transfer Based Reference Evapotranspiration Models under Humid Climate

Reference evapotranspiration is very important parameter in the hydrological, agricultural and environmental studies and is accurately estimated by the FAO Penman-Monteith equation (FAO-PM) under different climatic conditions. However, due to data requirement of the FAO-PM equation, there is a need to investigate the applicability of alternative ETo equations under limited data. The objectives of this study were to evaluate twelve mass transfer based reference evapotranspiration equations and determine the impact of ETo equation on long term water management sustainability in Tanzania and Kenya. The results showed that the Albrecht, Brockamp-Wenner, Dalto, Meyer, Rohwer and Oudin ETo equations systematically overestimated the daily ETo at all weather stations with relative errors that varied from 34% to 94% relative to the FAO-PM ETo estimates. The Penman, Mahringer, Trabert, and the Romanenko equations performed best across Tanzania and the South Western Kenya with root mean squared errors ranging from 0.98 to 1.48 mm/day, which are relatively high and mean bias error (MBE) varying from -0.33 to 0.02 mm/day and the absolute mean error (AME) from 0.79 to 1.16 mm/day. For sustainable water management, the Trabert equation could be adopted at Songea, the Mahringer equation at Tabora, the Dalton and/or the Rohwer equations at Eldoret, the Romanenko equation at Dodoma, Songea and Eldoret. However, regional calibration of the most performing equation could improve water management at regional level.

Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal carcinoma prognosis

BACKGROUND Rectal carcinoma(RC),one of the most common malignancies globally,presents an increasing incidence and mortality year by year,especially among young people,which seriously affects the prognosis and quality of life of patients.At present,dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum carbohydrate antigen 19-9(CA19-9)and CA125 Levels have been used in clinical practice to evaluate the T stage and differentiation of RC.However,the accuracy of these evaluation modalities still needs further research.This study explores the application and value of these methods in evaluating the T stage and differentiation degree of RC.AIM To analyze the diagnostic performance of DCE-MRI parameters combined with serum tumor markers(TMs)in assessing pathological processes and prognosis of RC patients.METHODS A retrospective analysis was performed on 104 RC patients treated at Yantai Yuhuangding Hospital from May 2018 to January 2022.Patients were categorized into stages T1,T2,T3,and T4,depending on their T stage and differentiation degree.In addition,they were assigned to low(L group)and moderate-high differentiation(M+H group)groups based on their differentiation degree.The levels of DCE-MRI parameters and serum CA19-9 and CA125 in different groups of patients were compared.In addition,the value of DCE-MRI parameters[volume transfer constant(Ktrans),rate constant(Kep),and extravascular extracellular volume fraction(Ve)in assessing the differentiation and T staging of RC patients was discussed.Furthermore,the usefulness of DCE-MRI parameters combined with serum CA19-9 and CA125 Levels in the evaluation of RC differentiation and T staging was analyzed.RESULTS Ktrans,Ve,CA19-9 and CA125 were higher in the high-stage group and L group than in the low-stage group and M+H Group,respectively(P<0.05).The areas under the curve(AUCs)of the Ktran and Ve parameters were 0.638 and 0.694 in the diagnosis of high and low stages,respectively,and 0.672 and 0.725 in diagnosing moderate-high and low differentiation,respectively.The AUC of DCE-MRI parameters(Ktrans+Ve)in the diagnosis of high and low stages was 0.742,and the AUC in diagnosing moderate-high and low differentiation was 0.769.The AUCs of CA19-9 and CA-125 were 0.773 and 0.802 in the diagnosis of high and low stages,respectively,and 0.834 and 0.796 in diagnosing moderate-high and low differentiation,respectively.Then,we combined DCE-MRI(Ktrans+Ve)parameters with CA19-9 and CA-125 and found that the AUC of DCE-MRI parameters plus serum TMs was 0.836 in the diagnosis of high and low stages and 0.946 in the diagnosis of moderate-high and low differentiation.According to the Delong test,the AUC of DCE-MRI parameters plus serum TMs increased significantly compared with serum TMs alone in the diagnosis of T stage and differentiation degree(P<0.001).CONCLUSION The levels of the DCE-MRI parameters Ktrans and Ve and the serum TMs CA19-9 and CA125 all increase with increasing T stage and decreasing differentiation degree of RC and can be used as indices to evaluate the differentiation degree of RC in clinical practice.Moreover,the combined evaluation of the above indices has a better effect and more obvious clinical value,providing important guiding importance for clinical condition judgment and treatment selection.

欧博Reference L9-1.0黑胶唱片播放机

为使音乐爱好者能够更好地领略LP唱片的非凡魅力,欧博特别开发了Ref LP-1.0重型转盘。这个转盘的设计是独特的,出色的音乐感和深刻的情感表现是Ref LP-1.0最为突出的特点。 Reference LP-1.0是中国第一台Hi-End级黑胶唱片播放系统。它由转盘、唱臂及唱头三部分组成。转盘部分按照当今世界最高级的转盘设计思路,采用白色亚克力(有机玻璃,与黑胶唱片相近的材料)加工而成转盘,有助于平衡谐振频率,使声音更加自然。基座由镁铝合金经特殊的锻造工艺及高精度CNC机床加工而成。厚重的基座有利于降低谐振频率点,使播放音乐时低频更加清晰。

Interfacial stress transfer behavior in a specially-shaped fiber/matrix pullout test

Specially designed fibers are widely used in engineering practice because the specially-designed shape can help to improve the bonding strength of the fiber and the interface. Studied in this paper is the interfacial shear stress transfer behavior on both sides of the specially designed fiber when it is being pulled out; in which automatic analysis of three-dimensional photoelasticity is employed and the finite element method is adopted. The results show that the stress transfer occurs mainly in the region near the fiber＇s embedded end where the stress reaches its critical point, leading to debonding of the interface. Before debonding, as the pullout loading increases, the peak value of shear stress transfers along the fiber from the embedded end to the interior of the matrix, and then stops at the hooked part of the fiber because of its impediment. When the interface begins to debond as the load increases, the shear stress can be transferred to the hooked part.

Kinetic Study of Atom Transfer Radical Polymerization of 2-(N,N-Dimethylamino)ethyl Methacrylate

A kinetic model was developed to describe the atom transfer radical polymerization (ATRP) of 2(N,N-dimethylarnino) ethyl methacrylate (DMAEMA). The model was based on a polymerization mechanism, which included the atom transfer equilibrium for primary radical, the propagation of growing polymer radical, and the atom transfer equilibrium for the growing polymer radical. An experiment was carried out to measure the conversion of monomer, the number-average molecular weight of polymer and molecular weight distribution for the ATRP process of DMAEMA. The experimental data were used to correlate the kinetic model and rate constants were obtained. The rate constants of activation and deactivation in the atom transfer equilibrium for primary radical are 1.0 x 10(4) L(.)mol(-1.)s(-1) and 0.04 L(.)mol(-1.)s(-1), respectively. The rate constant of the propagation of growing polymer radical is 8.50 L(.)mol(-1.)s(-1), and the rate constants of activation and deactivation in the atom transfer equilibrium for growing polymer radical are 0.045 L(.)mol(-1.)s(-1) and 1.2 x 10(5) L(.)mol(-1.)s(-1), respectively. The values of the rate constants represent the features of the ATRP process. The kinetic model was used to calculate the ATRP process of DMAEMA. The results show that the calculations agree well with the measurements.

Synthesis and characterization of Ca2Sn1-xCexO4 with blue luminescence originating from Ce^4＋ charge transfer transition

Ce^4＋-doped Ca2SnO4 with a one-dimensional structure, which emits bright blue light, is prepared by using a solid-state reaction method. The x-ray diffraction results show that the Ce^4＋ ions doped in Ca2SnO4 occupy the Sn^4＋ sites. The excitation and emission spectra of Ca2Sn1-xCexO4 appear to have broad bands with peaks at - 268nm and -442nm, respectively. A long excited-state lifetime （-83μs） for the emission from Ca2Sn1-xCexO4 suggests that the luminescence originates from a ligand-to-metal Ce^4＋ charge transfer （CT）. The luminescent properties of Ca2Snl_xCexO4 have been compared with those of Sr2CeO4, which is the only material reported so far to show Ce^4＋ CT luminescence. More interestingly, it is observed that the emission intensity of Ca2Sn1-xCexO4 with a small doping concentration （x - 0.03） is comparable to that of Sr2CeO4 in which the concentration of active centre is 100%.

Seasonally Varying Reference Atmospheres for East Asia

Vertical profiles of seasonally varying pressure, temperature, water vapor, and trace gases （O3, N2O, CO, CH4）, representing atmospheric conditions up to a height of 100 km over the East Asia region （30°-50°N, 110°-150°E） were constructed by using various observation data, model outputs of atmospheric thermodynamic parameters, and gaseous concentrations. Optical characteristics of the obtained East Asia reference atmospheres were compared with those from typical midlatitude summer and winter atmospheres. It was noted that, in the water vapor field, there are major differences between the two model atmospheres during the summer. The resultant impact during the summer of water vapor difference on incoming solar fluxes at the surface and emitted terrestrial fluxes at the top of the atmosphere are 14.3 W m^-2 and 6.5 W m^-2, respectively. On the other hand, the winter difference between East Asian and midlatitude atmospheres appears to be insignificant. Reference atmospheres for the spring and fall are also available. Utilizing the constructed atmospheric profiles as inputs to the radiative transfer model, it is expected that the constructed seasonally varying reference atmospheres can facilitate better descriptions of optical properties in East Asia.

2.0-μm emission and energy transfer of Ho^(3+)/Yb^(3+) co-doped LiYF_4 single crystal excited by 980 nm

Ho3＋/yb3＋ co-doped LiYF4 single crystals with various Yb3＋ concentrations and ,-~ 0.98 mol% Ho3＋ concentration are grown by the Bridgman method under the conditions of taking LiF and YF3 as raw materials and a temperature gradient （40 ~C/cm-50 ~C/cm） for the solid-liquid interface. The luminescent performances of the crystals are investigated through emission spectra, infrared transmittance spectrum, emission cross section, and decay curves under excitation by 980 nm. Compared with the Ho3＋ single-doped LiYF4 crystal, the Ho3＋/yb3＋ co-doped tiYf4 single crystal has an obviously enhanced emission band from 1850 nm to 2150 nm observed when excited by a 980-nm diode laser. The energy transfer from Yb3＋ to Ho3＋ and the optimum fluorescence emission around 2.0 p-m of Ho3＋ ions are investigated. The maximum emission cross section of the above sample at 2.0 p.m is calculated to be 1.08 × 10-20 cm2 for the LiYF4 single crystal of 1-mol% Ho3＋ and 6-mo1% Yb3＋ according to the measured absorption spectrum. The high energy transfer efficiency of 88.9% from Yb3＋ to Ho3＋ ion in the sample co-doped by Ho3＋ （1 mol%） and Yb3＋ （8 tool%） demonstrates that the Yb3＋ ions can efficiently sensitize the Ho3＋ ions.

Room Temperature Phosphorescence pH Switch Based on Photo-induced Electron Transfer

In this paper, photoinduced electron transfer(PET) phosphoroionophore, N-(1-bromo- 2-naphthylmethyl)-diethanolamine (BND) was synthesized and its phosphorescent characteristics were studied. The experimental results showed that strong phosphorescence could be observed in b-cyclodextrin aqueous solution only at low pH value. This system combined AND and NOT function to produce a three-input inhibit (INH) logic gate.

Theoretical Study of the Isomerization Reaction of 1-3 H Transfer on Formamidine Substituted by Halogen

The ab initio method has been used to study the 1-3 H transfer reaction on formamidine substituted by halogen. The calculation results show that the substituted halogen has two effects on the 1-3 H transfer reaction: decreasing the activation energy and stabilizing the C=N double bond owing to the conjugative effect of p-π-p of products and transition states.

Improvement in the calculation of anti-Stokes energy transfer and experimental justification based on Er_(0.01)Yb_xY_(1 0.01 x)VO_4 crystal

The improvement on the calculation of anti-Stokes energy transfer rate is studied in the present work. The additional proportion coefficient between Stokes and anti-Stokes light intensities of quantum Raman scattering theory as compared with the classical Raman theory is introduced to successfully describe the anti-Stokes energy transfer. The theoretical formula for the improvement on the calculation of anti-Stokes energy transfer rate is derived for the first time in this study. The correctness of introducing coefficient exp{△E/kT} from well-known Raman scatter theory is demonstrated also. Moreover, the experimental lifetime measurement in Er0.01YbxY1-0.01-xVO4 crystal is performed to justify the validity of our important improvement in the original phonon-assisted energy transfer theory for the first time.

Nondoped-type White Organic Light-Emitting Diode Using Star-Shaped Hexafluorenylbenzene as an Energy Transfer Layer

White organic light-emitting diodes （WOLEDs） with a structure of indium-tin-oxide （ITO）/N,N＇-bis- （1-naphthyl）-N,N＇-diphenyl- （1, 1＇-biphenyl）-4,4＇-diamine （NPB）/1,2,3,4,5,6-hexakis（9,9-diethyl-9H-fluoren-2- yl）benzene （HKEthFLYPh）/5,6,11,12-tetraphenylnaphtacene （rubrene）/tris（8-hydroxyquinoline） aluminum （Alq3）/Mg：Ag were fabricated by vacuum deposition method, in which a novel star-shaped hexafluorenyl- benzene HKEthFLYPh was used as an energy transfer layer, and an ultrathin layer of rubrene was inserted between HKEthFLYPh and Alq3 layers as a yellow light-emitting layer instead of using a time-consuming doping process. A fairly pure WOLED with Commissions Internationale De L＇Eclairage （CIE） coordinates of （0.32, 0.33） was obtained when the thickness of rubrene was 0.3 nm, and the spectrum was insensitive to the applied voltage. The device yielded a maximum luminance of 4816 cd/m2 at 18 V.

Charge Transfer Properties in MEH-PPV/PS:MWCNTs Nanocomposites

The effect of composition and annealing temperature on charge transfer properties, in a donor/acceptor nanocomposites based on poly (2-methoxy-5-(2-ethyhexyl-oxy)-p-phenylenevinylene) (MEH-PPV) and MWCNTs functionalized with Polystyrene (PS:MWCNTs), have been investigated. The quenching of photoluminescence (PL) intensity of pure MEH-PPV, by adding different amounts of functionalized carbon nanotubes, exhibits that a photoinduced charge transfer has been occurred. Charge transfer efficiency was obtained for an acceptable concentration of PS:MWCNTs about 0.5 wt% and at annealed temperature of about 80℃. Quenching efficiency studies imply that MEH-PPV/PS:MWCNTs nanocomposites reveal a high degree of PL quenching, reaching a value of η = 76.9%.

时间传递链路闭合钟差处理方法与性能分析

守时实验室和全球卫星导航系统(GNSS)维持的时间基准都通过不同溯源链路溯源至UTC(k),k为实验室代号。目前主流溯源方式包括光纤时间传递、卫星双向时间传递和GNSS共视时间传递。通过对不同溯源链路构造闭环钟差模型,利用间接平差修正各溯源链路钟差,消除了不同链路中存在在系统差和周期项等误差,提升了时间传递精度。采用5个时频站中8条独立不同溯源链路的钟差实测数据的对算法进行验证,结果表明:由于存在未消除空间误差的影响,卫星双向时间传递和GNSS共视时间传递在长基线条件下都存在明显的周期项,通过对溯源链路的平差修正,消除了溯源钟差不闭合的问题。通过对钟差的二次多项式拟合得到的残差计算,GNSS共视时间传递噪声由0.43ns降低至0.25 ns,卫星双向时间传递噪声0.21 ns降低至0.14 ns,光纤时间传递噪声由0.18 ns降低至0.12 ns。通过提升各溯源链路的时间传递精度,有效地改善了各时间基准的服务能力。

星间时间传递亚ps传播时延与不连续测量Allan方差的修正

星间信号非对称传播路径引起卫星接收信号时刻发生非相等延迟,需要在时间传递钟差解算过程中予以精确修正.通过分析钟差观测方法,对卫星运动引起的非对称传播时延进行归算,应用时间传递函数方法分项评估相对论性光线偏折引起的传播时延以及评估时延修正残差的附加稳定度,在当前定轨条件下传播时延修正精度可达亚ps量级.针对星间时频比对数据缺失的影响,拓展了Allan方差的自相关函数表示,提出采用统计方法分别计算不同幂律噪声的稳定度修正系数,分析了比对数据缺失对不同幂律噪声稳定度计算的影响.总体上提出一种星间时频比对传播时延与不连续测量Allan方差修正的系统性方法,可用于ps级星间时间传递的钟差修正.

Asymmetric Transfer Hydrogenation of Stable NH Imines for the Synthesis of Enantiopure α-Chiral Primary Amines

Although it offers a direct route to access synthetically valuableα-chiral primary amines,asymmetric transfer hydrogenation of NH imines has been rarely studied,due in large part to the inaccessibility and instability of NH imines.Herein,we report a Rh-catalyzed asymmetric transfer hydrogenation of a kind of novel and stable NH imines which are prepared via condensation of easily available sulfonylated 2'-aminoacetophenones with NH3 in methanol.With this method,enantioenriched chiral 2-(1-aminoalkyl)anilines,which are privileged pharmacore groups,have been synthesized with good functional group compatibility,and with up to 99%ee.A gram-scale reaction using 0.2 mol%of catalyst has been successfully performed to highlight the practicality.Furthermore,the products can be derivatized into enantiopure bioactive molecules as well as chiral tridentate ligands for metal catalysis.

一种天地一体时间基准建立模式的思考

随着低轨卫星导航系统、卫星物联网、远程时间比对等技术的发展,分布广泛的原子钟资源为构建天地一体时间基准提供了基础条件。根据原子钟位置不同,可将时间基准建立模式分为地面时间基准和天地一体时间基准。介绍各种模式的框架结构、设备构成、运行机制,分析了各种模式的异同。从数据融合、数据预处理、守时算法、实时信号控制等4个方面梳理了关键技术,为时间基准建立提供研究切入点。

基于细节增强框架的图像超分辨率算法

基于参考图像的图像超分辨率(Ref-SR)技术将高分辨率(HR)参考图像导入单输入图像超分辨率(SISR)方法中,利用参考图像中转移的纹理缓解了此方法中长期存在的不适定问题。尽管定量和定性结果的显著提升已经验证了Ref-SR方法的优越性,但在纹理转移之前存在的不对齐问题表明该方法中还有进一步提高性能的空间。现有方法忽视了在对齐特征时细节的重要性,因此没有充分利用低分辨率(LR)图像中包含的信息。文中提出一种基于细节增强框架(DEF)的参考图像超分辨率方法,该方法引入扩散模型来生成和增强LR图像中的潜在细节。如果参考图像中存在对应部分,设计方法可以使得图像特征的对齐更为准确;在参考图像缺少对应部分的情况下,LR图像中的细节仍然得到了增强,同时避免了参考图像转移错误纹理的影响。大量实验表明,提出的方法相比于以往方法在数值结果相仿的前提下取得了优越的视觉效果。